CSTF3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSTF3
Entrez Gene ID	1479
Full Name	cleavage stimulation factor subunit 3
Synonyms	CSTF-77
General protein information	Preferred Names cleavage stimulation factor subunit 3 Names cleavage stimulation factor subunit 3 CF-1 77 kDa subunit CSTF 77 kDa subunit cleavage stimulation factor 77 kDa subunit cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kD cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p13
Summary	The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	600367

mRNA and Protein(s)

mRNA	Protein	Name
NM_001326.2	NP_001317.1	cleavage stimulation factor subunit 3 isoform 1
NM_001033505.1	NP_001028677.1	cleavage stimulation factor subunit 3 isoform 2
NM_001326.3	NP_001317.1	cleavage stimulation factor subunit 3 isoform 1
NM_001033506.1	NP_001028678.1	cleavage stimulation factor subunit 3 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	CSTF3	NP_001317.1
Canis lupus familiaris (dog)	CSTF3	XP_533159.2
Drosophila melanogaster (fruit fly)	su(f)	NP_001015240.1
Saccharomyces cerevisiae (baker's yeast)	RNA14	NP_013777.1
Xenopus tropicalis (tropical clawed frog)	cstf3	NP_989162.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003019	XP_311858.5
Kluyveromyces lactis	KLLA0F26290g	XP_456251.1
Eremothecium gossypii	AGOS_ADR137W	NP_984233.1
Neurospora crassa	NCU09435	XP_958587.1
	CSTF3	XP_001083483.1
Caenorhabditis elegans (roundworm)	suf-1	NP_495825.1
Magnaporthe oryzae (rice blast fungus)	MGG_03265	XP_003716705.1
Oryza sativa (rice)	Os12g0571900	NP_001067088.1
Bos taurus (cattle)	CSTF3	NP_001093170.1
Rattus norvegicus (Norway rat)	Cstf3	NP_001071140.1
Schizosaccharomyces pombe (fission yeast)	rna14	NP_593303.1
Pan troglodytes (chimpanzee)	CSTF3	XP_508355.2
Mus musculus (house mouse)	Cstf3	NP_663504.1
Gallus gallus (chicken)	CSTF3	NP_001012586.1
Danio rerio (zebrafish)	cstf3	NP_998218.2
Arabidopsis thaliana (thale cress)	CSTF77	NP_173218.2

Gene Ontology
Bibliography

Related articles in PubMed

Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals.
Yang W, Hsu PL, Yang F, Song JE, Varani G
Nucleic acids research(2017 Nov)

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrent? L, Mar JC
PLoS genetics11(8)e1005428(2015 Aug)

Genome-wide association study of proneness to anger.
Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D, Goldberg RJ
PloS one9(1)e87257(2014)

The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP.
Luo W, Ji Z, Pan Z, You B, Hoque M, Li W, Gunderson SI, Tian B
PLoS genetics9(7)e1003613(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thus, the conserved intronic pA of the CstF-77 gene may function as a sensor for cellular C/P and splicing activities, controlling the homeostasis of CstF-77 and C/P activity and impacting cell proliferation and differentiation.
Title: The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP.

nuclear accumulation of CstF-64 depends on binding to CstF-77 not symplekin; interaction between CstF-64/CstF-64Tau and CstF-77 are important for maintenance of nuclear levels of CstF complex components and intracellular localization, stability, function
Title: Interactions of CstF-64, CstF-77, and symplekin: implications on localisation and function.

The Hinge domain is necessary for CstF-64 interaction with CstF-77 and consequent nuclear localization.
Title: The hinge domain of the cleavage stimulation factor protein CstF-64 is essential for CstF-77 interaction, nuclear localization, and polyadenylation.

chimeric human CstF-77/Drosophila suppressor of forked proteins rescue suppressor of forked mutant lethality and mrna 3' end processing in Drosophila
Title: Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila.

