CTAG1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTAG1B
Entrez Gene ID	1485
Full Name	cancer/testis antigen 1B
Synonyms	CT6.1,CTAG,CTAG1,ESO1,LAGE-2,LAGE2B,NY-ESO-1
General protein information	Preferred Names cancer/testis antigen 1B Names cancer/testis antigen 1 New York esophageal squamous cell carcinoma 1 autoimmunogenic cancer/testis antigen NY-ESO-1 cancer antigen 3 cancer/testis antigen 6.1 l antigen family member 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012].
Disorder MIM:	300156

mRNA and Protein(s)

mRNA	Protein	Name
NM_001327.2	NP_001318.1	cancer/testis antigen 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CTAG1B	NP_001318.1
Homo sapiens (human)	CTAG1A	NP_640343.1

Gene Ontology
Bibliography

Related articles in PubMed

NY-ESO-1- and survivin-specific T-cell responses in the peripheral blood from patients with glioma.
Liu Z, Poiret T, Persson O, Meng Q, Rane L, Bartek J Jr, Karbach J, Altmannsberger HM, Illies C, Luo X, Harvey-Peredo I, J?ger E, Dodoo E, Maeurer M
Cancer immunology, immunotherapy : CII(2017 Oct)

Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status.
Shiohama Y, Naito T, Matsuzaki T, Tanaka R, Tomoyose T, Takashima H, Fukushima T, Tanaka Y, Saito M
Virology journal14(1)130(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data demonstrate that MAGE-A1-, MAGE-A3-, and NY-ESO-1-specific T cells with antigen-specific cytotoxicity can be cultured from healthy donors and patient-derived cells making adoptive immunotherapy with these cytotoxic T lymphocyte feasible.
Title: Expansion of cancer germline antigen-specific cytotoxic T lymphocytes for immunotherapy.

Data suggest that only a small fraction of HLA-A*02:01- (HA)-binding ESO peptides are immunogenic, namely those that have high peptide-binding strength and peptide/HA complex stability. This study involved comparison of in silico-predicted and observed cytotoxic T-lymphocyte recognition of tumor antigen epitopes in melanoma patients and transgenic/knockout mice. (ESO = tumor antigen NY-ESO-1)

Results support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as targets for immunotherapy and as ancillary prognostic parameters in synovial sarcomas.
Title: Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1.

High NY-ESO-1 expression is associated with Lung Cancer.
Title: Case-Control Study: Smoking History Affects the Production of Tumor Antigen-Specific Antibodies NY-ESO-1 in Patients with Lung Cancer in Comparison with Cancer Disease-Free Group.

Comparing the overall expression of CTAs, a decreased expression of all melanoma-associated antigens (MAGEs) post-treatment and a slightly increased expression of New York esophageal squamous cell carcinoma 1 (NY-ESO-1) was visible. The simultaneous cytoplasmic and nuclear expression of pan-MAGE or MAGE-A3/A4 correlated with reduced treatment-failure-free-survival (TFFS).
Title: Influence of Photodynamic Therapy on the Expression of Cancer/Testis Antigens in Squamous Cell Carcinoma of the Head and Neck.

The following CTAG1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTAG1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu15131	NM_001327.2 Latest version!	Homo sapiens cancer/testis antigen 1B (CTAG1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTAG1B ( NM_001327.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001318.1 Homo sapiens cancer/testis antigen 1B (CTAG1B), mRNA.

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CloneID	OHu15131
Clone ID Related Accession (Same CDS sequence)	NM_001327.2
Accession Version	NM_001327.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Homo sapiens(human)
Product	cancer/testis antigen 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U87459.1. On Nov 27, 2008 this sequence version replaced NM_001327.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U87459.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCCG AAGGCCGGGG CACAGGGGGT TCGACGGGCG ATGCTGATGG CCCAGGAGGC 
CCTGGCATTC CTGATGGCCC AGGGGGCAAT GCTGGCGGCC CAGGAGAGGC GGGTGCCACG 
GGCGGCAGAG GTCCCCGGGG CGCAGGGGCA GCAAGGGCCT CGGGGCCGGG AGGAGGCGCC 
CCGCGGGGTC CGCATGGCGG CGCGGCTTCA GGGCTGAATG GATGCTGCAG ATGCGGGGCC 
AGGGGGCCGG AGAGCCGCCT GCTTGAGTTC TACCTCGCCA TGCCTTTCGC GACACCCATG 
GAAGCAGAGC TGGCCCGCAG GAGCCTGGCC CAGGATGCCC CACCGCTTCC CGTGCCAGGG 
GTGCTTCTGA AGGAGTTCAC TGTGTCCGGC AACATACTGA CTATCCGACT GACTGCTGCA 
GACCACCGCC AACTGCAGCT CTCCATCAGC TCCTGTCTCC AGCAGCTTTC CCTGTTGATG 
TGGATCACGC AGTGCTTTCT GCCCGTGTTT TTGGCTCAGC CTCCCTCAGG GCAGAGGCGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001318.1
CDS	54..596
Translation	MQAEGRGTGGSTGDADGPGGPGIPDGPGGNAGGPGEAGATGGRGPRGAGAARASGPGGGAPRGPHGGAASGLNGCCRCGARGPESRLLEFYLAMPFATPMEAELARRSLAQDAPPLPVPGVLLKEFTVSGNILTIRLTAADHRQLQLSISSCLQQLSLLMWITQCFLPVFLAQPPSGQRR

Target ORF information:

RefSeq Version	NM_001327.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer/testis antigen 1B (CTAG1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001327.2

ORF Insert Sequence:

ATGCAGGCCG AAGGCCGGGG CACAGGGGGT TCGACGGGCG ATGCTGATGG CCCAGGAGGC 
CCTGGCATTC CTGATGGCCC AGGGGGCAAT GCTGGCGGCC CAGGAGAGGC GGGTGCCACG 
GGCGGCAGAG GTCCCCGGGG CGCAGGGGCA GCAAGGGCCT CGGGGCCGGG AGGAGGCGCC 
CCGCGGGGTC CGCATGGCGG CGCGGCTTCA GGGCTGAATG GATGCTGCAG ATGCGGGGCC 
AGGGGGCCGG AGAGCCGCCT GCTTGAGTTC TACCTCGCCA TGCCTTTCGC GACACCCATG 
GAAGCAGAGC TGGCCCGCAG GAGCCTGGCC CAGGATGCCC CACCGCTTCC CGTGCCAGGG 
GTGCTTCTGA AGGAGTTCAC TGTGTCCGGC AACATACTGA CTATCCGACT GACTGCTGCA 
GACCACCGCC AACTGCAGCT CTCCATCAGC TCCTGTCTCC AGCAGCTTTC CCTGTTGATG 
TGGATCACGC AGTGCTTTCT GCCCGTGTTT TTGGCTCAGC CTCCCTCAGG GCAGAGGCGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NY-ESO-1- and survivin-specific T-cell responses in the peripheral blood from patients with glioma.
Cancer immunology, immunotherapy : CII(2017 Oct)
Liu Z,Poiret T,Persson O,Meng Q,Rane L,Bartek J Jr,Karbach J,Altmannsberger HM,Illies C,Luo X,Harvey-Peredo I,J?ger E,Dodoo E,Maeurer M

Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status.
Virology journal14(1)130(2017 Jul)
Shiohama Y,Naito T,Matsuzaki T,Tanaka R,Tomoyose T,Takashima H,Fukushima T,Tanaka Y,Saito M

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CTAG1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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