EXOC8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EXOC8
Entrez Gene ID	149371
Full Name	exocyst complex component 8
Synonyms	EXO84,Exo84p,SEC84
General protein information	Preferred Names exocyst complex component 8 Names exocyst complex component 8 exocyst complex 84 kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.2
Summary	This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016].
Disorder MIM:	615283

mRNA and Protein(s)

mRNA	Protein	Name
NM_175876.4	NP_787072.2	exocyst complex component 8
NM_175876.5	NP_787072.2	exocyst complex component 8

Pathways from BioSystems

Homologies

	EXOC8	XP_001104940.1
Gallus gallus (chicken)	EXOC8	NP_001006404.1
Homo sapiens (human)	EXOC8	NP_787072.2
Canis lupus familiaris (dog)	EXOC8	XP_005618878.1
Danio rerio (zebrafish)	exoc8	NP_001103945.1
Pan troglodytes (chimpanzee)	EXOC8	XP_513085.1
Mus musculus (house mouse)	Exoc8	NP_932771.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004207	XP_313109.5
Bos taurus (cattle)	EXOC8	NP_001091581.1
Rattus norvegicus (Norway rat)	Exoc8	NP_620612.1
Caenorhabditis elegans (roundworm)	exoc-8	NP_001021702.1
Drosophila melanogaster (fruit fly)	exo84	NP_651454.1
Xenopus tropicalis (tropical clawed frog)	exoc8	XP_002941641.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, M?nch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V
Developmental cell30(4)394-409(2014 Aug)

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.
Monteiro P, Ross? C, Castro-Castro A, Irondelle M, Lagoutte E, Paul-Gilloteaux P, Desnos C, Formstecher E, Darchen F, Perrais D, Gautreau A, Hertzog M, Chavrier P
The Journal of cell biology203(6)1063-79(2013 Dec)

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA
Nature cell biology15(10)1220-30(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified interactions between RalA and its effectors sec5 and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells.
Title: Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization.

shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells.
Title: Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.

evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84
Title: Ral GTPases regulate exocyst assembly through dual subunit interactions.

The following EXOC8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOC8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29257	NM_175876.5 Latest version!	Homo sapiens exocyst complex component 8 (EXOC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu29257	NM_175876.4	Homo sapiens exocyst complex component 8 (EXOC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EXOC8 ( NM_175876.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_787072.2 Homo sapiens exocyst complex component 8 (EXOC8), mRNA.

