OR52B4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OR52B4
Entrez Gene ID	143496
Full Name	olfactory receptor family 52 subfamily B member 4 (gene/pseudogene)
Synonyms	OR11-3
General protein information	Preferred Names olfactory receptor family 52 subfamily B member 4 (gene/pseudogene) Names olfactory receptor 52B4 olfactory receptor OR11-3 olfactory receptor, family 52, subfamily B, member 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001005161.3	NP_001005161.2	olfactory receptor 52B4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OR52B4	XP_002693464.1
Mus musculus (house mouse)	Olfr547	NP_667290.2
Pan troglodytes (chimpanzee)	LOC466330	XP_521729.1
Rattus norvegicus (Norway rat)	Olr41	NP_001000126.1
Homo sapiens (human)	OR52B4	NP_001005161.2
Canis lupus familiaris (dog)	OR52B4	XP_542341.1

Gene Ontology
Bibliography

Related articles in PubMed

GWAS study using DNA pooling strategy identifies association of variant rs4910623 in OR52B4 gene with anti-VEGF treatment response in age-related macular degeneration.
Riaz M, Lor?s-Motta L, Richardson AJ, Lu Y, Montgomery G, Omar A, Koenekoop RK, Chen J, Muether P, Altay L, Schick T, Fauser S, Smailhodzic D, van Asten F, de Jong EK, Hoyng CB, Burdon KP, MacGregor S, Guymer RH, den Hollander AI, Baird PN
Scientific reports637924(2016 Nov)

Personal receptor repertoires: olfaction as a model.
Olender T, Waszak SM, Viavant M, Khen M, Ben-Asher E, Reyes A, Nativ N, Wysocki CJ, Ge D, Lancet D
BMC genomics13414(2012 Aug)

Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
Swaminathan S, Huentelman MJ, Corneveaux JJ, Myers AJ, Faber KM, Foroud T, Mayeux R, Shen L, Kim S, Turk M, Hardy J, Reiman EM, Saykin AJ,
PloS one7(12)e50640(2012)

An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K
Human genetics128(4)433-41(2010 Oct)

A probabilistic classifier for olfactory receptor pseudogenes.
Menashe I, Aloni R, Lancet D
BMC bioinformatics7393(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.

The following OR52B4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OR52B4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11276	NM_001005161.3 Latest version!	Homo sapiens olfactory receptor family 52 subfamily B member 4 (gene/pseudogene) (OR52B4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OR52B4 ( NM_001005161.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005161.2 Homo sapiens olfactory receptor family 52 subfamily B member 4 (gene/pseudogene) (OR52B4), mRNA.

Price & Availability↑

CloneID	OHu11276
Clone ID Related Accession (Same CDS sequence)	NM_001005161.3
Accession Version	NM_001005161.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	olfactory receptor 52B4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009758.8. On Jan 20, 2010 this sequence version replaced NM_001005161.2. Sequence Note: This gene is a segregating pseudogene. This RefSeq represents the protein encoded by the reference genome allele, which is predicted to be non-functional as an olfactory receptor according to the Classifier for Olfactory Receptor Pseudogenes. This RefSeq was derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC140928.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000624801.3/ ENSP00000485530.1 polymorphic pseudogene :: PMID: 22908908 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCTACTG TAAACCACAG TGGCACTAGC CACACAGTCT TCCACTTGCT GGGCATCCCT 
GGCCTACAGG ACCAGCACAT GTGGATTTCT ATCCCATTCT TCATTTCCTA TGTCACCGCC 
CTTCTTGGGA ACAGCCTGCT CATCTTCATT ATCCTCACAA AGCGCAGCCT CCATGAACCC 
ATGTACCTCT TCCTCTGCAT GCTGGCTGGA GCAGACATTG TCCTCTCCAC GTGCACCATT 
CCTCAGGCCT TAGCTATCTT CTGGTTCCGT GCTGGGGACA TCTCCCTGGA TCGTTGCATC 
ACTCAGCTCT TCTTCATCCA TTCCACCTTC ATCTCTGAGT CAGGGATCTT GCTGGTGATG 
GCCTTTGACC ACTATATTGC CATATGCTAC CCACTGAGGT ACACCACCAT TCTTACAAAT 
GCTCTGATCA AGAAAATTTG TGTGACTGTC TCTCTGAGAA GTTATGGTAC AATTTTCCCT 
ATCATATTTC TTTTAAAAAG ATTGACTTTC TGCCAGAATA ATATTATTCC ACACACCTTT 
TGTGAACACA TTGGCCTAGC CAAATATGCA TGTAATGACA TTCGAATAAA CATTTGGTAT 
GGGTTTTCCA TTCTAATGTC GACGGTGGTC TTAGATGTTG TACTAATTTT TATTTCCTAT 
ATGCTGATTC TCCATGCTGT CTTCCACATG CCTTCTCCAG ATGCTTGCCA CAAAGCTCTC 
AACACATTTG GCTCCCATGT CTGCATCATC ATCCTCTTTT ATGGGTCTGG CATCTTCACA 
ATCCTTACCC AGAGGTTTGG ACGCCACATT CCACCTTGTA TCCACATCCC GTTGGCTAAT 
GTCTGCATTC TGGCTCCACC TATGCTGAAT CCCATTATTT ATGGGATCAA AACCAAGCAA 
ATCCAGGAAC AGGTGGTTCA GTTTTTGTTT ATAAAACAGA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005161.2
CDS	92..1036
Translation	MPTVNHSGTSHTVFHLLGIPGLQDQHMWISIPFFISYVTALLGNSLLIFIILTKRSLHEPMYLFLCMLAGADIVLSTCTIPQALAIFWFRAGDISLDRCITQLFFIHSTFISESGILLVMAFDHYIAICYPLRYTTILTNALIKKICVTVSLRSYGTIFPIIFLLKRLTFCQNNIIPHTFCEHIGLAKYACNDIRINIWYGFSILMSTVVLDVVLIFISYMLILHAVFHMPSPDACHKALNTFGSHVCIIILFYGSGIFTILTQRFGRHIPPCIHIPLANVCILAPPMLNPIIYGIKTKQIQEQVVQFLFIKQK

