TMEM65 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM65
Entrez Gene ID	157378
Full Name	transmembrane protein 65
General protein information	Preferred Names transmembrane protein 65 Names transmembrane protein 65
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.13
Disorder MIM:	616609

mRNA and Protein(s)

mRNA	Protein	Name
XM_017013104.1	XP_016868593.1	transmembrane protein 65 isoform X2
XM_017013105.1	XP_016868594.1	transmembrane protein 65 isoform X3
NM_194291.2	NP_919267.2	transmembrane protein 65
XM_011516847.2	XP_011515149.1	transmembrane protein 65 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tmem65	NP_780421.2
Gallus gallus (chicken)	TMEM65	NP_001026678.1
	TMEM65	XP_001101526.1
Bos taurus (cattle)	TMEM65	NP_001069786.1
Pan troglodytes (chimpanzee)	TMEM65	XP_003311963.1
Canis lupus familiaris (dog)	TMEM65	XP_005627969.1
Rattus norvegicus (Norway rat)	Tmem65	NP_001094465.1
Danio rerio (zebrafish)	tmem65	NP_001122284.1
Homo sapiens (human)	TMEM65	NP_919267.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009021	XP_319767.4
Xenopus tropicalis (tropical clawed frog)	tmem65	NP_001120365.1

Gene Ontology
Bibliography

Related articles in PubMed

A mutation in the TMEM65 gene results in mitochondrial myopathy with severe neurological manifestations.
Nazli A, Safdar A, Saleem A, Akhtar M, Brady LI, Schwartzentruber J, Tarnopolsky MA
European journal of human genetics : EJHG25(6)744-751(2017 06)

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Sharma P, Abbasi C, Lazic S, Teng AC, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO
Nature communications68391(2015 Sep)

TMEM65 is a mitochondrial inner-membrane protein.
Nishimura N, Gotoh T, Oike Y, Yano M
PeerJ2e349(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel homozygous splice variant (c.472+1G>A) in the TMEM65 gene identified in a patient with mitochondrial encephalomyopathy. TMEM65 mutation severely affected mitochondrial content and respiration rate in dermal fibroblasts.
Title: A mutation in the TMEM65 gene results in mitochondrial myopathy with severe neurological manifestations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following TMEM65 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM65 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu97759	XM_017013104.1 Latest version!	Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu02412	NM_194291.2 Latest version!	Homo sapiens transmembrane protein 65 (TMEM65), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu76883	XM_011516847.2 Latest version!	Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu97760	XM_017013105.1 Latest version!	Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM65 ( XM_017013104.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016868593.1 Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu97759
Clone ID Related Accession (Same CDS sequence)	XM_017013104.1
Accession Version	XM_017013104.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	transmembrane protein 65 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAACCC ATATTGAAAT GTCTATTGGA ATTATTTTGG GAATTTCAAC TATGGCAGCT 
GCTGCTTTGG GAAATCTTGT GTCAGATCTA GCTGGACTTG GACTTGCAGG CTACGTTGAA 
GCATTGGCTT CCAGGTTAGG CCTGTCAATT CCTGATCTCA CACCAAAGCA AGTTGACATG 
TGGCAAACAC GTCTTAGTAC ACATTTGGGC AAAGCTGTTG GGGTGACTAT TGGCTGCATT 
CTAGGAATGT TTCCTTTAAT TTTCTTTGGA GGAGGTGAAG AAGATGAAAA ACTGGAAACG 
AAAATGGTCC TTATGCTGGA TTCATTTATC TTGAAGGATG GGCAACTACA GCTGCAGACC 
AGTACACATC AAGCAATTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016868593.1
CDS	17..397
Translation	MGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKMVLMLDSFILKDGQLQLQTSTHQAI

Target ORF information:

RefSeq Version	XM_017013104.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017013104.1

ORF Insert Sequence:

ATGGGAACCC ATATTGAAAT GTCTATTGGA ATTATTTTGG GAATTTCAAC TATGGCAGCT 
GCTGCTTTGG GAAATCTTGT GTCAGATCTA GCTGGACTTG GACTTGCAGG CTACGTTGAA 
GCATTGGCTT CCAGGTTAGG CCTGTCAATT CCTGATCTCA CACCAAAGCA AGTTGACATG 
TGGCAAACAC GTCTTAGTAC ACATTTGGGC AAAGCTGTTG GGGTGACTAT TGGCTGCATT 
CTAGGAATGT TTCCTTTAAT TTTCTTTGGA GGAGGTGAAG AAGATGAAAA ACTGGAAACG 
AAAATGGTCC TTATGCTGGA TTCATTTATC TTGAAGGATG GGCAACTACA GCTGCAGACC 
AGTACACATC AAGCAATTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM65 ( NM_194291.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_919267.2 Homo sapiens transmembrane protein 65 (TMEM65), mRNA.

Price & Availability↑

CloneID	OHu02412
Clone ID Related Accession (Same CDS sequence)	NM_194291.2
Accession Version	NM_194291.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	transmembrane protein 65
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB479586.1, AC090192.19, BC032396.1, BM679703.1, BQ433192.1 and AW300050.1. On Apr 20, 2007 this sequence version replaced NM_194291.1. ##Evidence-Data-START## Transcript exon combination :: BC041379.1, SRR1803611.109757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGGC TGCTGCCGCT GCTGAGGAGC CGGACCGCGC GCAGCCTGAG GCCGGGCCCG 
GCCGCCGCCG CCGCGCCCCG CCCGCCGTCC TGGTGCTGCT GCGGGCGGGG GCTGCTGGCG 
CTCGCGCCCC CCGGCGGCTT GCCGGGCGGC CCCAGGCGGC TGGGCACGCA CCCCAAGAAG 
GAGCCCATGG AGGCGCTGAA CACGGCGCAG GGCGCGCGCG ACTTCATCTA CAGCCTGCAC 
TCCACGGAGA GGAGCTGCCT GCTCAAAGAG CTGCACCGCT TCGAGTCTAT TGCCATTGCC 
CAAGAAAAAT TGGAAGCTCC ACCACCCACC CCAGGACAGC TGAGATATGT ATTCATCCAC 
AATGCGATAC CTTTCATAGG GTTTGGCTTT TTGGATAATG CAATTATGAT TGTTGCTGGA 
ACCCATATTG AAATGTCTAT TGGAATTATT TTGGGAATTT CAACTATGGC AGCTGCTGCT 
TTGGGAAATC TTGTGTCAGA TCTAGCTGGA CTTGGACTTG CAGGCTACGT TGAAGCATTG 
GCTTCCAGGT TAGGCCTGTC AATTCCTGAT CTCACACCAA AGCAAGTTGA CATGTGGCAA 
ACACGTCTTA GTACACATTT GGGCAAAGCT GTTGGGGTGA CTATTGGCTG CATTCTAGGA 
ATGTTTCCTT TAATTTTCTT TGGAGGAGGT GAAGAAGATG AAAAACTGGA AACGAAAAGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919267.2
CDS	543..1265
Translation	MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS

Target ORF information:

RefSeq Version	NM_194291.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 65 (TMEM65), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194291.2

ORF Insert Sequence:

ATGTCCCGGC TGCTGCCGCT GCTGAGGAGC CGGACCGCGC GCAGCCTGAG GCCGGGCCCG 
GCCGCCGCCG CCGCGCCCCG CCCGCCGTCC TGGTGCTGCT GCGGGCGGGG GCTGCTGGCG 
CTCGCGCCCC CCGGCGGCTT GCCGGGCGGC CCCAGGCGGC TGGGCACGCA CCCCAAGAAG 
GAGCCCATGG AGGCGCTGAA CACGGCGCAG GGCGCGCGCG ACTTCATCTA CAGCCTGCAC 
TCCACGGAGA GGAGCTGCCT GCTCAAAGAG CTGCACCGCT TCGAGTCTAT TGCCATTGCC 
CAAGAAAAAT TGGAAGCTCC ACCACCCACC CCAGGACAGC TGAGATATGT ATTCATCCAC 
AATGCGATAC CTTTCATAGG GTTTGGCTTT TTGGATAATG CAATTATGAT TGTTGCTGGA 
ACCCATATTG AAATGTCTAT TGGAATTATT TTGGGAATTT CAACTATGGC AGCTGCTGCT 
TTGGGAAATC TTGTGTCAGA TCTAGCTGGA CTTGGACTTG CAGGCTACGT TGAAGCATTG 
GCTTCCAGGT TAGGCCTGTC AATTCCTGAT CTCACACCAA AGCAAGTTGA CATGTGGCAA 
ACACGTCTTA GTACACATTT GGGCAAAGCT GTTGGGGTGA CTATTGGCTG CATTCTAGGA 
ATGTTTCCTT TAATTTTCTT TGGAGGAGGT GAAGAAGATG AAAAACTGGA AACGAAAAGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM65 ( XM_011516847.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011515149.1 Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu76883
Clone ID Related Accession (Same CDS sequence)	XM_011516847.2
Accession Version	XM_011516847.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	transmembrane protein 65 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011516847.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCGGC TGCTGCCGCT GCTGAGGAGC CGGACCGCGC GCAGCCTGAG GCCGGGCCCG 
GCCGCCGCCG CCGCGCCCCG CCCGCCGTCC TGGTGCTGCT GCGGGCGGGG GCTGCTGGCG 
CTCGCGCCCC CCGGCGGCTT GCCGGGCGGC CCCAGGCGGC TGGGCACGCA CCCCAAGAAG 
GAGCCCATGG AGGCGCTGAA CACGGCGCAG GGCGCGCGCG ACTTCATCTA CAGCCTGCAC 
TCCACGGAGA GGAGCTGCCT GCTCAAAGAG CTGCACCGCT TCGAGTCTAT TGCCATTGCC 
CAAGAAAAAT TGGAAGCTCC ACCACCCACC CCAGGACAGC TGAGATATGT ATTCATCCAC 
AATGCGATAC CTTTCATAGG GTTTGGCTTT TTGGATAATG CAATTATGAT TGTTGCTGGA 
ACCCATATTG AAATGTCTAT TGGAATTATT TTGGGAATTT CAACTATGGC AGCTGCTGCT 
TTGGGAAATC TTGTGTCAGA TCTAGCTGGA CTTGGACTTG CAGGCTACGT TGAAGCATTG 
GCTTCCAGGT TAGGCCTGTC AATTCCTGAT CTCACACCAA AGCAAGTTGA CATGTGGCAA 
ACACGTCTTA GTACACATTT GGGCAAAGCT GTTGGGGTGA CTATTGGCTG CATTCTAGGA 
ATGTTTCCTT TAATTTTCTT TGGAGGAGGT GAAGAAGATG AAAAACTGGA AACGAAAATG 
GTCCTTATGC TGGATTCATT TATCTTGAAG GATGGGCAAC TACAGCTGCA GACCAGTACA 
CATCAAGCAA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011515149.1
CDS	537..1331
Translation	MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKMVLMLDSFILKDGQLQLQTSTHQAI

Target ORF information:

RefSeq Version	XM_011516847.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516847.2

ORF Insert Sequence:

ATGTCCCGGC TGCTGCCGCT GCTGAGGAGC CGGACCGCGC GCAGCCTGAG GCCGGGCCCG 
GCCGCCGCCG CCGCGCCCCG CCCGCCGTCC TGGTGCTGCT GCGGGCGGGG GCTGCTGGCG 
CTCGCGCCCC CCGGCGGCTT GCCGGGCGGC CCCAGGCGGC TGGGCACGCA CCCCAAGAAG 
GAGCCCATGG AGGCGCTGAA CACGGCGCAG GGCGCGCGCG ACTTCATCTA CAGCCTGCAC 
TCCACGGAGA GGAGCTGCCT GCTCAAAGAG CTGCACCGCT TCGAGTCTAT TGCCATTGCC 
CAAGAAAAAT TGGAAGCTCC ACCACCCACC CCAGGACAGC TGAGATATGT ATTCATCCAC 
AATGCGATAC CTTTCATAGG GTTTGGCTTT TTGGATAATG CAATTATGAT TGTTGCTGGA 
ACCCATATTG AAATGTCTAT TGGAATTATT TTGGGAATTT CAACTATGGC AGCTGCTGCT 
TTGGGAAATC TTGTGTCAGA TCTAGCTGGA CTTGGACTTG CAGGCTACGT TGAAGCATTG 
GCTTCCAGGT TAGGCCTGTC AATTCCTGAT CTCACACCAA AGCAAGTTGA CATGTGGCAA 
ACACGTCTTA GTACACATTT GGGCAAAGCT GTTGGGGTGA CTATTGGCTG CATTCTAGGA 
ATGTTTCCTT TAATTTTCTT TGGAGGAGGT GAAGAAGATG AAAAACTGGA AACGAAAATG 
GTCCTTATGC TGGATTCATT TATCTTGAAG GATGGGCAAC TACAGCTGCA GACCAGTACA 
CATCAAGCAA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM65 ( XM_017013105.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016868594.1 Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu97760
Clone ID Related Accession (Same CDS sequence)	XM_017013105.1
Accession Version	XM_017013105.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	transmembrane protein 65 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCGGC TGCTGCCGCT GCTGAGGAGC CGGACCGCGC GCAGCCTGAG GCCGGGCCCG 
GCCGCCGCCG CCGCGCCCCG CCCGCCGTCC TGGTGCTGCT GCGGGCGGGG GCTGCTGGCG 
CTCGCGCCCC CCGGCGGCTT GCCGGGCGGC CCCAGGCGGC TGGGCACGCA CCCCAAGAAG 
GAGCCCATGG AGGCGCTGAA CACGGCGCAG GGCGCGCGCG ACTTCATCTA CAGCCTGCAC 
TCCACGGAGA GGAGCTGCCT GCTCAAAGAG CTGCACCGCT TCGAGTCTAT TGCCATTGCC 
CAAGAAAAAT TGGAAGCTCC ACCACCCACC CCAGGACAGC TGAGATATGG GAACCCATAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016868594.1
CDS	537..899
Translation	MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYGNPY

Target ORF information:

RefSeq Version	XM_017013105.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 65 (TMEM65), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017013105.1

ORF Insert Sequence:

ATGTCCCGGC TGCTGCCGCT GCTGAGGAGC CGGACCGCGC GCAGCCTGAG GCCGGGCCCG 
GCCGCCGCCG CCGCGCCCCG CCCGCCGTCC TGGTGCTGCT GCGGGCGGGG GCTGCTGGCG 
CTCGCGCCCC CCGGCGGCTT GCCGGGCGGC CCCAGGCGGC TGGGCACGCA CCCCAAGAAG 
GAGCCCATGG AGGCGCTGAA CACGGCGCAG GGCGCGCGCG ACTTCATCTA CAGCCTGCAC 
TCCACGGAGA GGAGCTGCCT GCTCAAAGAG CTGCACCGCT TCGAGTCTAT TGCCATTGCC 
CAAGAAAAAT TGGAAGCTCC ACCACCCACC CCAGGACAGC TGAGATATGG GAACCCATAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A mutation in the TMEM65 gene results in mitochondrial myopathy with severe neurological manifestations.
European journal of human genetics : EJHG25(6)744-751(2017 06)
Nazli A,Safdar A,Saleem A,Akhtar M,Brady LI,Schwartzentruber J,Tarnopolsky MA

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Nature communications68391(2015 Sep)
Sharma P,Abbasi C,Lazic S,Teng AC,Wang D,Dubois N,Ignatchenko V,Wong V,Liu J,Araki T,Tiburcy M,Ackerley C,Zimmermann WH,Hamilton R,Sun Y,Liu PP,Keller G,Stagljar I,Scott IC,Kislinger T,Gramolini AO

TMEM65 is a mitochondrial inner-membrane protein.
PeerJ2e349(2014)
Nishimura N,Gotoh T,Oike Y,Yano M

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TMEM65 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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