ERFE cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ERFE
Entrez Gene ID	151176
Full Name	erythroferrone
Synonyms	C1QTNF15,CTRP15,FAM132B
General protein information	Preferred Names erythroferrone Names erythroferrone complement C1q tumor necrosis factor-related protein 15 family with sequence similarity 132, member B myonectin protein FAM132B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.3
Disorder MIM:	615099

mRNA and Protein(s)

mRNA	Protein	Name
NM_001291832.2	NP_001278761.1	erythroferrone precursor
NM_001291832.1	NP_001278761.1	erythroferrone precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FAM132B	XP_003950054.1
Homo sapiens (human)	FAM132B	XP_006712968.1
	LOC706226	XP_001094581.2
Bos taurus (cattle)	FAM132B	XP_005205094.1
Rattus norvegicus (Norway rat)	Fam132b	XP_001060107.2
Mus musculus (house mouse)	Fam132b	NP_775571.2

Gene Ontology
Bibliography

Related articles in PubMed

[The role of erythroferrone in iron metabolism: From experimental results to pathogenesis].
Vallet N,
La Revue de medecine interne(2017 Jun)

Increased levels of ERFE-encoding
Russo R, Andolfo I, Manna F, De Rosa G, De Falco L, Gambale A, Bruno M, Matt? A, Ricchi P, Girelli D, De Franceschi L, Iolascon A
Blood128(14)1899-1902(2016 10)

Regulation of Hepcidin by Erythropoiesis: The Story So Far.
Pasricha SR, McHugh K, Drakesmith H
Annual review of nutrition36417-34(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest hepcidin is the master regulator of systemic iron homeostasis; hepcidin levels are suppressed when erythropoiesis is stimulated; the erythroid-derived hormone erythroferrone appears to be a convincing candidate for link between increased erythropoiesis and hepcidin suppression. [REVIEW]
Title: Regulation of Hepcidin by Erythropoiesis: The Story So Far.

In hemodialysis patients DA and CERA increased levels of ERFE that regulated hepcidin 25 and led to iron mobilization from body stores during erythropoiesis.
Title: Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis.

Myonectin links skeletal muscle to lipid homeostasis in liver and adipose tissue in response to alterations in energy state, revealing a novel myonectin-mediated metabolic circuit.
Title: Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis.

The following ERFE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ERFE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17737	NM_001291832.2 Latest version!	Homo sapiens erythroferrone (ERFE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu17737	NM_001291832.1	Homo sapiens erythroferrone (ERFE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ERFE ( NM_001291832.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278761.1 Homo sapiens erythroferrone (ERFE), mRNA.

