WFDC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WFDC3
Entrez Gene ID	140686
Full Name	WAP four-disulfide core domain 3
Synonyms	WAP14,dJ447F3.3
General protein information	Preferred Names WAP four-disulfide core domain 3 Names WAP four-disulfide core domain protein 3 protease inhibitor WAP14 putative protease inhibitor WAP14 whey acidic protein 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017027668.1	XP_016883157.1	WAP four-disulfide core domain protein 3 isoform X2
NM_080614.1	NP_542181.1	WAP four-disulfide core domain protein 3 precursor
NM_080614.2	NP_542181.1	WAP four-disulfide core domain protein 3 precursor
XM_011528553.2	XP_011526855.1	WAP four-disulfide core domain protein 3 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	WFDC3	NP_542181.1
Pan troglodytes (chimpanzee)	WFDC3	XP_514681.3
Canis lupus familiaris (dog)	WFDC3	XP_003433266.1
	LOC709542	XP_001107248.1

Gene Ontology
Bibliography

Related articles in PubMed

Reproduction and immunity-driven natural selection in the human WFDC locus.
Ferreira Z, Seixas S, Andr?s AM, Kretzschmar WW, Mullikin JC, Cherukuri PF, Cruz P, Swanson WJ, , Clark AG, Green ED, Hurle B
Molecular biology and evolution30(4)938-50(2013 Apr)

The evolution of a genetic locus encoding small serine proteinase inhibitors.
Clauss A, Lilja H, Lundwall A
Biochemical and biophysical research communications333(2)383-9(2005 Jul)

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.
Clauss A, Lilja H, Lundwall A
The Biochemical journal368(Pt 1)233-42(2002 Nov)

The DNA sequence and comparative analysis of human chromosome 20.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J
Nature414(6866)865-71(2001 Dec 20-27)

The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling.
Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR
Journal of molecular graphics & modelling17(2)106-13, 134-6(1999 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following WFDC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WFDC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05776	NM_080614.2 Latest version!	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu75905	XM_011528553.2 Latest version!	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu92921	XM_017027668.1 Latest version!	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu05776	NM_080614.1	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WFDC3 ( NM_080614.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_542181.1 Homo sapiens WAP four-disulfide core domain 3 (WFDC3), mRNA.

Price & Availability↑

CloneID	OHu05776
Clone ID Related Accession (Same CDS sequence)	NM_080614.1 , NM_080614.2
Accession Version	NM_080614.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF488306.1. ##Evidence-Data-START## Transcript exon combination :: AF488306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTTAA GCTGCCTCTT TCTTCTGAAG GCACTTCTTG CTCTTGGGTC TCTGGAATCC 
TGGATAACTG CAGGAGAACA TGCAAAAGAG GGAGAATGCC CTCCCCATAA GAACCCATGC 
AAAGAGCTGT GCCAGGGTGA TGAATTGTGT CCGGCTGAAC AGAAGTGCTG CACCACAGGC 
TGTGGTCGGA TCTGCCGAGA CATTCCTAAG GGGAGGAAAA GAGATTGCCC TAGGGTTATT 
CGGAAACAAT CCTGTTTGAA AAGGTGCATC ACTGATGAGA CATGTCCAGG TGTAAAGAAA 
TGCTGCACGC TTGGCTGCAA CAAGAGCTGT GTAGTCCCAA TCTCTAAACA GAAGCTGGCA 
GAGTTTGGTG GTGAATGTCC CGCTGACCCC CTTCCGTGTG AGGAGCTGTG TGATGGGGAT 
GCATCCTGTC CCCAGGGGCA TAAATGCTGC AGCACCGGCT GTGGCCGCAC CTGCCTCGGA 
GACATTGAGG GAGGGCGGGG CGGTGATTGT CCAAAAGTTC TGGTGGGCCT GTGCATTGTT 
GGCTGTGTGA TGGATGAGAA TTGTCAAGCT GGAGAAAAAT GTTGCAAGTC AGGCTGTGGC 
CGCTTCTGTG TCCCACCAGT CCTGCCCCCA AAACTGACCA TGAACCCCAA CTGGACTGTG 
AGGTCTGATT CCGAATTAGA GATCCCGGTG CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542181.1
CDS	85..780
Translation	MMLSCLFLLKALLALGSLESWITAGEHAKEGECPPHKNPCKELCQGDELCPAEQKCCTTGCGRICRDIPKGRKRDCPRVIRKQSCLKRCITDETCPGVKKCCTLGCNKSCVVPISKQKLAEFGGECPADPLPCEELCDGDASCPQGHKCCSTGCGRTCLGDIEGGRGGDCPKVLVGLCIVGCVMDENCQAGEKCCKSGCGRFCVPPVLPPKLTMNPNWTVRSDSELEIPVP

