FBXL16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXL16
Entrez Gene ID	146330
Full Name	F-box and leucine rich repeat protein 16
Synonyms	C16orf22,Fbl16,c380A1.1
General protein information	Preferred Names F-box and leucine rich repeat protein 16 Names F-box/LRR-repeat protein 16 c380A1.1 (novel protein)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609082

mRNA and Protein(s)

mRNA	Protein	Name
NM_153350.3	NP_699181.2	F-box/LRR-repeat protein 16
NM_153350.4	NP_699181.2	F-box/LRR-repeat protein 16
XM_024450160.1	XP_024305928.1	F-box/LRR-repeat protein 16 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FBXL16	NP_001092682.1
Danio rerio (zebrafish)	fbxl16	NP_001188265.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012123	XP_320406.4
Xenopus tropicalis (tropical clawed frog)	fbxl16	NP_001096414.1
Homo sapiens (human)	FBXL16	NP_699181.2
	FBXL16	XP_001118521.2
Rattus norvegicus (Norway rat)	Fbxl16	NP_001009504.1
Pan troglodytes (chimpanzee)	FBXL16	XP_003314944.2
Mus musculus (house mouse)	Fbxl16	NP_001157697.1
Canis lupus familiaris (dog)	FBXL16	XP_547211.2
Gallus gallus (chicken)	FBXL16	XP_414720.3
Drosophila melanogaster (fruit fly)	CG32085	NP_729732.1

Gene Ontology
Bibliography

Related articles in PubMed

FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cells.
Sato K, Kusama Y, Tategu M, Yoshida K
International journal of oncology36(2)479-90(2010 Feb)

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
Ebstein F, Lange N, Urban S, Seifert U, Kr?ger E, Kloetzel PM
The international journal of biochemistry & cell biology41(5)1205-15(2009 May)

The sequence and analysis of duplication-rich human chromosome 16.
Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA
Nature432(7020)988-94(2004 Dec)

Systematic analysis and nomenclature of mammalian F-box proteins.
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW
Genes & development18(21)2573-80(2004 Nov)

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR
Human molecular genetics10(4)339-52(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the expression of FBXL16 reproducibly upregulated in p16INK4A and p14ARF knockdown HeLa cells
Title: FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cells.

The following FBXL16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXL16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10539	NM_153350.4 Latest version!	Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu10539	XM_024450160.1 Latest version!	Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu10539	NM_153350.3	Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXL16 ( NM_153350.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_699181.2 Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), mRNA.

