DNAAF4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNAAF4
Entrez Gene ID	161582
Full Name	dynein axonemal assembly factor 4
Synonyms	CILD25,DYX1,DYX1C1,DYXC1,EKN1,RD
General protein information	Preferred Names dynein axonemal assembly factor 4 Names dynein assembly factor 4, axonemal dyslexia susceptibility 1 candidate 1 dyslexia susceptibility 1 candidate gene 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q21.3
Summary	This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011].
Disorder MIM:	608706
Disorder Html:	{Dyslexia, susceptibility to, 1}, 127700 (3); Ciliary dyskinesia, primary, 25, 615482 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_130810.4	NP_570722.2	dynein assembly factor 4, axonemal isoform a
NM_001033560.1	NP_001028732.1	dynein assembly factor 4, axonemal isoform c
NM_001033559.2	NP_001028731.1	dynein assembly factor 4, axonemal isoform b
NM_130810.3	NP_570722.2	dynein assembly factor 4, axonemal isoform a

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DYX1C1	NP_001009083.1
Mus musculus (house mouse)	Dyx1c1	NP_080590.3
Danio rerio (zebrafish)	dyx1c1	NP_991251.1
Xenopus tropicalis (tropical clawed frog)	dyx1c1	NP_001011174.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001727	XP_001238468.1
Homo sapiens (human)	DYX1C1	NP_570722.2
Bos taurus (cattle)	DYX1C1	NP_001193117.1
Canis lupus familiaris (dog)	DYX1C1	XP_005638492.1
Rattus norvegicus (Norway rat)	Dyx1c1	NP_001007011.1
Gallus gallus (chicken)	DYX1C1	NP_001008674.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects.
Paff T, Loges NT, Aprea I, Wu K, Bakey Z, Haarman EG, Daniels JMA, Sistermans EA, Bogunovic N, Dougherty GW, H?ben IM, Gro?e-Onnebrink J, Matter A, Olbrich H, Werner C, Pals G, Schmidts M, Omran H, Micha D
American journal of human genetics100(1)160-168(2017 Jan)

Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.
Tammimies K, Bieder A, Lauter G, Sugiaman-Trapman D, Torchet R, Hokkanen ME, Burghoorn J, Castr?n E, Kere J, Tapia-P?ez I, Swoboda P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3578-3587(2016 10)

Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.
Massinen S, Tammimies K, Tapia-P?ez I, Matsson H, Hokkanen ME, S?derberg O, Landegren U, Castr?n E, Gustafsson JA, Treuter E, Kere J
Human molecular genetics18(15)2802-12(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that endogenous DYX1C1 localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium
Title: Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.

promoter SNP rs12899331 of DYX1C1 may contribute towards the manifestation of DD. This study supports the association of DYX1C1 with DD in an Indian population
Title: Association of SNPs of DYX1C1 with developmental dyslexia in an Indian population.

DYX1C1 is required for axonemal dynein assembly and ciliary motility.
Title: DYX1C1 is required for axonemal dynein assembly and ciliary motility.

The results of this study do not provide evidence for association between the putatively functional single nucleotide polymorphisms -3G/A and 1249G/T in DYX1C1 and reading disabilities.
Title: A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1.

Gene-by-environment effects were found between some specified environmental moderators (i.e. maternal smoke during pregnancy, birth weight and socio-economic status) and the DYX1C1-1259C/G marker
Title: An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes.

The following DNAAF4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNAAF4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20216	NM_130810.4 Latest version!	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu18539	NM_001033560.1 Latest version!	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu20271	NM_001033559.2 Latest version!	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu20216	NM_130810.3	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNAAF4 ( NM_130810.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_570722.2 Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20216
Clone ID Related Accession (Same CDS sequence)	NM_130810.4 , NM_130810.3
Accession Version	NM_130810.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	dynein assembly factor 4, axonemal isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF337549.1, AK095201.1 and BC017392.1. On May 17, 2019 this sequence version replaced NM_130810.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF337549.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000321149.7/ ENSP00000323275.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGCA CTGGAATTAT TGATGCCACC TGTTACAGAC 
AATGCTAATG CAAGAATGAA GGCACATGTA CGACGTGGAA CAGCATTCTG TCAACTAGAA 
TTGTATGTAG AAGGCCTACA GGATTATGAA GCGGCACTTA AGATTGATCC ATCCAACAAA 
ATTGTACAAA TTGATGCTGA GAAGATTCGG AATGTAATTC AAGGAACAGA ACTAAAATCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570722.2
CDS	369..1631
Translation	MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNKIVQIDAEKIRNVIQGTELKS