Price & Availability↑

CloneID	OHu29257
Clone ID Related Accession (Same CDS sequence)	NM_175876.4 , NM_175876.5
Accession Version	NM_175876.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2178bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	exocyst complex component 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB442221.1, AK096460.1, BC035763.1, DA884148.1, CA775845.1 and BM998007.1. This sequence is a reference standard in the RefSeqGene project. On Jan 30, 2015 this sequence version replaced NM_175876.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCGATGG CGATGTCGGA CAGTGGGGCG AGCCGCCTGC GTCGGCAGCT GGAGTCAGGG 
GGTTTTGAGG CGCGGCTGTA CGTGAAGCAG CTCTCGCAGC AGTCGGATGG GGACCGGGAC 
CTCCAGGAGC ACCGGCAGCG CATCCAGGCG CTGGCGGAGG AGACGGCGCA GAACCTGAAG 
CGCAACGTCT ACCAGAACTA CCGGCAGTTC ATAGAGACGG CCCGCGAGAT CTCCTACCTG 
GAGAGCGAGA TGTACCAGCT CAGCCATTTG CTGACCGAGC AGAAAAGCAG CCTGGAGAGC 
ATCCCGCTTA CGTTGCTGCC TGCCGCTGCT GCCGCCGGAG CCGCCGCCGC CTCTGGAGGG 
GAGGAGGGAG TCGGTGGGGC GGGGGGCCGA GACCACCTCC GAGGCCAGGC CGGCTTTTTC 
TCCACCCCCG GGGGTGCCTC CCGCGACGGC TCCGGTCCAG GCGAGGAAGG AAAGCAGCGC 
ACTCTCACCA CCCTGCTTGA GAAGGTGGAA GGCTGCAGGC ATCTGCTGGA GACGCCGGGA 
CAGTACTTGG TGTACAATGG GGACCTAGTG GAATACGATG CGGACCACAT GGCCCAACTG 
CAGCGGGTGC ACGGCTTTCT CATGAACGAT TGCTTGTTGG TGGCTACCTG GCTGCCTCAG 
CGGCGTGGGA TGTATCGCTA CAACGCTCTC TATTCCCTAG ATGGTTTGGC CGTAGTCAAT 
GTCAAGGACA ACCCGCCCAT GAAGGACATG TTCAAGCTGC TTATGTTCCC CGAGAGCCGT 
ATTTTCCAGG CCGAAAATGC TAAAATCAAA CGAGAGTGGC TGGAAGTGCT GGAGGACACC 
AAGAGGGCCC TCAGTGAGAA AAGGCGAAGG GAGCAGGAGG AGGCAGCGGC CCCTCGAGGG 
CCACCCCAAG TGACTTCCAA GGCCACTAAC CCATTTGAGG ATGACGAAGA AGAAGAACCA 
GCTGTTCCTG AGGTAGAGGA AGAGAAGGTG GACCTCTCCA TGGAATGGAT CCAGGAGTTA 
CCTGAAGACC TGGATGTCTG CATTGCGCAG AGAGACTTTG AAGGGGCGGT TGACCTGCTG 
GATAAATTGA ACCATTACCT GGAAGATAAA CCTAGCCCAC CTCCTGTAAA AGAACTAAGG 
GCCAAAGTGG AGGAGCGAGT TCGACAGCTC ACTGAGGTGC TAGTTTTCGA ACTCTCCCCA 
