DCANP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DCANP1
Entrez Gene ID	140947
Full Name	dendritic cell associated nuclear protein
Synonyms	C5orf20,DCNP1
General protein information	Preferred Names dendritic cell associated nuclear protein Names dendritic cell nuclear protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.1
Summary	This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008].
Disorder MIM:	609710

mRNA and Protein(s)

mRNA	Protein	Name
NM_130848.2	NP_570900.1	dendritic cell nuclear protein 1
NM_130848.3	NP_570900.1	dendritic cell nuclear protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C5H5orf20	XP_003954540.1
Homo sapiens (human)	C5orf20	NP_570900.1

Gene Ontology
Bibliography

Related articles in PubMed

Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells.
Chen D, Li YP, Yu YX, Zhou T, Liu C, Fei EK, Gao F, Mu CC, Ren HG, Wang GH
Acta pharmacologica Sinica(2017 Dec)

Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population.
Li H, Wang YJ, Hua L, Yang YT, Zhang M, Zhang D, Wang C, Xu ZQ
Progress in neuro-psychopharmacology & biological psychiatry457-10(2013 Aug)

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Schr?der JC, L??ig AK, Galetzka D, Peters A, Castle JC, Diederich S, Zechner U, M?ller-Forell W, Keilmann A, Bartsch O
Behavioral and brain functions : BBF97(2013 Feb)

Poor replication of candidate genes for major depressive disorder using genome-wide association data.
Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, van Veen T, Willemsen G, DeRijk RH, de Geus EJ, Hoogendijk WJ, Sullivan PF, Penninx BW, Boomsma DI, Snieder H, Nolen WA
Molecular psychiatry16(5)516-32(2011 May)

Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression.
Zhou T, Wang S, Ren H, Qi XR, Luchetti S, Kamphuis W, Zhou JN, Wang G, Swaab DF
Brain : a journal of neurology133(10)3069-79(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the Han Chinese population, common DCNP1 polymorphisms are unlikely to be important in the genetic susceptibility to MDD.
Title: Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population.

Observational study of gene-disease association. (HuGE Navigator)
Title: Poor replication of candidate genes for major depressive disorder using genome-wide association data.

We propose that full-length dendritic cell nucleus protein-1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus.
Title: Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression.

Observational study of gene-disease association. (HuGE Navigator)
Title: A promoter nucleotide variant of the dendritic cell-specific DCNP1 associates with serum IgE levels specific for dust mite allergens among the Korean asthmatics.

Marker rs12520799, in dendritic cell nuclear protein 1 on chromosome 5, yielded a significant association with lifetime major depression.
Title: DCNP1: a novel candidate gene for major depression.

The following DCANP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DCANP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08900	NM_130848.3 Latest version!	Homo sapiens dendritic cell associated nuclear protein (DCANP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu08900	NM_130848.2	Homo sapiens dendritic cell associated nuclear protein (DCANP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DCANP1 ( NM_130848.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_570900.1 Homo sapiens dendritic cell associated nuclear protein (DCANP1), mRNA.

Price & Availability↑

CloneID	OHu08900
Clone ID Related Accession (Same CDS sequence)	NM_130848.2 , NM_130848.3
Accession Version	NM_130848.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	dendritic cell nuclear protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB074498.1 and AC022092.8. On Oct 26, 2006 this sequence version replaced NM_130848.1. ##Evidence-Data-START## Transcript is intronless :: AB074498.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATTACG GAGCAGCAAC CCACATACAG AACTCGAGAA GCCACGGCCT GGAGACTGTA 
CCTGGACACC AAAGACTGGA GAGAGGAGCT GGTGGGGAAA CCCCAGAGTT CCCAGGGTGC 
CACTCCCCAG CTCCACCAGA GAACTTTGGG AATGAGCTGC TGCCCCTGAG TGCCCCTCTC 
CAGGGCCTCA GTGAGGGTCT CTACCCTCCA GGGAGGAACA AAACCTTGCC AGCTGGGGTC 
CTGCGAGAGG GGGCAGTTCA ATTCCTCCAC AGGGGACTCT GCAACTCCAA TCTTTCGAGT 
GAAGCATCTG CGAGGCCCTC AGGGACCCAG GATGAACTGC ATAGCAGCAG AAGGAAGACA 
GGCCAGACCA GGCGGGAGGG AGCCCGGAAA CATCTGGTTT GTAGTTTCAG ACTCTACCCG 
TTCACAGTTC ACACAGTCTC ACCGGGAAAC TCACACCTTG CCCTGTACCA AGTTTTTAAG 
GCAGTTAAGC TCTGCCCATC CGAGACTTCA TTTTTCTTGA GTAGAAAATC ACTGAAATCA 
TCAGATCCAT GGCACCCACC TTCACTTTCT CCTAACAGCT GGAACCGTCA GGCTGGCTTC 
AGGGCCTGGT CTTCGCACTT GATATCACTA TCCCTCACCT GCTCAGACAG CCAGAGCAGG 
CGGGTGAGTT CCTCCCAACA ACCTCCACTG CATTCTCTCA GCTCCCACCG CAGGGCAGCC 
CACGTGCCTG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570900.1
CDS	241..975
Translation	MHYGAATHIQNSRSHGLETVPGHQRLERGAGGETPEFPGCHSPAPPENFGNELLPLSAPLQGLSEGLYPPGRNKTLPAGVLREGAVQFLHRGLCNSNLSSEASARPSGTQDELHSSRRKTGQTRREGARKHLVCSFRLYPFTVHTVSPGNSHLALYQVFKAVKLCPSETSFFLSRKSLKSSDPWHPPSLSPNSWNRQAGFRAWSSHLISLSLTCSDSQSRRVSSSQQPPLHSLSSHRRAAHVPE