Target ORF information:

RefSeq Version	NM_130810.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130810.4

ORF Insert Sequence:

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGCA CTGGAATTAT TGATGCCACC TGTTACAGAC 
AATGCTAATG CAAGAATGAA GGCACATGTA CGACGTGGAA CAGCATTCTG TCAACTAGAA 
TTGTATGTAG AAGGCCTACA GGATTATGAA GCGGCACTTA AGATTGATCC ATCCAACAAA 
ATTGTACAAA TTGATGCTGA GAAGATTCGG AATGTAATTC AAGGAACAGA ACTAAAATCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNAAF4 ( NM_130810.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_570722.2 Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20216
Clone ID Related Accession (Same CDS sequence)	NM_130810.4 , NM_130810.3
Accession Version	NM_130810.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	dynein assembly factor 4, axonemal isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF337549.1, AK095201.1 and BC017392.1. On or before Aug 31, 2013 this sequence version replaced XM_005254197.1, NM_130810.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF337549.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGCA CTGGAATTAT TGATGCCACC TGTTACAGAC 
AATGCTAATG CAAGAATGAA GGCACATGTA CGACGTGGAA CAGCATTCTG TCAACTAGAA 
TTGTATGTAG AAGGCCTACA GGATTATGAA GCGGCACTTA AGATTGATCC ATCCAACAAA 
ATTGTACAAA TTGATGCTGA GAAGATTCGG AATGTAATTC AAGGAACAGA ACTAAAATCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570722.2
CDS	369..1631
Translation	MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNKIVQIDAEKIRNVIQGTELKS

Target ORF information:

RefSeq Version	NM_130810.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130810.3

ORF Insert Sequence:

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGCA CTGGAATTAT TGATGCCACC TGTTACAGAC 
AATGCTAATG CAAGAATGAA GGCACATGTA CGACGTGGAA CAGCATTCTG TCAACTAGAA 
TTGTATGTAG AAGGCCTACA GGATTATGAA GCGGCACTTA AGATTGATCC ATCCAACAAA 
ATTGTACAAA TTGATGCTGA GAAGATTCGG AATGTAATTC AAGGAACAGA ACTAAAATCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNAAF4 ( NM_001033560.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001028732.1 Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu18539
Clone ID Related Accession (Same CDS sequence)	NM_001033560.1
Accession Version	NM_001033560.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	dynein assembly factor 4, axonemal isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF337549.1, BC062564.1, AK095201.1 and BM971229.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2013 this sequence version replaced XM_005254198.1. Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC062564.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGAA TTCTGTTCTC TTGAGGGCAT TGAATGTCAG 
GCCTCTGAGC CCAAGCTAAG CCATCATATC CCTAGTGACC TGCACGTATA CATCCAGATG 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028732.1
CDS	369..1514
Translation	MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKEFCSLEGIECQASEPKLSHHIPSDLHVYIQMA

Target ORF information:

RefSeq Version	NM_001033560.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033560.1

ORF Insert Sequence:

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGAA TTCTGTTCTC TTGAGGGCAT TGAATGTCAG 
GCCTCTGAGC CCAAGCTAAG CCATCATATC CCTAGTGACC TGCACGTATA CATCCAGATG 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNAAF4 ( NM_001033559.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001028731.1 Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 2, mRNA.