GATCGTTCCC TGAGAGGTGG TCCGAAGGCT ACTCGCAGAG CAGTTTCGCA ACTGATCCGG 
CTGGGCCAGT GCACGAAGGC CTGTGAGCTA TTTTTGAGAA ACAGGGCAGC CGCTGTTCAT 
ACTGCAATTC GTCAGCTTCG CATCGAAGGT GCCACTTTAC TCTATATTCA TAAGCTGTGC 
CATGTCTTCT TTACCAGCCT TCTCGAGACT GCAAGAGAAT TTGAGATCGA TTTTGCAGGC 
ACTGACAGCG GCTGCTACTC TGCCTTTGTG GTCTGGGCAA GATCAGCCAT GGGCATGTTC 
GTGGATGCTT TTAGCAAGCA GGTGTTTGAT AGTAAGGAGA GCCTCTCTAC AGCAGCTGAG 
TGTGTAAAAG TGGCTAAGGA GCATTGCCAG CAACTGGGTG ATATCGGACT GGATCTCACC 
TTCATCATCC ATGCCCTTCT GGTGAAAGAC ATCCAAGGGG CCTTGCACAG TTACAAAGAA 
ATCATCATTG AAGCCACTAA ACATCGCAAC TCTGAAGAGA TGTGGAGGAG GATGAACTTG 
ATGACGCCAG AAGCCCTGGG TAAGCTCAAA GAAGAGATGA AAAGTTGTGG GGTAAGTAAC 
TTTGAGCAGT ACACAGGGGA TGACTGCTGG GTGAACCTAA GTTACACAGT GGTTGCTTTC 
ACCAAACAGA CCATGGGCTT CTTGGAAGAG GCCCTGAAGC TGTATTTCCC AGAGCTGCAC 
ATGGTACTTT TGGAGAGCCT GGTGGAAATC ATTTTGGTTG CTGTTCAGCA TGTGGATTAT 
AGTCTTCGAT GTGAGCAGGA TCCAGAGAAG AAAGCTTTTA TCAGACAGAA TGCATCCTTT 
TTATATGAAA CAGTCCTCCC TGTGGTGGAG AAAAGGTTTG AAGAAGGTGT GGGGAAACCT 
GCCAAGCAAC TCCAAGATCT GAGGAATGCA TCTAGACTTA TTCGTGTGAA TCCTGAAAGT 
ACAACATCAG TGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787072.2
CDS	128..2305
Translation	MAMAMSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRIQALAEETAQNLKRNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLTLLPAAAAAGAAAASGGEEGVGGAGGRDHLRGQAGFFSTPGGASRDGSGPGEEGKQRTLTTLLEKVEGCRHLLETPGQYLVYNGDLVEYDADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYSLDGLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEVLEDTKRALSEKRRREQEEAAAPRGPPQVTSKATNPFEDDEEEEPAVPEVEEEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPPVKELRAKVEERVRQLTEVLVFELSPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFEIDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHCQQLGDIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHRNSEEMWRRMNLMTPEALGKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEIILVAVQHVDYSLRCEQDPEKKAFIRQNASFLYETVLPVVEKRFEEGVGKPAKQLQDLRNASRLIRVNPESTTSVV

