KCTD7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCTD7
Entrez Gene ID	154881
Full Name	potassium channel tetramerization domain containing 7
Synonyms	CLN14,EPM3
General protein information	Preferred Names potassium channel tetramerization domain containing 7 Names BTB/POZ domain-containing protein KCTD7 potassium channel tetramerisation domain containing 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q11.21
Summary	This gene encodes a member of the potassium channel tetramerization domain-containing protein family. Family members are identified on a structural basis and contain an amino-terminal domain similar to the T1 domain present in the voltage-gated potassium channel. Mutations in this gene have been associated with progressive myoclonic epilepsy-3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011].
Disorder MIM:	611725
Disorder Html:	Epilepsy, progressive myoclonic 3, with or without intracellular inclusions, 611726 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_153033.4	NP_694578.1	BTB/POZ domain-containing protein KCTD7 isoform 1
NM_001167961.2	NP_001161433.1	BTB/POZ domain-containing protein KCTD7 isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	kctd7	NP_001038798.1
Homo sapiens (human)	KCTD7	NP_694578.1
Bos taurus (cattle)	KCTD7	NP_001096015.1
Xenopus tropicalis (tropical clawed frog)	kctd7	XP_004911762.1
	KCTD7	XP_001092395.2
Mus musculus (house mouse)	Kctd7	NP_766097.1
Rattus norvegicus (Norway rat)	Kctd7	NP_001121666.1
Pan troglodytes (chimpanzee)	KCTD7	XP_001149057.2
Gallus gallus (chicken)	KCTD7	NP_001034358.1

Gene Ontology
Bibliography

Related articles in PubMed

Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport.
Moen MN, Fj?r R, Hamdani EH, Laerdahl JK, Menchini RJ, Vigeland MD, Sheng Y, Undlien DE, Hassel B, Salih MA, El Khashab HY, Selmer KK, Chaudhry FA
Brain : a journal of neurology139(Pt 12)3109-3120(2016 Dec)

KCTD7-related progressive myoclonus epilepsy.
Van Bogaert P
Epileptic disorders : international epilepsy journal with videotape18(S2)115-119(2016 Sep)

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
Patel YM, Stram DO, Wilkens LR, Park SS, Henderson BE, Le Marchand L, Haiman CA, Murphy SE
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology24(1)119-27(2015 Jan)

Novel mutation in potassium channel related gene KCTD7 and progressive myoclonic epilepsy.
Krabichler B, Rostasy K, Baumann M, Karall D, Scholl-B?rgi S, Schwarzer C, Gautsch K, Spreiz A, Kotzot D, Zschocke J, Fauth C, Haberlandt E
Annals of human genetics76(4)326-31(2012 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KCTD7 has an impact on K+ fluxes, neurotransmitter synthesis and neuronal function, and that malfunction of the encoded protein may lead to progressive myoclonus epilepsy.
Title: Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport.

reviews the phenotype of progressive myoclonic epilepsy associated with KCTD7 mutations [review]
Title: KCTD7-related progressive myoclonus epilepsy.

This study identified that novel KCTD7 mutation in patients with progressive myoclonus epilepsy with ataxia.
Title: Linkage analysis and exome sequencing identify a novel mutation in KCTD7 in patients with progressive myoclonus epilepsy with ataxia.

this study clearly demonstrates that KCTD7 mutations also cause a rare, infantile-onset NCL subtype designated as CLN14.
Title: A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.

The KCTD7 gene, previously associated with progressive myoclonus epilepsies (PMEs) in a single inbred family, was screened for mutations in 18 Turkish PME patients.
Title: Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene.

The following KCTD7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCTD7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu23028	NM_001167961.2 Latest version!	Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu22416	NM_153033.4 Latest version!	Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCTD7 ( NM_001167961.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161433.1 Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23028
Clone ID Related Accession (Same CDS sequence)	NM_001167961.2
Accession Version	NM_001167961.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD7 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA493191.1, BC042482.1, AK055201.1, AC006001.2, BU682845.1 and BY795857.2. On Jan 21, 2011 this sequence version replaced NM_001167961.1. Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) is 1-aa shorter at the C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042482.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC 
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT 
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG 
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT 
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG 
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG 
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG 
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG 
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC 
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG 
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT 
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC 
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC 
ATCTATGAGT TCAAGATCAC ATGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161433.1
CDS	185..1051
Translation	MVVVTGREPDSRRQDGAMSSSDAEDDFLEPATPTATQAGHALPLLPQEFPEVVPLNIGGAHFTTRLSTLRCYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGTHFGDVLNFLRSGDLPPRERVRAVYKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLMPYYKDHLERIVEIARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESDGQLFEHHCEVDVSFGPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLVNHYYCKRPIYEFKITW

Target ORF information:

RefSeq Version	NM_001167961.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001167961.2

ORF Insert Sequence:

ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC 
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT 
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG 
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT 
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG 
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG 
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG 
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG 
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC 
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG 
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT 
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC 
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC 
ATCTATGAGT TCAAGATCAC ATGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCTD7 ( NM_153033.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_694578.1 Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22416
Clone ID Related Accession (Same CDS sequence)	NM_153033.4
Accession Version	NM_153033.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD7 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA493191.1, AK056631.1, AK055201.1, AC006001.2, BU682845.1 and BY795857.2. This sequence is a reference standard in the RefSeqGene project. On Jan 21, 2011 this sequence version replaced NM_153033.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.263165.1, SRR1803611.209964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC 
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT 
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG 
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT 
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG 
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG 
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG 
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG 
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC 
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG 
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT 
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC 
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC 
ATCTATGAGT TCAAGATCAC ATGGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694578.1
CDS	185..1054
Translation	MVVVTGREPDSRRQDGAMSSSDAEDDFLEPATPTATQAGHALPLLPQEFPEVVPLNIGGAHFTTRLSTLRCYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGTHFGDVLNFLRSGDLPPRERVRAVYKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLMPYYKDHLERIVEIARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESDGQLFEHHCEVDVSFGPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLVNHYYCKRPIYEFKITWW

Target ORF information:

RefSeq Version	NM_153033.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 7 (KCTD7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153033.4

ORF Insert Sequence:

ATGGTGGTAG TCACGGGGCG GGAGCCAGAC AGCCGTCGTC AGGACGGTGC CATGTCCAGC 
TCTGACGCCG AAGACGACTT TCTGGAGCCG GCCACGCCGA CGGCCACGCA GGCGGGGCAC 
GCGCTGCCCC TGCTGCCACA GGAGTTTCCT GAGGTTGTTC CCCTTAACAT CGGAGGGGCT 
CACTTCACTA CACGCCTGTC CACACTGCGG TGCTACGAAG ACACCATGTT GGCAGCCATG 
TTCAGTGGGC GGCACTACAT CCCCACGGAC TCCGAGGGCC GGTACTTCAT CGACCGAGAT 
GGCACACACT TTGGAGATGT GCTGAATTTC CTGCGCTCAG GGGACCTCCC ACCCAGGGAG 
CGTGTTCGAG CTGTGTACAA AGAGGCCCAG TACTATGCCA TCGGGCCCCT CCTGGAGCAG 
CTGGAGAACA TGCAGCCACT GAAGGGCGAG AAGGTGCGCC AAGCGTTTCT GGGACTCATG 
CCCTATTACA AAGACCACTT GGAGCGGATT GTGGAGATCG CCCGGCTGCG TGCGGTCCAG 
CGGAAGGCCC GCTTTGCCAA GCTCAAGGTC TGTGTCTTCA AGGAGGAGAT GCCCATCACC 
CCCTATGAGT GTCCGCTCCT CAACTCCCTG CGATTTGAGC GGAGTGAGAG TGACGGGCAG 
CTTTTTGAGC ACCACTGTGA AGTGGATGTG TCTTTTGGGC CCTGGGAGGC TGTGGCTGAT 
GTTTATGACC TGCTGCACTG CCTGGTCACG GACCTCTCGG CCCAGGGTCT CACCGTGGAC 
CACCAGTGCA TCGGGGTGTG TGACAAGCAC CTCGTGAACC ACTACTACTG CAAGCGCCCC 
ATCTATGAGT TCAAGATCAC ATGGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport.
Brain : a journal of neurology139(Pt 12)3109-3120(2016 Dec)
Moen MN,Fj?r R,Hamdani EH,Laerdahl JK,Menchini RJ,Vigeland MD,Sheng Y,Undlien DE,Hassel B,Salih MA,El Khashab HY,Selmer KK,Chaudhry FA

KCTD7-related progressive myoclonus epilepsy.
Epileptic disorders : international epilepsy journal with videotape18(S2)115-119(2016 Sep)
Van Bogaert P

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology24(1)119-27(2015 Jan)
Patel YM,Stram DO,Wilkens LR,Park SS,Henderson BE,Le Marchand L,Haiman CA,Murphy SE

Novel mutation in potassium channel related gene KCTD7 and progressive myoclonic epilepsy.
Annals of human genetics76(4)326-31(2012 Jul)
Krabichler B,Rostasy K,Baumann M,Karall D,Scholl-B?rgi S,Schwarzer C,Gautsch K,Spreiz A,Kotzot D,Zschocke J,Fauth C,Haberlandt E

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KCTD7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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