Target ORF information:

RefSeq Version	NM_130848.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dendritic cell associated nuclear protein (DCANP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130848.2

ORF Insert Sequence:

ATGCATTACG GAGCAGCAAC CCACATACAG AACTCGAGAA GCCACGGCCT GGAGACTGTA 
CCTGGACACC AAAGACTGGA GAGAGGAGCT GGTGGGGAAA CCCCAGAGTT CCCAGGGTGC 
CACTCCCCAG CTCCACCAGA GAACTTTGGG AATGAGCTGC TGCCCCTGAG TGCCCCTCTC 
CAGGGCCTCA GTGAGGGTCT CTACCCTCCA GGGAGGAACA AAACCTTGCC AGCTGGGGTC 
CTGCGAGAGG GGGCAGTTCA ATTCCTCCAC AGGGGACTCT GCAACTCCAA TCTTTCGAGT 
GAAGCATCTG CGAGGCCCTC AGGGACCCAG GATGAACTGC ATAGCAGCAG AAGGAAGACA 
GGCCAGACCA GGCGGGAGGG AGCCCGGAAA CATCTGGTTT GTAGTTTCAG ACTCTACCCG 
TTCACAGTTC ACACAGTCTC ACCGGGAAAC TCACACCTTG CCCTGTACCA AGTTTTTAAG 
GCAGTTAAGC TCTGCCCATC CGAGACTTCA TTTTTCTTGA GTAGAAAATC ACTGAAATCA 
TCAGATCCAT GGCACCCACC TTCACTTTCT CCTAACAGCT GGAACCGTCA GGCTGGCTTC 
AGGGCCTGGT CTTCGCACTT GATATCACTA TCCCTCACCT GCTCAGACAG CCAGAGCAGG 
CGGGTGAGTT CCTCCCAACA ACCTCCACTG CATTCTCTCA GCTCCCACCG CAGGGCAGCC 
CACGTGCCTG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCANP1 ( NM_130848.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_570900.1 Homo sapiens dendritic cell associated nuclear protein (DCANP1), mRNA.

