DAP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DAP
Entrez Gene ID	1611
Full Name	death associated protein
General protein information	Preferred Names death associated protein Names death-associated protein 1 DAP-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p15.2
Summary	This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
Disorder MIM:	600954

mRNA and Protein(s)

mRNA	Protein	Name
NM_004394.3	NP_004385.1	death-associated protein 1 isoform 2
NM_001291963.1	NP_001278892.1	death-associated protein 1 isoform 1
NM_001291963.2	NP_001278892.1	death-associated protein 1 isoform 1
NM_004394.2	NP_004385.1	death-associated protein 1 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	DAP	NP_004385.1
Pan troglodytes (chimpanzee)	DAP	XP_001146746.1
Canis lupus familiaris (dog)	DAP	XP_849018.1
Bos taurus (cattle)	DAP	NP_001071526.1
Mus musculus (house mouse)	Dap	NP_666169.1
Gallus gallus (chicken)	DAP	NP_001026174.1
	DAP	XP_002804355.1
Rattus norvegicus (Norway rat)	Dap	NP_071971.1
Danio rerio (zebrafish)	dap	NP_571647.1
Xenopus tropicalis (tropical clawed frog)	dap	NP_001017164.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of the knockdown of death-associated protein 1 expression on cell adhesion, growth and migration in breast cancer cells.
Wazir U, Sanders AJ, Wazir A, Baig RM, Jiang WG, Ster IC, Sharma AK, Mokbel K
Oncology reports33(3)1450-8(2015 Mar)

Death associated protein 1 is correlated with the clinical outcome of patients with colorectal cancer and has a role in the regulation of cell death.
Jia Y, Ye L, Ji K, Toms AM, Davies ML, Ruge F, Ji J, Hargest R, Jiang WG
Oncology reports31(1)175-82(2014 Jan)

Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA, Boerwinkle E
Genetic epidemiology37(8)840-5(2013 Dec)

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, B?ning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, , Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC, Cho JH
Nature491(7422)119-24(2012 Nov)

The mRNA expression of DAP1 in human breast cancer: correlation with clinicopathological parameters.
Wazir U, Jiang WG, Sharma AK, Mokbel K
Cancer genomics & proteomics9(4)199-201(2012 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DAP1 may have an important role in cell adhesion, migration and growth in the context of breast cancer and has significant associations with the apoptosis pathway.
Title: Effect of the knockdown of death-associated protein 1 expression on cell adhesion, growth and migration in breast cancer cells.

DAP1 was found to be correlated with disease progression and long-term survival of the colorectal patients. DAP1 is also a pivotal regulator of the growth and apoptosis and cellular response to chemotherapy agents.
Title: Death associated protein 1 is correlated with the clinical outcome of patients with colorectal cancer and has a role in the regulation of cell death.

This study demonstrates an inverse association between DAP1 mRNA levels and tumour stage and clinical outcome in breast cancer
Title: The mRNA expression of DAP1 in human breast cancer: correlation with clinicopathological parameters.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Mapping of the phosphorylation sites and analysis of phosphorylation mutants indicated that DAP1 is functionally silenced in growing cells through mTOR-dependent phosphorylations on Ser3 and Ser51
Title: DAP1, a novel substrate of mTOR, negatively regulates autophagy.

The following DAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24526	NM_004394.3 Latest version!	Homo sapiens death associated protein (DAP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24567	NM_001291963.2 Latest version!	Homo sapiens death associated protein (DAP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu24567	NM_001291963.1	Homo sapiens death associated protein (DAP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu24526	NM_004394.2	Homo sapiens death associated protein (DAP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DAP ( NM_004394.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004385.1 Homo sapiens death associated protein (DAP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24526
Clone ID Related Accession (Same CDS sequence)	NM_004394.3 , NM_004394.2
Accession Version	NM_004394.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	death-associated protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC395850.1, BP265421.1 and BC002726.2. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_004394.2. Transcript Variant: This variant (2) has an additional exon in the coding region, which causes a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002726.2, SRR7346977.1185587.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGTCCACCTA AACCCACTGT GTTCATCTCT 
GGGGTCATCG CCCGGGGTGA CAAAGATTTC CCCCCGGCGG CTGCGCAGGT GGCTCACCAG 
AAGCCGCATG CCTCCATGGA CAAGCATCCT TCCCCAAGAA CCCAGCACAT CCAGCAGCCA 
CGCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004385.1
CDS	167..475
Translation	MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK

Target ORF information:

RefSeq Version	NM_004394.3
Organism	Homo sapiens(human)
Definition	Homo sapiens death associated protein (DAP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004394.3

ORF Insert Sequence:

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGTCCACCTA AACCCACTGT GTTCATCTCT 
GGGGTCATCG CCCGGGGTGA CAAAGATTTC CCCCCGGCGG CTGCGCAGGT GGCTCACCAG 
AAGCCGCATG CCTCCATGGA CAAGCATCCT TCCCCAAGAA CCCAGCACAT CCAGCAGCCA 
CGCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAP ( NM_004394.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004385.1 Homo sapiens death associated protein (DAP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24526
Clone ID Related Accession (Same CDS sequence)	NM_004394.3 , NM_004394.2
Accession Version	NM_004394.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	death-associated protein 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC395850.1, BP265421.1 and BC002726.2. This sequence is a reference standard in the RefSeqGene project. On Jun 28, 2007 this sequence version replaced NM_004394.1. Transcript Variant: This variant (2) has an additional exon in the coding region, which causes a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002726.2, SRR1163655.421476.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGTCCACCTA AACCCACTGT GTTCATCTCT 
GGGGTCATCG CCCGGGGTGA CAAAGATTTC CCCCCGGCGG CTGCGCAGGT GGCTCACCAG 
AAGCCGCATG CCTCCATGGA CAAGCATCCT TCCCCAAGAA CCCAGCACAT CCAGCAGCCA 
CGCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004385.1
CDS	208..516
Translation	MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK

Target ORF information:

RefSeq Version	NM_004394.2
Organism	Homo sapiens(human)
Definition	Homo sapiens death associated protein (DAP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004394.2

ORF Insert Sequence:

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGTCCACCTA AACCCACTGT GTTCATCTCT 
GGGGTCATCG CCCGGGGTGA CAAAGATTTC CCCCCGGCGG CTGCGCAGGT GGCTCACCAG 
AAGCCGCATG CCTCCATGGA CAAGCATCCT TCCCCAAGAA CCCAGCACAT CCAGCAGCCA 
CGCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAP ( NM_001291963.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278892.1 Homo sapiens death associated protein (DAP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24567
Clone ID Related Accession (Same CDS sequence)	NM_001291963.1 , NM_001291963.2
Accession Version	NM_001291963.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	death-associated protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC395850.1, BI823002.1 and BC002726.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298670.1, DC428766.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145245, SAMEA2147920 [ECO:0000350] ##Evidence-Data-END##

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGGGTGACAA AGATTTCCCC CCGGCGGCTG 
CGCAGGTGGC TCACCAGAAG CCGCATGCCT CCATGGACAA GCATCCTTCC CCAAGAACCC 
AGCACATCCA GCAGCCACGC AAGTGAGCCT GGAGTCCACC AGCCTGCCCC ATGGCCCCGG 
CTCTGCTGCA CTTGGTATTT CCCTGACAGA GAGAACCAGC AGTTTCGCCC AAATCCTACT 
CTGCTGGGAA ATCTAAGGCA AAACCAAGTG CTCTGTCCTT TGCCTTACAT TTCCATATTT 
AAAACTAGAA ACAGCTCCAG CCCAAACCTT GTTTATGGGG AGTCTGGTTG GATGTCATTT 
GAGGATCATT GTGCCCCTAG AGGTGCCATT AGCAGAATTT GCCAAGATCC GAGAAAAATT 
TTAGCTTTAG TTCTATTTCA GCAGTCACCT GACGTCCTTG TCTATGGTCT TAAAAACAAG 
AAGGCACACA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278892.1
CDS	208..822
Translation	MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPRVTKISPRRLRRWLTRSRMPPWTSILPQEPSTSSSHASEPGVHQPAPWPRLCCTWYFPDRENQQFRPNPTLLGNLRQNQVLCPLPYISIFKTRNSSSPNLVYGESGWMSFEDHCAPRGAISRICQDPRKILALVLFQQSPDVLVYGLKNKKAHI