Target ORF information:

RefSeq Version	NM_080614.1
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080614.1

ORF Insert Sequence:

ATGATGTTAA GCTGCCTCTT TCTTCTGAAG GCACTTCTTG CTCTTGGGTC TCTGGAATCC 
TGGATAACTG CAGGAGAACA TGCAAAAGAG GGAGAATGCC CTCCCCATAA GAACCCATGC 
AAAGAGCTGT GCCAGGGTGA TGAATTGTGT CCGGCTGAAC AGAAGTGCTG CACCACAGGC 
TGTGGTCGGA TCTGCCGAGA CATTCCTAAG GGGAGGAAAA GAGATTGCCC TAGGGTTATT 
CGGAAACAAT CCTGTTTGAA AAGGTGCATC ACTGATGAGA CATGTCCAGG TGTAAAGAAA 
TGCTGCACGC TTGGCTGCAA CAAGAGCTGT GTAGTCCCAA TCTCTAAACA GAAGCTGGCA 
GAGTTTGGTG GTGAATGTCC CGCTGACCCC CTTCCGTGTG AGGAGCTGTG TGATGGGGAT 
GCATCCTGTC CCCAGGGGCA TAAATGCTGC AGCACCGGCT GTGGCCGCAC CTGCCTCGGA 
GACATTGAGG GAGGGCGGGG CGGTGATTGT CCAAAAGTTC TGGTGGGCCT GTGCATTGTT 
GGCTGTGTGA TGGATGAGAA TTGTCAAGCT GGAGAAAAAT GTTGCAAGTC AGGCTGTGGC 
CGCTTCTGTG TCCCACCAGT CCTGCCCCCA AAACTGACCA TGAACCCCAA CTGGACTGTG 
AGGTCTGATT CCGAATTAGA GATCCCGGTG CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC3 ( NM_080614.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_542181.1 Homo sapiens WAP four-disulfide core domain 3 (WFDC3), mRNA.

Price & Availability↑

CloneID	OHu05776
Clone ID Related Accession (Same CDS sequence)	NM_080614.1 , NM_080614.2
Accession Version	NM_080614.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL050348.22. On Nov 26, 2018 this sequence version replaced NM_080614.1. ##Evidence-Data-START## Transcript exon combination :: AF488306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243938.9/ ENSP00000243938.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGTTAA GCTGCCTCTT TCTTCTGAAG GCACTTCTTG CTCTTGGGTC TCTGGAATCC 
TGGATAACTG CAGGAGAACA TGCAAAAGAG GGAGAATGCC CTCCCCATAA GAACCCATGC 
AAAGAGCTGT GCCAGGGTGA TGAATTGTGT CCGGCTGAAC AGAAGTGCTG CACCACAGGC 
TGTGGTCGGA TCTGCCGAGA CATTCCTAAG GGGAGGAAAA GAGATTGCCC TAGGGTTATT 
CGGAAACAAT CCTGTTTGAA AAGGTGCATC ACTGATGAGA CATGTCCAGG TGTAAAGAAA 
TGCTGCACGC TTGGCTGCAA CAAGAGCTGT GTAGTCCCAA TCTCTAAACA GAAGCTGGCA 
GAGTTTGGTG GTGAATGTCC CGCTGACCCC CTTCCGTGTG AGGAGCTGTG TGATGGGGAT 
GCATCCTGTC CCCAGGGGCA TAAATGCTGC AGCACCGGCT GTGGCCGCAC CTGCCTCGGA 
GACATTGAGG GAGGGCGGGG CGGTGATTGT CCAAAAGTTC TGGTGGGCCT GTGCATTGTT 
GGCTGTGTGA TGGATGAGAA TTGTCAAGCT GGAGAAAAAT GTTGCAAGTC AGGCTGTGGC 
CGCTTCTGTG TCCCACCAGT CCTGCCCCCA AAACTGACCA TGAACCCCAA CTGGACTGTG 
AGGTCTGATT CCGAATTAGA GATCCCGGTG CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542181.1
CDS	60..755
Translation	MMLSCLFLLKALLALGSLESWITAGEHAKEGECPPHKNPCKELCQGDELCPAEQKCCTTGCGRICRDIPKGRKRDCPRVIRKQSCLKRCITDETCPGVKKCCTLGCNKSCVVPISKQKLAEFGGECPADPLPCEELCDGDASCPQGHKCCSTGCGRTCLGDIEGGRGGDCPKVLVGLCIVGCVMDENCQAGEKCCKSGCGRFCVPPVLPPKLTMNPNWTVRSDSELEIPVP