Price & Availability↑

CloneID	OHu08900
Clone ID Related Accession (Same CDS sequence)	NM_130848.2 , NM_130848.3
Accession Version	NM_130848.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	dendritic cell nuclear protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC022092.8. On Apr 1, 2019 this sequence version replaced NM_130848.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: AB074498.1, BC069610.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000503143.3/ ENSP00000421871.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCATTACG GAGCAGCAAC CCACATACAG AACTCGAGAA GCCACGGCCT GGAGACTGTA 
CCTGGACACC AAAGACTGGA GAGAGGAGCT GGTGGGGAAA CCCCAGAGTT CCCAGGGTGC 
CACTCCCCAG CTCCACCAGA GAACTTTGGG AATGAGCTGC TGCCCCTGAG TGCCCCTCTC 
CAGGGCCTCA GTGAGGGTCT CTACCCTCCA GGGAGGAACA AAACCTTGCC AGCTGGGGTC 
CTGCGAGAGG GGGCAGTTCA ATTCCTCCAC AGGGGACTCT GCAACTCCAA TCTTTCGAGT 
GAAGCATCTG CGAGGCCCTC AGGGACCCAG GATGAACTGC ATAGCAGCAG AAGGAAGACA 
GGCCAGACCA GGCGGGAGGG AGCCCGGAAA CATCTGGTTT GTAGTTTCAG ACTCTACCCG 
TTCACAGTTC ACACAGTCTC ACCGGGAAAC TCACACCTTG CCCTGTACCA AGTTTTTAAG 
GCAGTTAAGC TCTGCCCATC CGAGACTTCA TTTTTCTTGA GTAGAAAATC ACTGAAATCA 
TCAGATCCAT GGCACCCACC TTCACTTTCT CCTAACAGCT GGAACCGTCA GGCTGGCTTC 
AGGGCCTGGT CTTCGCACTT GATATCACTA TCCCTCACCT GCTCAGACAG CCAGAGCAGG 
CGGGTGAGTT CCTCCCAACA ACCTCCACTG CATTCTCTCA GCTCCCACCG CAGGGCAGCC 
CACGTGCCTG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570900.1
CDS	241..975
Translation	MHYGAATHIQNSRSHGLETVPGHQRLERGAGGETPEFPGCHSPAPPENFGNELLPLSAPLQGLSEGLYPPGRNKTLPAGVLREGAVQFLHRGLCNSNLSSEASARPSGTQDELHSSRRKTGQTRREGARKHLVCSFRLYPFTVHTVSPGNSHLALYQVFKAVKLCPSETSFFLSRKSLKSSDPWHPPSLSPNSWNRQAGFRAWSSHLISLSLTCSDSQSRRVSSSQQPPLHSLSSHRRAAHVPE

Target ORF information:

RefSeq Version	NM_130848.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dendritic cell associated nuclear protein (DCANP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130848.3

ORF Insert Sequence:

ATGCATTACG GAGCAGCAAC CCACATACAG AACTCGAGAA GCCACGGCCT GGAGACTGTA 
CCTGGACACC AAAGACTGGA GAGAGGAGCT GGTGGGGAAA CCCCAGAGTT CCCAGGGTGC 
CACTCCCCAG CTCCACCAGA GAACTTTGGG AATGAGCTGC TGCCCCTGAG TGCCCCTCTC 
CAGGGCCTCA GTGAGGGTCT CTACCCTCCA GGGAGGAACA AAACCTTGCC AGCTGGGGTC 
CTGCGAGAGG GGGCAGTTCA ATTCCTCCAC AGGGGACTCT GCAACTCCAA TCTTTCGAGT 
GAAGCATCTG CGAGGCCCTC AGGGACCCAG GATGAACTGC ATAGCAGCAG AAGGAAGACA 
GGCCAGACCA GGCGGGAGGG AGCCCGGAAA CATCTGGTTT GTAGTTTCAG ACTCTACCCG 
TTCACAGTTC ACACAGTCTC ACCGGGAAAC TCACACCTTG CCCTGTACCA AGTTTTTAAG 
GCAGTTAAGC TCTGCCCATC CGAGACTTCA TTTTTCTTGA GTAGAAAATC ACTGAAATCA 
TCAGATCCAT GGCACCCACC TTCACTTTCT CCTAACAGCT GGAACCGTCA GGCTGGCTTC 
AGGGCCTGGT CTTCGCACTT GATATCACTA TCCCTCACCT GCTCAGACAG CCAGAGCAGG 
CGGGTGAGTT CCTCCCAACA ACCTCCACTG CATTCTCTCA GCTCCCACCG CAGGGCAGCC 
CACGTGCCTG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells.
Acta pharmacologica Sinica(2017 Dec)
Chen D,Li YP,Yu YX,Zhou T,Liu C,Fei EK,Gao F,Mu CC,Ren HG,Wang GH

Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population.
Progress in neuro-psychopharmacology & biological psychiatry457-10(2013 Aug)
Li H,Wang YJ,Hua L,Yang YT,Zhang M,Zhang D,Wang C,Xu ZQ

A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
Behavioral and brain functions : BBF97(2013 Feb)
Schr?der JC,L??ig AK,Galetzka D,Peters A,Castle JC,Diederich S,Zechner U,M?ller-Forell W,Keilmann A,Bartsch O

Poor replication of candidate genes for major depressive disorder using genome-wide association data.
Molecular psychiatry16(5)516-32(2011 May)
Bosker FJ,Hartman CA,Nolte IM,Prins BP,Terpstra P,Posthuma D,van Veen T,Willemsen G,DeRijk RH,de Geus EJ,Hoogendijk WJ,Sullivan PF,Penninx BW,Boomsma DI,Snieder H,Nolen WA

Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression.
Brain : a journal of neurology133(10)3069-79(2010 Oct)
Zhou T,Wang S,Ren H,Qi XR,Luchetti S,Kamphuis W,Zhou JN,Wang G,Swaab DF

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DCANP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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