DYNLL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DYNLL2
Entrez Gene ID	140735
Full Name	dynein light chain LC8-type 2
Synonyms	DNCL1B,Dlc2,RSPH22
General protein information	Preferred Names dynein light chain LC8-type 2 Names dynein light chain 2, cytoplasmic 8 kDa dynein light chain b DLC8b radial spoke 22 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q22
Disorder MIM:	608942

mRNA and Protein(s)

mRNA	Protein	Name
NM_080677.2	NP_542408.1	dynein light chain 2, cytoplasmic
NM_080677.3	NP_542408.1	dynein light chain 2, cytoplasmic

Pathways from BioSystems

Homologies

Homo sapiens (human)	DYNLL2	NP_542408.1
Mus musculus (house mouse)	Dynll2	NP_080832.1
Rattus norvegicus (Norway rat)	Dynll2	NP_542428.1
Drosophila melanogaster (fruit fly)	ctp	NP_001245530.1
Drosophila melanogaster (fruit fly)	Cdlc2	NP_001245836.1
Magnaporthe oryzae (rice blast fungus)	MGG_15645	XP_003714113.1
Danio rerio (zebrafish)	dynll2a	NP_956393.1
Xenopus tropicalis (tropical clawed frog)	dynll2	NP_001165079.1
Pan troglodytes (chimpanzee)	DYNLL2	NP_001229550.1
Canis lupus familiaris (dog)	DYNLL2	XP_005624774.1
Bos taurus (cattle)	DYNLL2	NP_001106774.1
Gallus gallus (chicken)	DYNLL2	XP_004946822.1
Danio rerio (zebrafish)	dynll2b	NP_001025171.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001335	XP_321810.4
Caenorhabditis elegans (roundworm)	dlc-1	NP_498422.1
Schizosaccharomyces pombe (fission yeast)	dlc2	NP_594368.1
Oryza sativa (rice)	Os01g0256400	NP_001042625.1

Gene Ontology
Bibliography

Related articles in PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Gupta GD, Coyaud ?, Gon?alves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, Hildebrandt F, Moffat J, Gingras AC, Raught B, Pelletier L
Cell163(6)1484-99(2015 Dec)

DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity.
Bodor A, Radnai L, Het?nyi C, Rapali P, L?ng A, K?v?r KE, Perczel A, Wahlgren WY, Katona G, Nyitray L
Biochemistry53(45)7107-22(2014 Nov)

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
Hauri S, Wepf A, van Drogen A, Varjosalo M, Tapon N, Aebersold R, Gstaiger M
Molecular systems biology9713(2013)

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
Simonis N, Rual JF, Lemmens I, Boxus M, Hirozane-Kishikawa T, Gatot JS, Dricot A, Hao T, Vertommen D, Legros S, Daakour S, Klitgord N, Martin M, Willaert JF, Dequiedt F, Navratil V, Cusick ME, Burny A, Van Lint C, Hill DE, Tavernier J, Kettmann R, Vidal M, Twizere JC
Retrovirology926(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The DYNLL2 binding region, located in an intrinsically disordered domain of the myo5a tail, has a nascent helical character.
Title: DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity.

the thermodynamic and kinetic fine-tuning of binding of various ligands to DYNLL could have physiological relevance in its interaction network.
Title: Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.

The following DYNLL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DYNLL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31347	NM_080677.3 Latest version!	Homo sapiens dynein light chain LC8-type 2 (DYNLL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31347	NM_080677.2	Homo sapiens dynein light chain LC8-type 2 (DYNLL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DYNLL2 ( NM_080677.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_542408.1 Homo sapiens dynein light chain LC8-type 2 (DYNLL2), mRNA.

Price & Availability↑

CloneID	OHu31347
Clone ID Related Accession (Same CDS sequence)	NM_080677.2 , NM_080677.3
Accession Version	NM_080677.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	dynein light chain 2, cytoplasmic
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA140058.1, BF528423.1, BC010744.1, DB022843.1 and CN280282.1. On Jan 30, 2009 this sequence version replaced NM_080677.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA140058.1, SRR1803617.212461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGACC GGAAGGCAGT GATCAAGAAC GCAGACATGT CTGAGGACAT GCAACAGGAT 
GCCGTTGACT GCGCCACGCA GGCCATGGAG AAGTACAATA TAGAGAAGGA CATTGCTGCC 
TATATCAAGA AGGAATTTGA CAAGAAATAT AACCCTACCT GGCATTGTAT CGTGGGCCGA 
AATTTTGGCA GCTACGTCAC ACACGAGACA AAGCACTTCA TCTATTTTTA CTTGGGTCAA 
GTTGCAATCC TCCTCTTCAA GTCAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542408.1
CDS	275..544
Translation	MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_080677.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 2 (DYNLL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080677.2