The following CSTF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSTF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26458	NM_001033506.1 Latest version!	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26470	NM_001033505.1 Latest version!	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26444	NM_001326.3 Latest version!	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
View Old Accession Versions >>
OHu26444	NM_001326.2	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSTF3 ( NM_001033506.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001028678.1 Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu26458
Clone ID Related Accession (Same CDS sequence)	NM_001033506.1
Accession Version	NM_001033506.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 135bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	cleavage stimulation factor subunit 3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG435786.1 and BC009792.1. Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 3) is shorter and has a unique C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.51871.1, SRR1803614.112856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGG TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028678.1
CDS	167..301
Translation	MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQV

Target ORF information:

RefSeq Version	NM_001033506.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033506.1

ORF Insert Sequence:

1
61
121

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGG TTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSTF3 ( NM_001033505.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001028677.1 Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26470
Clone ID Related Accession (Same CDS sequence)	NM_001033505.1
Accession Version	NM_001033505.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	cleavage stimulation factor subunit 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG435786.1 and BC009792.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter and has a unique C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009792.1, SRR1163657.347337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGA ATCAACCTAT AGACAAAGCA CGGAAGACTT ATGAACGCCT TGTTGCCCAG 
TTCCCCAGTT CTGGCAGATT CTGGAAACTG TACATTGAAG CAGAGGTTAC TATTTTATTT 
TATTTTTTCT TATATCAGTA TTGCAGCATT CACTGTAGTG ATAGAAAACA AGTTAGGAAC 
ATAGCCAATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028677.1
CDS	167..478
Translation	MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEVTILFYFFLYQYCSIHCSDRKQVRNIAN

Target ORF information:

RefSeq Version	NM_001033505.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033505.1

ORF Insert Sequence:

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGA ATCAACCTAT AGACAAAGCA CGGAAGACTT ATGAACGCCT TGTTGCCCAG 
TTCCCCAGTT CTGGCAGATT CTGGAAACTG TACATTGAAG CAGAGGTTAC TATTTTATTT 
TATTTTTTCT TATATCAGTA TTGCAGCATT CACTGTAGTG ATAGAAAACA AGTTAGGAAC 
ATAGCCAATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSTF3 ( NM_001326.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317.1 Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26444
Clone ID Related Accession (Same CDS sequence)	NM_001326.2 , NM_001326.3
Accession Version	NM_001326.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2154bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cleavage stimulation factor subunit 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG435786.1, U15782.1 and BC010533.1. On Sep 15, 2005 this sequence version replaced NM_001326.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.71570.1, BC108319.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGA ATCAACCTAT AGACAAAGCA CGGAAGACTT ATGAACGCCT TGTTGCCCAG 
TTCCCCAGTT CTGGCAGATT CTGGAAACTG TACATTGAAG CAGAGATTAA AGCTAAAAAT 
TATGACAAGG TTGAAAAGCT ATTTCAGAGA TGCCTTATGA AGGTTTTGCA CATTGATTTA 
TGGAAGTGTT ATCTTTCATA TGTCCGAGAA ACCAAGGGTA AACTACCAAG TTACAAAGAA 
AAAATGGCTC AAGCATATGA CTTTGCACTG GATAAAATTG GAATGGAAAT TATGTCCTAT 
CAGATTTGGG TGGATTACAT CAATTTCCTA AAAGGCGTGG AAGCTGTAGG ATCTTATGCA 
GAAAATCAAA GAATAACAGC TGTCCGAAGA GTTTATCAAC GAGGTTGTGT TAATCCGATG 
ATCAACATTG AACAGCTCTG GAGAGACTAT AACAAGTATG AAGAGGGTAT CAATATTCAT 
TTAGCTAAAA AAATGATTGA AGATCGGAGT AGAGATTATA TGAATGCTAG ACGTGTAGCA 
AAGGAATATG AGACAGTAAT GAAAGGCTTG GACCGTAATG CTCCCTCGGT GCCTCCTCAG 
AATACTCCTC AAGAAGCTCA ACAAGTAGAT ATGTGGAAGA AATATATACA GTGGGAAAAG 
AGCAACCCTC TTCGTACAGA GGATCAGACC CTTATAACAA AAAGAGTTAT GTTTGCTTAT 
GAACAGTGCC TGCTTGTGCT GGGCCATCAC CCTGATATTT GGTATGAAGC TGCCCAGTAT 
CTTGAGCAGT CAAGTAAACT GCTCGCAGAA AAGGGAGATA TGAATAATGC CAAATTATTT 
AGTGATGAAG CTGCTAATAT ATATGAAAGA GCCATAAGCA CTTTATTGAA GAAGAATATG 
CTTCTTTATT TTGCATATGC AGATTATGAA GAGAGTCGCA TGAAGTATGA AAAGGTTCAC 
AGTATATATA ACAGACTTCT GGCAATTGAG GATATTGACC CTACCTTGGT ATATATCCAA 
TATATGAAAT TTGCACGGAG AGCAGAAGGC ATCAAATCTG GAAGAATGAT ATTTAAAAAA 
GCAAGAGAAG ATACCAGAAC CCGCCACCAT GTCTATGTTA CTGCAGCACT CATGGAATAT 
TACTGTAGTA AGGACAAATC TGTTGCCTTT AAGATTTTTG AGCTGGGGCT AAAAAAATAT 
GGAGACATTC CAGAGTATGT CCTGGCCTAT ATTGACTATC TTTCTCACCT CAATGAGGAC 
AATAATACCC GAGTTTTGTT TGAACGAGTT TTAACATCTG GAAGCCTTCC TCCTGAGAAG 
TCTGGAGAAA TCTGGGCCCG ATTTCTAGCA TTTGAAAGTA ATATTGGTGA TCTAGCTAGT 
ATACTCAAAG TGGAGAAAAG ACGGTTTACA GCATTCAAAG AAGAGTATGA AGGGAAAGAA 
ACGGCTTTAC TAGTAGATAG ATACAAGTTC ATGGATTTAT ATCCTTGCTC TGCAAGTGAA 
TTAAAAGCAC TTGGTTATAA GGATGTCTCC CGTGCTAAGC TAGCAGCTAT AATTCCGGAC 
CCAGTTGTAG CTCCTTCTAT AGTGCCTGTT CTGAAAGATG AAGTGGATAG AAAACCAGAA 
TACCCTAAAC CAGACACTCA GCAGATGATT CCATTTCAGC CACGACATTT AGCACCTCCA 
GGTTTACACC CTGTACCTGG TGGAGTGTTC CCAGTCCCTC CTGCAGCTGT TGTTTTAATG 
AAACTTCTCC CTCCTCCTAT CTGTTTCCAG GGTCCTTTTG TACAAGTGGA TGAACTGATG 
GAAATTTTCC GAAGATGCAA GATACCAAAT ACTGTTGAGG AAGCTGTGAG GATCATTACT 
GGTGGGGCCC CAGAGCTAGC TGTAGAAGGC AACGGCCCCG TGGAAAGTAA TGCAGTACTC 
ACCAAGGCCG TCAAAAGGCC CAACGAGGAT TCAGATGAAG ATGAAGAAAA GGGAGCCGTT 
GTCCCCCCTG TTCATGACAT TTACAGAGCA CGGCAGCAGA AGCGGATTCG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317.1
CDS	167..2320
Translation	MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR

Target ORF information:

RefSeq Version	NM_001326.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001326.2

ORF Insert Sequence:

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGA ATCAACCTAT AGACAAAGCA CGGAAGACTT ATGAACGCCT TGTTGCCCAG 
TTCCCCAGTT CTGGCAGATT CTGGAAACTG TACATTGAAG CAGAGATTAA AGCTAAAAAT 
TATGACAAGG TTGAAAAGCT ATTTCAGAGA TGCCTTATGA AGGTTTTGCA CATTGATTTA 
TGGAAGTGTT ATCTTTCATA TGTCCGAGAA ACCAAGGGTA AACTACCAAG TTACAAAGAA 
AAAATGGCTC AAGCATATGA CTTTGCACTG GATAAAATTG GAATGGAAAT TATGTCCTAT 
CAGATTTGGG TGGATTACAT CAATTTCCTA AAAGGCGTGG AAGCTGTAGG ATCTTATGCA 
GAAAATCAAA GAATAACAGC TGTCCGAAGA GTTTATCAAC GAGGTTGTGT TAATCCGATG 
ATCAACATTG AACAGCTCTG GAGAGACTAT AACAAGTATG AAGAGGGTAT CAATATTCAT 
TTAGCTAAAA AAATGATTGA AGATCGGAGT AGAGATTATA TGAATGCTAG ACGTGTAGCA 
AAGGAATATG AGACAGTAAT GAAAGGCTTG GACCGTAATG CTCCCTCGGT GCCTCCTCAG 
AATACTCCTC AAGAAGCTCA ACAAGTAGAT ATGTGGAAGA AATATATACA GTGGGAAAAG 
AGCAACCCTC TTCGTACAGA GGATCAGACC CTTATAACAA AAAGAGTTAT GTTTGCTTAT 
GAACAGTGCC TGCTTGTGCT GGGCCATCAC CCTGATATTT GGTATGAAGC TGCCCAGTAT 
CTTGAGCAGT CAAGTAAACT GCTCGCAGAA AAGGGAGATA TGAATAATGC CAAATTATTT 
AGTGATGAAG CTGCTAATAT ATATGAAAGA GCCATAAGCA CTTTATTGAA GAAGAATATG 
CTTCTTTATT TTGCATATGC AGATTATGAA GAGAGTCGCA TGAAGTATGA AAAGGTTCAC 
AGTATATATA ACAGACTTCT GGCAATTGAG GATATTGACC CTACCTTGGT ATATATCCAA 
TATATGAAAT TTGCACGGAG AGCAGAAGGC ATCAAATCTG GAAGAATGAT ATTTAAAAAA 
GCAAGAGAAG ATACCAGAAC CCGCCACCAT GTCTATGTTA CTGCAGCACT CATGGAATAT 
TACTGTAGTA AGGACAAATC TGTTGCCTTT AAGATTTTTG AGCTGGGGCT AAAAAAATAT 
GGAGACATTC CAGAGTATGT CCTGGCCTAT ATTGACTATC TTTCTCACCT CAATGAGGAC 
AATAATACCC GAGTTTTGTT TGAACGAGTT TTAACATCTG GAAGCCTTCC TCCTGAGAAG 
TCTGGAGAAA TCTGGGCCCG ATTTCTAGCA TTTGAAAGTA ATATTGGTGA TCTAGCTAGT 
ATACTCAAAG TGGAGAAAAG ACGGTTTACA GCATTCAAAG AAGAGTATGA AGGGAAAGAA 
ACGGCTTTAC TAGTAGATAG ATACAAGTTC ATGGATTTAT ATCCTTGCTC TGCAAGTGAA 
TTAAAAGCAC TTGGTTATAA GGATGTCTCC CGTGCTAAGC TAGCAGCTAT AATTCCGGAC 
CCAGTTGTAG CTCCTTCTAT AGTGCCTGTT CTGAAAGATG AAGTGGATAG AAAACCAGAA 