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CloneID	OHu20271
Clone ID Related Accession (Same CDS sequence)	NM_001033559.2
Accession Version	NM_001033559.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	dynein assembly factor 4, axonemal isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF337549.1, AK095201.1 and BC017392.1. On or before Aug 31, 2013 this sequence version replaced XM_005254199.1, NM_001033559.1. Transcript Variant: This variant (2) lacks an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC017392.1, AK095201.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGCC TACAGGATTA TGAAGCGGCA CTTAAGATTG 
ATCCATCCAA CAAAATTGTA CAAATTGATG CTGAGAAGAT TCGGAATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028731.1
CDS	369..1499
Translation	MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAYRIMKRHLRLIHPTKLYKLMLRRFGM

Target ORF information:

RefSeq Version	NM_001033559.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein axonemal assembly factor 4 (DNAAF4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033559.2

ORF Insert Sequence:

ATGCCTCTTC AGGTTAGCGA TTACAGCTGG CAGCAGACGA AGACTGCGGT CTTTCTGTCT 
CTGCCCCTCA AAGGCGTGTG CGTCAGAGAC ACGGACGTGT TCTGCACGGA AAACTATCTG 
AAGGTCAACT TTCCTCCATT TTTATTTGAG GCATTTCTTT ATGCTCCCAT AGACGATGAG 
AGCAGCAAAG CAAAGATTGG GAATGACACC ATTGTCTTCA CCTTGTATAA AAAAGAAGCG 
GCCATGTGGG AGACCCTTTC TGTGACGGGT GTTGACAAAG AGATGATGCA AAGAATTAGA 
GAAAAATCTA TTTTACAAGC ACAAGAGAGA GCAAAAGAAG CTACAGAAGC AAAAGCTGCA 
GCAAAGCGGG AAGATCAAAA ATACGCACTA AGTGTCATGA TGAAGATTGA AGAAGAAGAG 
AGGAAAAAAA TAGAAGATAT GAAAGAAAAT GAACGGATAA AAGCCACTAA AGCATTGGAA 
GCCTGGAAAG AATATCAAAG AAAAGCTGAG GAGCAAAAAA AAATTCAGAG AGAAGAGAAA 
TTATGTCAAA AAGAAAAGCA AATTAAAGAA GAAAGAAAAA AAATAAAATA TAAGAGTCTT 
ACTAGAAATT TGGCATCTAG AAATCTTGCT CCAAAAGGGA GAAATTCAGA AAATATATTT 
ACTGAGAAGT TAAAGGAAGA CAGTATTCCT GCTCCTCGCT CTGTTGGCAG TATTAAAATC 
AACTTTACCC CTCGAGTATT CCCAACAGCT CTTCGTGAAT CACAAGTAGC AGAAGAGGAG 
GAGTGGCTAC ACAAACAAGC TGAGGCACGA AGAGCAATGA ATACTGACAT AGCTGAACTT 
TGCGATTTAA AAGAAGAAGA AAAGAACCCA GAATGGTTGA AGGATAAAGG AAACAAATTG 
TTTGCAACGG AAAACTATTT GGCAGCTATC AATGCATATA ATTTAGCCAT AAGACTAAAT 
AATAAGATGC CACTATTGTA TTTGAACCGG GCTGCTTGCC ACCTAAAACT AAAAAACTTA 
CACAAGGCTA TTGAAGATTC TTCTAAGGCC TACAGGATTA TGAAGCGGCA CTTAAGATTG 
ATCCATCCAA CAAAATTGTA CAAATTGATG CTGAGAAGAT TCGGAATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects.
American journal of human genetics100(1)160-168(2017 Jan)
Paff T,Loges NT,Aprea I,Wu K,Bakey Z,Haarman EG,Daniels JMA,Sistermans EA,Bogunovic N,Dougherty GW,H?ben IM,Gro?e-Onnebrink J,Matter A,Olbrich H,Werner C,Pals G,Schmidts M,Omran H,Micha D

Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3578-3587(2016 10)
Tammimies K,Bieder A,Lauter G,Sugiaman-Trapman D,Torchet R,Hokkanen ME,Burghoorn J,Castr?n E,Kere J,Tapia-P?ez I,Swoboda P

Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.
Human molecular genetics18(15)2802-12(2009 Aug)
Massinen S,Tammimies K,Tapia-P?ez I,Matsson H,Hokkanen ME,S?derberg O,Landegren U,Castr?n E,Gustafsson JA,Treuter E,Kere J

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DNAAF4 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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