CYC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYC1
Entrez Gene ID	1537
Full Name	cytochrome c1
Synonyms	MC3DN6,UQCR4
General protein information	Preferred Names cytochrome c1 Names cytochrome c1, heme protein, mitochondrial complex III subunit 4 complex III subunit IV cytochrome b-c1 complex subunit 4 cytochrome c-1 ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.3
Summary	This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013].
Disorder MIM:	123980
Disorder Html:	Mitochondrial complex III deficiency, nuclear type 6, 615453 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017013102.1	XP_016868591.1	cytochrome c1, heme protein, mitochondrial isoform X1
XM_024447072.1	XP_024302840.1	cytochrome c1, heme protein, mitochondrial isoform X2
NM_001916.4	NP_001907.2	cytochrome c1, heme protein, mitochondrial precursor
NM_001916.5	NP_001907.3	cytochrome c1, heme protein, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CYC1	XP_528263.3
	CYC1	XP_001089897.1
Canis lupus familiaris (dog)	CYC1	XP_532351.2
Bos taurus (cattle)	CYC1	NP_001033179.1
Eremothecium gossypii	AGOS_ADR208W	NP_984304.2
Magnaporthe oryzae (rice blast fungus)	MGG_16462	XP_003710661.1
Arabidopsis thaliana (thale cress)	AT3G27240	NP_189360.1
Xenopus tropicalis (tropical clawed frog)	MGC75973	NP_989234.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006936	XP_001688099.1
Neurospora crassa	NCU09816	XP_963756.1
Mus musculus (house mouse)	Cyc1	NP_079843.1
Rattus norvegicus (Norway rat)	Cyc1	NP_001264123.1
Drosophila melanogaster (fruit fly)	CG4769	NP_001246637.1
Saccharomyces cerevisiae (baker's yeast)	CYT1	NP_014708.1
Kluyveromyces lactis	KLLA0F16555g	XP_455824.1
Schizosaccharomyces pombe (fission yeast)	cyt1	NP_595846.1
Arabidopsis thaliana (thale cress)	AT5G40810	NP_198897.1
Oryza sativa (rice)	Os05g0301700	NP_001055136.1
Oryza sativa (rice)	Os01g0935700	NP_001045322.1
Caenorhabditis elegans (roundworm)	cyc-1	NP_492207.1
Homo sapiens (human)	CYC1	NP_001907.2
Danio rerio (zebrafish)	cyc1	NP_001032470.1

Gene Ontology
Bibliography

Related articles in PubMed

Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.
Chishiki M, Takagi K, Sato A, Miki Y, Yamamoto Y, Ebata A, Shibahara Y, Watanabe M, Ishida T, Sasano H, Suzuki T
Cancer science108(7)1510-1519(2017 Jul)

MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.
Fan L, Zhu C, Qiu R, Zan P, Zheng Z, Xu T, Li G
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(5)1935-1946(2017)

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers20163528064(2016)

Apoptosis Markers in Breast Cancer Therapy.
Kadam CY, Abhang SA
Advances in clinical chemistry74143-93(2016)

Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase.
Smith HT, Ahmed AJ, Millett F
The Journal of biological chemistry256(10)4984-90(1981 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results indicate that CYC1 plays important roles in cell proliferation and comedo necrosis through the elevated oxidative phosphorylation activity in human ductal carcinoma in situ
Title: Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.

results indicate that miR-661 plays a tumor suppressor role in OS mediated by the downregulation of CYC1, suggesting a potential mechanism underlying cell death resistance in Osteosarcoma.
Title: MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.

CYC1 promoted tumor metastasis via suppressing activation of AMPK and contributed to tumor growth via facilitating production of ATP.
Title: CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

FASL, granzyme B, and cytochrome c blood expression reflects breast cancer progression and response to therapy. (Review)
Title: Apoptosis Markers in Breast Cancer Therapy.

our results provide evidence that CYC1 plays an important role in OS tumorigenesis, and modulation of CYC1 may be an effective strategy to potentiate OS to apoptotic induction by TRAIL.
Title: CYC1 silencing sensitizes osteosarcoma cells to TRAIL-induced apoptosis.

The following CYC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu107704	NM_001916.5 Latest version!	Homo sapiens cytochrome c1 (CYC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu105987	XM_024447072.1 Latest version!	Homo sapiens cytochrome c1 (CYC1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu97757	XM_017013102.1 Latest version!	Homo sapiens cytochrome c1 (CYC1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu21551	NM_001916.4 Latest version!	Homo sapiens cytochrome c1 (CYC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYC1 ( NM_001916.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001907.3 Homo sapiens cytochrome c1 (CYC1), mRNA.