Target ORF information:

RefSeq Version	NM_080614.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080614.2

ORF Insert Sequence:

ATGATGTTAA GCTGCCTCTT TCTTCTGAAG GCACTTCTTG CTCTTGGGTC TCTGGAATCC 
TGGATAACTG CAGGAGAACA TGCAAAAGAG GGAGAATGCC CTCCCCATAA GAACCCATGC 
AAAGAGCTGT GCCAGGGTGA TGAATTGTGT CCGGCTGAAC AGAAGTGCTG CACCACAGGC 
TGTGGTCGGA TCTGCCGAGA CATTCCTAAG GGGAGGAAAA GAGATTGCCC TAGGGTTATT 
CGGAAACAAT CCTGTTTGAA AAGGTGCATC ACTGATGAGA CATGTCCAGG TGTAAAGAAA 
TGCTGCACGC TTGGCTGCAA CAAGAGCTGT GTAGTCCCAA TCTCTAAACA GAAGCTGGCA 
GAGTTTGGTG GTGAATGTCC CGCTGACCCC CTTCCGTGTG AGGAGCTGTG TGATGGGGAT 
GCATCCTGTC CCCAGGGGCA TAAATGCTGC AGCACCGGCT GTGGCCGCAC CTGCCTCGGA 
GACATTGAGG GAGGGCGGGG CGGTGATTGT CCAAAAGTTC TGGTGGGCCT GTGCATTGTT 
GGCTGTGTGA TGGATGAGAA TTGTCAAGCT GGAGAAAAAT GTTGCAAGTC AGGCTGTGGC 
CGCTTCTGTG TCCCACCAGT CCTGCCCCCA AAACTGACCA TGAACCCCAA CTGGACTGTG 
AGGTCTGATT CCGAATTAGA GATCCCGGTG CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC3 ( XM_011528553.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526855.1 Homo sapiens WAP four-disulfide core domain 3 (WFDC3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu75905
Clone ID Related Accession (Same CDS sequence)	XM_011528553.2
Accession Version	XM_011528553.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528553.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGCGG GCATCATCAT GATGTTAAGC TGCCTCTTTC TTCTGAAGGC ACTTCTTGCT 
CTTGGGTCTC TGGAATCCTG GATAACTGCA GGAGAACATG CAAAAGAGGG AGAATGCCCT 
CCCCATAAGA ACCCATGCAA AGAGCTGTGC CAGGGTGATG AATTGTGTCC GGCTGAACAG 
AAGTGCTGCA CCACAGGCTG TGGTCGGATC TGCCGAGACA TTCCTAAGGG GAGGAAAAGA 
GATTGCCCTA GGGTTATTCG GAAACAATCC TGTTTGAAAA GGTGCATCAC TGATGAGACA 
TGTCCAGGTG TAAAGAAATG CTGCACGCTT GGCTGCAACA AGAGCTGTGT AGTCCCAATC 
TCTAAACAGA AGCTGGCAGA GTTTGGTGGT GAATGTCCCG CTGACCCCCT TCCGTGTGAG 
GAGCTGTGTG ATGGGGATGC ATCCTGTCCC CAGGGGCATA AATGCTGCAG CACCGGCTGT 
GGCCGCACCT GCCTCGGAGA CATTGAGGGA GGGCGGGGCG GTGATTGTCC AAAAGTTCTG 
GTGGGCCTGT GCATTGTTGG CTGTGTGATG GATGAGAATT GTCAAGCTGG AGAAAAATGT 
TGCAAGTCAG GCTGTGGCCG CTTCTGTGTC CCACCAGTCC TGCCCCCAAA ACTGACCATG 
AACCCCAACT GGACTGTGAG GTCTGATTCC GAATTAGAGA TCCCGGTGCC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526855.1
CDS	77..790
Translation	MTAGIIMMLSCLFLLKALLALGSLESWITAGEHAKEGECPPHKNPCKELCQGDELCPAEQKCCTTGCGRICRDIPKGRKRDCPRVIRKQSCLKRCITDETCPGVKKCCTLGCNKSCVVPISKQKLAEFGGECPADPLPCEELCDGDASCPQGHKCCSTGCGRTCLGDIEGGRGGDCPKVLVGLCIVGCVMDENCQAGEKCCKSGCGRFCVPPVLPPKLTMNPNWTVRSDSELEIPVP

