WFDC6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WFDC6
Entrez Gene ID	140870
Full Name	WAP four-disulfide core domain 6
Synonyms	C20orf171,HEL-S-295,WAP6,dJ461P17.11
General protein information	Preferred Names WAP four-disulfide core domain 6 Names WAP four-disulfide core domain protein 6 epididymis secretory protein Li 295 protease inhibitor WAP6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080827.1	NP_543017.1	WAP four-disulfide core domain protein 6 precursor
NM_080827.2	NP_543017.1	WAP four-disulfide core domain protein 6 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Reproduction and immunity-driven natural selection in the human WFDC locus.
Ferreira Z, Seixas S, Andr?s AM, Kretzschmar WW, Mullikin JC, Cherukuri PF, Cruz P, Swanson WJ, , Clark AG, Green ED, Hurle B
Molecular biology and evolution30(4)938-50(2013 Apr)

The evolution of a genetic locus encoding small serine proteinase inhibitors.
Clauss A, Lilja H, Lundwall A
Biochemical and biophysical research communications333(2)383-9(2005 Jul)

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.
Clauss A, Lilja H, Lundwall A
The Biochemical journal368(Pt 1)233-42(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following WFDC6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WFDC6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29220	NM_080827.2 Latest version!	Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29220	NM_080827.1	Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WFDC6 ( NM_080827.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_543017.1 Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA.

Price & Availability↑

CloneID	OHu29220
Clone ID Related Accession (Same CDS sequence)	NM_080827.1 , NM_080827.2
Accession Version	NM_080827.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 261bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF411861.1. ##Evidence-Data-START## Transcript exon combination :: AF411861.1, BC101604.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG 
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC 
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT 
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC 
CATAAGGAGG AGCTTGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543017.1
CDS	89..349
Translation	MGLSGLLPILVPFILLGDIQEPGHAEGILGKPCPKIKVECEVEEIDQCTKPRDCPENMKCCPFSRGKKCLDFRKVSLTLYHKEELE

Target ORF information:

RefSeq Version	NM_080827.1
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080827.1

ORF Insert Sequence:

ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG 
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC 
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT 
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC 
CATAAGGAGG AGCTTGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC6 ( NM_080827.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_543017.1 Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA.

Price & Availability↑

CloneID	OHu29220
Clone ID Related Accession (Same CDS sequence)	NM_080827.1 , NM_080827.2
Accession Version	NM_080827.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 261bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF411861.1 and AL031663.2. On Jun 2, 2019 this sequence version replaced NM_080827.1. ##Evidence-Data-START## Transcript exon combination :: AF411861.1, GQ472217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG 
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC 
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT 
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC 
CATAAGGAGG AGCTTGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543017.1
CDS	76..336
Translation	MGLSGLLPILVPFILLGDIQEPGHAEGILGKPCPKIKVECEVEEIDQCTKPRDCPENMKCCPFSRGKKCLDFRKVSLTLYHKEELE

Target ORF information:

RefSeq Version	NM_080827.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080827.2

ORF Insert Sequence:

ATGGGACTCT CAGGACTTCT GCCAATCCTG GTACCATTCA TCCTTTTGGG GGACATCCAG 
GAACCTGGGC ACGCTGAAGG CATCCTTGGC AAGCCGTGTC CCAAAATCAA AGTGGAATGC 
GAAGTGGAAG AAATAGACCA GTGTACCAAA CCCAGAGATT GCCCAGAAAA CATGAAGTGT 
TGCCCGTTCA GCCGTGGAAA GAAATGTTTA GACTTCAGAA AGGTCAGCCT TACTTTATAC 
CATAAGGAGG AGCTTGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reproduction and immunity-driven natural selection in the human WFDC locus.
Molecular biology and evolution30(4)938-50(2013 Apr)
Ferreira Z,Seixas S,Andr?s AM,Kretzschmar WW,Mullikin JC,Cherukuri PF,Cruz P,Swanson WJ,,Clark AG,Green ED,Hurle B

The evolution of a genetic locus encoding small serine proteinase inhibitors.
Biochemical and biophysical research communications333(2)383-9(2005 Jul)
Clauss A,Lilja H,Lundwall A

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.
The Biochemical journal368(Pt 1)233-42(2002 Nov)
Clauss A,Lilja H,Lundwall A

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WFDC6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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