Price & Availability↑

CloneID	OHu10539
Clone ID Related Accession (Same CDS sequence)	NM_153350.3 , NM_153350.4 , XM_024450160.1
Accession Version	NM_153350.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 16
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Z97653.14 and Z92544.1. On Feb 27, 2010 this sequence version replaced NM_153350.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## CDS exon combination :: BC036680.2 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGCC CGGGCATCGA CGGCGACCCC AAGCCTCCAT GCTTGCCTCG AAACGGTCTG 
GTGAAGCTGC CGGGCCAGCC CAACGGCCTG GGTGCGGCCA GCATCACCAA GGGCACGCCA 
GCCACCAAGA ACCGCCCCTG CCAGCCACCA CCCCCACCCA CCCTCCCACC ACCCAGCCTG 
GCTGCTCCAC TGTCCCGGGC TGCCCTGGCT GGGGGCCCGT GCACCCCGGC AGGTGGACCA 
GCCTCAGCCT TGGCACCTGG GCACCCAGCG GAGCGGCCGC CGCTGGCCAC GGACGAGAAG 
ATCCTCAATG GGCTCTTCTG GTATTTCTCG GCCTGCGAGA AGTGTGTGCT GGCCCAGGTG 
TGCAAGGCCT GGCGGCGCGT GCTGTACCAG CCCAAGTTCT GGGCAGGCCT CACGCCGGTG 
CTGCATGCCA AGGAGCTCTA CAACGTGCTG CCTGGTGGCG AGAAGGAGTT CGTGAACCTG 
CAGGGTTTTG CCGCCAGAGG CTTCGAGGGC TTCTGCCTGG TTGGCGTCTC CGACCTGGAC 
ATCTGTGAGT TCATTGACAA CTATGCGCTC TCCAAGAAGG GTGTCAAAGC CATGAGCCTC 
AAGCGCTCCA CCATCACGGA CGCAGGCCTC GAGGTTATGC TTGAACAGAT GCAGGGCGTG 
GTGCGTCTGG AGCTGTCGGG CTGCAACGAC TTCACCGAGG CCGGGCTGTG GTCCAGCCTG 
AGCGCGCGCA TCACCTCGCT GAGCGTGAGT GACTGCATCA ACGTGGCCGA CGACGCCATC 
GCGGCCATCT CGCAGCTGCT GCCCAACCTG GCGGAGCTGA GCCTGCAGGC CTACCACGTG 
ACGGACACGG CGCTGGCCTA CTTCACGGCG CGCCAGGGCC ACAGCACGCA CACGCTGCGC 
CTGCTCTCCT GCTGGGAGAT CACCAACCAC GGCGTGGTCA ACGTGGTGCA CAGCCTGCCC 
AACCTCACCG CGCTCAGCCT CTCGGGCTGC TCCAAGGTCA CCGACGACGG CGTGGAGCTC 
GTGGCCGAGA ACCTGCGCAA GCTGCGCAGC CTTGACCTCT CGTGGTGCCC ACGCATCACC 
GACATGGCGC TGGAGTACGT GGCCTGCGAC CTGCACCGCC TAGAGGAGCT CGTGCTCGAC 
AGGTGTGTAC GCATCACGGA CACTGGCCTC AGCTATCTGT CCACCATGTC GTCCCTCCGC 
AGCCTCTACC TGCGATGGTG CTGCCAGGTG CAAGACTTCG GGCTGAAGCA CCTCCTGGCC 
CTGGGGAGTT TGCGCCTCCT GTCTCTGGCA GGCTGCCCGC TGCTCACCAC CACCGGGCTG 
TCGGGCCTGG TGCAGCTGCA GGAGCTGGAG GAGCTGGAGC TGACCAACTG CCCCGGGGCC 
ACCCCCGAGC TCTTCAAGTA TTTCTCGCAG CACCTGCCCC GCTGCCTCGT CATTGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_699181.2
CDS	329..1768
Translation	MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE

Target ORF information:

RefSeq Version	NM_153350.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153350.3

ORF Insert Sequence:

ATGTCGAGCC CGGGCATCGA CGGCGACCCC AAGCCTCCAT GCTTGCCTCG AAACGGTCTG 
GTGAAGCTGC CGGGCCAGCC CAACGGCCTG GGTGCGGCCA GCATCACCAA GGGCACGCCA 
GCCACCAAGA ACCGCCCCTG CCAGCCACCA CCCCCACCCA CCCTCCCACC ACCCAGCCTG 
GCTGCTCCAC TGTCCCGGGC TGCCCTGGCT GGGGGCCCGT GCACCCCGGC AGGTGGACCA 
GCCTCAGCCT TGGCACCTGG GCACCCAGCG GAGCGGCCGC CGCTGGCCAC GGACGAGAAG 
ATCCTCAATG GGCTCTTCTG GTATTTCTCG GCCTGCGAGA AGTGTGTGCT GGCCCAGGTG 
TGCAAGGCCT GGCGGCGCGT GCTGTACCAG CCCAAGTTCT GGGCAGGCCT CACGCCGGTG 
CTGCATGCCA AGGAGCTCTA CAACGTGCTG CCTGGTGGCG AGAAGGAGTT CGTGAACCTG 
CAGGGTTTTG CCGCCAGAGG CTTCGAGGGC TTCTGCCTGG TTGGCGTCTC CGACCTGGAC 
ATCTGTGAGT TCATTGACAA CTATGCGCTC TCCAAGAAGG GTGTCAAAGC CATGAGCCTC 
AAGCGCTCCA CCATCACGGA CGCAGGCCTC GAGGTTATGC TTGAACAGAT GCAGGGCGTG 
GTGCGTCTGG AGCTGTCGGG CTGCAACGAC TTCACCGAGG CCGGGCTGTG GTCCAGCCTG 
AGCGCGCGCA TCACCTCGCT GAGCGTGAGT GACTGCATCA ACGTGGCCGA CGACGCCATC 
GCGGCCATCT CGCAGCTGCT GCCCAACCTG GCGGAGCTGA GCCTGCAGGC CTACCACGTG 
ACGGACACGG CGCTGGCCTA CTTCACGGCG CGCCAGGGCC ACAGCACGCA CACGCTGCGC 
CTGCTCTCCT GCTGGGAGAT CACCAACCAC GGCGTGGTCA ACGTGGTGCA CAGCCTGCCC 
AACCTCACCG CGCTCAGCCT CTCGGGCTGC TCCAAGGTCA CCGACGACGG CGTGGAGCTC 
GTGGCCGAGA ACCTGCGCAA GCTGCGCAGC CTTGACCTCT CGTGGTGCCC ACGCATCACC 
GACATGGCGC TGGAGTACGT GGCCTGCGAC CTGCACCGCC TAGAGGAGCT CGTGCTCGAC 
AGGTGTGTAC GCATCACGGA CACTGGCCTC AGCTATCTGT CCACCATGTC GTCCCTCCGC 
AGCCTCTACC TGCGATGGTG CTGCCAGGTG CAAGACTTCG GGCTGAAGCA CCTCCTGGCC 
CTGGGGAGTT TGCGCCTCCT GTCTCTGGCA GGCTGCCCGC TGCTCACCAC CACCGGGCTG 
TCGGGCCTGG TGCAGCTGCA GGAGCTGGAG GAGCTGGAGC TGACCAACTG CCCCGGGGCC 
ACCCCCGAGC TCTTCAAGTA TTTCTCGCAG CACCTGCCCC GCTGCCTCGT CATTGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL16 ( NM_153350.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_699181.2 Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), mRNA.

