SIK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIK1
Entrez Gene ID	150094
Full Name	salt inducible kinase 1
Synonyms	MSK,SIK,SIK-1,SNF1LK
General protein information	Preferred Names salt inducible kinase 1 Names serine/threonine-protein kinase SIK1 SNF1-like kinase myocardial SNF1-like kinase salt-inducible protein kinase 1 serine/threonine-protein kinase SNF1-like kinase 1 serine/threonine-protein kinase SNF1LK
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016].
Disorder MIM:	605705
Disorder Html:	Epileptic encephalopathy, early infantile, 30, 616341 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011529474.2	XP_011527776.1	serine/threonine-protein kinase SIK1 isoform X1
NM_173354.3	NP_775490.2	serine/threonine-protein kinase SIK1
NM_173354.4	NP_775490.2	serine/threonine-protein kinase SIK1
NM_173354.5	NP_775490.2	serine/threonine-protein kinase SIK1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LOC102724428	XP_006723983.1
Danio rerio (zebrafish)	si:ch211-235e18.3	NP_001119855.1
Homo sapiens (human)	SIK1	NP_775490.2

Gene Ontology
Bibliography

Related articles in PubMed

14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
Sonntag T, Vaughan JM, Montminy M
The FEBS journal(2017 Dec)

Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention.
Zhang Y, Takemori H, Wang C, Fu J, Xu M, Xiong L, Li N, Wen X
Life sciences173107-115(2017 Mar)

Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology.
Pr?schel C, Hansen JN, Ali A, Tuttle E, Lacagnina M, Buscaglia G, Halterman MW, Paciorkowski AR
European journal of human genetics : EJHG25(2)216-221(2017 02)

Down-regulation of salt-inducible kinase 1 (SIK1) is mediated by RNF2 in hepatocarcinogenesis.
Qu C, Qu Y
Oncotarget8(2)3144-3155(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SIK1 plays a vital role in high glucose-induced lipid accumulation, and metformin suppresses lipogenesis via the induction and activation of SIK1.
Title: Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention.

SIK1 sequence variation was associated with abnormal neuronal morphology, abnormalities in the MEF2C-ARC pathway of neuronal development and synapse activity.
Title: Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology.

Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase.
Title: GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.

SIK1 was downregulated in ovarian cancer by miR-141.
Title: Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues.

the results showed that miR-203 promotes proliferation, migration and invasion in pancreatic cancer cells, whereas the restoration of SIK1 abrogated the regulation of pre-miR203-mediated proliferation, migration and invasion.
Title: miR-203 promotes proliferation, migration and invasion by degrading SIK1 in pancreatic cancer.

The following SIK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07231	NM_173354.5 Latest version!	Homo sapiens salt inducible kinase 1 (SIK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu76499	XM_011529474.2 Latest version!	Homo sapiens salt inducible kinase 1 (SIK1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu07231	NM_173354.3	Homo sapiens salt-inducible kinase 1 (SIK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu07231	NM_173354.4	Homo sapiens salt inducible kinase 1 (SIK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIK1 ( NM_173354.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_775490.2 Homo sapiens salt-inducible kinase 1 (SIK1), mRNA.

Price & Availability↑

CloneID	OHu07231
Clone ID Related Accession (Same CDS sequence)	NM_173354.3 , NM_173354.4 , NM_173354.5
Accession Version	NM_173354.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-05-06
Organism	Homo sapiens(Human)
Product	serine/threonine-protein kinase SIK1
Comment