Price & Availability↑

CloneID	OHu17737
Clone ID Related Accession (Same CDS sequence)	NM_001291832.2 , NM_001291832.1
Accession Version	NM_001291832.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Homo sapiens(human)
Product	erythroferrone precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC016757.10, KF984314.1, BC047423.1, AI362696.1 and H05276.1. On Nov 22, 2018 this sequence version replaced NM_001291832.1. ##Evidence-Data-START## Transcript exon combination :: KF984314.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000546354.6/ ENSP00000442304.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCCGG CCCGCCGCCC CGCCGGAGCC CGCCTGCTGC TCGTCTACGC GGGCCTGCTG 
GCCGCCGCCG CCGCGGGCCT GGGGTCCCCG GAGCCTGGGG CGCCCTCGAG GAGCCGCGCC 
CGCAGGGAGC CGCCGCCCGG GAACGAGCTG CCCCGGGGCC CCGGGGAGAG CCGCGCGGGG 
CCGGCCGCTC GTCCGCCGGA GCCCACCGCT GAGCGTGCAC ACAGCGTCGA CCCCCGGGAC 
GCCTGGATGC TCTTCGTCAG GCAGAGTGAC AAGGGTGTCA ATGGCAAGAA GAGGAGCAGG 
GGCAAGGCCA AGAAGCTGAA GTTCGGCTTG CCAGGGCCCC CTGGGCCTCC CGGTCCCCAG 
GGCCCCCCAG GCCCCATCAT CCCACCCGAG GCGCTGCTGA AGGAGTTCCA GCTGCTGCTG 
AAAGGTGCGG TGCGGCAGCG GGAGCGCGCG GAGCCCGAAC CCTGTACGTG TGGCCCCGCC 
GGGCCGGTCG CTGCGAGCCT CGCCCCGGTC TCGGCCACCG CCGGGGAGGA CGACGACGAC 
GTGGTGGGGG ACGTGCTGGC ACTGCTGGCC GCGCCCCTGG CCCCGGGGCC GCGGGCGCCG 
CGCGTGGAGG CCGCTTTCCT CTGCCGCCTG CGCCGGGACG CGTTGGTGGA GCGGCGCGCG 
CTGCACGAGC TTGGCGTCTA CTACCTGCCC GACGCCGAGG GTGCCTTCCG CCGCGGCCCG 
GGCCTGAACT TGACCAGCGG CCAGTACAGG GCGCCCGTGG CTGGCTTCTA CGCTCTCGCC 
GCCACGCTGC ACGTGGCGCT CGGGGAGCCG CCGAGGAGGG GGCCGCCGCG CCCCCGGGAC 
CACCTGCGCC TGCTCATCTG CATCCAGTCC CGGTGCCAGC GCAACGCCTC CCTGGAGGCC 
ATCATGGGCC TGGAGAGCAG CAGTGAGCTC TTCACCATCT CTGTGAATGG CGTCCTGTAC 
CTGCAGATGG GGCAGTGGAC CTCCGTGTTC TTGGACAACG CCAGCGGCTG CTCCCTCACA 
GTGCGCAGTG GCTCCCACTT CAGTGCTGTC CTCCTGGGCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278761.1
CDS	39..1103
Translation	MAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREPPPGNELPRGPGESRAGPAARPPEPTAERAHSVDPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFGLPGPPGPPGPQGPPGPIIPPEALLKEFQLLLKGAVRQRERAEPEPCTCGPAGPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVERRALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNASGCSLTVRSGSHFSAVLLGV

Target ORF information:

RefSeq Version	NM_001291832.2
Organism	Homo sapiens(human)
Definition	Homo sapiens erythroferrone (ERFE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291832.2

ORF Insert Sequence:

ATGGCCCCGG CCCGCCGCCC CGCCGGAGCC CGCCTGCTGC TCGTCTACGC GGGCCTGCTG 
GCCGCCGCCG CCGCGGGCCT GGGGTCCCCG GAGCCTGGGG CGCCCTCGAG GAGCCGCGCC 
CGCAGGGAGC CGCCGCCCGG GAACGAGCTG CCCCGGGGCC CCGGGGAGAG CCGCGCGGGG 
CCGGCCGCTC GTCCGCCGGA GCCCACCGCT GAGCGTGCAC ACAGCGTCGA CCCCCGGGAC 
GCCTGGATGC TCTTCGTCAG GCAGAGTGAC AAGGGTGTCA ATGGCAAGAA GAGGAGCAGG 
GGCAAGGCCA AGAAGCTGAA GTTCGGCTTG CCAGGGCCCC CTGGGCCTCC CGGTCCCCAG 
GGCCCCCCAG GCCCCATCAT CCCACCCGAG GCGCTGCTGA AGGAGTTCCA GCTGCTGCTG 
AAAGGTGCGG TGCGGCAGCG GGAGCGCGCG GAGCCCGAAC CCTGTACGTG TGGCCCCGCC 
GGGCCGGTCG CTGCGAGCCT CGCCCCGGTC TCGGCCACCG CCGGGGAGGA CGACGACGAC 
GTGGTGGGGG ACGTGCTGGC ACTGCTGGCC GCGCCCCTGG CCCCGGGGCC GCGGGCGCCG 
CGCGTGGAGG CCGCTTTCCT CTGCCGCCTG CGCCGGGACG CGTTGGTGGA GCGGCGCGCG 
CTGCACGAGC TTGGCGTCTA CTACCTGCCC GACGCCGAGG GTGCCTTCCG CCGCGGCCCG 
GGCCTGAACT TGACCAGCGG CCAGTACAGG GCGCCCGTGG CTGGCTTCTA CGCTCTCGCC 
GCCACGCTGC ACGTGGCGCT CGGGGAGCCG CCGAGGAGGG GGCCGCCGCG CCCCCGGGAC 
CACCTGCGCC TGCTCATCTG CATCCAGTCC CGGTGCCAGC GCAACGCCTC CCTGGAGGCC 
ATCATGGGCC TGGAGAGCAG CAGTGAGCTC TTCACCATCT CTGTGAATGG CGTCCTGTAC 
CTGCAGATGG GGCAGTGGAC CTCCGTGTTC TTGGACAACG CCAGCGGCTG CTCCCTCACA 
GTGCGCAGTG GCTCCCACTT CAGTGCTGTC CTCCTGGGCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ERFE ( NM_001291832.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278761.1 Homo sapiens erythroferrone (ERFE), mRNA.

