ASB7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ASB7
Entrez Gene ID	140460
Full Name	ankyrin repeat and SOCS box containing 7
General protein information	Preferred Names ankyrin repeat and SOCS box containing 7 Names ankyrin repeat and SOCS box protein 7 ASB-7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q26.3
Summary	The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:	615052

mRNA and Protein(s)

mRNA	Protein	Name
NM_198243.2	NP_937886.1	ankyrin repeat and SOCS box protein 7 isoform 2
NM_198243.3	NP_937886.1	ankyrin repeat and SOCS box protein 7 isoform 2
NM_024708.3	NP_078984.2	ankyrin repeat and SOCS box protein 7 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Asb7	NP_536691.2
Pan troglodytes (chimpanzee)	ASB7	XP_523240.3
	ASB7	XP_001083533.1
Bos taurus (cattle)	ASB7	NP_001179080.1
Homo sapiens (human)	ASB7	NP_937886.1
Gallus gallus (chicken)	ASB7	NP_001012788.1
Xenopus tropicalis (tropical clawed frog)	asb7	NP_001017154.1
Danio rerio (zebrafish)	asb7	NP_999895.1
Canis lupus familiaris (dog)	ASB7	XP_545824.1
Rattus norvegicus (Norway rat)	Asb7	NP_001102385.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T
The Journal of cell biology215(1)95-106(2016 Oct)

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
Niu N, Schaid DJ, Abo RP, Kalari K, Fridley BL, Feng Q, Jenkins G, Batzler A, Brisbin AG, Cunningham JM, Li L, Sun Z, Yang P, Wang L
BMC cancer12422(2012 Sep)

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
Kohroki J, Nishiyama T, Nakamura T, Masuho Y
FEBS letters579(30)6796-802(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these data indicate that ASB7 plays a crucial role in regulating spindle dynamics and genome integrity by controlling the expression of DDA3.
Title: ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.

The following ASB7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASB7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31594	NM_024708.3 Latest version!	Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu08385	NM_198243.3 Latest version!	Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu08385	NM_198243.2	Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ASB7 ( NM_024708.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_078984.2 Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31594
Clone ID Related Accession (Same CDS sequence)	NM_024708.3
Accession Version	NM_024708.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 7 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD632230.1, AK026204.1 and BC063581.1. On Feb 28, 2009 this sequence version replaced NM_024708.2. Transcript Variant: This variant (1) encodes the shorter isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC063581.1, SRR1803611.639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC 
GCGGTGGCTG CTGGGGATGT CCACACAGTG CGAAAGATGC TAGAACAAGG CTATTCCCCG 
AATGGCCGAG ATGCGAATGG CTGGACTCTG CTTCATTTCT CTGCAGCAAG AGGAAAGGAA 
AGATGTGTTC GGGTTTTTCT AGAACACGGA GCTGATCCTA CAGTTAAAGA CTTAATCGGA 
GGCTTCACGG CTCTTCACTA TGCAGCCATG CATGGCCGGG CCCGCATTGC ACGCTTGATG 
TTAGAATCTG AATACAGGAG CGACATCATT AATGCAAAAA GCAATGACGG CTGGACTCCC 
CTCCATGTGG CTGCCCACTA CGGCAGGGAC TCATTTGTCC GGCTCCTCCT GGAGTTCAAG 
GCTGAGGTTG ACCCACTCAG TGATAAAGGT ACCACACCGC TTCAGCTCGC CATTATCCGA 
GAGAGGTCAA GCTGTGTGAA AATCCTCCTG GACCACAATG CCAACATCGA CATTCAGAAT 
GGTTTCCTGT TGCGATACGC CGTGATCAAA AGCAATCACT CTTATTGCCG AATGTTCCTT 
CAGAGAGGGG CAGACACAAA CTTGGGTCGC TTAGAAGACG GACAGACTCC TTTACACTTA 
TCTGCCCTTA GGGATGATGT GCTGTGTGCA CGGATGTTAT ATAATTACGG AGCAGACACG 
AACACACGGA ACTATGAAGG ACAGACCCCA TTGGCTGTTT CAATAAGTAT TTCTGGAAGT 
AGTCGACCAT GTTTGGATTT CTTACAAGAA GTCACAAGTA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078984.2
CDS	770..1594
Translation	MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTSM

Target ORF information:

RefSeq Version	NM_024708.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024708.3

ORF Insert Sequence:

ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC 
GCGGTGGCTG CTGGGGATGT CCACACAGTG CGAAAGATGC TAGAACAAGG CTATTCCCCG 
AATGGCCGAG ATGCGAATGG CTGGACTCTG CTTCATTTCT CTGCAGCAAG AGGAAAGGAA 
AGATGTGTTC GGGTTTTTCT AGAACACGGA GCTGATCCTA CAGTTAAAGA CTTAATCGGA 
GGCTTCACGG CTCTTCACTA TGCAGCCATG CATGGCCGGG CCCGCATTGC ACGCTTGATG 
TTAGAATCTG AATACAGGAG CGACATCATT AATGCAAAAA GCAATGACGG CTGGACTCCC 
CTCCATGTGG CTGCCCACTA CGGCAGGGAC TCATTTGTCC GGCTCCTCCT GGAGTTCAAG 
GCTGAGGTTG ACCCACTCAG TGATAAAGGT ACCACACCGC TTCAGCTCGC CATTATCCGA 
GAGAGGTCAA GCTGTGTGAA AATCCTCCTG GACCACAATG CCAACATCGA CATTCAGAAT 
GGTTTCCTGT TGCGATACGC CGTGATCAAA AGCAATCACT CTTATTGCCG AATGTTCCTT 
CAGAGAGGGG CAGACACAAA CTTGGGTCGC TTAGAAGACG GACAGACTCC TTTACACTTA 
TCTGCCCTTA GGGATGATGT GCTGTGTGCA CGGATGTTAT ATAATTACGG AGCAGACACG 
AACACACGGA ACTATGAAGG ACAGACCCCA TTGGCTGTTT CAATAAGTAT TTCTGGAAGT 
AGTCGACCAT GTTTGGATTT CTTACAAGAA GTCACAAGTA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASB7 ( NM_198243.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_937886.1 Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08385
Clone ID Related Accession (Same CDS sequence)	NM_198243.2 , NM_198243.3
Accession Version	NM_198243.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-28
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 7 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD632230.1, AK289860.1, AC090695.14 and AA830153.1. On Feb 28, 2009 this sequence version replaced NM_198243.1. Transcript Variant: This variant (2) differs in the 3' CDS and UTR, compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.242666.1, SRR1660805.30148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC 
GCGGTGGCTG CTGGGGATGT CCACACAGTG CGAAAGATGC TAGAACAAGG CTATTCCCCG 
AATGGCCGAG ATGCGAATGG CTGGACTCTG CTTCATTTCT CTGCAGCAAG AGGAAAGGAA 
AGATGTGTTC GGGTTTTTCT AGAACACGGA GCTGATCCTA CAGTTAAAGA CTTAATCGGA 
GGCTTCACGG CTCTTCACTA TGCAGCCATG CATGGCCGGG CCCGCATTGC ACGCTTGATG 
TTAGAATCTG AATACAGGAG CGACATCATT AATGCAAAAA GCAATGACGG CTGGACTCCC 
CTCCATGTGG CTGCCCACTA CGGCAGGGAC TCATTTGTCC GGCTCCTCCT GGAGTTCAAG 
GCTGAGGTTG ACCCACTCAG TGATAAAGGT ACCACACCGC TTCAGCTCGC CATTATCCGA 
GAGAGGTCAA GCTGTGTGAA AATCCTCCTG GACCACAATG CCAACATCGA CATTCAGAAT 
GGTTTCCTGT TGCGATACGC CGTGATCAAA AGCAATCACT CTTATTGCCG AATGTTCCTT 
CAGAGAGGGG CAGACACAAA CTTGGGTCGC TTAGAAGACG GACAGACTCC TTTACACTTA 
TCTGCCCTTA GGGATGATGT GCTGTGTGCA CGGATGTTAT ATAATTACGG AGCAGACACG 
AACACACGGA ACTATGAAGG ACAGACCCCA TTGGCTGTTT CAATAAGTAT TTCTGGAAGT 
AGTCGACCAT GTTTGGATTT CTTACAAGAA GTCACAAGAC AGCCCAGAAA CTTGCAGGAC 
CTGTGCCGAA TTAAAATTCG ACAATGTATA GGCCTTCAAA ACCTAAAGCT ACTTGATGAA 
CTACCAATTG CCAAGGTCAT GAAAGACTAC TTAAAACACA AATTTGATGA TATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937886.1
CDS	770..1726
Translation	MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI