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGTCACTGCA AAACAGCAGC TATAACCACT TTGCTGCCAT TTATTACCTC 
CTCCTTGAGC GGCTCAAGGA GTATCGGAAT GCCCAGTGCG CCCGCCCCGG GCCTGCCAGG 
CAGCCGCGGC CTCGGAGCTC GGACCTCAGT GGTTTGGAGG TGCCTCAGGA AGGTCTTTCC 
ACCGACCCTT TCCGACCTGC CTTGCTGTGC CCGCAGCCGC AGACCTTGGT GCAGTCCGTC 
CTCCAGGCCG AGATGGACTG TGAGCTCCAG AGCTCGCTGC AGTGGCCCTT GTTCTTCCCG 
GTGGATGCCA GCTGCAGCGG AGTGTTCCGG CCCCGGCCCG TGTCCCCAAG CAGCCTGCTG 
GACACAGCCA TCAGTGAGGA GGCCAGGCAG GGGCCGGGCC TAGAGGAGGA GCAGGACACG 
CAGGAGTCCC TGCCCAGCAG CACGGGCCGG AGGCACACCC TGGCCGAGGT CTCCACCCGC 
CTCTCCCCAC TCACCGCGCC ATGTATAGTC GTCTCCCCCT CCACCACGGC AAGTCCTGCA 
GAGGGAACCA GCTCTGACAG TTGTCTGACC TTCTCTGCGA GCAAAAGCCC CGCGGGGCTC 
AGTGGCACCC CGGCCACTCA GGGGCTGCTG GGCGCCTGCT CCCCGGTCAG GCTGGCCTCG 
CCCTTCCTGG GGTCGCAGTC CGCCACCCCA GTGCTGCAGG CTCAGGGGGG CTTGGGAGGA 
GCTGTTCTGC TCCCTGTCAG CTTCCAGGAG GGACGGCGGG CGTCGGACAC CTCACTGACT 
CAAGGGCTGA AGGCCTTTCG GCAGCAGCTG AGGAAGACCA CGCGGACCAA AGGGTTTCTG 
GGACTGAACA AAATCAAGGG GCTGGCTCGC CAGGTGTGCC AGGCCCCCGC CAGCCGGGCC 
AGCAGGGGCG GCCTGAGCCC CTTCCACGCC CCTGCACAGA GCCCAGGCCT GCACGGCGGC 
GCAGCCGGCA GCCGGGAGGG CTGGAGCCTG CTGGAGGAGG TGCTAGAGCA GCAGAGGCTG 
CTCCAGTTAC AGCACCACCC GGCCGCTGCA CCCGGCTGCT CCCAGGCCCC CCAGCCGGCC 
CCTGCCCCGT TTGTGATCGC CCCCTGTGAT GGCCCTGGGG CTGCCCCGCT CCCCAGCACC 
CTCCTCACGT CGGGGCTCCC GCTGCTGCCG CCCCCACTCC TGCAGACCGG CGCGTCCCCG 
GTGGCCTCAG CGGCGCAGCT CCTGGACACA CACCTGCACA TTGGCACCGG CCCCACCGCC 
CTCCCCGCTG TGCCCCCACC ACGCCTGGCC AGGCTGGCCC CAGGTTGTGA GCCCCTGGGG 
CTGCTGCAGG GGGACTGTGA GATGGAGGAC CTGATGCCCT GCTCCCTAGG CACGTTTGTC 
CTGGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_775490.2

Translation

MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ

Target ORF information:

RefSeq Version	NM_173354.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens salt-inducible kinase 1 (SIK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173354.3

ORF Insert Sequence:

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGTCACTGCA AAACAGCAGC TATAACCACT TTGCTGCCAT TTATTACCTC 
CTCCTTGAGC GGCTCAAGGA GTATCGGAAT GCCCAGTGCG CCCGCCCCGG GCCTGCCAGG 
CAGCCGCGGC CTCGGAGCTC GGACCTCAGT GGTTTGGAGG TGCCTCAGGA AGGTCTTTCC 
ACCGACCCTT TCCGACCTGC CTTGCTGTGC CCGCAGCCGC AGACCTTGGT GCAGTCCGTC 
CTCCAGGCCG AGATGGACTG TGAGCTCCAG AGCTCGCTGC AGTGGCCCTT GTTCTTCCCG 
GTGGATGCCA GCTGCAGCGG AGTGTTCCGG CCCCGGCCCG TGTCCCCAAG CAGCCTGCTG 
GACACAGCCA TCAGTGAGGA GGCCAGGCAG GGGCCGGGCC TAGAGGAGGA GCAGGACACG 
CAGGAGTCCC TGCCCAGCAG CACGGGCCGG AGGCACACCC TGGCCGAGGT CTCCACCCGC 
CTCTCCCCAC TCACCGCGCC ATGTATAGTC GTCTCCCCCT CCACCACGGC AAGTCCTGCA 
GAGGGAACCA GCTCTGACAG TTGTCTGACC TTCTCTGCGA GCAAAAGCCC CGCGGGGCTC 
AGTGGCACCC CGGCCACTCA GGGGCTGCTG GGCGCCTGCT CCCCGGTCAG GCTGGCCTCG 
CCCTTCCTGG GGTCGCAGTC CGCCACCCCA GTGCTGCAGG CTCAGGGGGG CTTGGGAGGA 
GCTGTTCTGC TCCCTGTCAG CTTCCAGGAG GGACGGCGGG CGTCGGACAC CTCACTGACT 
CAAGGGCTGA AGGCCTTTCG GCAGCAGCTG AGGAAGACCA CGCGGACCAA AGGGTTTCTG 
GGACTGAACA AAATCAAGGG GCTGGCTCGC CAGGTGTGCC AGGCCCCCGC CAGCCGGGCC 
AGCAGGGGCG GCCTGAGCCC CTTCCACGCC CCTGCACAGA GCCCAGGCCT GCACGGCGGC 
GCAGCCGGCA GCCGGGAGGG CTGGAGCCTG CTGGAGGAGG TGCTAGAGCA GCAGAGGCTG 
CTCCAGTTAC AGCACCACCC GGCCGCTGCA CCCGGCTGCT CCCAGGCCCC CCAGCCGGCC 
CCTGCCCCGT TTGTGATCGC CCCCTGTGAT GGCCCTGGGG CTGCCCCGCT CCCCAGCACC 
CTCCTCACGT CGGGGCTCCC GCTGCTGCCG CCCCCACTCC TGCAGACCGG CGCGTCCCCG 
GTGGCCTCAG CGGCGCAGCT CCTGGACACA CACCTGCACA TTGGCACCGG CCCCACCGCC 
CTCCCCGCTG TGCCCCCACC ACGCCTGGCC AGGCTGGCCC CAGGTTGTGA GCCCCTGGGG 
CTGCTGCAGG GGGACTGTGA GATGGAGGAC CTGATGCCCT GCTCCCTAGG CACGTTTGTC 
CTGGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIK1 ( NM_173354.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_775490.2 Homo sapiens salt inducible kinase 1 (SIK1), mRNA.

Price & Availability↑

CloneID	OHu07231
Clone ID Related Accession (Same CDS sequence)	NM_173354.3 , NM_173354.4 , NM_173354.5
Accession Version	NM_173354.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase SIK1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY008464.1 and AB047786.1. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2016 this sequence version replaced NM_173354.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB047786.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGTCACTGCA AAACAGCAGC TATAACCACT TTGCTGCCAT TTATTACCTC 
CTCCTTGAGC GGCTCAAGGA GTATCGGAAT GCCCAGTGCG CCCGCCCCGG GCCTGCCAGG 
CAGCCGCGGC CTCGGAGCTC GGACCTCAGT GGTTTGGAGG TGCCTCAGGA AGGTCTTTCC 
ACCGACCCTT TCCGACCTGC CTTGCTGTGC CCGCAGCCGC AGACCTTGGT GCAGTCCGTC 
CTCCAGGCCG AGATGGACTG TGAGCTCCAG AGCTCGCTGC AGTGGCCCTT GTTCTTCCCG 
GTGGATGCCA GCTGCAGCGG AGTGTTCCGG CCCCGGCCCG TGTCCCCAAG CAGCCTGCTG 
GACACAGCCA TCAGTGAGGA GGCCAGGCAG GGGCCGGGCC TAGAGGAGGA GCAGGACACG 
CAGGAGTCCC TGCCCAGCAG CACGGGCCGG AGGCACACCC TGGCCGAGGT CTCCACCCGC 
CTCTCCCCAC TCACCGCGCC ATGTATAGTC GTCTCCCCCT CCACCACGGC AAGTCCTGCA 
GAGGGAACCA GCTCTGACAG TTGTCTGACC TTCTCTGCGA GCAAAAGCCC CGCGGGGCTC 
AGTGGCACCC CGGCCACTCA GGGGCTGCTG GGCGCCTGCT CCCCGGTCAG GCTGGCCTCG 
CCCTTCCTGG GGTCGCAGTC CGCCACCCCA GTGCTGCAGG CTCAGGGGGG CTTGGGAGGA 
GCTGTTCTGC TCCCTGTCAG CTTCCAGGAG GGACGGCGGG CGTCGGACAC CTCACTGACT 
CAAGGGCTGA AGGCCTTTCG GCAGCAGCTG AGGAAGACCA CGCGGACCAA AGGGTTTCTG 
GGACTGAACA AAATCAAGGG GCTGGCTCGC CAGGTGTGCC AGGCCCCCGC CAGCCGGGCC 
AGCAGGGGCG GCCTGAGCCC CTTCCACGCC CCTGCACAGA GCCCAGGCCT GCACGGCGGC 
GCAGCCGGCA GCCGGGAGGG CTGGAGCCTG CTGGAGGAGG TGCTAGAGCA GCAGAGGCTG 
CTCCAGTTAC AGCACCACCC GGCCGCTGCA CCCGGCTGCT CCCAGGCCCC CCAGCCGGCC 
CCTGCCCCGT TTGTGATCGC CCCCTGTGAT GGCCCTGGGG CTGCCCCGCT CCCCAGCACC 
CTCCTCACGT CGGGGCTCCC GCTGCTGCCG CCCCCACTCC TGCAGACCGG CGCGTCCCCG 
GTGGCCTCAG CGGCGCAGCT CCTGGACACA CACCTGCACA TTGGCACCGG CCCCACCGCC 
CTCCCCGCTG TGCCCCCACC ACGCCTGGCC AGGCTGGCCC CAGGTTGTGA GCCCCTGGGG 
CTGCTGCAGG GGGACTGTGA GATGGAGGAC CTGATGCCCT GCTCCCTAGG CACGTTTGTC 
CTGGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775490.2
CDS	138..2489
Translation	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ

Target ORF information:

RefSeq Version	NM_173354.4
Organism	Homo sapiens(human)
Definition	Homo sapiens salt inducible kinase 1 (SIK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173354.4

ORF Insert Sequence:

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGTCACTGCA AAACAGCAGC TATAACCACT TTGCTGCCAT TTATTACCTC 
CTCCTTGAGC GGCTCAAGGA GTATCGGAAT GCCCAGTGCG CCCGCCCCGG GCCTGCCAGG 
CAGCCGCGGC CTCGGAGCTC GGACCTCAGT GGTTTGGAGG TGCCTCAGGA AGGTCTTTCC 
ACCGACCCTT TCCGACCTGC CTTGCTGTGC CCGCAGCCGC AGACCTTGGT GCAGTCCGTC 
CTCCAGGCCG AGATGGACTG TGAGCTCCAG AGCTCGCTGC AGTGGCCCTT GTTCTTCCCG 
GTGGATGCCA GCTGCAGCGG AGTGTTCCGG CCCCGGCCCG TGTCCCCAAG CAGCCTGCTG 
GACACAGCCA TCAGTGAGGA GGCCAGGCAG GGGCCGGGCC TAGAGGAGGA GCAGGACACG 
CAGGAGTCCC TGCCCAGCAG CACGGGCCGG AGGCACACCC TGGCCGAGGT CTCCACCCGC 
CTCTCCCCAC TCACCGCGCC ATGTATAGTC GTCTCCCCCT CCACCACGGC AAGTCCTGCA 
GAGGGAACCA GCTCTGACAG TTGTCTGACC TTCTCTGCGA GCAAAAGCCC CGCGGGGCTC 
AGTGGCACCC CGGCCACTCA GGGGCTGCTG GGCGCCTGCT CCCCGGTCAG GCTGGCCTCG 
CCCTTCCTGG GGTCGCAGTC CGCCACCCCA GTGCTGCAGG CTCAGGGGGG CTTGGGAGGA 
GCTGTTCTGC TCCCTGTCAG CTTCCAGGAG GGACGGCGGG CGTCGGACAC CTCACTGACT 
CAAGGGCTGA AGGCCTTTCG GCAGCAGCTG AGGAAGACCA CGCGGACCAA AGGGTTTCTG 
GGACTGAACA AAATCAAGGG GCTGGCTCGC CAGGTGTGCC AGGCCCCCGC CAGCCGGGCC 
AGCAGGGGCG GCCTGAGCCC CTTCCACGCC CCTGCACAGA GCCCAGGCCT GCACGGCGGC 
GCAGCCGGCA GCCGGGAGGG CTGGAGCCTG CTGGAGGAGG TGCTAGAGCA GCAGAGGCTG 
CTCCAGTTAC AGCACCACCC GGCCGCTGCA CCCGGCTGCT CCCAGGCCCC CCAGCCGGCC 
CCTGCCCCGT TTGTGATCGC CCCCTGTGAT GGCCCTGGGG CTGCCCCGCT CCCCAGCACC 
CTCCTCACGT CGGGGCTCCC GCTGCTGCCG CCCCCACTCC TGCAGACCGG CGCGTCCCCG 
GTGGCCTCAG CGGCGCAGCT CCTGGACACA CACCTGCACA TTGGCACCGG CCCCACCGCC 
CTCCCCGCTG TGCCCCCACC ACGCCTGGCC AGGCTGGCCC CAGGTTGTGA GCCCCTGGGG 
CTGCTGCAGG GGGACTGTGA GATGGAGGAC CTGATGCCCT GCTCCCTAGG CACGTTTGTC 
CTGGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIK1 ( NM_173354.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_775490.2 Homo sapiens salt inducible kinase 1 (SIK1), mRNA.

