CRYBA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRYBA2
Entrez Gene ID	1412
Full Name	crystallin beta A2
Synonyms	CTRCT42
General protein information	Preferred Names crystallin beta A2 Names beta-crystallin A2 eye lens structural protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Summary	Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form aggregates of different sizes and are able to form homodimers through self-association or heterodimers with other beta-crystallins. This gene is a beta acidic group member. Three alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq, Jul 2008].
Disorder MIM:	600836
Disorder Html:	?Cataract 42, 115900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011510660.1	XP_011508962.1	beta-crystallin A2 isoform X1
NM_057093.1	NP_476434.1	beta-crystallin A2
NM_057094.1	NP_476435.1	beta-crystallin A2
NM_057093.2	NP_476434.1	beta-crystallin A2
NM_057094.2	NP_476435.1	beta-crystallin A2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cryba2a	NP_001002049.1
Homo sapiens (human)	CRYBA2	NP_476435.1
	CRYBA2	XP_001096534.1
Mus musculus (house mouse)	Cryba2	NP_067516.1
Canis lupus familiaris (dog)	CRYBA2	XP_545651.3
Rattus norvegicus (Norway rat)	Cryba2	NP_775163.1
Danio rerio (zebrafish)	cryba2b	NP_001002584.1
Xenopus tropicalis (tropical clawed frog)	LOC100496418	XP_002933987.1
Pan troglodytes (chimpanzee)	CRYBA2	XP_001159761.1
Bos taurus (cattle)	CRYBA2	NP_776949.1
Gallus gallus (chicken)	CRYBA2	NP_989510.1

Gene Ontology
Bibliography

Related articles in PubMed

Phospho-tyrosine dependent protein-protein interaction network.
Grossmann A, Benlasfer N, Birth P, Hegele A, Wachsmuth F, Apelt L, Stelzl U
Molecular systems biology11(3)794(2015 Mar)

Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.
Reis LM, Tyler RC, Muheisen S, Raggio V, Salviati L, Han DP, Costakos D, Yonath H, Hall S, Power P, Semina EV
Human genetics132(7)761-70(2013 Jul)

Cell stress molecules in the skeletal muscle of GNE myopathy.
Fischer C, Kleinschnitz K, Wrede A, Muth I, Kruse N, Nishino I, Schmidt J
BMC neurology1324(2013 Mar)

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou C, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF
BMC medical genetics1196(2010 Jun)

An empirical framework for binary interactome mapping.
Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, Hirozane-Kishikawa T, Hao T, Zenkner M, Xin X, Goh KI, Yildirim MA, Simonis N, Heinzmann K, Gebreab F, Sahalie JM, Cevik S, Simon C, de Smet AS, Dann E, Smolyar A, Vinayagam A, Yu H, Szeto D, Borick H, Dricot A, Klitgord N, Murray RR, Lin C, Lalowski M, Timm J, Rau K, Boone C, Braun P, Cusick ME, Roth FP, Hill DE, Tavernier J, Wanker EE, Barab?si AL, Vidal M
Nature methods6(1)83-90(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.
Title: Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.

The cell-stress molecules alphaB-crystallin and iNOS are overexpressed in GNE myopathy muscle and may identify early disease mechanisms.
Title: Cell stress molecules in the skeletal muscle of GNE myopathy.

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

The following CRYBA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRYBA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05678	NM_057093.2 Latest version!	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu05678	NM_057094.2 Latest version!	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu05678	XM_011510660.1 Latest version!	Homo sapiens crystallin, beta A2 (CRYBA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05678	NM_057093.1	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu05678	NM_057094.1	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRYBA2 ( NM_057093.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_476434.1 Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05678
Clone ID Related Accession (Same CDS sequence)	XM_011510660.1 , NM_057093.1 , NM_057094.1 , NM_057093.2 , NM_057094.2
Accession Version	NM_057093.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	beta-crystallin A2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC006285.2. Transcript Variant: This variant (2) contains an alternate 5' UTR region as compared to variant 1, but encodes the identical protein. ##Evidence-Data-START## Transcript exon combination :: BC006285.2, BE901645.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476434.1
CDS	230..823
Translation	MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH

Target ORF information:

RefSeq Version	NM_057093.1
Organism	Homo sapiens(human)
Definition	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057093.1

ORF Insert Sequence:

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRYBA2 ( NM_057094.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_476435.1 Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu05678
Clone ID Related Accession (Same CDS sequence)	XM_011510660.1 , NM_057093.1 , NM_057094.1 , NM_057093.2 , NM_057094.2
Accession Version	NM_057094.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	beta-crystallin A2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC006285.2. This sequence is a reference standard in the RefSeqGene project. On Jun 12, 2012 this sequence version replaced NM_005209.1. Transcript Variant: This variant (3) contains a different 5' UTR region when compared to variant 1, and lacks an internal 5' UTR region when compared to variant 2. It encodes a protein identical to that encoded by variants 2 and 3. ##Evidence-Data-START## Transcript exon combination :: AF166331.1, BM697019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476435.1
CDS	36..629
Translation	MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH

Target ORF information:

RefSeq Version	NM_057094.1
Organism	Homo sapiens(human)
Definition	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057094.1

ORF Insert Sequence:

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRYBA2 ( NM_057093.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_476434.1 Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05678
Clone ID Related Accession (Same CDS sequence)	XM_011510660.1 , NM_057093.1 , NM_057094.1 , NM_057093.2 , NM_057094.2
Accession Version	NM_057093.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	beta-crystallin A2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097468.3 and BC006285.2. On Nov 23, 2018 this sequence version replaced NM_057093.1. Transcript Variant: This variant (2) contains an alternate 5' UTR region as compared to variant 1, but encodes the identical protein. ##Evidence-Data-START## Transcript exon combination :: BC006285.2, BE901645.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295728.7/ ENSP00000295728.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476434.1
CDS	247..840
Translation	MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH

Target ORF information:

RefSeq Version	NM_057093.2
Organism	Homo sapiens(human)
Definition	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057093.2

ORF Insert Sequence:

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRYBA2 ( NM_057094.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_476435.1 Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu05678
Clone ID Related Accession (Same CDS sequence)	XM_011510660.1 , NM_057093.1 , NM_057094.1 , NM_057093.2 , NM_057094.2
Accession Version	NM_057094.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	beta-crystallin A2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097468.3. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_057094.1. Transcript Variant: This variant (3) contains a different 5' UTR region when compared to variant 1, and lacks an internal 5' UTR region when compared to variant 2. It encodes a protein identical to that encoded by variants 2 and 3. ##Evidence-Data-START## Transcript exon combination :: AF166331.1, DRR138519.194751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476435.1
CDS	53..646
Translation	MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH

Target ORF information:

RefSeq Version	NM_057094.2
Organism	Homo sapiens(human)
Definition	Homo sapiens crystallin beta A2 (CRYBA2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057094.2

ORF Insert Sequence:

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRYBA2 ( XM_011510660.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508962.1 Homo sapiens crystallin, beta A2 (CRYBA2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu05678
Clone ID Related Accession (Same CDS sequence)	XM_011510660.1 , NM_057093.1 , NM_057094.1 , NM_057093.2 , NM_057094.2
Accession Version	XM_011510660.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	beta-crystallin A2 isoform X1
Comment

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508962.1
Translation	MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHTGQLQSIRRVQH

Target ORF information:

RefSeq Version	XM_011510660.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens crystallin, beta A2 (CRYBA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510660.1

ORF Insert Sequence:

ATGAGCAGCG CCCCCGCGCC GGGCCCGGCG CCCGCCAGCC TCACGCTCTG GGACGAGGAG 
GACTTCCAGG GCCGTCGCTG TCGGCTGCTA AGCGACTGTG CGAACGTCTG CGAGCGCGGA 
GGCCTGCCCA GGGTGCGCTC GGTCAAGGTG GAAAACGGCG TTTGGGTGGC CTTTGAGTAC 
CCCGACTTCC AGGGACAGCA GTTCATTCTG GAGAAGGGAG ACTATCCTCG CTGGAGCGCC 
TGGAGTGGCA GCAGCAGCCA CAACAGCAAC CAGCTGCTGT CCTTCCGGCC AGTGCTCTGC 
GCGAACCACA ATGACAGCCG TGTGACACTG TTTGAGGGGG ACAACTTCCA AGGCTGCAAG 
TTTGACCTCG TTGATGACTA CCCATCCCTG CCCTCCATGG GCTGGGCCAG CAAGGATGTG 
GGTTCCCTCA AAGTCAGCTC CGGAGCGTGG GTGGCCTACC AGTACCCAGG CTACCGAGGC 
TACCAGTATG TGTTGGAGCG GGACCGGCAC AGCGGAGAGT TCTGTACTTA CGGTGAGCTC 
GGCACACAGG CCCACACTGG GCAGCTGCAG TCCATCCGGA GAGTCCAGCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phospho-tyrosine dependent protein-protein interaction network.
Molecular systems biology11(3)794(2015 Mar)
Grossmann A,Benlasfer N,Birth P,Hegele A,Wachsmuth F,Apelt L,Stelzl U

Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.
Human genetics132(7)761-70(2013 Jul)
Reis LM,Tyler RC,Muheisen S,Raggio V,Salviati L,Han DP,Costakos D,Yonath H,Hall S,Power P,Semina EV

Cell stress molecules in the skeletal muscle of GNE myopathy.
BMC neurology1324(2013 Mar)
Fischer C,Kleinschnitz K,Wrede A,Muth I,Kruse N,Nishino I,Schmidt J

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
BMC medical genetics1196(2010 Jun)
Zhao J,Li M,Bradfield JP,Zhang H,Mentch FD,Wang K,Sleiman PM,Kim CE,Glessner JT,Hou C,Keating BJ,Thomas KA,Garris ML,Deliard S,Frackelton EC,Otieno FG,Chiavacci RM,Berkowitz RI,Hakonarson H,Grant SF

An empirical framework for binary interactome mapping.
Nature methods6(1)83-90(2009 Jan)
Venkatesan K,Rual JF,Vazquez A,Stelzl U,Lemmens I,Hirozane-Kishikawa T,Hao T,Zenkner M,Xin X,Goh KI,Yildirim MA,Simonis N,Heinzmann K,Gebreab F,Sahalie JM,Cevik S,Simon C,de Smet AS,Dann E,Smolyar A,Vinayagam A,Yu H,Szeto D,Borick H,Dricot A,Klitgord N,Murray RR,Lin C,Lalowski M,Timm J,Rau K,Boone C,Braun P,Cusick ME,Roth FP,Hill DE,Tavernier J,Wanker EE,Barab?si AL,Vidal M

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CRYBA2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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