Target ORF information:

RefSeq Version	NM_175876.4
Organism	Homo sapiens(human)
Definition	Homo sapiens exocyst complex component 8 (EXOC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175876.4

ORF Insert Sequence:

ATGGCGATGG CGATGTCGGA CAGTGGGGCG AGCCGCCTGC GTCGGCAGCT GGAGTCAGGG 
GGTTTTGAGG CGCGGCTGTA CGTGAAGCAG CTCTCGCAGC AGTCGGATGG GGACCGGGAC 
CTCCAGGAGC ACCGGCAGCG CATCCAGGCG CTGGCGGAGG AGACGGCGCA GAACCTGAAG 
CGCAACGTCT ACCAGAACTA CCGGCAGTTC ATAGAGACGG CCCGCGAGAT CTCCTACCTG 
GAGAGCGAGA TGTACCAGCT CAGCCATTTG CTGACCGAGC AGAAAAGCAG CCTGGAGAGC 
ATCCCGCTTA CGTTGCTGCC TGCCGCTGCT GCCGCCGGAG CCGCCGCCGC CTCTGGAGGG 
GAGGAGGGAG TCGGTGGGGC GGGGGGCCGA GACCACCTCC GAGGCCAGGC CGGCTTTTTC 
TCCACCCCCG GGGGTGCCTC CCGCGACGGC TCCGGTCCAG GCGAGGAAGG AAAGCAGCGC 
ACTCTCACCA CCCTGCTTGA GAAGGTGGAA GGCTGCAGGC ATCTGCTGGA GACGCCGGGA 
CAGTACTTGG TGTACAATGG GGACCTAGTG GAATACGATG CGGACCACAT GGCCCAACTG 
CAGCGGGTGC ACGGCTTTCT CATGAACGAT TGCTTGTTGG TGGCTACCTG GCTGCCTCAG 
CGGCGTGGGA TGTATCGCTA CAACGCTCTC TATTCCCTAG ATGGTTTGGC CGTAGTCAAT 
GTCAAGGACA ACCCGCCCAT GAAGGACATG TTCAAGCTGC TTATGTTCCC CGAGAGCCGT 
ATTTTCCAGG CCGAAAATGC TAAAATCAAA CGAGAGTGGC TGGAAGTGCT GGAGGACACC 
AAGAGGGCCC TCAGTGAGAA AAGGCGAAGG GAGCAGGAGG AGGCAGCGGC CCCTCGAGGG 
CCACCCCAAG TGACTTCCAA GGCCACTAAC CCATTTGAGG ATGACGAAGA AGAAGAACCA 
GCTGTTCCTG AGGTAGAGGA AGAGAAGGTG GACCTCTCCA TGGAATGGAT CCAGGAGTTA 
CCTGAAGACC TGGATGTCTG CATTGCGCAG AGAGACTTTG AAGGGGCGGT TGACCTGCTG 
GATAAATTGA ACCATTACCT GGAAGATAAA CCTAGCCCAC CTCCTGTAAA AGAACTAAGG 
GCCAAAGTGG AGGAGCGAGT TCGACAGCTC ACTGAGGTGC TAGTTTTCGA ACTCTCCCCA 
GATCGTTCCC TGAGAGGTGG TCCGAAGGCT ACTCGCAGAG CAGTTTCGCA ACTGATCCGG 
CTGGGCCAGT GCACGAAGGC CTGTGAGCTA TTTTTGAGAA ACAGGGCAGC CGCTGTTCAT 
ACTGCAATTC GTCAGCTTCG CATCGAAGGT GCCACTTTAC TCTATATTCA TAAGCTGTGC 
CATGTCTTCT TTACCAGCCT TCTCGAGACT GCAAGAGAAT TTGAGATCGA TTTTGCAGGC 
ACTGACAGCG GCTGCTACTC TGCCTTTGTG GTCTGGGCAA GATCAGCCAT GGGCATGTTC 
GTGGATGCTT TTAGCAAGCA GGTGTTTGAT AGTAAGGAGA GCCTCTCTAC AGCAGCTGAG 
TGTGTAAAAG TGGCTAAGGA GCATTGCCAG CAACTGGGTG ATATCGGACT GGATCTCACC 
TTCATCATCC ATGCCCTTCT GGTGAAAGAC ATCCAAGGGG CCTTGCACAG TTACAAAGAA 
ATCATCATTG AAGCCACTAA ACATCGCAAC TCTGAAGAGA TGTGGAGGAG GATGAACTTG 
ATGACGCCAG AAGCCCTGGG TAAGCTCAAA GAAGAGATGA AAAGTTGTGG GGTAAGTAAC 
TTTGAGCAGT ACACAGGGGA TGACTGCTGG GTGAACCTAA GTTACACAGT GGTTGCTTTC 
ACCAAACAGA CCATGGGCTT CTTGGAAGAG GCCCTGAAGC TGTATTTCCC AGAGCTGCAC 
ATGGTACTTT TGGAGAGCCT GGTGGAAATC ATTTTGGTTG CTGTTCAGCA TGTGGATTAT 
AGTCTTCGAT GTGAGCAGGA TCCAGAGAAG AAAGCTTTTA TCAGACAGAA TGCATCCTTT 
TTATATGAAA CAGTCCTCCC TGTGGTGGAG AAAAGGTTTG AAGAAGGTGT GGGGAAACCT 
GCCAAGCAAC TCCAAGATCT GAGGAATGCA TCTAGACTTA TTCGTGTGAA TCCTGAAAGT 
ACAACATCAG TGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOC8 ( NM_175876.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_787072.2 Homo sapiens exocyst complex component 8 (EXOC8), mRNA.