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CloneID	OHu07231
Clone ID Related Accession (Same CDS sequence)	NM_173354.3 , NM_173354.4 , NM_173354.5
Accession Version	NM_173354.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase SIK1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY008464.1, AB047786.1 and AP001046.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_173354.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB047786.1, SRR7346977.2153149.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000270162.8/ ENSP00000270162.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGTCACTGCA AAACAGCAGC TATAACCACT TTGCTGCCAT TTATTACCTC 
CTCCTTGAGC GGCTCAAGGA GTATCGGAAT GCCCAGTGCG CCCGCCCCGG GCCTGCCAGG 
CAGCCGCGGC CTCGGAGCTC GGACCTCAGT GGTTTGGAGG TGCCTCAGGA AGGTCTTTCC 
ACCGACCCTT TCCGACCTGC CTTGCTGTGC CCGCAGCCGC AGACCTTGGT GCAGTCCGTC 
CTCCAGGCCG AGATGGACTG TGAGCTCCAG AGCTCGCTGC AGTGGCCCTT GTTCTTCCCG 
GTGGATGCCA GCTGCAGCGG AGTGTTCCGG CCCCGGCCCG TGTCCCCAAG CAGCCTGCTG 
GACACAGCCA TCAGTGAGGA GGCCAGGCAG GGGCCGGGCC TAGAGGAGGA GCAGGACACG 
CAGGAGTCCC TGCCCAGCAG CACGGGCCGG AGGCACACCC TGGCCGAGGT CTCCACCCGC 
CTCTCCCCAC TCACCGCGCC ATGTATAGTC GTCTCCCCCT CCACCACGGC AAGTCCTGCA 
GAGGGAACCA GCTCTGACAG TTGTCTGACC TTCTCTGCGA GCAAAAGCCC CGCGGGGCTC 
AGTGGCACCC CGGCCACTCA GGGGCTGCTG GGCGCCTGCT CCCCGGTCAG GCTGGCCTCG 
CCCTTCCTGG GGTCGCAGTC CGCCACCCCA GTGCTGCAGG CTCAGGGGGG CTTGGGAGGA 
GCTGTTCTGC TCCCTGTCAG CTTCCAGGAG GGACGGCGGG CGTCGGACAC CTCACTGACT 
CAAGGGCTGA AGGCCTTTCG GCAGCAGCTG AGGAAGACCA CGCGGACCAA AGGGTTTCTG 
GGACTGAACA AAATCAAGGG GCTGGCTCGC CAGGTGTGCC AGGCCCCCGC CAGCCGGGCC 
AGCAGGGGCG GCCTGAGCCC CTTCCACGCC CCTGCACAGA GCCCAGGCCT GCACGGCGGC 
GCAGCCGGCA GCCGGGAGGG CTGGAGCCTG CTGGAGGAGG TGCTAGAGCA GCAGAGGCTG 
CTCCAGTTAC AGCACCACCC GGCCGCTGCA CCCGGCTGCT CCCAGGCCCC CCAGCCGGCC 
CCTGCCCCGT TTGTGATCGC CCCCTGTGAT GGCCCTGGGG CTGCCCCGCT CCCCAGCACC 
CTCCTCACGT CGGGGCTCCC GCTGCTGCCG CCCCCACTCC TGCAGACCGG CGCGTCCCCG 
GTGGCCTCAG CGGCGCAGCT CCTGGACACA CACCTGCACA TTGGCACCGG CCCCACCGCC 
CTCCCCGCTG TGCCCCCACC ACGCCTGGCC AGGCTGGCCC CAGGTTGTGA GCCCCTGGGG 
CTGCTGCAGG GGGACTGTGA GATGGAGGAC CTGATGCCCT GCTCCCTAGG CACGTTTGTC 
CTGGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775490.2
CDS	137..2488
Translation	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ

Target ORF information:

RefSeq Version	NM_173354.5
Organism	Homo sapiens(human)
Definition	Homo sapiens salt inducible kinase 1 (SIK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173354.5

ORF Insert Sequence:

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGTCACTGCA AAACAGCAGC TATAACCACT TTGCTGCCAT TTATTACCTC 
CTCCTTGAGC GGCTCAAGGA GTATCGGAAT GCCCAGTGCG CCCGCCCCGG GCCTGCCAGG 
CAGCCGCGGC CTCGGAGCTC GGACCTCAGT GGTTTGGAGG TGCCTCAGGA AGGTCTTTCC 
ACCGACCCTT TCCGACCTGC CTTGCTGTGC CCGCAGCCGC AGACCTTGGT GCAGTCCGTC 
CTCCAGGCCG AGATGGACTG TGAGCTCCAG AGCTCGCTGC AGTGGCCCTT GTTCTTCCCG 
GTGGATGCCA GCTGCAGCGG AGTGTTCCGG CCCCGGCCCG TGTCCCCAAG CAGCCTGCTG 
GACACAGCCA TCAGTGAGGA GGCCAGGCAG GGGCCGGGCC TAGAGGAGGA GCAGGACACG 
CAGGAGTCCC TGCCCAGCAG CACGGGCCGG AGGCACACCC TGGCCGAGGT CTCCACCCGC 
CTCTCCCCAC TCACCGCGCC ATGTATAGTC GTCTCCCCCT CCACCACGGC AAGTCCTGCA 
GAGGGAACCA GCTCTGACAG TTGTCTGACC TTCTCTGCGA GCAAAAGCCC CGCGGGGCTC 
AGTGGCACCC CGGCCACTCA GGGGCTGCTG GGCGCCTGCT CCCCGGTCAG GCTGGCCTCG 
CCCTTCCTGG GGTCGCAGTC CGCCACCCCA GTGCTGCAGG CTCAGGGGGG CTTGGGAGGA 
GCTGTTCTGC TCCCTGTCAG CTTCCAGGAG GGACGGCGGG CGTCGGACAC CTCACTGACT 
CAAGGGCTGA AGGCCTTTCG GCAGCAGCTG AGGAAGACCA CGCGGACCAA AGGGTTTCTG 
GGACTGAACA AAATCAAGGG GCTGGCTCGC CAGGTGTGCC AGGCCCCCGC CAGCCGGGCC 
AGCAGGGGCG GCCTGAGCCC CTTCCACGCC CCTGCACAGA GCCCAGGCCT GCACGGCGGC 
GCAGCCGGCA GCCGGGAGGG CTGGAGCCTG CTGGAGGAGG TGCTAGAGCA GCAGAGGCTG 
CTCCAGTTAC AGCACCACCC GGCCGCTGCA CCCGGCTGCT CCCAGGCCCC CCAGCCGGCC 
CCTGCCCCGT TTGTGATCGC CCCCTGTGAT GGCCCTGGGG CTGCCCCGCT CCCCAGCACC 
CTCCTCACGT CGGGGCTCCC GCTGCTGCCG CCCCCACTCC TGCAGACCGG CGCGTCCCCG 
GTGGCCTCAG CGGCGCAGCT CCTGGACACA CACCTGCACA TTGGCACCGG CCCCACCGCC 
CTCCCCGCTG TGCCCCCACC ACGCCTGGCC AGGCTGGCCC CAGGTTGTGA GCCCCTGGGG 
CTGCTGCAGG GGGACTGTGA GATGGAGGAC CTGATGCCCT GCTCCCTAGG CACGTTTGTC 
CTGGTGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIK1 ( XM_011529474.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527776.1 Homo sapiens salt inducible kinase 1 (SIK1), transcript variant X1, mRNA.