Price & Availability↑

CloneID	OHu107704
Clone ID Related Accession (Same CDS sequence)	NM_001916.5
Accession Version	NM_001916.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cytochrome c1, heme protein, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104592.6. On Nov 23, 2018 this sequence version replaced NM_001916.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.160191.1, SRR1163655.670400.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000318911.5/ ENSP00000317159.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCAG CTGCGGCTTC GCTTCGCGGG GTAGTGTTGG GCCCGCGGGG CGCGGGGCTC 
CCGGGCGCGC GTGCCCGGGG TCTGCTGTGC AGCGCGCGTC CCGGGCAGCT CCCGCTACGG 
ACACCTCAGG CAGTGGCCTT GTCGTCGAAG TCTGGCCTTT CCCGAGGCCG GAAAGTGATG 
CTGTCAGCGC TGGGCATGCT GGCGGCAGGG GGTGCGGGGC TGGCCATGGC TCTGCATTCG 
GCTGTGAGTG CCAGTGACCT GGAGCTGCAC CCCCCCAGCT ATCCGTGGTC TCACCGTGGC 
CTCCTCTCTT CCTTGGACCA CACCAGCATC CGGAGGGGTT TCCAGGTATA TAAGCAGGTG 
TGCGCCTCCT GCCACAGCAT GGACTTCGTG GCCTACCGCC ACCTGGTGGG CGTGTGCTAC 
ACGGAGGATG AAGCTAAGGA GCTGGCTGCG GAGGTGGAGG TTCAAGACGG CCCCAATGAA 
GATGGGGAGA TGTTCATGCG GCCAGGGAAG CTGTTCGACT ATTTCCCAAA ACCATACCCC 
AACAGTGAGG CTGCTCGAGC TGCCAACAAC GGAGCATTGC CCCCTGACCT CAGCTACATC 
GTGCGAGCTA GGCATGGTGG TGAGGACTAC GTCTTCTCCC TGCTCACGGG CTACTGCGAG 
CCACCCACCG GGGTGTCACT GCGGGAAGGT CTCTACTTCA ACCCCTACTT TCCTGGCCAG 
GCCATTGCCA TGGCCCCTCC CATCTACACA GATGTCTTAG AGTTTGACGA TGGCACCCCA 
GCTACCATGT CCCAGATAGC CAAGGATGTG TGCACCTTCC TGCGCTGGGC ATCTGAGCCA 
GAGCACGACC ATCGAAAACG CATGGGGCTC AAGATGTTGA TGATGATGGC TCTGCTGGTG 
CCCCTGGTCT ACACCATAAA GCGGCACAAG TGGTCAGTCC TGAAGAGTCG GAAGCTGGCA 
TATCGGCCGC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001907.3
CDS	25..1002
Translation	MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

Target ORF information:

RefSeq Version	NM_001916.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c1 (CYC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001916.5

ORF Insert Sequence:

ATGGCGGCAG CTGCGGCTTC GCTTCGCGGG GTAGTGTTGG GCCCGCGGGG CGCGGGGCTC 
CCGGGCGCGC GTGCCCGGGG TCTGCTGTGC AGCGCGCGTC CCGGGCAGCT CCCGCTACGG 
ACACCTCAGG CAGTGGCCTT GTCGTCGAAG TCTGGCCTTT CCCGAGGCCG GAAAGTGATG 
CTGTCAGCGC TGGGCATGCT GGCGGCAGGG GGTGCGGGGC TGGCCATGGC TCTGCATTCG 
GCTGTGAGTG CCAGTGACCT GGAGCTGCAC CCCCCCAGCT ATCCGTGGTC TCACCGTGGC 
CTCCTCTCTT CCTTGGACCA CACCAGCATC CGGAGGGGTT TCCAGGTATA TAAGCAGGTG 
TGCGCCTCCT GCCACAGCAT GGACTTCGTG GCCTACCGCC ACCTGGTGGG CGTGTGCTAC 
ACGGAGGATG AAGCTAAGGA GCTGGCTGCG GAGGTGGAGG TTCAAGACGG CCCCAATGAA 
GATGGGGAGA TGTTCATGCG GCCAGGGAAG CTGTTCGACT ATTTCCCAAA ACCATACCCC 
AACAGTGAGG CTGCTCGAGC TGCCAACAAC GGAGCATTGC CCCCTGACCT CAGCTACATC 
GTGCGAGCTA GGCATGGTGG TGAGGACTAC GTCTTCTCCC TGCTCACGGG CTACTGCGAG 
CCACCCACCG GGGTGTCACT GCGGGAAGGT CTCTACTTCA ACCCCTACTT TCCTGGCCAG 
GCCATTGCCA TGGCCCCTCC CATCTACACA GATGTCTTAG AGTTTGACGA TGGCACCCCA 
GCTACCATGT CCCAGATAGC CAAGGATGTG TGCACCTTCC TGCGCTGGGC ATCTGAGCCA 
GAGCACGACC ATCGAAAACG CATGGGGCTC AAGATGTTGA TGATGATGGC TCTGCTGGTG 
CCCCTGGTCT ACACCATAAA GCGGCACAAG TGGTCAGTCC TGAAGAGTCG GAAGCTGGCA 
TATCGGCCGC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYC1 ( XM_024447072.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302840.1 Homo sapiens cytochrome c1 (CYC1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu105987
Clone ID Related Accession (Same CDS sequence)	XM_024447072.1
Accession Version	XM_024447072.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome c1, heme protein, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTCAG CGCTGGGCAT GCTGGCGGCA GGGGGTGCGG GGCTGGCCAT GGCTCTGCAT 
TCGGCTGTGA GTGCCAGTGA CCTGGAGCTG CACCCCCCCA GCTATCCGTG GTCTCACCGT 
GGCCTCCTCT CTTCCTTGGA CCACACCAGC ATCCGGAGGG GTTTCCAGGT ATATAAGCAG 
GTGTGCGCCT CCTGCCACAG CATGGACTTC GTGGCCTACC GCCACCTGGT GGGCGTGTGC 
TACACGGAGG ATGAAGCTAA GGAGCTGGCT GCGGAGGTGG AGGTTCAAGA CGGCCCCAAT 
GAAGATGGGG AGATGTTCAT GCGGCCAGGG AAGCTGTTCG ACTATTTCCC AAAACCATAC 
CCCAACAGTG AGGCTGCTCG AGCTGCCAAC AACGGAGCAT TGCCCCCTGA CCTCAGCTAC 
ATCGTGCGAG CTAGGCATGG TGGTGAGGAC TACGTCTTCT CCCTGCTCAC GGGCTACTGC 
GAGCCACCCA CCGGGGTGTC ACTGCGGGAA GGTCTCTACT TCAACCCCTA CTTTCCTGGC 
CAGGCCATTG CCATGGCCCC TCCCATCTAC ACAGATGTCT TAGAGTTTGA CGATGGCACC 
CCAGCTACCA TGTCCCAGAT AGCCAAGGAT GTGTGCACCT TCCTGCGCTG GGCATCTGAG 
CCAGAGCACG ACCATCGAAA ACGCATGGGG CTCAAGATGT TGATGATGAT GGCTCTGCTG 
GTGCCCCTGG TCTACACCAT AAAGCGGCAC AAGTGGTCAG TCCTGAAGAG TCGGAAGCTG 
GCATATCGGC CGCCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302840.1
CDS	451..1251
Translation	MLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

Target ORF information:

RefSeq Version	XM_024447072.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c1 (CYC1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447072.1

ORF Insert Sequence:

ATGCTGTCAG CGCTGGGCAT GCTGGCGGCA GGGGGTGCGG GGCTGGCCAT GGCTCTGCAT 
TCGGCTGTGA GTGCCAGTGA CCTGGAGCTG CACCCCCCCA GCTATCCGTG GTCTCACCGT 
GGCCTCCTCT CTTCCTTGGA CCACACCAGC ATCCGGAGGG GTTTCCAGGT ATATAAGCAG 
GTGTGCGCCT CCTGCCACAG CATGGACTTC GTGGCCTACC GCCACCTGGT GGGCGTGTGC 
TACACGGAGG ATGAAGCTAA GGAGCTGGCT GCGGAGGTGG AGGTTCAAGA CGGCCCCAAT 
GAAGATGGGG AGATGTTCAT GCGGCCAGGG AAGCTGTTCG ACTATTTCCC AAAACCATAC 
CCCAACAGTG AGGCTGCTCG AGCTGCCAAC AACGGAGCAT TGCCCCCTGA CCTCAGCTAC 
ATCGTGCGAG CTAGGCATGG TGGTGAGGAC TACGTCTTCT CCCTGCTCAC GGGCTACTGC 
GAGCCACCCA CCGGGGTGTC ACTGCGGGAA GGTCTCTACT TCAACCCCTA CTTTCCTGGC 
CAGGCCATTG CCATGGCCCC TCCCATCTAC ACAGATGTCT TAGAGTTTGA CGATGGCACC 
CCAGCTACCA TGTCCCAGAT AGCCAAGGAT GTGTGCACCT TCCTGCGCTG GGCATCTGAG 
CCAGAGCACG ACCATCGAAA ACGCATGGGG CTCAAGATGT TGATGATGAT GGCTCTGCTG 
GTGCCCCTGG TCTACACCAT AAAGCGGCAC AAGTGGTCAG TCCTGAAGAG TCGGAAGCTG 
GCATATCGGC CGCCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYC1 ( XM_017013102.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016868591.1 Homo sapiens cytochrome c1 (CYC1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu97757
Clone ID Related Accession (Same CDS sequence)	XM_017013102.1
Accession Version	XM_017013102.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome c1, heme protein, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTCAG CGCTGGGCAT GCTGGCGGCA GGGGGTGCGG GGCTGGCCAT GGCTCTGCAT 
TCGGCTGTGA GTGCCAGTGA CCTGGAGCTG CACCCCCCCA GCTATCCGTG GTCTCACCGT 
GGCCTCCTCT CTTCCTTGGA CCACACCAGC ATCCGGAGGG GTTTCCAGGT ATATAAGCAG 
GTGTGCGCCT CCTGCCACAG CATGGACTTC GTGGCCTACC GCCACCTGGT GGGCGTGTGC 
TACACGGAGG ATGAAGCTAA GGAGCTGGCT GCGGAGGTGG AGGTTCAAGA CGGCCCCAAT 
GAAGATGGGG AGATGTTCAT GCGGCCAGGG AAGCTGTTCG ACTATTTCCC AAAACCATAC 
CCCAACAGTG AGGCTGCTCG AGCTGCCAAC AACGGAGCAT TGCCCCCTGA CCTCAGCTAC 
ATCGTGCGAG CTAGGCATGG TGGTGAGGAC TACGTCTTCT CCCTGCTCAC GGGCTACTGC 
GAGCCACCCA CCGGGGTGTC ACTGCGGGAA GGTCTCTACT TCAACCCCTA CTTTCCTGGC 
CAGGCCATTG CCATGGCCCC TCCCATCTAC ACAGATGTCT TAGAGTTTGA CGATGGCACC 
CCAGCTACCA TGTCCCAGAT AGCCAAGGAT GTGTGCACCT TCCTGCGCTG GGCATCTGAG 
CCAGAGCACG ACCATCGAAA ACGCATGGGG CTCAAGGTAA AAGGGTTGGG AGGCCATGGT 
GGGTATCAGA GAAGGGCTGG GAGCTGGGCA GGGCTCCTCC CCACTCCCTT CTCTGAGCCT 
TCCTTGTCTG CAGATGTTGA TGATGATGGC TCTGCTGGTG CCCCTGGTCT ACACCATAAA 
GCGGCACAAG TGGTCAGTCC TGAAGAGTCG GAAGCTGGCA TATCGGCCGC CCAAGTGACC 
CTGTCCAGTG TCTGCTTGCC ATCCTGCCAG AACAGGCCCT CAAGCCCAAG AGCCATCCCA 
GGCCTGTTCA GGCCTCAGCT AAGCCTCTCT TCATCTGGAA GAAGAGGCAA GGGGGCAGGA 
GACCAGGCTC TAGCTCTGGG CCCTCCTTCA GCCCCCATCA TGGGAATAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016868591.1
CDS	776..1849
Translation	MLSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKVKGLGGHGGYQRRAGSWAGLLPTPFSEPSLSADVDDDGSAGAPGLHHKAAQVVSPEESEAGISAAQVTLSSVCLPSCQNRPSSPRAIPGLFRPQLSLSSSGRRGKGAGDQALALGPPSAPIMGIN

Target ORF information:

RefSeq Version	XM_017013102.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c1 (CYC1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017013102.1

ORF Insert Sequence:

ATGCTGTCAG CGCTGGGCAT GCTGGCGGCA GGGGGTGCGG GGCTGGCCAT GGCTCTGCAT 
TCGGCTGTGA GTGCCAGTGA CCTGGAGCTG CACCCCCCCA GCTATCCGTG GTCTCACCGT 
GGCCTCCTCT CTTCCTTGGA CCACACCAGC ATCCGGAGGG GTTTCCAGGT ATATAAGCAG 
GTGTGCGCCT CCTGCCACAG CATGGACTTC GTGGCCTACC GCCACCTGGT GGGCGTGTGC 
TACACGGAGG ATGAAGCTAA GGAGCTGGCT GCGGAGGTGG AGGTTCAAGA CGGCCCCAAT 
GAAGATGGGG AGATGTTCAT GCGGCCAGGG AAGCTGTTCG ACTATTTCCC AAAACCATAC 
CCCAACAGTG AGGCTGCTCG AGCTGCCAAC AACGGAGCAT TGCCCCCTGA CCTCAGCTAC 
ATCGTGCGAG CTAGGCATGG TGGTGAGGAC TACGTCTTCT CCCTGCTCAC GGGCTACTGC 
GAGCCACCCA CCGGGGTGTC ACTGCGGGAA GGTCTCTACT TCAACCCCTA CTTTCCTGGC 
CAGGCCATTG CCATGGCCCC TCCCATCTAC ACAGATGTCT TAGAGTTTGA CGATGGCACC 
CCAGCTACCA TGTCCCAGAT AGCCAAGGAT GTGTGCACCT TCCTGCGCTG GGCATCTGAG 
CCAGAGCACG ACCATCGAAA ACGCATGGGG CTCAAGGTAA AAGGGTTGGG AGGCCATGGT 
GGGTATCAGA GAAGGGCTGG GAGCTGGGCA GGGCTCCTCC CCACTCCCTT CTCTGAGCCT 
TCCTTGTCTG CAGATGTTGA TGATGATGGC TCTGCTGGTG CCCCTGGTCT ACACCATAAA 
GCGGCACAAG TGGTCAGTCC TGAAGAGTCG GAAGCTGGCA TATCGGCCGC CCAAGTGACC 
CTGTCCAGTG TCTGCTTGCC ATCCTGCCAG AACAGGCCCT CAAGCCCAAG AGCCATCCCA 
GGCCTGTTCA GGCCTCAGCT AAGCCTCTCT TCATCTGGAA GAAGAGGCAA GGGGGCAGGA 
GACCAGGCTC TAGCTCTGGG CCCTCCTTCA GCCCCCATCA TGGGAATAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYC1 ( NM_001916.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001907.2 Homo sapiens cytochrome c1 (CYC1), mRNA.

Price & Availability↑

CloneID	OHu21551
Clone ID Related Accession (Same CDS sequence)	NM_001916.4
Accession Version	NM_001916.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	cytochrome c1, heme protein, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG328536.1, AK225796.1, CN369438.1, AK026633.1 and BQ574597.1. This sequence is a reference standard in the RefSeqGene project. On Jan 1, 2014 this sequence version replaced NM_001916.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.182395.1, SRR1163655.685048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG CTGCGGCTTC GCTTCGCGGG GTAGTGTTGG GCCCGCGGGG CGCGGGGCTC 
CCGGGCGCGC GTGCCCGGGG TCTGCTGTGC AGCGCGCGTC CCGGGCAGCT CCCGCTACGG 
ACACCTCAGG CAGTGGCCTT GTCGTCGAAG TCTGGCCTTT CCCGAGGCCG GAAAGTGATG 
CTGTCAGCGC TGGGCATGCT GGCGGCAGGG GGTGCGGGGC TGGCCGTGGC TCTGCATTCG 
GCTGTGAGTG CCAGTGACCT GGAGCTGCAC CCCCCCAGCT ATCCGTGGTC TCACCGTGGC 
CTCCTCTCTT CCTTGGACCA CACCAGCATC CGGAGGGGTT TCCAGGTATA TAAGCAGGTG 
TGCGCCTCCT GCCACAGCAT GGACTTCGTG GCCTACCGCC ACCTGGTGGG CGTGTGCTAC 
ACGGAGGATG AAGCTAAGGA GCTGGCTGCG GAGGTGGAGG TTCAAGACGG CCCCAATGAA 
GATGGGGAGA TGTTCATGCG GCCAGGGAAG CTGTTCGACT ATTTCCCAAA ACCATACCCC 
AACAGTGAGG CTGCTCGAGC TGCCAACAAC GGAGCATTGC CCCCTGACCT CAGCTACATC 
GTGCGAGCTA GGCATGGTGG TGAGGACTAC GTCTTCTCCC TGCTCACGGG CTACTGCGAG 
CCACCCACCG GGGTGTCACT GCGGGAAGGT CTCTACTTCA ACCCCTACTT TCCTGGCCAG 
GCCATTGCCA TGGCCCCTCC CATCTACACA GATGTCTTAG AGTTTGACGA TGGCACCCCA 
GCTACCATGT CCCAGATAGC CAAGGATGTG TGCACCTTCC TGCGCTGGGC ATCTGAGCCA 
GAGCACGACC ATCGAAAACG CATGGGGCTC AAGATGTTGA TGATGATGGC TCTGCTGGTG 
CCCCTGGTCT ACACCATAAA GCGGCACAAG TGGTCAGTCC TGAAGAGTCG GAAGCTGGCA 
TATCGGCCGC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001907.2
CDS	66..1043
Translation	MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