Price & Availability↑

CloneID	OHu29257
Clone ID Related Accession (Same CDS sequence)	NM_175876.4 , NM_175876.5
Accession Version	NM_175876.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2178bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	exocyst complex component 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB442221.1, AK096460.1, BC035763.1, DA884148.1 and CA775845.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_175876.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK096460.1, BC035763.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366645.1/ ENSP00000355605.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGATGG CGATGTCGGA CAGTGGGGCG AGCCGCCTGC GTCGGCAGCT GGAGTCAGGG 
GGTTTTGAGG CGCGGCTGTA CGTGAAGCAG CTCTCGCAGC AGTCGGATGG GGACCGGGAC 
CTCCAGGAGC ACCGGCAGCG CATCCAGGCG CTGGCGGAGG AGACGGCGCA GAACCTGAAG 
CGCAACGTCT ACCAGAACTA CCGGCAGTTC ATAGAGACGG CCCGCGAGAT CTCCTACCTG 
GAGAGCGAGA TGTACCAGCT CAGCCATTTG CTGACCGAGC AGAAAAGCAG CCTGGAGAGC 
ATCCCGCTTA CGTTGCTGCC TGCCGCTGCT GCCGCCGGAG CCGCCGCCGC CTCTGGAGGG 
GAGGAGGGAG TCGGTGGGGC GGGGGGCCGA GACCACCTCC GAGGCCAGGC CGGCTTTTTC 
TCCACCCCCG GGGGTGCCTC CCGCGACGGC TCCGGTCCAG GCGAGGAAGG AAAGCAGCGC 
ACTCTCACCA CCCTGCTTGA GAAGGTGGAA GGCTGCAGGC ATCTGCTGGA GACGCCGGGA 
CAGTACTTGG TGTACAATGG GGACCTAGTG GAATACGATG CGGACCACAT GGCCCAACTG 
CAGCGGGTGC ACGGCTTTCT CATGAACGAT TGCTTGTTGG TGGCTACCTG GCTGCCTCAG 
CGGCGTGGGA TGTATCGCTA CAACGCTCTC TATTCCCTAG ATGGTTTGGC CGTAGTCAAT 
GTCAAGGACA ACCCGCCCAT GAAGGACATG TTCAAGCTGC TTATGTTCCC CGAGAGCCGT 
ATTTTCCAGG CCGAAAATGC TAAAATCAAA CGAGAGTGGC TGGAAGTGCT GGAGGACACC 
AAGAGGGCCC TCAGTGAGAA AAGGCGAAGG GAGCAGGAGG AGGCAGCGGC CCCTCGAGGG 
CCACCCCAAG TGACTTCCAA GGCCACTAAC CCATTTGAGG ATGACGAAGA AGAAGAACCA 
GCTGTTCCTG AGGTAGAGGA AGAGAAGGTG GACCTCTCCA TGGAATGGAT CCAGGAGTTA 
CCTGAAGACC TGGATGTCTG CATTGCGCAG AGAGACTTTG AAGGGGCGGT TGACCTGCTG 
GATAAATTGA ACCATTACCT GGAAGATAAA CCTAGCCCAC CTCCTGTAAA AGAACTAAGG 
GCCAAAGTGG AGGAGCGAGT TCGACAGCTC ACTGAGGTGC TAGTTTTCGA ACTCTCCCCA 