TACCCTAAAC CAGACACTCA GCAGATGATT CCATTTCAGC CACGACATTT AGCACCTCCA 
GGTTTACACC CTGTACCTGG TGGAGTGTTC CCAGTCCCTC CTGCAGCTGT TGTTTTAATG 
AAACTTCTCC CTCCTCCTAT CTGTTTCCAG GGTCCTTTTG TACAAGTGGA TGAACTGATG 
GAAATTTTCC GAAGATGCAA GATACCAAAT ACTGTTGAGG AAGCTGTGAG GATCATTACT 
GGTGGGGCCC CAGAGCTAGC TGTAGAAGGC AACGGCCCCG TGGAAAGTAA TGCAGTACTC 
ACCAAGGCCG TCAAAAGGCC CAACGAGGAT TCAGATGAAG ATGAAGAAAA GGGAGCCGTT 
GTCCCCCCTG TTCATGACAT TTACAGAGCA CGGCAGCAGA AGCGGATTCG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSTF3 ( NM_001326.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317.1 Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26444
Clone ID Related Accession (Same CDS sequence)	NM_001326.2 , NM_001326.3
Accession Version	NM_001326.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2154bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	cleavage stimulation factor subunit 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG435786.1, U15782.1 and BC010533.1. On Nov 23, 2018 this sequence version replaced NM_001326.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.11290.1, SRR1660805.258395.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323959.9/ ENSP00000315791.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGA ATCAACCTAT AGACAAAGCA CGGAAGACTT ATGAACGCCT TGTTGCCCAG 
TTCCCCAGTT CTGGCAGATT CTGGAAACTG TACATTGAAG CAGAGATTAA AGCTAAAAAT 
TATGACAAGG TTGAAAAGCT ATTTCAGAGA TGCCTTATGA AGGTTTTGCA CATTGATTTA 
TGGAAGTGTT ATCTTTCATA TGTCCGAGAA ACCAAGGGTA AACTACCAAG TTACAAAGAA 
AAAATGGCTC AAGCATATGA CTTTGCACTG GATAAAATTG GAATGGAAAT TATGTCCTAT 
CAGATTTGGG TGGATTACAT CAATTTCCTA AAAGGCGTGG AAGCTGTAGG ATCTTATGCA 
GAAAATCAAA GAATAACAGC TGTCCGAAGA GTTTATCAAC GAGGTTGTGT TAATCCGATG 
ATCAACATTG AACAGCTCTG GAGAGACTAT AACAAGTATG AAGAGGGTAT CAATATTCAT 
TTAGCTAAAA AAATGATTGA AGATCGGAGT AGAGATTATA TGAATGCTAG ACGTGTAGCA 