Target ORF information:

RefSeq Version	NM_001916.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c1 (CYC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001916.4

ORF Insert Sequence:

ATGGCGGCAG CTGCGGCTTC GCTTCGCGGG GTAGTGTTGG GCCCGCGGGG CGCGGGGCTC 
CCGGGCGCGC GTGCCCGGGG TCTGCTGTGC AGCGCGCGTC CCGGGCAGCT CCCGCTACGG 
ACACCTCAGG CAGTGGCCTT GTCGTCGAAG TCTGGCCTTT CCCGAGGCCG GAAAGTGATG 
CTGTCAGCGC TGGGCATGCT GGCGGCAGGG GGTGCGGGGC TGGCCGTGGC TCTGCATTCG 
GCTGTGAGTG CCAGTGACCT GGAGCTGCAC CCCCCCAGCT ATCCGTGGTC TCACCGTGGC 
CTCCTCTCTT CCTTGGACCA CACCAGCATC CGGAGGGGTT TCCAGGTATA TAAGCAGGTG 
TGCGCCTCCT GCCACAGCAT GGACTTCGTG GCCTACCGCC ACCTGGTGGG CGTGTGCTAC 
ACGGAGGATG AAGCTAAGGA GCTGGCTGCG GAGGTGGAGG TTCAAGACGG CCCCAATGAA 
GATGGGGAGA TGTTCATGCG GCCAGGGAAG CTGTTCGACT ATTTCCCAAA ACCATACCCC 
AACAGTGAGG CTGCTCGAGC TGCCAACAAC GGAGCATTGC CCCCTGACCT CAGCTACATC 
GTGCGAGCTA GGCATGGTGG TGAGGACTAC GTCTTCTCCC TGCTCACGGG CTACTGCGAG 
CCACCCACCG GGGTGTCACT GCGGGAAGGT CTCTACTTCA ACCCCTACTT TCCTGGCCAG 
GCCATTGCCA TGGCCCCTCC CATCTACACA GATGTCTTAG AGTTTGACGA TGGCACCCCA 
GCTACCATGT CCCAGATAGC CAAGGATGTG TGCACCTTCC TGCGCTGGGC ATCTGAGCCA 
GAGCACGACC ATCGAAAACG CATGGGGCTC AAGATGTTGA TGATGATGGC TCTGCTGGTG 
CCCCTGGTCT ACACCATAAA GCGGCACAAG TGGTCAGTCC TGAAGAGTCG GAAGCTGGCA 
TATCGGCCGC CCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.
Cancer science108(7)1510-1519(2017 Jul)
Chishiki M,Takagi K,Sato A,Miki Y,Yamamoto Y,Ebata A,Shibahara Y,Watanabe M,Ishida T,Sasano H,Suzuki T

MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(5)1935-1946(2017)
Fan L,Zhu C,Qiu R,Zan P,Zheng Z,Xu T,Li G

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Disease markers20163528064(2016)
Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Apoptosis Markers in Breast Cancer Therapy.
Advances in clinical chemistry74143-93(2016)
Kadam CY,Abhang SA

Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase.
The Journal of biological chemistry256(10)4984-90(1981 May)
Smith HT,Ahmed AJ,Millett F

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CYC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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