GATCGTTCCC TGAGAGGTGG TCCGAAGGCT ACTCGCAGAG CAGTTTCGCA ACTGATCCGG 
CTGGGCCAGT GCACGAAGGC CTGTGAGCTA TTTTTGAGAA ACAGGGCAGC CGCTGTTCAT 
ACTGCAATTC GTCAGCTTCG CATCGAAGGT GCCACTTTAC TCTATATTCA TAAGCTGTGC 
CATGTCTTCT TTACCAGCCT TCTCGAGACT GCAAGAGAAT TTGAGATCGA TTTTGCAGGC 
ACTGACAGCG GCTGCTACTC TGCCTTTGTG GTCTGGGCAA GATCAGCCAT GGGCATGTTC 
GTGGATGCTT TTAGCAAGCA GGTGTTTGAT AGTAAGGAGA GCCTCTCTAC AGCAGCTGAG 
TGTGTAAAAG TGGCTAAGGA GCATTGCCAG CAACTGGGTG ATATCGGACT GGATCTCACC 
TTCATCATCC ATGCCCTTCT GGTGAAAGAC ATCCAAGGGG CCTTGCACAG TTACAAAGAA 
ATCATCATTG AAGCCACTAA ACATCGCAAC TCTGAAGAGA TGTGGAGGAG GATGAACTTG 
ATGACGCCAG AAGCCCTGGG TAAGCTCAAA GAAGAGATGA AAAGTTGTGG GGTAAGTAAC 
TTTGAGCAGT ACACAGGGGA TGACTGCTGG GTGAACCTAA GTTACACAGT GGTTGCTTTC 
ACCAAACAGA CCATGGGCTT CTTGGAAGAG GCCCTGAAGC TGTATTTCCC AGAGCTGCAC 
ATGGTACTTT TGGAGAGCCT GGTGGAAATC ATTTTGGTTG CTGTTCAGCA TGTGGATTAT 
AGTCTTCGAT GTGAGCAGGA TCCAGAGAAG AAAGCTTTTA TCAGACAGAA TGCATCCTTT 
TTATATGAAA CAGTCCTCCC TGTGGTGGAG AAAAGGTTTG AAGAAGGTGT GGGGAAACCT 
GCCAAGCAAC TCCAAGATCT GAGGAATGCA TCTAGACTTA TTCGTGTGAA TCCTGAAAGT 
ACAACATCAG TGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787072.2
CDS	108..2285
Translation	MAMAMSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRIQALAEETAQNLKRNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLTLLPAAAAAGAAAASGGEEGVGGAGGRDHLRGQAGFFSTPGGASRDGSGPGEEGKQRTLTTLLEKVEGCRHLLETPGQYLVYNGDLVEYDADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYSLDGLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEVLEDTKRALSEKRRREQEEAAAPRGPPQVTSKATNPFEDDEEEEPAVPEVEEEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPPVKELRAKVEERVRQLTEVLVFELSPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFEIDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHCQQLGDIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHRNSEEMWRRMNLMTPEALGKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEIILVAVQHVDYSLRCEQDPEKKAFIRQNASFLYETVLPVVEKRFEEGVGKPAKQLQDLRNASRLIRVNPESTTSVV