Price & Availability↑

CloneID	OHu17737
Clone ID Related Accession (Same CDS sequence)	NM_001291832.2 , NM_001291832.1
Accession Version	NM_001291832.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	erythroferrone precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from KF984314.1, BC047423.1, AI362696.1 and H05276.1. ##Evidence-Data-START## Transcript exon combination :: KF984314.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END##

ATGGCCCCGG CCCGCCGCCC CGCCGGAGCC CGCCTGCTGC TCGTCTACGC GGGCCTGCTG 
GCCGCCGCCG CCGCGGGCCT GGGGTCCCCG GAGCCTGGGG CGCCCTCGAG GAGCCGCGCC 
CGCAGGGAGC CGCCGCCCGG GAACGAGCTG CCCCGGGGCC CCGGGGAGAG CCGCGCGGGG 
CCGGCCGCTC GTCCGCCGGA GCCCACCGCT GAGCGTGCAC ACAGCGTCGA CCCCCGGGAC 
GCCTGGATGC TCTTCGTCAG GCAGAGTGAC AAGGGTGTCA ATGGCAAGAA GAGGAGCAGG 
GGCAAGGCCA AGAAGCTGAA GTTCGGCTTG CCAGGGCCCC CTGGGCCTCC CGGTCCCCAG 
GGCCCCCCAG GCCCCATCAT CCCACCCGAG GCGCTGCTGA AGGAGTTCCA GCTGCTGCTG 
AAAGGTGCGG TGCGGCAGCG GGAGCGCGCG GAGCCCGAAC CCTGTACGTG TGGCCCCGCC 
GGGCCGGTCG CTGCGAGCCT CGCCCCGGTC TCGGCCACCG CCGGGGAGGA CGACGACGAC 
GTGGTGGGGG ACGTGCTGGC ACTGCTGGCC GCGCCCCTGG CCCCGGGGCC GCGGGCGCCG 
CGCGTGGAGG CCGCTTTCCT CTGCCGCCTG CGCCGGGACG CGTTGGTGGA GCGGCGCGCG 
CTGCACGAGC TTGGCGTCTA CTACCTGCCC GACGCCGAGG GTGCCTTCCG CCGCGGCCCG 
GGCCTGAACT TGACCAGCGG CCAGTACAGG GCGCCCGTGG CTGGCTTCTA CGCTCTCGCC 
GCCACGCTGC ACGTGGCGCT CGGGGAGCCG CCGAGGAGGG GGCCGCCGCG CCCCCGGGAC 
CACCTGCGCC TGCTCATCTG CATCCAGTCC CGGTGCCAGC GCAACGCCTC CCTGGAGGCC 
ATCATGGGCC TGGAGAGCAG CAGTGAGCTC TTCACCATCT CTGTGAATGG CGTCCTGTAC 
CTGCAGATGG GGCAGTGGAC CTCCGTGTTC TTGGACAACG CCAGCGGCTG CTCCCTCACA 
GTGCGCAGTG GCTCCCACTT CAGTGCTGTC CTCCTGGGCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278761.1
CDS	1..1065
Translation	MAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREPPPGNELPRGPGESRAGPAARPPEPTAERAHSVDPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFGLPGPPGPPGPQGPPGPIIPPEALLKEFQLLLKGAVRQRERAEPEPCTCGPAGPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVERRALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNASGCSLTVRSGSHFSAVLLGV