Target ORF information:

RefSeq Version	NM_198243.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198243.2

ORF Insert Sequence:

ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC 
GCGGTGGCTG CTGGGGATGT CCACACAGTG CGAAAGATGC TAGAACAAGG CTATTCCCCG 
AATGGCCGAG ATGCGAATGG CTGGACTCTG CTTCATTTCT CTGCAGCAAG AGGAAAGGAA 
AGATGTGTTC GGGTTTTTCT AGAACACGGA GCTGATCCTA CAGTTAAAGA CTTAATCGGA 
GGCTTCACGG CTCTTCACTA TGCAGCCATG CATGGCCGGG CCCGCATTGC ACGCTTGATG 
TTAGAATCTG AATACAGGAG CGACATCATT AATGCAAAAA GCAATGACGG CTGGACTCCC 
CTCCATGTGG CTGCCCACTA CGGCAGGGAC TCATTTGTCC GGCTCCTCCT GGAGTTCAAG 
GCTGAGGTTG ACCCACTCAG TGATAAAGGT ACCACACCGC TTCAGCTCGC CATTATCCGA 
GAGAGGTCAA GCTGTGTGAA AATCCTCCTG GACCACAATG CCAACATCGA CATTCAGAAT 
GGTTTCCTGT TGCGATACGC CGTGATCAAA AGCAATCACT CTTATTGCCG AATGTTCCTT 
CAGAGAGGGG CAGACACAAA CTTGGGTCGC TTAGAAGACG GACAGACTCC TTTACACTTA 
TCTGCCCTTA GGGATGATGT GCTGTGTGCA CGGATGTTAT ATAATTACGG AGCAGACACG 
AACACACGGA ACTATGAAGG ACAGACCCCA TTGGCTGTTT CAATAAGTAT TTCTGGAAGT 
AGTCGACCAT GTTTGGATTT CTTACAAGAA GTCACAAGAC AGCCCAGAAA CTTGCAGGAC 
CTGTGCCGAA TTAAAATTCG ACAATGTATA GGCCTTCAAA ACCTAAAGCT ACTTGATGAA 
CTACCAATTG CCAAGGTCAT GAAAGACTAC TTAAAACACA AATTTGATGA TATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASB7 ( NM_198243.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_937886.1 Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08385
Clone ID Related Accession (Same CDS sequence)	NM_198243.2 , NM_198243.3
Accession Version	NM_198243.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 7 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD632230.1, AK289860.1, AC090695.14 and AA830153.1. On Jun 2, 2019 this sequence version replaced NM_198243.2. Transcript Variant: This variant (2) differs in the 3' CDS and UTR, compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.175659.1, SRR1660803.242666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC 
GCGGTGGCTG CTGGGGATGT CCACACAGTG CGAAAGATGC TAGAACAAGG CTATTCCCCG 
AATGGCCGAG ATGCGAATGG CTGGACTCTG CTTCATTTCT CTGCAGCAAG AGGAAAGGAA 
AGATGTGTTC GGGTTTTTCT AGAACACGGA GCTGATCCTA CAGTTAAAGA CTTAATCGGA 
GGCTTCACGG CTCTTCACTA TGCAGCCATG CATGGCCGGG CCCGCATTGC ACGCTTGATG 
TTAGAATCTG AATACAGGAG CGACATCATT AATGCAAAAA GCAATGACGG CTGGACTCCC 
CTCCATGTGG CTGCCCACTA CGGCAGGGAC TCATTTGTCC GGCTCCTCCT GGAGTTCAAG 
GCTGAGGTTG ACCCACTCAG TGATAAAGGT ACCACACCGC TTCAGCTCGC CATTATCCGA 
GAGAGGTCAA GCTGTGTGAA AATCCTCCTG GACCACAATG CCAACATCGA CATTCAGAAT 
GGTTTCCTGT TGCGATACGC CGTGATCAAA AGCAATCACT CTTATTGCCG AATGTTCCTT 
CAGAGAGGGG CAGACACAAA CTTGGGTCGC TTAGAAGACG GACAGACTCC TTTACACTTA 
TCTGCCCTTA GGGATGATGT GCTGTGTGCA CGGATGTTAT ATAATTACGG AGCAGACACG 
AACACACGGA ACTATGAAGG ACAGACCCCA TTGGCTGTTT CAATAAGTAT TTCTGGAAGT 
AGTCGACCAT GTTTGGATTT CTTACAAGAA GTCACAAGAC AGCCCAGAAA CTTGCAGGAC 
CTGTGCCGAA TTAAAATTCG ACAATGTATA GGCCTTCAAA ACCTAAAGCT ACTTGATGAA 
CTACCAATTG CCAAGGTCAT GAAAGACTAC TTAAAACACA AATTTGATGA TATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937886.1
CDS	731..1687
Translation	MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI

Target ORF information:

RefSeq Version	NM_198243.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 7 (ASB7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198243.3

ORF Insert Sequence:

ATGTTACACC ATCATTGTCG AAGGAACCCT GAGCTCCAGG AAGAGTTGCA GATTCAGGCC 
GCGGTGGCTG CTGGGGATGT CCACACAGTG CGAAAGATGC TAGAACAAGG CTATTCCCCG 
AATGGCCGAG ATGCGAATGG CTGGACTCTG CTTCATTTCT CTGCAGCAAG AGGAAAGGAA 
AGATGTGTTC GGGTTTTTCT AGAACACGGA GCTGATCCTA CAGTTAAAGA CTTAATCGGA 
GGCTTCACGG CTCTTCACTA TGCAGCCATG CATGGCCGGG CCCGCATTGC ACGCTTGATG 
TTAGAATCTG AATACAGGAG CGACATCATT AATGCAAAAA GCAATGACGG CTGGACTCCC 
CTCCATGTGG CTGCCCACTA CGGCAGGGAC TCATTTGTCC GGCTCCTCCT GGAGTTCAAG 
GCTGAGGTTG ACCCACTCAG TGATAAAGGT ACCACACCGC TTCAGCTCGC CATTATCCGA 
GAGAGGTCAA GCTGTGTGAA AATCCTCCTG GACCACAATG CCAACATCGA CATTCAGAAT 
GGTTTCCTGT TGCGATACGC CGTGATCAAA AGCAATCACT CTTATTGCCG AATGTTCCTT 
CAGAGAGGGG CAGACACAAA CTTGGGTCGC TTAGAAGACG GACAGACTCC TTTACACTTA 
TCTGCCCTTA GGGATGATGT GCTGTGTGCA CGGATGTTAT ATAATTACGG AGCAGACACG 
AACACACGGA ACTATGAAGG ACAGACCCCA TTGGCTGTTT CAATAAGTAT TTCTGGAAGT 
AGTCGACCAT GTTTGGATTT CTTACAAGAA GTCACAAGAC AGCCCAGAAA CTTGCAGGAC 
CTGTGCCGAA TTAAAATTCG ACAATGTATA GGCCTTCAAA ACCTAAAGCT ACTTGATGAA 
CTACCAATTG CCAAGGTCAT GAAAGACTAC TTAAAACACA AATTTGATGA TATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
The Journal of cell biology215(1)95-106(2016 Oct)
Uematsu K,Okumura F,Tonogai S,Joo-Okumura A,Alemayehu DH,Nishikimi A,Fukui Y,Nakatsukasa K,Kamura T

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
BMC cancer12422(2012 Sep)
Niu N,Schaid DJ,Abo RP,Kalari K,Fridley BL,Feng Q,Jenkins G,Batzler A,Brisbin AG,Cunningham JM,Li L,Sun Z,Yang P,Wang L

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
FEBS letters579(30)6796-802(2005 Dec)
Kohroki J,Nishiyama T,Nakamura T,Masuho Y

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ASB7 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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