Price & Availability↑

CloneID	OHu10539
Clone ID Related Accession (Same CDS sequence)	NM_153350.3 , NM_153350.4 , XM_024450160.1
Accession Version	NM_153350.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 16
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Z97653.14 and Z92544.1. On Nov 22, 2018 this sequence version replaced NM_153350.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## CDS exon combination :: BC036680.2 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000397621.6/ ENSP00000380746.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGAGCC CGGGCATCGA CGGCGACCCC AAGCCTCCAT GCTTGCCTCG AAACGGTCTG 
GTGAAGCTGC CGGGCCAGCC CAACGGCCTG GGTGCGGCCA GCATCACCAA GGGCACGCCA 
GCCACCAAGA ACCGCCCCTG CCAGCCACCA CCCCCACCCA CCCTCCCACC ACCCAGCCTG 
GCTGCTCCAC TGTCCCGGGC TGCCCTGGCT GGGGGCCCGT GCACCCCGGC AGGTGGACCA 
GCCTCAGCCT TGGCACCTGG GCACCCAGCG GAGCGGCCGC CGCTGGCCAC GGACGAGAAG 
ATCCTCAATG GGCTCTTCTG GTATTTCTCG GCCTGCGAGA AGTGTGTGCT GGCCCAGGTG 
TGCAAGGCCT GGCGGCGCGT GCTGTACCAG CCCAAGTTCT GGGCAGGCCT CACGCCGGTG 
CTGCATGCCA AGGAGCTCTA CAACGTGCTG CCTGGTGGCG AGAAGGAGTT CGTGAACCTG 
CAGGGTTTTG CCGCCAGAGG CTTCGAGGGC TTCTGCCTGG TTGGCGTCTC CGACCTGGAC 
ATCTGTGAGT TCATTGACAA CTATGCGCTC TCCAAGAAGG GTGTCAAAGC CATGAGCCTC 
AAGCGCTCCA CCATCACGGA CGCAGGCCTC GAGGTTATGC TTGAACAGAT GCAGGGCGTG 
GTGCGTCTGG AGCTGTCGGG CTGCAACGAC TTCACCGAGG CCGGGCTGTG GTCCAGCCTG 
AGCGCGCGCA TCACCTCGCT GAGCGTGAGT GACTGCATCA ACGTGGCCGA CGACGCCATC 
GCGGCCATCT CGCAGCTGCT GCCCAACCTG GCGGAGCTGA GCCTGCAGGC CTACCACGTG 
ACGGACACGG CGCTGGCCTA CTTCACGGCG CGCCAGGGCC ACAGCACGCA CACGCTGCGC 
CTGCTCTCCT GCTGGGAGAT CACCAACCAC GGCGTGGTCA ACGTGGTGCA CAGCCTGCCC 
AACCTCACCG CGCTCAGCCT CTCGGGCTGC TCCAAGGTCA CCGACGACGG CGTGGAGCTC 
GTGGCCGAGA ACCTGCGCAA GCTGCGCAGC CTTGACCTCT CGTGGTGCCC ACGCATCACC 
GACATGGCGC TGGAGTACGT GGCCTGCGAC CTGCACCGCC TAGAGGAGCT CGTGCTCGAC 
AGGTGTGTAC GCATCACGGA CACTGGCCTC AGCTATCTGT CCACCATGTC GTCCCTCCGC 
AGCCTCTACC TGCGATGGTG CTGCCAGGTG CAAGACTTCG GGCTGAAGCA CCTCCTGGCC 
CTGGGGAGTT TGCGCCTCCT GTCTCTGGCA GGCTGCCCGC TGCTCACCAC CACCGGGCTG 
TCGGGCCTGG TGCAGCTGCA GGAGCTGGAG GAGCTGGAGC TGACCAACTG CCCCGGGGCC 
ACCCCCGAGC TCTTCAAGTA TTTCTCGCAG CACCTGCCCC GCTGCCTCGT CATTGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_699181.2
CDS	305..1744
Translation	MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE

Target ORF information:

RefSeq Version	NM_153350.4
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153350.4

ORF Insert Sequence:

ATGTCGAGCC CGGGCATCGA CGGCGACCCC AAGCCTCCAT GCTTGCCTCG AAACGGTCTG 
GTGAAGCTGC CGGGCCAGCC CAACGGCCTG GGTGCGGCCA GCATCACCAA GGGCACGCCA 
GCCACCAAGA ACCGCCCCTG CCAGCCACCA CCCCCACCCA CCCTCCCACC ACCCAGCCTG 
GCTGCTCCAC TGTCCCGGGC TGCCCTGGCT GGGGGCCCGT GCACCCCGGC AGGTGGACCA 
GCCTCAGCCT TGGCACCTGG GCACCCAGCG GAGCGGCCGC CGCTGGCCAC GGACGAGAAG 
ATCCTCAATG GGCTCTTCTG GTATTTCTCG GCCTGCGAGA AGTGTGTGCT GGCCCAGGTG 
TGCAAGGCCT GGCGGCGCGT GCTGTACCAG CCCAAGTTCT GGGCAGGCCT CACGCCGGTG 
CTGCATGCCA AGGAGCTCTA CAACGTGCTG CCTGGTGGCG AGAAGGAGTT CGTGAACCTG 
CAGGGTTTTG CCGCCAGAGG CTTCGAGGGC TTCTGCCTGG TTGGCGTCTC CGACCTGGAC 
ATCTGTGAGT TCATTGACAA CTATGCGCTC TCCAAGAAGG GTGTCAAAGC CATGAGCCTC 
AAGCGCTCCA CCATCACGGA CGCAGGCCTC GAGGTTATGC TTGAACAGAT GCAGGGCGTG 
GTGCGTCTGG AGCTGTCGGG CTGCAACGAC TTCACCGAGG CCGGGCTGTG GTCCAGCCTG 
AGCGCGCGCA TCACCTCGCT GAGCGTGAGT GACTGCATCA ACGTGGCCGA CGACGCCATC 
GCGGCCATCT CGCAGCTGCT GCCCAACCTG GCGGAGCTGA GCCTGCAGGC CTACCACGTG 
ACGGACACGG CGCTGGCCTA CTTCACGGCG CGCCAGGGCC ACAGCACGCA CACGCTGCGC 
CTGCTCTCCT GCTGGGAGAT CACCAACCAC GGCGTGGTCA ACGTGGTGCA CAGCCTGCCC 
AACCTCACCG CGCTCAGCCT CTCGGGCTGC TCCAAGGTCA CCGACGACGG CGTGGAGCTC 
GTGGCCGAGA ACCTGCGCAA GCTGCGCAGC CTTGACCTCT CGTGGTGCCC ACGCATCACC 
GACATGGCGC TGGAGTACGT GGCCTGCGAC CTGCACCGCC TAGAGGAGCT CGTGCTCGAC 
AGGTGTGTAC GCATCACGGA CACTGGCCTC AGCTATCTGT CCACCATGTC GTCCCTCCGC 
AGCCTCTACC TGCGATGGTG CTGCCAGGTG CAAGACTTCG GGCTGAAGCA CCTCCTGGCC 
CTGGGGAGTT TGCGCCTCCT GTCTCTGGCA GGCTGCCCGC TGCTCACCAC CACCGGGCTG 
TCGGGCCTGG TGCAGCTGCA GGAGCTGGAG GAGCTGGAGC TGACCAACTG CCCCGGGGCC 
ACCCCCGAGC TCTTCAAGTA TTTCTCGCAG CACCTGCCCC GCTGCCTCGT CATTGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL16 ( XM_024450160.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305928.1 Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu10539
Clone ID Related Accession (Same CDS sequence)	NM_153350.3 , NM_153350.4 , XM_024450160.1
Accession Version	XM_024450160.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 16 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGAGCC CGGGCATCGA CGGCGACCCC AAGCCTCCAT GCTTGCCTCG AAACGGTCTG 
GTGAAGCTGC CGGGCCAGCC CAACGGCCTG GGTGCGGCCA GCATCACCAA GGGCACGCCA 
GCCACCAAGA ACCGCCCCTG CCAGCCACCA CCCCCACCCA CCCTCCCACC ACCCAGCCTG 
GCTGCTCCAC TGTCCCGGGC TGCCCTGGCT GGGGGCCCGT GCACCCCGGC AGGTGGACCA 
GCCTCAGCCT TGGCACCTGG GCACCCAGCG GAGCGGCCGC CGCTGGCCAC GGACGAGAAG 
ATCCTCAATG GGCTCTTCTG GTATTTCTCG GCCTGCGAGA AGTGTGTGCT GGCCCAGGTG 
TGCAAGGCCT GGCGGCGCGT GCTGTACCAG CCCAAGTTCT GGGCAGGCCT CACGCCGGTG 
CTGCATGCCA AGGAGCTCTA CAACGTGCTG CCTGGTGGCG AGAAGGAGTT CGTGAACCTG 
CAGGGTTTTG CCGCCAGAGG CTTCGAGGGC TTCTGCCTGG TTGGCGTCTC CGACCTGGAC 
ATCTGTGAGT TCATTGACAA CTATGCGCTC TCCAAGAAGG GTGTCAAAGC CATGAGCCTC 
AAGCGCTCCA CCATCACGGA CGCAGGCCTC GAGGTTATGC TTGAACAGAT GCAGGGCGTG 
GTGCGTCTGG AGCTGTCGGG CTGCAACGAC TTCACCGAGG CCGGGCTGTG GTCCAGCCTG 
AGCGCGCGCA TCACCTCGCT GAGCGTGAGT GACTGCATCA ACGTGGCCGA CGACGCCATC 
GCGGCCATCT CGCAGCTGCT GCCCAACCTG GCGGAGCTGA GCCTGCAGGC CTACCACGTG 
ACGGACACGG CGCTGGCCTA CTTCACGGCG CGCCAGGGCC ACAGCACGCA CACGCTGCGC 
CTGCTCTCCT GCTGGGAGAT CACCAACCAC GGCGTGGTCA ACGTGGTGCA CAGCCTGCCC 
AACCTCACCG CGCTCAGCCT CTCGGGCTGC TCCAAGGTCA CCGACGACGG CGTGGAGCTC 
GTGGCCGAGA ACCTGCGCAA GCTGCGCAGC CTTGACCTCT CGTGGTGCCC ACGCATCACC 
GACATGGCGC TGGAGTACGT GGCCTGCGAC CTGCACCGCC TAGAGGAGCT CGTGCTCGAC 
AGGTGTGTAC GCATCACGGA CACTGGCCTC AGCTATCTGT CCACCATGTC GTCCCTCCGC 
AGCCTCTACC TGCGATGGTG CTGCCAGGTG CAAGACTTCG GGCTGAAGCA CCTCCTGGCC 
CTGGGGAGTT TGCGCCTCCT GTCTCTGGCA GGCTGCCCGC TGCTCACCAC CACCGGGCTG 
TCGGGCCTGG TGCAGCTGCA GGAGCTGGAG GAGCTGGAGC TGACCAACTG CCCCGGGGCC 
ACCCCCGAGC TCTTCAAGTA TTTCTCGCAG CACCTGCCCC GCTGCCTCGT CATTGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305928.1
CDS	787..2226
Translation	MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE

Target ORF information:

RefSeq Version	XM_024450160.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450160.1

ORF Insert Sequence:

ATGTCGAGCC CGGGCATCGA CGGCGACCCC AAGCCTCCAT GCTTGCCTCG AAACGGTCTG 
GTGAAGCTGC CGGGCCAGCC CAACGGCCTG GGTGCGGCCA GCATCACCAA GGGCACGCCA 
GCCACCAAGA ACCGCCCCTG CCAGCCACCA CCCCCACCCA CCCTCCCACC ACCCAGCCTG 
GCTGCTCCAC TGTCCCGGGC TGCCCTGGCT GGGGGCCCGT GCACCCCGGC AGGTGGACCA 
GCCTCAGCCT TGGCACCTGG GCACCCAGCG GAGCGGCCGC CGCTGGCCAC GGACGAGAAG 
ATCCTCAATG GGCTCTTCTG GTATTTCTCG GCCTGCGAGA AGTGTGTGCT GGCCCAGGTG 
TGCAAGGCCT GGCGGCGCGT GCTGTACCAG CCCAAGTTCT GGGCAGGCCT CACGCCGGTG 
CTGCATGCCA AGGAGCTCTA CAACGTGCTG CCTGGTGGCG AGAAGGAGTT CGTGAACCTG 
CAGGGTTTTG CCGCCAGAGG CTTCGAGGGC TTCTGCCTGG TTGGCGTCTC CGACCTGGAC 
ATCTGTGAGT TCATTGACAA CTATGCGCTC TCCAAGAAGG GTGTCAAAGC CATGAGCCTC 
AAGCGCTCCA CCATCACGGA CGCAGGCCTC GAGGTTATGC TTGAACAGAT GCAGGGCGTG 
GTGCGTCTGG AGCTGTCGGG CTGCAACGAC TTCACCGAGG CCGGGCTGTG GTCCAGCCTG 
AGCGCGCGCA TCACCTCGCT GAGCGTGAGT GACTGCATCA ACGTGGCCGA CGACGCCATC 
GCGGCCATCT CGCAGCTGCT GCCCAACCTG GCGGAGCTGA GCCTGCAGGC CTACCACGTG 
ACGGACACGG CGCTGGCCTA CTTCACGGCG CGCCAGGGCC ACAGCACGCA CACGCTGCGC 
CTGCTCTCCT GCTGGGAGAT CACCAACCAC GGCGTGGTCA ACGTGGTGCA CAGCCTGCCC 
AACCTCACCG CGCTCAGCCT CTCGGGCTGC TCCAAGGTCA CCGACGACGG CGTGGAGCTC 
GTGGCCGAGA ACCTGCGCAA GCTGCGCAGC CTTGACCTCT CGTGGTGCCC ACGCATCACC 
GACATGGCGC TGGAGTACGT GGCCTGCGAC CTGCACCGCC TAGAGGAGCT CGTGCTCGAC 
AGGTGTGTAC GCATCACGGA CACTGGCCTC AGCTATCTGT CCACCATGTC GTCCCTCCGC 
AGCCTCTACC TGCGATGGTG CTGCCAGGTG CAAGACTTCG GGCTGAAGCA CCTCCTGGCC 
CTGGGGAGTT TGCGCCTCCT GTCTCTGGCA GGCTGCCCGC TGCTCACCAC CACCGGGCTG 
TCGGGCCTGG TGCAGCTGCA GGAGCTGGAG GAGCTGGAGC TGACCAACTG CCCCGGGGCC 
ACCCCCGAGC TCTTCAAGTA TTTCTCGCAG CACCTGCCCC GCTGCCTCGT CATTGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cells.
International journal of oncology36(2)479-90(2010 Feb)
Sato K,Kusama Y,Tategu M,Yoshida K