Target ORF information:

RefSeq Version	NM_175876.5
Organism	Homo sapiens(human)
Definition	Homo sapiens exocyst complex component 8 (EXOC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175876.5

ORF Insert Sequence:

ATGGCGATGG CGATGTCGGA CAGTGGGGCG AGCCGCCTGC GTCGGCAGCT GGAGTCAGGG 
GGTTTTGAGG CGCGGCTGTA CGTGAAGCAG CTCTCGCAGC AGTCGGATGG GGACCGGGAC 
CTCCAGGAGC ACCGGCAGCG CATCCAGGCG CTGGCGGAGG AGACGGCGCA GAACCTGAAG 
CGCAACGTCT ACCAGAACTA CCGGCAGTTC ATAGAGACGG CCCGCGAGAT CTCCTACCTG 
GAGAGCGAGA TGTACCAGCT CAGCCATTTG CTGACCGAGC AGAAAAGCAG CCTGGAGAGC 
ATCCCGCTTA CGTTGCTGCC TGCCGCTGCT GCCGCCGGAG CCGCCGCCGC CTCTGGAGGG 
GAGGAGGGAG TCGGTGGGGC GGGGGGCCGA GACCACCTCC GAGGCCAGGC CGGCTTTTTC 
TCCACCCCCG GGGGTGCCTC CCGCGACGGC TCCGGTCCAG GCGAGGAAGG AAAGCAGCGC 
ACTCTCACCA CCCTGCTTGA GAAGGTGGAA GGCTGCAGGC ATCTGCTGGA GACGCCGGGA 
CAGTACTTGG TGTACAATGG GGACCTAGTG GAATACGATG CGGACCACAT GGCCCAACTG 
CAGCGGGTGC ACGGCTTTCT CATGAACGAT TGCTTGTTGG TGGCTACCTG GCTGCCTCAG 
CGGCGTGGGA TGTATCGCTA CAACGCTCTC TATTCCCTAG ATGGTTTGGC CGTAGTCAAT 
GTCAAGGACA ACCCGCCCAT GAAGGACATG TTCAAGCTGC TTATGTTCCC CGAGAGCCGT 
ATTTTCCAGG CCGAAAATGC TAAAATCAAA CGAGAGTGGC TGGAAGTGCT GGAGGACACC 
AAGAGGGCCC TCAGTGAGAA AAGGCGAAGG GAGCAGGAGG AGGCAGCGGC CCCTCGAGGG 
CCACCCCAAG TGACTTCCAA GGCCACTAAC CCATTTGAGG ATGACGAAGA AGAAGAACCA 
GCTGTTCCTG AGGTAGAGGA AGAGAAGGTG GACCTCTCCA TGGAATGGAT CCAGGAGTTA 
CCTGAAGACC TGGATGTCTG CATTGCGCAG AGAGACTTTG AAGGGGCGGT TGACCTGCTG 
GATAAATTGA ACCATTACCT GGAAGATAAA CCTAGCCCAC CTCCTGTAAA AGAACTAAGG 
GCCAAAGTGG AGGAGCGAGT TCGACAGCTC ACTGAGGTGC TAGTTTTCGA ACTCTCCCCA 
GATCGTTCCC TGAGAGGTGG TCCGAAGGCT ACTCGCAGAG CAGTTTCGCA ACTGATCCGG 
CTGGGCCAGT GCACGAAGGC CTGTGAGCTA TTTTTGAGAA ACAGGGCAGC CGCTGTTCAT 
ACTGCAATTC GTCAGCTTCG CATCGAAGGT GCCACTTTAC TCTATATTCA TAAGCTGTGC 
CATGTCTTCT TTACCAGCCT TCTCGAGACT GCAAGAGAAT TTGAGATCGA TTTTGCAGGC 
ACTGACAGCG GCTGCTACTC TGCCTTTGTG GTCTGGGCAA GATCAGCCAT GGGCATGTTC 
GTGGATGCTT TTAGCAAGCA GGTGTTTGAT AGTAAGGAGA GCCTCTCTAC AGCAGCTGAG 
TGTGTAAAAG TGGCTAAGGA GCATTGCCAG CAACTGGGTG ATATCGGACT GGATCTCACC 
TTCATCATCC ATGCCCTTCT GGTGAAAGAC ATCCAAGGGG CCTTGCACAG TTACAAAGAA 
ATCATCATTG AAGCCACTAA ACATCGCAAC TCTGAAGAGA TGTGGAGGAG GATGAACTTG 
ATGACGCCAG AAGCCCTGGG TAAGCTCAAA GAAGAGATGA AAAGTTGTGG GGTAAGTAAC 
TTTGAGCAGT ACACAGGGGA TGACTGCTGG GTGAACCTAA GTTACACAGT GGTTGCTTTC 
ACCAAACAGA CCATGGGCTT CTTGGAAGAG GCCCTGAAGC TGTATTTCCC AGAGCTGCAC 
ATGGTACTTT TGGAGAGCCT GGTGGAAATC ATTTTGGTTG CTGTTCAGCA TGTGGATTAT 
AGTCTTCGAT GTGAGCAGGA TCCAGAGAAG AAAGCTTTTA TCAGACAGAA TGCATCCTTT 
TTATATGAAA CAGTCCTCCC TGTGGTGGAG AAAAGGTTTG AAGAAGGTGT GGGGAAACCT 
GCCAAGCAAC TCCAAGATCT GAGGAATGCA TCTAGACTTA TTCGTGTGAA TCCTGAAAGT 
ACAACATCAG TGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Developmental cell30(4)394-409(2014 Aug)
Mandell MA,Jain A,Arko-Mensah J,Chauhan S,Kimura T,Dinkins C,Silvestri G,M?nch J,Kirchhoff F,Simonsen A,Wei Y,Levine B,Johansen T,Deretic V

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.
The Journal of cell biology203(6)1063-79(2013 Dec)
Monteiro P,Ross? C,Castro-Castro A,Irondelle M,Lagoutte E,Paul-Gilloteaux P,Desnos C,Formstecher E,Darchen F,Perrais D,Gautreau A,Hertzog M,Chavrier P

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Nature cell biology15(10)1220-30(2013 Oct)
Simicek M,Lievens S,Laga M,Guzenko D,Aushev VN,Kalev P,Baietti MF,Strelkov SV,Gevaert K,Tavernier J,Sablina AA

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EXOC8 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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