ORF Insert Sequence:

ATGTCTGACC GGAAGGCAGT GATCAAGAAC GCAGACATGT CTGAGGACAT GCAACAGGAT 
GCCGTTGACT GCGCCACGCA GGCCATGGAG AAGTACAATA TAGAGAAGGA CATTGCTGCC 
TATATCAAGA AGGAATTTGA CAAGAAATAT AACCCTACCT GGCATTGTAT CGTGGGCCGA 
AATTTTGGCA GCTACGTCAC ACACGAGACA AAGCACTTCA TCTATTTTTA CTTGGGTCAA 
GTTGCAATCC TCCTCTTCAA GTCAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLL2 ( NM_080677.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542408.1 Homo sapiens dynein light chain LC8-type 2 (DYNLL2), mRNA.

Price & Availability↑

CloneID	OHu31347
Clone ID Related Accession (Same CDS sequence)	NM_080677.2 , NM_080677.3
Accession Version	NM_080677.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	dynein light chain 2, cytoplasmic
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA140058.1, BF528423.1, BC010744.1, DB022843.1, CN280282.1 and AC015813.12. On Nov 22, 2018 this sequence version replaced NM_080677.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA140058.1, SRR3476690.1025326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000579991.3/ ENSP00000477310.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGACC GGAAGGCAGT GATCAAGAAC GCAGACATGT CTGAGGACAT GCAACAGGAT 
GCCGTTGACT GCGCCACGCA GGCCATGGAG AAGTACAATA TAGAGAAGGA CATTGCTGCC 
TATATCAAGA AGGAATTTGA CAAGAAATAT AACCCTACCT GGCATTGTAT CGTGGGCCGA 
AATTTTGGCA GCTACGTCAC ACACGAGACA AAGCACTTCA TCTATTTTTA CTTGGGTCAA 
GTTGCAATCC TCCTCTTCAA GTCAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542408.1
CDS	275..544
Translation	MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_080677.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain LC8-type 2 (DYNLL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080677.3

ORF Insert Sequence:

ATGTCTGACC GGAAGGCAGT GATCAAGAAC GCAGACATGT CTGAGGACAT GCAACAGGAT 
GCCGTTGACT GCGCCACGCA GGCCATGGAG AAGTACAATA TAGAGAAGGA CATTGCTGCC 
TATATCAAGA AGGAATTTGA CAAGAAATAT AACCCTACCT GGCATTGTAT CGTGGGCCGA 
AATTTTGGCA GCTACGTCAC ACACGAGACA AAGCACTTCA TCTATTTTTA CTTGGGTCAA 
GTTGCAATCC TCCTCTTCAA GTCAGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Cell163(6)1484-99(2015 Dec)
Gupta GD,Coyaud ?,Gon?alves J,Mojarad BA,Liu Y,Wu Q,Gheiratmand L,Comartin D,Tkach JM,Cheung SW,Bashkurov M,Hasegan M,Knight JD,Lin ZY,Schueler M,Hildebrandt F,Moffat J,Gingras AC,Raught B,Pelletier L

DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity.
Biochemistry53(45)7107-22(2014 Nov)
Bodor A,Radnai L,Het?nyi C,Rapali P,L?ng A,K?v?r KE,Perczel A,Wahlgren WY,Katona G,Nyitray L

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
Molecular systems biology9713(2013)
Hauri S,Wepf A,van Drogen A,Varjosalo M,Tapon N,Aebersold R,Gstaiger M

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
Retrovirology926(2012 Mar)
Simonis N,Rual JF,Lemmens I,Boxus M,Hirozane-Kishikawa T,Gatot JS,Dricot A,Hao T,Vertommen D,Legros S,Daakour S,Klitgord N,Martin M,Willaert JF,Dequiedt F,Navratil V,Cusick ME,Burny A,Van Lint C,Hill DE,Tavernier J,Kettmann R,Vidal M,Twizere JC

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DYNLL2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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