AAGGAATATG AGACAGTAAT GAAAGGCTTG GACCGTAATG CTCCCTCGGT GCCTCCTCAG 
AATACTCCTC AAGAAGCTCA ACAAGTAGAT ATGTGGAAGA AATATATACA GTGGGAAAAG 
AGCAACCCTC TTCGTACAGA GGATCAGACC CTTATAACAA AAAGAGTTAT GTTTGCTTAT 
GAACAGTGCC TGCTTGTGCT GGGCCATCAC CCTGATATTT GGTATGAAGC TGCCCAGTAT 
CTTGAGCAGT CAAGTAAACT GCTCGCAGAA AAGGGAGATA TGAATAATGC CAAATTATTT 
AGTGATGAAG CTGCTAATAT ATATGAAAGA GCCATAAGCA CTTTATTGAA GAAGAATATG 
CTTCTTTATT TTGCATATGC AGATTATGAA GAGAGTCGCA TGAAGTATGA AAAGGTTCAC 
AGTATATATA ACAGACTTCT GGCAATTGAG GATATTGACC CTACCTTGGT ATATATCCAA 
TATATGAAAT TTGCACGGAG AGCAGAAGGC ATCAAATCTG GAAGAATGAT ATTTAAAAAA 
GCAAGAGAAG ATACCAGAAC CCGCCACCAT GTCTATGTTA CTGCAGCACT CATGGAATAT 
TACTGTAGTA AGGACAAATC TGTTGCCTTT AAGATTTTTG AGCTGGGGCT AAAAAAATAT 
GGAGACATTC CAGAGTATGT CCTGGCCTAT ATTGACTATC TTTCTCACCT CAATGAGGAC 
AATAATACCC GAGTTTTGTT TGAACGAGTT TTAACATCTG GAAGCCTTCC TCCTGAGAAG 
TCTGGAGAAA TCTGGGCCCG ATTTCTAGCA TTTGAAAGTA ATATTGGTGA TCTAGCTAGT 
ATACTCAAAG TGGAGAAAAG ACGGTTTACA GCATTCAAAG AAGAGTATGA AGGGAAAGAA 
ACGGCTTTAC TAGTAGATAG ATACAAGTTC ATGGATTTAT ATCCTTGCTC TGCAAGTGAA 
TTAAAAGCAC TTGGTTATAA GGATGTCTCC CGTGCTAAGC TAGCAGCTAT AATTCCGGAC 
CCAGTTGTAG CTCCTTCTAT AGTGCCTGTT CTGAAAGATG AAGTGGATAG AAAACCAGAA 
TACCCTAAAC CAGACACTCA GCAGATGATT CCATTTCAGC CACGACATTT AGCACCTCCA 
GGTTTACACC CTGTACCTGG TGGAGTGTTC CCAGTCCCTC CTGCAGCTGT TGTTTTAATG 
AAACTTCTCC CTCCTCCTAT CTGTTTCCAG GGTCCTTTTG TACAAGTGGA TGAACTGATG 
GAAATTTTCC GAAGATGCAA GATACCAAAT ACTGTTGAGG AAGCTGTGAG GATCATTACT 
GGTGGGGCCC CAGAGCTAGC TGTAGAAGGC AACGGCCCCG TGGAAAGTAA TGCAGTACTC 
ACCAAGGCCG TCAAAAGGCC CAACGAGGAT TCAGATGAAG ATGAAGAAAA GGGAGCCGTT 
GTCCCCCCTG TTCATGACAT TTACAGAGCA CGGCAGCAGA AGCGGATTCG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317.1
CDS	156..2309
Translation	MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR

Target ORF information:

RefSeq Version	NM_001326.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cleavage stimulation factor subunit 3 (CSTF3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001326.3

ORF Insert Sequence:

ATGTCAGGAG ACGGAGCCAC GGAGCAGGCA GCTGAGTATG TCCCAGAGAA GGTGAAGAAA 
GCGGAAAAGA AATTAGAAGA GAATCCATAT GACCTTGATG CTTGGAGCAT TCTCATTCGA 
GAGGCACAGA ATCAACCTAT AGACAAAGCA CGGAAGACTT ATGAACGCCT TGTTGCCCAG 
TTCCCCAGTT CTGGCAGATT CTGGAAACTG TACATTGAAG CAGAGATTAA AGCTAAAAAT 
TATGACAAGG TTGAAAAGCT ATTTCAGAGA TGCCTTATGA AGGTTTTGCA CATTGATTTA 
TGGAAGTGTT ATCTTTCATA TGTCCGAGAA ACCAAGGGTA AACTACCAAG TTACAAAGAA 
AAAATGGCTC AAGCATATGA CTTTGCACTG GATAAAATTG GAATGGAAAT TATGTCCTAT 
CAGATTTGGG TGGATTACAT CAATTTCCTA AAAGGCGTGG AAGCTGTAGG ATCTTATGCA 
GAAAATCAAA GAATAACAGC TGTCCGAAGA GTTTATCAAC GAGGTTGTGT TAATCCGATG 
ATCAACATTG AACAGCTCTG GAGAGACTAT AACAAGTATG AAGAGGGTAT CAATATTCAT 
TTAGCTAAAA AAATGATTGA AGATCGGAGT AGAGATTATA TGAATGCTAG ACGTGTAGCA 
AAGGAATATG AGACAGTAAT GAAAGGCTTG GACCGTAATG CTCCCTCGGT GCCTCCTCAG 
AATACTCCTC AAGAAGCTCA ACAAGTAGAT ATGTGGAAGA AATATATACA GTGGGAAAAG 
AGCAACCCTC TTCGTACAGA GGATCAGACC CTTATAACAA AAAGAGTTAT GTTTGCTTAT 
GAACAGTGCC TGCTTGTGCT GGGCCATCAC CCTGATATTT GGTATGAAGC TGCCCAGTAT 
CTTGAGCAGT CAAGTAAACT GCTCGCAGAA AAGGGAGATA TGAATAATGC CAAATTATTT 
AGTGATGAAG CTGCTAATAT ATATGAAAGA GCCATAAGCA CTTTATTGAA GAAGAATATG 
CTTCTTTATT TTGCATATGC AGATTATGAA GAGAGTCGCA TGAAGTATGA AAAGGTTCAC 
AGTATATATA ACAGACTTCT GGCAATTGAG GATATTGACC CTACCTTGGT ATATATCCAA 
TATATGAAAT TTGCACGGAG AGCAGAAGGC ATCAAATCTG GAAGAATGAT ATTTAAAAAA 
GCAAGAGAAG ATACCAGAAC CCGCCACCAT GTCTATGTTA CTGCAGCACT CATGGAATAT 
TACTGTAGTA AGGACAAATC TGTTGCCTTT AAGATTTTTG AGCTGGGGCT AAAAAAATAT 
GGAGACATTC CAGAGTATGT CCTGGCCTAT ATTGACTATC TTTCTCACCT CAATGAGGAC 
AATAATACCC GAGTTTTGTT TGAACGAGTT TTAACATCTG GAAGCCTTCC TCCTGAGAAG 
TCTGGAGAAA TCTGGGCCCG ATTTCTAGCA TTTGAAAGTA ATATTGGTGA TCTAGCTAGT 
ATACTCAAAG TGGAGAAAAG ACGGTTTACA GCATTCAAAG AAGAGTATGA AGGGAAAGAA 
ACGGCTTTAC TAGTAGATAG ATACAAGTTC ATGGATTTAT ATCCTTGCTC TGCAAGTGAA 
TTAAAAGCAC TTGGTTATAA GGATGTCTCC CGTGCTAAGC TAGCAGCTAT AATTCCGGAC 
CCAGTTGTAG CTCCTTCTAT AGTGCCTGTT CTGAAAGATG AAGTGGATAG AAAACCAGAA 
TACCCTAAAC CAGACACTCA GCAGATGATT CCATTTCAGC CACGACATTT AGCACCTCCA 
GGTTTACACC CTGTACCTGG TGGAGTGTTC CCAGTCCCTC CTGCAGCTGT TGTTTTAATG 
AAACTTCTCC CTCCTCCTAT CTGTTTCCAG GGTCCTTTTG TACAAGTGGA TGAACTGATG 
GAAATTTTCC GAAGATGCAA GATACCAAAT ACTGTTGAGG AAGCTGTGAG GATCATTACT 
GGTGGGGCCC CAGAGCTAGC TGTAGAAGGC AACGGCCCCG TGGAAAGTAA TGCAGTACTC 
ACCAAGGCCG TCAAAAGGCC CAACGAGGAT TCAGATGAAG ATGAAGAAAA GGGAGCCGTT 
GTCCCCCCTG TTCATGACAT TTACAGAGCA CGGCAGCAGA AGCGGATTCG GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals.
Nucleic acids research(2017 Nov)
Yang W,Hsu PL,Yang F,Song JE,Varani G

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
PLoS genetics11(8)e1005428(2015 Aug)
Hasegawa Y,Taylor D,Ovchinnikov DA,Wolvetang EJ,de Torrent? L,Mar JC

Genome-wide association study of proneness to anger.
PloS one9(1)e87257(2014)
Mick E,McGough J,Deutsch CK,Frazier JA,Kennedy D,Goldberg RJ

The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP.
PLoS genetics9(7)e1003613(2013)
Luo W,Ji Z,Pan Z,You B,Hoque M,Li W,Gunderson SI,Tian B

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CSTF3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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