CTSZ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTSZ
Entrez Gene ID	1522
Full Name	cathepsin Z
Synonyms	CTSX
General protein information	Preferred Names cathepsin Z Names cathepsin Z carboxypeptidase LB cathepsin B2 cathepsin IV cathepsin P cathepsin X cathepsin Y cathepsin Z1 cysteine-type carboxypeptidase lysosomal carboxypeptidase B preprocathepsin P
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.32
Summary	The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008].
Disorder MIM:	603169

mRNA and Protein(s)

mRNA	Protein	Name
NM_001336.3	NP_001327.2	cathepsin Z preproprotein
NM_001336.4	NP_001327.2	cathepsin Z preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CTSZ	XP_005635417.1
Bos taurus (cattle)	CTSZ	NP_001071303.1
Caenorhabditis elegans (roundworm)	cpz-1	NP_491023.2
Pan troglodytes (chimpanzee)	CTSZ	XP_001140086.1
Xenopus tropicalis (tropical clawed frog)	ctsz	NP_001106427.1
Danio rerio (zebrafish)	ctsz	NP_001006043.1
Homo sapiens (human)	CTSZ	NP_001327.2
Mus musculus (house mouse)	Ctsz	NP_071720.1
Rattus norvegicus (Norway rat)	Ctsz	NP_899159.1
Gallus gallus (chicken)	CTSZ	XP_417483.3

Gene Ontology
Bibliography

Related articles in PubMed

Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells.
Mitrovi? A, Pe?ar Fonovi? U, Kos J
European journal of cell biology96(6)622-631(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis
Title: Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.

Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer.
Title: Characterization of cathepsin X in colorectal cancer development and progression.

The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy.
Title: Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients.

Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample ian population.
Title: Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis.

Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
Title: Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.

The following CTSZ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTSZ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19043	NM_001336.3 Latest version!	Homo sapiens cathepsin Z (CTSZ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu107205	NM_001336.4 Latest version!	Homo sapiens cathepsin Z (CTSZ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTSZ ( NM_001336.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001327.2 Homo sapiens cathepsin Z (CTSZ), mRNA.

Price & Availability↑

CloneID	OHu19043
Clone ID Related Accession (Same CDS sequence)	NM_001336.3
Accession Version	NM_001336.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	cathepsin Z preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314931.1 and BC042168.1. This sequence is a reference standard in the RefSeqGene project. On Oct 10, 2008 this sequence version replaced NM_001336.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042168.1, SRR1163657.203888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAGGC GCGGGCCAGG GTGGCGGCCG CTTCTGCTGC TCGTGCTGCT GGCGGGCGCG 
GCGCAGGGCG GCCTCTACTT CCGCCGGGGA CAGACCTGCT ACCGGCCTCT GCGGGGGGAC 
GGGCTGGCTC CGCTGGGGCG CAGCACATAC CCCCGGCCTC ATGAGTACCT GTCCCCAGCG 
GATCTGCCCA AGAGCTGGGA CTGGCGCAAT GTGGATGGTG TCAACTATGC CAGCATCACC 
CGGAACCAGC ACATCCCCCA ATACTGCGGC TCCTGCTGGG CCCACGCCAG CACCAGCGCT 
ATGGCGGATC GGATCAACAT CAAGAGGAAG GGAGCGTGGC CCTCCACCCT CCTGTCCGTG 
CAGAACGTCA TCGACTGCGG TAACGCTGGC TCCTGTGAAG GGGGTAATGA CCTGTCCGTG 
TGGGACTACG CCCACCAGCA CGGCATCCCT GACGAGACCT GCAACAACTA CCAGGCCAAG 
GACCAGGAGT GTGACAAGTT TAACCAATGT GGGACATGCA ATGAATTCAA AGAGTGCCAC 
GCCATCCGGA ACTACACCCT CTGGAGGGTG GGAGACTACG GCTCCCTCTC TGGGAGGGAG 
AAGATGATGG CAGAAATCTA CGCAAATGGT CCCATCAGCT GTGGAATAAT GGCAACAGAA 
AGACTGGCTA ACTACACCGG AGGCATCTAT GCCGAATACC AGGACACCAC ATATATAAAC 
CATGTCGTTT CTGTGGCTGG GTGGGGCATC AGTGATGGGA CTGAGTACTG GATTGTCCGG 
AATTCATGGG GTGAACCATG GGGCGAGAGA GGCTGGCTGA GGATCGTGAC CAGCACCTAT 
AAGGATGGGA AGGGCGCCAG ATACAACCTT GCCATCGAGG AGCACTGTAC ATTTGGGGAC 
CCCATCGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001327.2
CDS	127..1038
Translation	MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV

Target ORF information:

RefSeq Version	NM_001336.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin Z (CTSZ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001336.3

ORF Insert Sequence:

ATGGCGAGGC GCGGGCCAGG GTGGCGGCCG CTTCTGCTGC TCGTGCTGCT GGCGGGCGCG 
GCGCAGGGCG GCCTCTACTT CCGCCGGGGA CAGACCTGCT ACCGGCCTCT GCGGGGGGAC 
GGGCTGGCTC CGCTGGGGCG CAGCACATAC CCCCGGCCTC ATGAGTACCT GTCCCCAGCG 
GATCTGCCCA AGAGCTGGGA CTGGCGCAAT GTGGATGGTG TCAACTATGC CAGCATCACC 
CGGAACCAGC ACATCCCCCA ATACTGCGGC TCCTGCTGGG CCCACGCCAG CACCAGCGCT 
ATGGCGGATC GGATCAACAT CAAGAGGAAG GGAGCGTGGC CCTCCACCCT CCTGTCCGTG 
CAGAACGTCA TCGACTGCGG TAACGCTGGC TCCTGTGAAG GGGGTAATGA CCTGTCCGTG 
TGGGACTACG CCCACCAGCA CGGCATCCCT GACGAGACCT GCAACAACTA CCAGGCCAAG 
GACCAGGAGT GTGACAAGTT TAACCAATGT GGGACATGCA ATGAATTCAA AGAGTGCCAC 
GCCATCCGGA ACTACACCCT CTGGAGGGTG GGAGACTACG GCTCCCTCTC TGGGAGGGAG 
AAGATGATGG CAGAAATCTA CGCAAATGGT CCCATCAGCT GTGGAATAAT GGCAACAGAA 
AGACTGGCTA ACTACACCGG AGGCATCTAT GCCGAATACC AGGACACCAC ATATATAAAC 
CATGTCGTTT CTGTGGCTGG GTGGGGCATC AGTGATGGGA CTGAGTACTG GATTGTCCGG 
AATTCATGGG GTGAACCATG GGGCGAGAGA GGCTGGCTGA GGATCGTGAC CAGCACCTAT 
AAGGATGGGA AGGGCGCCAG ATACAACCTT GCCATCGAGG AGCACTGTAC ATTTGGGGAC 
CCCATCGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSZ ( NM_001336.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001327.2 Homo sapiens cathepsin Z (CTSZ), mRNA.