Target ORF information:

RefSeq Version	NM_001291963.1
Organism	Homo sapiens(human)
Definition	Homo sapiens death associated protein (DAP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291963.1

ORF Insert Sequence:

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGGGTGACAA AGATTTCCCC CCGGCGGCTG 
CGCAGGTGGC TCACCAGAAG CCGCATGCCT CCATGGACAA GCATCCTTCC CCAAGAACCC 
AGCACATCCA GCAGCCACGC AAGTGAGCCT GGAGTCCACC AGCCTGCCCC ATGGCCCCGG 
CTCTGCTGCA CTTGGTATTT CCCTGACAGA GAGAACCAGC AGTTTCGCCC AAATCCTACT 
CTGCTGGGAA ATCTAAGGCA AAACCAAGTG CTCTGTCCTT TGCCTTACAT TTCCATATTT 
AAAACTAGAA ACAGCTCCAG CCCAAACCTT GTTTATGGGG AGTCTGGTTG GATGTCATTT 
GAGGATCATT GTGCCCCTAG AGGTGCCATT AGCAGAATTT GCCAAGATCC GAGAAAAATT 
TTAGCTTTAG TTCTATTTCA GCAGTCACCT GACGTCCTTG TCTATGGTCT TAAAAACAAG 
AAGGCACACA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAP ( NM_001291963.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278892.1 Homo sapiens death associated protein (DAP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24567
Clone ID Related Accession (Same CDS sequence)	NM_001291963.1 , NM_001291963.2
Accession Version	NM_001291963.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	death-associated protein 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC395850.1, BI823002.1 and BC002726.2. On Jun 2, 2019 this sequence version replaced NM_001291963.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298670.1, DC428766.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145245, SAMEA2147920 [ECO:0000350] ##Evidence-Data-END##

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGGGTGACAA AGATTTCCCC CCGGCGGCTG 
CGCAGGTGGC TCACCAGAAG CCGCATGCCT CCATGGACAA GCATCCTTCC CCAAGAACCC 
AGCACATCCA GCAGCCACGC AAGTGAGCCT GGAGTCCACC AGCCTGCCCC ATGGCCCCGG 
CTCTGCTGCA CTTGGTATTT CCCTGACAGA GAGAACCAGC AGTTTCGCCC AAATCCTACT 
CTGCTGGGAA ATCTAAGGCA AAACCAAGTG CTCTGTCCTT TGCCTTACAT TTCCATATTT 
AAAACTAGAA ACAGCTCCAG CCCAAACCTT GTTTATGGGG AGTCTGGTTG GATGTCATTT 
GAGGATCATT GTGCCCCTAG AGGTGCCATT AGCAGAATTT GCCAAGATCC GAGAAAAATT 
TTAGCTTTAG TTCTATTTCA GCAGTCACCT GACGTCCTTG TCTATGGTCT TAAAAACAAG 
AAGGCACACA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278892.1
CDS	167..781
Translation	MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPRVTKISPRRLRRWLTRSRMPPWTSILPQEPSTSSSHASEPGVHQPAPWPRLCCTWYFPDRENQQFRPNPTLLGNLRQNQVLCPLPYISIFKTRNSSSPNLVYGESGWMSFEDHCAPRGAISRICQDPRKILALVLFQQSPDVLVYGLKNKKAHI

Target ORF information:

RefSeq Version	NM_001291963.2
Organism	Homo sapiens(human)
Definition	Homo sapiens death associated protein (DAP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291963.2

ORF Insert Sequence:

ATGTCTTCGC CTCCCGAAGG GAAACTAGAG ACTAAAGCTG GACACCCGCC CGCCGTGAAA 
GCTGGTGGAA TGCGAATTGT GCAGAAACAC CCACATACAG GAGACACCAA AGAAGAGAAA 
GACAAGGATG ACCAGGAATG GGAAAGCCCC AGGGTGACAA AGATTTCCCC CCGGCGGCTG 
CGCAGGTGGC TCACCAGAAG CCGCATGCCT CCATGGACAA GCATCCTTCC CCAAGAACCC 
AGCACATCCA GCAGCCACGC AAGTGAGCCT GGAGTCCACC AGCCTGCCCC ATGGCCCCGG 
CTCTGCTGCA CTTGGTATTT CCCTGACAGA GAGAACCAGC AGTTTCGCCC AAATCCTACT 
CTGCTGGGAA ATCTAAGGCA AAACCAAGTG CTCTGTCCTT TGCCTTACAT TTCCATATTT 
AAAACTAGAA ACAGCTCCAG CCCAAACCTT GTTTATGGGG AGTCTGGTTG GATGTCATTT 
GAGGATCATT GTGCCCCTAG AGGTGCCATT AGCAGAATTT GCCAAGATCC GAGAAAAATT 
TTAGCTTTAG TTCTATTTCA GCAGTCACCT GACGTCCTTG TCTATGGTCT TAAAAACAAG 
AAGGCACACA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of the knockdown of death-associated protein 1 expression on cell adhesion, growth and migration in breast cancer cells.
Oncology reports33(3)1450-8(2015 Mar)
Wazir U,Sanders AJ,Wazir A,Baig RM,Jiang WG,Ster IC,Sharma AK,Mokbel K

Death associated protein 1 is correlated with the clinical outcome of patients with colorectal cancer and has a role in the regulation of cell death.
Oncology reports31(1)175-82(2014 Jan)
Jia Y,Ye L,Ji K,Toms AM,Davies ML,Ruge F,Ji J,Hargest R,Jiang WG

Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
Genetic epidemiology37(8)840-5(2013 Dec)
Yu B,Zheng Y,Alexander D,Manolio TA,Alonso A,Nettleton JA,Boerwinkle E

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Nature491(7422)119-24(2012 Nov)
Jostins L,Ripke S,Weersma RK,Duerr RH,McGovern DP,Hui KY,Lee JC,Schumm LP,Sharma Y,Anderson CA,Essers J,Mitrovic M,Ning K,Cleynen I,Theatre E,Spain SL,Raychaudhuri S,Goyette P,Wei Z,Abraham C,Achkar JP,Ahmad T,Amininejad L,Ananthakrishnan AN,Andersen V,Andrews JM,Baidoo L,Balschun T,Bampton PA,Bitton A,Boucher G,Brand S,B?ning C,Cohain A,Cichon S,D'Amato M,De Jong D,Devaney KL,Dubinsky M,Edwards C,Ellinghaus D,Ferguson LR,Franchimont D,Fransen K,Gearry R,Georges M,Gieger C,Glas J,Haritunians T,Hart A,Hawkey C,Hedl M,Hu X,Karlsen TH,Kupcinskas L,Kugathasan S,Latiano A,Laukens D,Lawrance IC,Lees CW,Louis E,Mahy G,Mansfield J,Morgan AR,Mowat C,Newman W,Palmieri O,Ponsioen CY,Potocnik U,Prescott NJ,Regueiro M,Rotter JI,Russell RK,Sanderson JD,Sans M,Satsangi J,Schreiber S,Simms LA,Sventoraityte J,Targan SR,Taylor KD,Tremelling M,Verspaget HW,De Vos M,Wijmenga C,Wilson DC,Winkelmann J,Xavier RJ,Zeissig S,Zhang B,Zhang CK,Zhao H,,Silverberg MS,Annese V,Hakonarson H,Brant SR,Radford-Smith G,Mathew CG,Rioux JD,Schadt EE,Daly MJ,Franke A,Parkes M,Vermeire S,Barrett JC,Cho JH

The mRNA expression of DAP1 in human breast cancer: correlation with clinicopathological parameters.
Cancer genomics & proteomics9(4)199-201(2012 Jul-Aug)
Wazir U,Jiang WG,Sharma AK,Mokbel K

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DAP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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