TICAM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TICAM1
Entrez Gene ID	148022
Full Name	toll like receptor adaptor molecule 1
Synonyms	IIAE6,MyD88-3,PRVTIRB,TICAM-1,TRIF
General protein information	Preferred Names toll like receptor adaptor molecule 1 Names TIR domain-containing adapter molecule 1 TIR domain containing adaptor inducing interferon-beta TIR domain-containing adapter protein inducing IFN-beta proline-rich, vinculin and TIR domain-containing protein B putative NF-kappa-B-activating protein 502H toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012].
Disorder MIM:	607601
Disorder Html:	{Herpes simplex encephalitic, susceptibility to, 6}, 614850 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_182919.3	NP_891549.1	TIR domain-containing adapter molecule 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TICAM1	XP_854666.2
Mus musculus (house mouse)	Ticam1	NP_778154.1
Homo sapiens (human)	TICAM1	NP_891549.1
Pan troglodytes (chimpanzee)	TICAM1	NP_001123604.1
	TICAM1	NP_001123900.1
Bos taurus (cattle)	TICAM1	NP_001025472.1
Rattus norvegicus (Norway rat)	Ticam1	XP_003750678.1

Gene Ontology
Bibliography

Related articles in PubMed

TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation.
Wang FX, Yang XL, Ma YS, Wei YJ, Yang MH, Chen X, Chen B, He Q, Yang QW, Yang H, Liu SY
Brain, behavior, and immunity6765-76(2018 Jan)

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.
Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M
Yonsei medical journal59(1)43-50(2018 Jan)

Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Funami K, Matsumoto M, Oshiumi H, Inagaki F, Seya T
Biochemical Society transactions45(4)929-935(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Therefore, Seneca Valley virus suppressed antiviral interferon production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS, TRIF, and TANK by its 3C protease.
Title: Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.

TRIF gene may contribute to susceptibility of T2DM.
Title: The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental factors on type 2 diabetes mellitus and vascular complications in a Han Chinese population.

Data suggest that endosomal localization of TICAM2 is essential for TLR4-mediated type I interferon-inducing signaling from endosomes; TICAM2 acts as scaffold protein and activates TICAM1; N-terminal myristoylation allows TICAM2 to anchor to endosomal membrane. (TICAM2 = toll like receptor adaptor molecule-2; TICAM1 = toll like receptor adaptor molecule-1; TLR4 = toll-like receptor 4) [REVIEW]
Title: Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.

Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (TRIF) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF/RIPK1/caspase-8 occurs in fibrillary platforms.
Title: TIR-domain-containing adapter-inducing interferon-? (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy.

The NF-kappaB activated by dsRNA appears not to be the canonical p65/p50 heterodimers.
Title: Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-?B pathway.

The following TICAM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TICAM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu21097	NM_182919.3 Latest version!	Homo sapiens toll like receptor adaptor molecule 1 (TICAM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TICAM1 ( NM_182919.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_891549.1 Homo sapiens toll like receptor adaptor molecule 1 (TICAM1), mRNA.