Target ORF information:

RefSeq Version	XM_011528553.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528553.2

ORF Insert Sequence:

ATGACTGCGG GCATCATCAT GATGTTAAGC TGCCTCTTTC TTCTGAAGGC ACTTCTTGCT 
CTTGGGTCTC TGGAATCCTG GATAACTGCA GGAGAACATG CAAAAGAGGG AGAATGCCCT 
CCCCATAAGA ACCCATGCAA AGAGCTGTGC CAGGGTGATG AATTGTGTCC GGCTGAACAG 
AAGTGCTGCA CCACAGGCTG TGGTCGGATC TGCCGAGACA TTCCTAAGGG GAGGAAAAGA 
GATTGCCCTA GGGTTATTCG GAAACAATCC TGTTTGAAAA GGTGCATCAC TGATGAGACA 
TGTCCAGGTG TAAAGAAATG CTGCACGCTT GGCTGCAACA AGAGCTGTGT AGTCCCAATC 
TCTAAACAGA AGCTGGCAGA GTTTGGTGGT GAATGTCCCG CTGACCCCCT TCCGTGTGAG 
GAGCTGTGTG ATGGGGATGC ATCCTGTCCC CAGGGGCATA AATGCTGCAG CACCGGCTGT 
GGCCGCACCT GCCTCGGAGA CATTGAGGGA GGGCGGGGCG GTGATTGTCC AAAAGTTCTG 
GTGGGCCTGT GCATTGTTGG CTGTGTGATG GATGAGAATT GTCAAGCTGG AGAAAAATGT 
TGCAAGTCAG GCTGTGGCCG CTTCTGTGTC CCACCAGTCC TGCCCCCAAA ACTGACCATG 
AACCCCAACT GGACTGTGAG GTCTGATTCC GAATTAGAGA TCCCGGTGCC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC3 ( XM_017027668.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883157.1 Homo sapiens WAP four-disulfide core domain 3 (WFDC3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu92921
Clone ID Related Accession (Same CDS sequence)	XM_017027668.1
Accession Version	XM_017027668.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGCGG GCATCATCAT GATGTTAAGC TGCCTCTTTC TTCTGAAGGC ACTTCTTGCT 
CTTGGGTCTC TGGAATCCTG GATAACTGCA GGAGAACATG TATCTTTTGC AGCAAAAGAG 
GGAGAATGCC CTCCCCATAA GAACCCATGC AAAGAGCTGT GCCAGGGTGA TGAATTGTGT 
CCGGCTGAAC AGAAGTGCTG CACCACAGGC TGTGGTCGGA TCTGCCGAGA CATTCCTAAG 
GGAAGAGGAC ACCCACCCTG GTACCTGGTC CCTGGCGAGA GTCTTGTGAA AATGAAGAAC 
AATTGCTTAT GCTGTTTTCC TAATGAGGAA CACAAGGCTC ACTGGTACAG AGTTGGAAGG 
AATGGAGGCA AGCAGAGAAA GGCCCAGGCT TTGTGGAGCT TGATGCTTGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883157.1
CDS	83..496
Translation	MTAGIIMMLSCLFLLKALLALGSLESWITAGEHVSFAAKEGECPPHKNPCKELCQGDELCPAEQKCCTTGCGRICRDIPKGRGHPPWYLVPGESLVKMKNNCLCCFPNEEHKAHWYRVGRNGGKQRKAQALWSLMLV