Target ORF information:

RefSeq Version	NM_001005161.3
Organism	Homo sapiens(human)
Definition	Homo sapiens olfactory receptor family 52 subfamily B member 4 (gene/pseudogene) (OR52B4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005161.3

ORF Insert Sequence:

ATGCCTACTG TAAACCACAG TGGCACTAGC CACACAGTCT TCCACTTGCT GGGCATCCCT 
GGCCTACAGG ACCAGCACAT GTGGATTTCT ATCCCATTCT TCATTTCCTA TGTCACCGCC 
CTTCTTGGGA ACAGCCTGCT CATCTTCATT ATCCTCACAA AGCGCAGCCT CCATGAACCC 
ATGTACCTCT TCCTCTGCAT GCTGGCTGGA GCAGACATTG TCCTCTCCAC GTGCACCATT 
CCTCAGGCCT TAGCTATCTT CTGGTTCCGT GCTGGGGACA TCTCCCTGGA TCGTTGCATC 
ACTCAGCTCT TCTTCATCCA TTCCACCTTC ATCTCTGAGT CAGGGATCTT GCTGGTGATG 
GCCTTTGACC ACTATATTGC CATATGCTAC CCACTGAGGT ACACCACCAT TCTTACAAAT 
GCTCTGATCA AGAAAATTTG TGTGACTGTC TCTCTGAGAA GTTATGGTAC AATTTTCCCT 
ATCATATTTC TTTTAAAAAG ATTGACTTTC TGCCAGAATA ATATTATTCC ACACACCTTT 
TGTGAACACA TTGGCCTAGC CAAATATGCA TGTAATGACA TTCGAATAAA CATTTGGTAT 
GGGTTTTCCA TTCTAATGTC GACGGTGGTC TTAGATGTTG TACTAATTTT TATTTCCTAT 
ATGCTGATTC TCCATGCTGT CTTCCACATG CCTTCTCCAG ATGCTTGCCA CAAAGCTCTC 
AACACATTTG GCTCCCATGT CTGCATCATC ATCCTCTTTT ATGGGTCTGG CATCTTCACA 
ATCCTTACCC AGAGGTTTGG ACGCCACATT CCACCTTGTA TCCACATCCC GTTGGCTAAT 
GTCTGCATTC TGGCTCCACC TATGCTGAAT CCCATTATTT ATGGGATCAA AACCAAGCAA 
ATCCAGGAAC AGGTGGTTCA GTTTTTGTTT ATAAAACAGA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GWAS study using DNA pooling strategy identifies association of variant rs4910623 in OR52B4 gene with anti-VEGF treatment response in age-related macular degeneration.
Scientific reports637924(2016 Nov)
Riaz M,Lor?s-Motta L,Richardson AJ,Lu Y,Montgomery G,Omar A,Koenekoop RK,Chen J,Muether P,Altay L,Schick T,Fauser S,Smailhodzic D,van Asten F,de Jong EK,Hoyng CB,Burdon KP,MacGregor S,Guymer RH,den Hollander AI,Baird PN

Personal receptor repertoires: olfaction as a model.
BMC genomics13414(2012 Aug)
Olender T,Waszak SM,Viavant M,Khen M,Ben-Asher E,Reyes A,Nativ N,Wysocki CJ,Ge D,Lancet D

Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
PloS one7(12)e50640(2012)
Swaminathan S,Huentelman MJ,Corneveaux JJ,Myers AJ,Faber KM,Foroud T,Mayeux R,Shen L,Kim S,Turk M,Hardy J,Reiman EM,Saykin AJ,

An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Human genetics128(4)433-41(2010 Oct)
Shimada M,Miyagawa T,Kawashima M,Tanaka S,Honda Y,Honda M,Tokunaga K

A probabilistic classifier for olfactory receptor pseudogenes.
BMC bioinformatics7393(2006 Aug)
Menashe I,Aloni R,Lancet D

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OR52B4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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