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CloneID	OHu21097
Clone ID Related Accession (Same CDS sequence)	NM_182919.3
Accession Version	NM_182919.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2139bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	TIR domain-containing adapter molecule 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC027319.5, DR000002.1, BC035331.1, AB086380.1 and BX349282.2. This sequence is a reference standard in the RefSeqGene project. On Jan 11, 2012 this sequence version replaced NM_182919.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035331.1, SRR1163658.173895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2151358 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCTGCA CAGGCCCATC ACTTCCTAGC GCCTTCGACA TTCTAGGTGC AGCAGGCCAG 
GACAAGCTCT TGTATCTGAA GCACAAACTG AAGACCCCAC GCCCAGGCTG CCAGGGGCAG 
GACCTCCTGC ATGCCATGGT TCTCCTGAAG CTGGGCCAGG AAACTGAGGC CAGGATCTCT 
CTAGAGGCAT TGAAGGCCGA TGCGGTGGCC CGGCTGGTGG CCCGCCAGTG GGCTGGCGTG 
GACAGCACCG AGGACCCAGA GGAGCCCCCA GATGTGTCCT GGGCTGTGGC CCGCTTGTAC 
CACCTGCTGG CTGAGGAGAA GCTGTGCCCC GCCTCGCTGC GGGACGTGGC CTACCAGGAA 
GCCGTCCGCA CCCTCAGCTC CAGGGACGAC CACCGGCTGG GGGAACTTCA GGATGAGGCC 
CGAAACCGGT GTGGGTGGGA CATTGCTGGG GATCCAGGGA GCATCCGGAC GCTCCAGTCC 
AATCTGGGCT GCCTCCCACC ATCCTCGGCT TTGCCCTCTG GGACCAGGAG CCTCCCACGC 
CCCATTGACG GTGTTTCGGA CTGGAGCCAA GGGTGCTCCC TGCGATCCAC TGGCAGCCCT 
GCCTCCCTGG CCAGCAACTT GGAAATCAGC CAGTCCCCTA CCATGCCCTT CCTCAGCCTG 
CACCGCAGCC CACATGGGCC CAGCAAGCTC TGTGACGACC CCCAGGCCAG CTTGGTGCCC 
GAGCCTGTCC CCGGTGGCTG CCAGGAGCCT GAGGAGATGA GCTGGCCGCC ATCGGGGGAG 
ATTGCCAGCC CACCAGAGCT GCCAAGCAGC CCACCTCCTG GGCTTCCCGA AGTGGCCCCA 
GATGCAACCT CCACTGGCCT CCCTGATACC CCCGCAGCTC CAGAAACCAG CACCAACTAC 
CCAGTGGAGT GCACCGAGGG GTCTGCAGGC CCCCAGTCTC TCCCCTTGCC TATTCTGGAG 
CCGGTCAAAA ACCCCTGCTC TGTCAAAGAC CAGACGCCAC TCCAACTTTC TGTAGAAGAT 
ACCACCTCTC CAAATACCAA GCCGTGCCCA CCTACTCCCA CCACCCCAGA AACATCCCCT 
CCTCCTCCTC CTCCTCCTCC TTCATCTACT CCTTGTTCAG CTCACCTGAC CCCCTCCTCC 