Target ORF information:

RefSeq Version	XM_017027668.1
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 3 (WFDC3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027668.1

ORF Insert Sequence:

ATGACTGCGG GCATCATCAT GATGTTAAGC TGCCTCTTTC TTCTGAAGGC ACTTCTTGCT 
CTTGGGTCTC TGGAATCCTG GATAACTGCA GGAGAACATG TATCTTTTGC AGCAAAAGAG 
GGAGAATGCC CTCCCCATAA GAACCCATGC AAAGAGCTGT GCCAGGGTGA TGAATTGTGT 
CCGGCTGAAC AGAAGTGCTG CACCACAGGC TGTGGTCGGA TCTGCCGAGA CATTCCTAAG 
GGAAGAGGAC ACCCACCCTG GTACCTGGTC CCTGGCGAGA GTCTTGTGAA AATGAAGAAC 
AATTGCTTAT GCTGTTTTCC TAATGAGGAA CACAAGGCTC ACTGGTACAG AGTTGGAAGG 
AATGGAGGCA AGCAGAGAAA GGCCCAGGCT TTGTGGAGCT TGATGCTTGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reproduction and immunity-driven natural selection in the human WFDC locus.
Molecular biology and evolution30(4)938-50(2013 Apr)
Ferreira Z,Seixas S,Andr?s AM,Kretzschmar WW,Mullikin JC,Cherukuri PF,Cruz P,Swanson WJ,,Clark AG,Green ED,Hurle B

The evolution of a genetic locus encoding small serine proteinase inhibitors.
Biochemical and biophysical research communications333(2)383-9(2005 Jul)
Clauss A,Lilja H,Lundwall A

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.
The Biochemical journal368(Pt 1)233-42(2002 Nov)
Clauss A,Lilja H,Lundwall A

The DNA sequence and comparative analysis of human chromosome 20.
Nature414(6866)865-71(2001 Dec 20-27)
Deloukas P,Matthews LH,Ashurst J,Burton J,Gilbert JG,Jones M,Stavrides G,Almeida JP,Babbage AK,Bagguley CL,Bailey J,Barlow KF,Bates KN,Beard LM,Beare DM,Beasley OP,Bird CP,Blakey SE,Bridgeman AM,Brown AJ,Buck D,Burrill W,Butler AP,Carder C,Carter NP,Chapman JC,Clamp M,Clark G,Clark LN,Clark SY,Clee CM,Clegg S,Cobley VE,Collier RE,Connor R,Corby NR,Coulson A,Coville GJ,Deadman R,Dhami P,Dunn M,Ellington AG,Frankland JA,Fraser A,French L,Garner P,Grafham DV,Griffiths C,Griffiths MN,Gwilliam R,Hall RE,Hammond S,Harley JL,Heath PD,Ho S,Holden JL,Howden PJ,Huckle E,Hunt AR,Hunt SE,Jekosch K,Johnson CM,Johnson D,Kay MP,Kimberley AM,King A,Knights A,Laird GK,Lawlor S,Lehvaslaiho MH,Leversha M,Lloyd C,Lloyd DM,Lovell JD,Marsh VL,Martin SL,McConnachie LJ,McLay K,McMurray AA,Milne S,Mistry D,Moore MJ,Mullikin JC,Nickerson T,Oliver K,Parker A,Patel R,Pearce TA,Peck AI,Phillimore BJ,Prathalingam SR,Plumb RW,Ramsay H,Rice CM,Ross MT,Scott CE,Sehra HK,Shownkeen R,Sims S,Skuce CD,Smith ML,Soderlund C,Steward CA,Sulston JE,Swann M,Sycamore N,Taylor R,Tee L,Thomas DW,Thorpe A,Tracey A,Tromans AC,Vaudin M,Wall M,Wallis JM,Whitehead SL,Whittaker P,Willey DL,Williams L,Williams SA,Wilming L,Wray PW,Hubbard T,Durbin RM,Bentley DR,Beck S,Rogers J

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WFDC3 cDNA ORF clone, Homo sapiens(human)

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