Target ORF information:

RefSeq Version	NM_001291832.1
Organism	Homo sapiens(human)
Definition	Homo sapiens erythroferrone (ERFE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291832.1

ORF Insert Sequence:

ATGGCCCCGG CCCGCCGCCC CGCCGGAGCC CGCCTGCTGC TCGTCTACGC GGGCCTGCTG 
GCCGCCGCCG CCGCGGGCCT GGGGTCCCCG GAGCCTGGGG CGCCCTCGAG GAGCCGCGCC 
CGCAGGGAGC CGCCGCCCGG GAACGAGCTG CCCCGGGGCC CCGGGGAGAG CCGCGCGGGG 
CCGGCCGCTC GTCCGCCGGA GCCCACCGCT GAGCGTGCAC ACAGCGTCGA CCCCCGGGAC 
GCCTGGATGC TCTTCGTCAG GCAGAGTGAC AAGGGTGTCA ATGGCAAGAA GAGGAGCAGG 
GGCAAGGCCA AGAAGCTGAA GTTCGGCTTG CCAGGGCCCC CTGGGCCTCC CGGTCCCCAG 
GGCCCCCCAG GCCCCATCAT CCCACCCGAG GCGCTGCTGA AGGAGTTCCA GCTGCTGCTG 
AAAGGTGCGG TGCGGCAGCG GGAGCGCGCG GAGCCCGAAC CCTGTACGTG TGGCCCCGCC 
GGGCCGGTCG CTGCGAGCCT CGCCCCGGTC TCGGCCACCG CCGGGGAGGA CGACGACGAC 
GTGGTGGGGG ACGTGCTGGC ACTGCTGGCC GCGCCCCTGG CCCCGGGGCC GCGGGCGCCG 
CGCGTGGAGG CCGCTTTCCT CTGCCGCCTG CGCCGGGACG CGTTGGTGGA GCGGCGCGCG 
CTGCACGAGC TTGGCGTCTA CTACCTGCCC GACGCCGAGG GTGCCTTCCG CCGCGGCCCG 
GGCCTGAACT TGACCAGCGG CCAGTACAGG GCGCCCGTGG CTGGCTTCTA CGCTCTCGCC 
GCCACGCTGC ACGTGGCGCT CGGGGAGCCG CCGAGGAGGG GGCCGCCGCG CCCCCGGGAC 
CACCTGCGCC TGCTCATCTG CATCCAGTCC CGGTGCCAGC GCAACGCCTC CCTGGAGGCC 
ATCATGGGCC TGGAGAGCAG CAGTGAGCTC TTCACCATCT CTGTGAATGG CGTCCTGTAC 
CTGCAGATGG GGCAGTGGAC CTCCGTGTTC TTGGACAACG CCAGCGGCTG CTCCCTCACA 
GTGCGCAGTG GCTCCCACTT CAGTGCTGTC CTCCTGGGCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[The role of erythroferrone in iron metabolism: From experimental results to pathogenesis].
La Revue de medecine interne(2017 Jun)
Vallet N,

Increased levels of ERFE-encoding
Blood128(14)1899-1902(2016 10)
Russo R,Andolfo I,Manna F,De Rosa G,De Falco L,Gambale A,Bruno M,Matt? A,Ricchi P,Girelli D,De Franceschi L,Iolascon A

Regulation of Hepcidin by Erythropoiesis: The Story So Far.
Annual review of nutrition36417-34(2016 Jul)
Pasricha SR,McHugh K,Drakesmith H

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ERFE cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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