Price & Availability↑

CloneID	OHu107205
Clone ID Related Accession (Same CDS sequence)	NM_001336.4
Accession Version	NM_001336.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cathepsin Z preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL109840.24. On Nov 22, 2018 this sequence version replaced NM_001336.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.203888.1, AF136273.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000217131.6/ ENSP00000217131.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGAGGC GCGGGCCAGG GTGGCGGCCG CTTCTGCTGC TCGTGCTGCT GGCGGGCGCG 
GCGCAGGGCG GCCTCTACTT CCGCCGGGGA CAGACCTGCT ACCGGCCTCT GCGGGGGGAC 
GGGCTGGCTC CGCTGGGGCG CAGCACATAC CCCCGGCCTC ATGAGTACCT GTCCCCAGCG 
GATCTGCCCA AGAGCTGGGA CTGGCGCAAT GTGGATGGTG TCAACTATGC CAGCATCACC 
CGGAACCAGC ACATCCCCCA ATACTGCGGC TCCTGCTGGG CCCACGCCAG CACCAGCGCT 
ATGGCGGATC GGATCAACAT CAAGAGGAAG GGAGCGTGGC CCTCCACCCT CCTGTCCGTG 
CAGAACGTCA TCGACTGCGG TAACGCTGGC TCCTGTGAAG GGGGTAATGA CCTGTCCGTG 
TGGGACTACG CCCACCAGCA CGGCATCCCT GACGAGACCT GCAACAACTA CCAGGCCAAG 
GACCAGGAGT GTGACAAGTT TAACCAATGT GGGACATGCA ATGAATTCAA AGAGTGCCAC 
GCCATCCGGA ACTACACCCT CTGGAGGGTG GGAGACTACG GCTCCCTCTC TGGGAGGGAG 
AAGATGATGG CAGAAATCTA TGCAAATGGT CCCATCAGCT GTGGAATAAT GGCAACAGAA 
AGACTGGCTA ACTACACCGG AGGCATCTAT GCCGAATACC AGGACACCAC ATATATAAAC 
CATGTCGTTT CTGTGGCTGG GTGGGGCATC AGTGATGGGA CTGAGTACTG GATTGTCCGG 
AATTCATGGG GTGAACCATG GGGCGAGAGA GGCTGGCTGA GGATCGTGAC CAGCACCTAT 
AAGGATGGGA AGGGCGCCAG ATACAACCTT GCCATCGAGG AGCACTGTAC ATTTGGGGAC 
CCCATCGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001327.2
CDS	127..1038
Translation	MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV

Target ORF information:

RefSeq Version	NM_001336.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin Z (CTSZ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001336.4

ORF Insert Sequence:

ATGGCGAGGC GCGGGCCAGG GTGGCGGCCG CTTCTGCTGC TCGTGCTGCT GGCGGGCGCG 
GCGCAGGGCG GCCTCTACTT CCGCCGGGGA CAGACCTGCT ACCGGCCTCT GCGGGGGGAC 
GGGCTGGCTC CGCTGGGGCG CAGCACATAC CCCCGGCCTC ATGAGTACCT GTCCCCAGCG 
GATCTGCCCA AGAGCTGGGA CTGGCGCAAT GTGGATGGTG TCAACTATGC CAGCATCACC 
CGGAACCAGC ACATCCCCCA ATACTGCGGC TCCTGCTGGG CCCACGCCAG CACCAGCGCT 
ATGGCGGATC GGATCAACAT CAAGAGGAAG GGAGCGTGGC CCTCCACCCT CCTGTCCGTG 
CAGAACGTCA TCGACTGCGG TAACGCTGGC TCCTGTGAAG GGGGTAATGA CCTGTCCGTG 
TGGGACTACG CCCACCAGCA CGGCATCCCT GACGAGACCT GCAACAACTA CCAGGCCAAG 
GACCAGGAGT GTGACAAGTT TAACCAATGT GGGACATGCA ATGAATTCAA AGAGTGCCAC 
GCCATCCGGA ACTACACCCT CTGGAGGGTG GGAGACTACG GCTCCCTCTC TGGGAGGGAG 
AAGATGATGG CAGAAATCTA TGCAAATGGT CCCATCAGCT GTGGAATAAT GGCAACAGAA 
AGACTGGCTA ACTACACCGG AGGCATCTAT GCCGAATACC AGGACACCAC ATATATAAAC 
CATGTCGTTT CTGTGGCTGG GTGGGGCATC AGTGATGGGA CTGAGTACTG GATTGTCCGG 
AATTCATGGG GTGAACCATG GGGCGAGAGA GGCTGGCTGA GGATCGTGAC CAGCACCTAT 
AAGGATGGGA AGGGCGCCAG ATACAACCTT GCCATCGAGG AGCACTGTAC ATTTGGGGAC 
CCCATCGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells.
European journal of cell biology96(6)622-631(2017 Sep)
Mitrovi? A,Pe?ar Fonovi? U,Kos J

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CTSZ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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