CTGTTCCCTT CCTCCCTGGA ATCATCATCG GAACAGAAAT TCTATAACTT TGTGATCCTC 
CACGCCAGGG CAGACGAACA CATCGCCCTG CGGGTTCGGG AGAAGCTGGA GGCCCTTGGC 
GTGCCCGACG GGGCCACCTT CTGCGAGGAT TTCCAGGTGC CGGGGCGCGG GGAGCTGAGC 
TGCCTGCAGG ACGCCATAGA CCACTCAGCT TTCATCATCC TACTTCTCAC CTCCAACTTC 
GACTGTCGCC TGAGCCTGCA CCAGGTGAAC CAAGCCATGA TGAGCAACCT CACGCGACAG 
GGGTCGCCAG ACTGTGTCAT CCCCTTCCTG CCCCTGGAGA GCTCCCCGGC CCAGCTCAGC 
TCCGACACGG CCAGCCTGCT CTCCGGGCTG GTGCGGCTGG ACGAACACTC CCAGATCTTC 
GCCAGGAAGG TGGCCAACAC CTTCAAGCCC CACAGGCTTC AGGCCCGAAA GGCCATGTGG 
AGGAAGGAAC AGGACACCCG AGCCCTGCGG GAACAGAGCC AACACCTGGA CGGTGAGCGG 
ATGCAGGCGG CGGCACTGAA CGCAGCCTAC TCAGCCTACC TCCAGAGCTA CTTGTCCTAC 
CAGGCACAGA TGGAGCAGCT CCAGGTGGCT TTTGGGAGCC ACATGTCATT TGGGACTGGG 
GCGCCCTATG GGGCTCGAAT GCCCTTTGGG GGCCAGGTGC CCCTGGGAGC CCCGCCACCC 
TTTCCCACTT GGCCGGGGTG CCCGCAGCCG CCACCCCTGC ACGCATGGCA GGCTGGCACC 
CCCCCACCGC CCTCCCCACA GCCAGCAGCC TTTCCACAGT CACTGCCCTT CCCGCAGTCC 
CCAGCCTTCC CTACGGCCTC ACCCGCACCC CCTCAGAGCC CAGGGCTGCA ACCCCTCATT 
ATCCACCACG CACAGATGGT ACAGCTGGGG CTGAACAACC ACATGTGGAA CCAGAGAGGG 
TCCCAGGCGC CCGAGGACAA GACGCAGGAG GCAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_891549.1
CDS	269..2407
Translation	MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARISLEALKADAVARLVARQWAGVDSTEDPEEPPDVSWAVARLYHLLAEEKLCPASLRDVAYQEAVRTLSSRDDHRLGELQDEARNRCGWDIAGDPGSIRTLQSNLGCLPPSSALPSGTRSLPRPIDGVSDWSQGCSLRSTGSPASLASNLEISQSPTMPFLSLHRSPHGPSKLCDDPQASLVPEPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLPEVAPDATSTGLPDTPAAPETSTNYPVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPLQLSVEDTTSPNTKPCPPTPTTPETSPPPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALGVPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNFDCRLSLHQVNQAMMSNLTRQGSPDCVIPFLPLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFKPHRLQARKAMWRKEQDTRALREQSQHLDGERMQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTGAPYGARMPFGGQVPLGAPPPFPTWPGCPQPPPLHAWQAGTPPPPSPQPAAFPQSLPFPQSPAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRGSQAPEDKTQEAE

Target ORF information:

RefSeq Version	NM_182919.3
Organism	Homo sapiens(human)
Definition	Homo sapiens toll like receptor adaptor molecule 1 (TICAM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182919.3

ORF Insert Sequence:

ATGGCCTGCA CAGGCCCATC ACTTCCTAGC GCCTTCGACA TTCTAGGTGC AGCAGGCCAG 
GACAAGCTCT TGTATCTGAA GCACAAACTG AAGACCCCAC GCCCAGGCTG CCAGGGGCAG 
GACCTCCTGC ATGCCATGGT TCTCCTGAAG CTGGGCCAGG AAACTGAGGC CAGGATCTCT 
CTAGAGGCAT TGAAGGCCGA TGCGGTGGCC CGGCTGGTGG CCCGCCAGTG GGCTGGCGTG 
GACAGCACCG AGGACCCAGA GGAGCCCCCA GATGTGTCCT GGGCTGTGGC CCGCTTGTAC 
CACCTGCTGG CTGAGGAGAA GCTGTGCCCC GCCTCGCTGC GGGACGTGGC CTACCAGGAA 
GCCGTCCGCA CCCTCAGCTC CAGGGACGAC CACCGGCTGG GGGAACTTCA GGATGAGGCC 
CGAAACCGGT GTGGGTGGGA CATTGCTGGG GATCCAGGGA GCATCCGGAC GCTCCAGTCC 
AATCTGGGCT GCCTCCCACC ATCCTCGGCT TTGCCCTCTG GGACCAGGAG CCTCCCACGC 
CCCATTGACG GTGTTTCGGA CTGGAGCCAA GGGTGCTCCC TGCGATCCAC TGGCAGCCCT 
GCCTCCCTGG CCAGCAACTT GGAAATCAGC CAGTCCCCTA CCATGCCCTT CCTCAGCCTG 
CACCGCAGCC CACATGGGCC CAGCAAGCTC TGTGACGACC CCCAGGCCAG CTTGGTGCCC 
GAGCCTGTCC CCGGTGGCTG CCAGGAGCCT GAGGAGATGA GCTGGCCGCC ATCGGGGGAG 
ATTGCCAGCC CACCAGAGCT GCCAAGCAGC CCACCTCCTG GGCTTCCCGA AGTGGCCCCA 
GATGCAACCT CCACTGGCCT CCCTGATACC CCCGCAGCTC CAGAAACCAG CACCAACTAC 
CCAGTGGAGT GCACCGAGGG GTCTGCAGGC CCCCAGTCTC TCCCCTTGCC TATTCTGGAG 
CCGGTCAAAA ACCCCTGCTC TGTCAAAGAC CAGACGCCAC TCCAACTTTC TGTAGAAGAT 
ACCACCTCTC CAAATACCAA GCCGTGCCCA CCTACTCCCA CCACCCCAGA AACATCCCCT 
CCTCCTCCTC CTCCTCCTCC TTCATCTACT CCTTGTTCAG CTCACCTGAC CCCCTCCTCC 
CTGTTCCCTT CCTCCCTGGA ATCATCATCG GAACAGAAAT TCTATAACTT TGTGATCCTC 
CACGCCAGGG CAGACGAACA CATCGCCCTG CGGGTTCGGG AGAAGCTGGA GGCCCTTGGC 
GTGCCCGACG GGGCCACCTT CTGCGAGGAT TTCCAGGTGC CGGGGCGCGG GGAGCTGAGC 
TGCCTGCAGG ACGCCATAGA CCACTCAGCT TTCATCATCC TACTTCTCAC CTCCAACTTC 
GACTGTCGCC TGAGCCTGCA CCAGGTGAAC CAAGCCATGA TGAGCAACCT CACGCGACAG 
GGGTCGCCAG ACTGTGTCAT CCCCTTCCTG CCCCTGGAGA GCTCCCCGGC CCAGCTCAGC 
TCCGACACGG CCAGCCTGCT CTCCGGGCTG GTGCGGCTGG ACGAACACTC CCAGATCTTC 
GCCAGGAAGG TGGCCAACAC CTTCAAGCCC CACAGGCTTC AGGCCCGAAA GGCCATGTGG 
AGGAAGGAAC AGGACACCCG AGCCCTGCGG GAACAGAGCC AACACCTGGA CGGTGAGCGG 
ATGCAGGCGG CGGCACTGAA CGCAGCCTAC TCAGCCTACC TCCAGAGCTA CTTGTCCTAC 
CAGGCACAGA TGGAGCAGCT CCAGGTGGCT TTTGGGAGCC ACATGTCATT TGGGACTGGG 
GCGCCCTATG GGGCTCGAAT GCCCTTTGGG GGCCAGGTGC CCCTGGGAGC CCCGCCACCC 
TTTCCCACTT GGCCGGGGTG CCCGCAGCCG CCACCCCTGC ACGCATGGCA GGCTGGCACC 
CCCCCACCGC CCTCCCCACA GCCAGCAGCC TTTCCACAGT CACTGCCCTT CCCGCAGTCC 
CCAGCCTTCC CTACGGCCTC ACCCGCACCC CCTCAGAGCC CAGGGCTGCA ACCCCTCATT 
ATCCACCACG CACAGATGGT ACAGCTGGGG CTGAACAACC ACATGTGGAA CCAGAGAGGG 
TCCCAGGCGC CCGAGGACAA GACGCAGGAG GCAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation.
Brain, behavior, and immunity6765-76(2018 Jan)
Wang FX,Yang XL,Ma YS,Wei YJ,Yang MH,Chen X,Chen B,He Q,Yang QW,Yang H,Liu SY

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.
Yonsei medical journal59(1)43-50(2018 Jan)
Chen Y,Zhao J,Li D,Hao J,He P,Wang H,Zhang M

Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Biochemical Society transactions45(4)929-935(2017 08)
Funami K,Matsumoto M,Oshiumi H,Inagaki F,Seya T

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TICAM1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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