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CloneID	OHu76499
Clone ID Related Accession (Same CDS sequence)	XM_011529474.2
Accession Version	XM_011529474.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase SIK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000021.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011529474.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGGTGCCTCA GGAAGGTCTT TCCACCGACC CTTTCCGACC TGCCTTGCTG 
TGCCCGCAGC CGCAGACCTT GGTGCAGTCC GTCCTCCAGG CCGAGATGGA CTGTGAGCTC 
CAGAGCTCGC TGCAGTGGCC CTTGTTCTTC CCGGTGGATG CCAGCTGCAG CGGAGTGTTC 
CGGCCCCGGC CCGTGTCCCC AAGCAGCCTG CTGGACACAG CCATCAGTGA GGAGGCCAGG 
CAGGGGCCGG GCCTAGAGGA GGAGCAGGAC ACGCAGGAGT CCCTGCCCAG CAGCACGGGC 
CGGAGGCACA CCCTGGCCGA GGTCTCCACC CGCCTCTCCC CACTCACCGC GCCATGTATA 
GTCGTCTCCC CCTCCACCAC GGCAAGTCCT GCAGAGGGAA CCAGCTCTGA CAGTTGTCTG 
ACCTTCTCTG CGAGCAAAAG CCCCGCGGGG CTCAGTGGCA CCCCGGCCAC TCAGGGGCTG 
CTGGGCGCCT GCTCCCCGGT CAGGCTGGCC TCGCCCTTCC TGGGGTCGCA GTCCGCCACC 
CCAGTGCTGC AGGCTCAGGG GGGCTTGGGA GGAGCTGTTC TGCTCCCTGT CAGCTTCCAG 
GAGGGACGGC GGGCGTCGGA CACCTCACTG ACTCAAGGGC TGAAGGCCTT TCGGCAGCAG 
CTGAGGAAGA CCACGCGGAC CAAAGGGTTT CTGGGACTGA ACAAAATCAA GGGGCTGGCT 
CGCCAGGTGT GCCAGGCCCC CGCCAGCCGG GCCAGCAGGG GCGGCCTGAG CCCCTTCCAC 
GCCCCTGCAC AGAGCCCAGG CCTGCACGGC GGCGCAGCCG GCAGCCGGGA GGGCTGGAGC 
CTGCTGGAGG AGGTGCTAGA GCAGCAGAGG CTGCTCCAGT TACAGCACCA CCCGGCCGCT 
GCACCCGGCT GCTCCCAGGC CCCCCAGCCG GCCCCTGCCC CGTTTGTGAT CGCCCCCTGT 
GATGGCCCTG GGGCTGCCCC GCTCCCCAGC ACCCTCCTCA CGTCGGGGCT CCCGCTGCTG 
CCGCCCCCAC TCCTGCAGAC CGGCGCGTCC CCGGTGGCCT CAGCGGCGCA GCTCCTGGAC 
ACACACCTGC ACATTGGCAC CGGCCCCACC GCCCTCCCCG CTGTGCCCCC ACCACGCCTG 
GCCAGGCTGG CCCCAGGTTG TGAGCCCCTG GGGCTGCTGC AGGGGGACTG TGAGATGGAG 
GACCTGATGC CCTGCTCCCT AGGCACGTTT GTCCTGGTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527776.1
CDS	132..2336
Translation	MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ

Target ORF information:

RefSeq Version	XM_011529474.2
Organism	Homo sapiens(human)
Definition	Homo sapiens salt inducible kinase 1 (SIK1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011529474.2

ORF Insert Sequence:

ATGGTTATCA TGTCGGAGTT CAGCGCGGAC CCCGCGGGCC AGGGTCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGTTTTTA CGACATCGAG CGGACCCTGG GCAAAGGCAA CTTCGCGGTG 
GTGAAGCTGG CGCGGCATCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGATAAA 
ACACGATTAG ATTCAAGCAA TTTGGAGAAA ATCTATCGTG AGGTTCAGCT GATGAAGCTT 
CTGAACCATC CACACATCAT AAAGCTTTAC CAGGTTATGG AAACAAAGGA CATGCTTTAC 
ATCGTCACTG AATTTGCTAA AAATGGAGAA ATGTTTGATT ATTTGACTTC CAACGGGCAC 
CTGAGTGAGA ACGAGGCGCG GAAGAAGTTC TGGCAAATCC TGTCGGCCGT GGAGTACTGT 
CACGACCATC ACATCGTCCA CCGGGACCTC AAGACCGAGA ACCTCCTGCT GGATGGCAAC 
ATGGACATCA AGCTGGCAGA TTTTGGATTT GGGAATTTCT ACAAGTCAGG AGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCC GCCCCGGAAG TCTTTGAGGG GAAGGAGTAT 
GAAGGCCCCC AGCTGGACAT CTGGAGCCTG GGCGTGGTGC TGTACGTCCT GGTCTGCGGT 
TCTCTCCCCT TCGATGGGCC TAACCTGCCG ACGCTGAGAC AGCGGGTGCT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGAGCC TGATCCGCCG CATGCTGGTG 
GTGGACCCCG CCAGGCGCAT CACCATCGCC CAGATCCGGC AGCACCGGTG GATGCGGGCT 
GAGCCCTGCT TGCCGGGACC CGCCTGCCCC GCCTTCTCCG CACACAGCTA CACCTCCAAC 
CTGGGCGACT ACGATGAGCA GGCGCTGGGT ATCATGCAGA CCCTGGGCGT GGACCGGCAG 
AGGACGGTGG AGGTGCCTCA GGAAGGTCTT TCCACCGACC CTTTCCGACC TGCCTTGCTG 
TGCCCGCAGC CGCAGACCTT GGTGCAGTCC GTCCTCCAGG CCGAGATGGA CTGTGAGCTC 
CAGAGCTCGC TGCAGTGGCC CTTGTTCTTC CCGGTGGATG CCAGCTGCAG CGGAGTGTTC 
CGGCCCCGGC CCGTGTCCCC AAGCAGCCTG CTGGACACAG CCATCAGTGA GGAGGCCAGG 
CAGGGGCCGG GCCTAGAGGA GGAGCAGGAC ACGCAGGAGT CCCTGCCCAG CAGCACGGGC 
CGGAGGCACA CCCTGGCCGA GGTCTCCACC CGCCTCTCCC CACTCACCGC GCCATGTATA 
GTCGTCTCCC CCTCCACCAC GGCAAGTCCT GCAGAGGGAA CCAGCTCTGA CAGTTGTCTG 
ACCTTCTCTG CGAGCAAAAG CCCCGCGGGG CTCAGTGGCA CCCCGGCCAC TCAGGGGCTG 
CTGGGCGCCT GCTCCCCGGT CAGGCTGGCC TCGCCCTTCC TGGGGTCGCA GTCCGCCACC 
CCAGTGCTGC AGGCTCAGGG GGGCTTGGGA GGAGCTGTTC TGCTCCCTGT CAGCTTCCAG 
GAGGGACGGC GGGCGTCGGA CACCTCACTG ACTCAAGGGC TGAAGGCCTT TCGGCAGCAG 
CTGAGGAAGA CCACGCGGAC CAAAGGGTTT CTGGGACTGA ACAAAATCAA GGGGCTGGCT 
CGCCAGGTGT GCCAGGCCCC CGCCAGCCGG GCCAGCAGGG GCGGCCTGAG CCCCTTCCAC 
GCCCCTGCAC AGAGCCCAGG CCTGCACGGC GGCGCAGCCG GCAGCCGGGA GGGCTGGAGC 
CTGCTGGAGG AGGTGCTAGA GCAGCAGAGG CTGCTCCAGT TACAGCACCA CCCGGCCGCT 
GCACCCGGCT GCTCCCAGGC CCCCCAGCCG GCCCCTGCCC CGTTTGTGAT CGCCCCCTGT 
GATGGCCCTG GGGCTGCCCC GCTCCCCAGC ACCCTCCTCA CGTCGGGGCT CCCGCTGCTG 
CCGCCCCCAC TCCTGCAGAC CGGCGCGTCC CCGGTGGCCT CAGCGGCGCA GCTCCTGGAC 
ACACACCTGC ACATTGGCAC CGGCCCCACC GCCCTCCCCG CTGTGCCCCC ACCACGCCTG 
GCCAGGCTGG CCCCAGGTTG TGAGCCCCTG GGGCTGCTGC AGGGGGACTG TGAGATGGAG 
GACCTGATGC CCTGCTCCCT AGGCACGTTT GTCCTGGTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
The FEBS journal(2017 Dec)
Sonntag T,Vaughan JM,Montminy M

Role of salt inducible kinase 1 in high glucose-induced lipid accumulation in HepG2 cells and metformin intervention.
Life sciences173107-115(2017 Mar)
Zhang Y,Takemori H,Wang C,Fu J,Xu M,Xiong L,Li N,Wen X

Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology.
European journal of human genetics : EJHG25(2)216-221(2017 02)
Pr?schel C,Hansen JN,Ali A,Tuttle E,Lacagnina M,Buscaglia G,Halterman MW,Paciorkowski AR

Down-regulation of salt-inducible kinase 1 (SIK1) is mediated by RNF2 in hepatocarcinogenesis.
Oncotarget8(2)3144-3155(2017 Jan)
Qu C,Qu Y

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SIK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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