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
The international journal of biochemistry & cell biology41(5)1205-15(2009 May)
Ebstein F,Lange N,Urban S,Seifert U,Kr?ger E,Kloetzel PM

The sequence and analysis of duplication-rich human chromosome 16.
Nature432(7020)988-94(2004 Dec)
Martin J,Han C,Gordon LA,Terry A,Prabhakar S,She X,Xie G,Hellsten U,Chan YM,Altherr M,Couronne O,Aerts A,Bajorek E,Black S,Blumer H,Branscomb E,Brown NC,Bruno WJ,Buckingham JM,Callen DF,Campbell CS,Campbell ML,Campbell EW,Caoile C,Challacombe JF,Chasteen LA,Chertkov O,Chi HC,Christensen M,Clark LM,Cohn JD,Denys M,Detter JC,Dickson M,Dimitrijevic-Bussod M,Escobar J,Fawcett JJ,Flowers D,Fotopulos D,Glavina T,Gomez M,Gonzales E,Goodstein D,Goodwin LA,Grady DL,Grigoriev I,Groza M,Hammon N,Hawkins T,Haydu L,Hildebrand CE,Huang W,Israni S,Jett J,Jewett PB,Kadner K,Kimball H,Kobayashi A,Krawczyk MC,Leyba T,Longmire JL,Lopez F,Lou Y,Lowry S,Ludeman T,Manohar CF,Mark GA,McMurray KL,Meincke LJ,Morgan J,Moyzis RK,Mundt MO,Munk AC,Nandkeshwar RD,Pitluck S,Pollard M,Predki P,Parson-Quintana B,Ramirez L,Rash S,Retterer J,Ricke DO,Robinson DL,Rodriguez A,Salamov A,Saunders EH,Scott D,Shough T,Stallings RL,Stalvey M,Sutherland RD,Tapia R,Tesmer JG,Thayer N,Thompson LS,Tice H,Torney DC,Tran-Gyamfi M,Tsai M,Ulanovsky LE,Ustaszewska A,Vo N,White PS,Williams AL,Wills PL,Wu JR,Wu K,Yang J,Dejong P,Bruce D,Doggett NA,Deaven L,Schmutz J,Grimwood J,Richardson P,Rokhsar DS,Eichler EE,Gilna P,Lucas SM,Myers RM,Rubin EM,Pennacchio LA

Systematic analysis and nomenclature of mammalian F-box proteins.
Genes & development18(21)2573-80(2004 Nov)
Jin J,Cardozo T,Lovering RC,Elledge SJ,Pagano M,Harper JW

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
Human molecular genetics10(4)339-52(2001 Feb)
Daniels RJ,Peden JF,Lloyd C,Horsley SW,Clark K,Tufarelli C,Kearney L,Buckle VJ,Doggett NA,Flint J,Higgs DR

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FBXL16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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