ADORA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADORA3
Entrez Gene ID	140
Full Name	adenosine A3 receptor
Synonyms	A3AR
General protein information	Preferred Names adenosine A3 receptor Names adenosine receptor A3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.2
Summary	This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014].
Disorder MIM:	600445

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302679.2	NP_001289608.1	adenosine receptor A3 isoform C
NM_001302679.1	NP_001289608.1	adenosine receptor A3 isoform C
NM_001302678.1	NP_001289607.1	adenosine receptor A3 isoform B
NM_000677.4	NP_000668.1	adenosine receptor A3 isoform A
NM_000677.3	NP_000668.1	adenosine receptor A3 isoform A
NM_001302678.2	NP_001289607.1	adenosine receptor A3 isoform B

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100496142	XP_002932848.2
Xenopus tropicalis (tropical clawed frog)	LOC100496301	XP_002932849.2
Danio rerio (zebrafish)	LOC571410	XP_700086.1
Xenopus tropicalis (tropical clawed frog)	LOC101734629	XP_004910785.1
Pan troglodytes (chimpanzee)	ADORA3	XP_001158919.1
Canis lupus familiaris (dog)	ADORA3	NP_001003178.1
Bos taurus (cattle)	ADORA3	NP_001098081.1
Homo sapiens (human)	ADORA3	NP_000668.1
Gallus gallus (chicken)	ADORA3	NP_989482.1
Mus musculus (house mouse)	Adora3	NP_033761.2

Gene Ontology
Bibliography

Related articles in PubMed

Cordycepin induces apoptosis in human bladder cancer cells via activation of A3 adenosine receptors.
Cao HL, Liu ZJ, Chang Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317706915(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these findings propose that A3AR agonist induces cell cycle arrest and apoptosis in breast cancer stem cells by inhibition of ERK1/2 and GLI-1 cascade.
Title: A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells via GLI-1 and ERK1/2 Pathway.

Mast cells are directly activated by contact with cancer cell membranes by a mechanism involving autocrine formation of adenosine and autocrine/paracrine signaling of the adenosine A3 receptor.
Title: Mast cells are directly activated by contact with cancer cells by a mechanism involving autocrine formation of adenosine and autocrine/paracrine signaling of the adenosine A3 receptor.

these data suggest that Cordyceps militaris hot water extracts containing cordycepin may be a promising treatment for bladder cancer via A3 adenosine receptor activation.
Title: Cordycepin induces apoptosis in human bladder cancer cells via activation of A3 adenosine receptors.

Differential regulation in patients with LTP-induced anaphylaxis and those with NSAID-LTP-induced anaphylaxis of the IFN-gamma pathway, IgG receptors, and ADORA3 might provide the pathogenic basis of their distinct responses
Title: Distinct transcriptome profiles differentiate nonsteroidal anti-inflammatory drug-dependent from nonsteroidal anti-inflammatory drug-independent food-induced anaphylaxis.

This study identifies human mast cell A3R as regulator of tissue remodeling gene expression in human mast cells and demonstrates a heretofore-unrecognized mode of feedback regulation that is exerted by this receptor.
Title: Down-regulation of the A3 adenosine receptor in human mast cells upregulates mediators of angiogenesis and remodeling.

The following ADORA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADORA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18228	NM_000677.4 Latest version!	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu56183	NM_001302678.2 Latest version!	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu56184	NM_001302679.2 Latest version!	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant C, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu56184	NM_001302679.1	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant C, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu18228	NM_000677.3	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu56183	NM_001302678.1	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADORA3 ( NM_000677.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000668.1 Homo sapiens adenosine A3 receptor (ADORA3), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu18228
Clone ID Related Accession (Same CDS sequence)	NM_000677.4 , NM_000677.3
Accession Version	NM_000677.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	adenosine receptor A3 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC029831.1, AL390195.10 and BM675096.1. On Aug 31, 2019 this sequence version replaced NM_000677.3. Transcript Variant: This variant (A) encodes the longest isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L22607.1, X76981.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG ATACAAGAGG 
GTCACCACTC ACAGAAGAAT ATGGCTGGCC CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGATTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA CCTCAGAGTA CCACAGAAAT 
GTCACCTTCC TTTCATGCCA ATTTGTTTCC GTCATGAGAA TGGACTACAT GGTATACTTC 
AGCTTCCTCA CCTGGATTTT CATCCCCCTG GTTGTCATGT GCGCCATCTA TCTTGACATC 
TTTTACATCA TTCGGAACAA ACTCAGTCTG AACTTATCTA ACTCCAAAGA GACAGGTGCA 
TTTTATGGAC GGGAGTTCAA GACGGCTAAG TCCTTGTTTC TGGTTCTTTT CTTGTTTGCT 
CTGTCATGGC TGCCTTTATC TATCATCAAC TGCATCATCT ACTTTAATGG TGAGGTACCA 
CAGCTTGTGC TGTACATGGG CATCCTGCTG TCCCATGCCA ACTCCATGAT GAACCCTATC 
GTCTATGCCT ATAAAATAAA GAAGTTCAAG GAAACCTACC TTTTGATCCT CAAAGCTTGT 
GTGGTCTGCC ATCCCTCTGA TTCTTTGGAC ACAAGCATTG AGAAGAATTC TGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000668.1
CDS	280..1236
Translation	MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE

Target ORF information:

RefSeq Version	NM_000677.4
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000677.4

ORF Insert Sequence:

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG ATACAAGAGG 
GTCACCACTC ACAGAAGAAT ATGGCTGGCC CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGATTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA CCTCAGAGTA CCACAGAAAT 
GTCACCTTCC TTTCATGCCA ATTTGTTTCC GTCATGAGAA TGGACTACAT GGTATACTTC 
AGCTTCCTCA CCTGGATTTT CATCCCCCTG GTTGTCATGT GCGCCATCTA TCTTGACATC 
TTTTACATCA TTCGGAACAA ACTCAGTCTG AACTTATCTA ACTCCAAAGA GACAGGTGCA 
TTTTATGGAC GGGAGTTCAA GACGGCTAAG TCCTTGTTTC TGGTTCTTTT CTTGTTTGCT 
CTGTCATGGC TGCCTTTATC TATCATCAAC TGCATCATCT ACTTTAATGG TGAGGTACCA 
CAGCTTGTGC TGTACATGGG CATCCTGCTG TCCCATGCCA ACTCCATGAT GAACCCTATC 
GTCTATGCCT ATAAAATAAA GAAGTTCAAG GAAACCTACC TTTTGATCCT CAAAGCTTGT 
GTGGTCTGCC ATCCCTCTGA TTCTTTGGAC ACAAGCATTG AGAAGAATTC TGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADORA3 ( NM_000677.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000668.1 Homo sapiens adenosine A3 receptor (ADORA3), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu18228
Clone ID Related Accession (Same CDS sequence)	NM_000677.4 , NM_000677.3
Accession Version	NM_000677.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	adenosine receptor A3 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390195.10, BC029831.1 and BM675096.1. This sequence is a reference standard in the RefSeqGene project. On Mar 14, 2007 this sequence version replaced NM_000677.2. Transcript Variant: This variant (A) encodes the longest isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029831.1, SRR1803615.111774.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG ATACAAGAGG 
GTCACCACTC ACAGAAGAAT ATGGCTGGCC CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGATTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA CCTCAGAGTA CCACAGAAAT 
GTCACCTTCC TTTCATGCCA ATTTGTTTCC GTCATGAGAA TGGACTACAT GGTATACTTC 
AGCTTCCTCA CCTGGATTTT CATCCCCCTG GTTGTCATGT GCGCCATCTA TCTTGACATC 
TTTTACATCA TTCGGAACAA ACTCAGTCTG AACTTATCTA ACTCCAAAGA GACAGGTGCA 
TTTTATGGAC GGGAGTTCAA GACGGCTAAG TCCTTGTTTC TGGTTCTTTT CTTGTTTGCT 
CTGTCATGGC TGCCTTTATC TATCATCAAC TGCATCATCT ACTTTAATGG TGAGGTACCA 
CAGCTTGTGC TGTACATGGG CATCCTGCTG TCCCATGCCA ACTCCATGAT GAACCCTATC 
GTCTATGCCT ATAAAATAAA GAAGTTCAAG GAAACCTACC TTTTGATCCT CAAAGCTTGT 
GTGGTCTGCC ATCCCTCTGA TTCTTTGGAC ACAAGCATTG AGAAGAATTC TGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000668.1
CDS	768..1724
Translation	MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE

Target ORF information:

RefSeq Version	NM_000677.3
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000677.3

ORF Insert Sequence:

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG ATACAAGAGG 
GTCACCACTC ACAGAAGAAT ATGGCTGGCC CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGATTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA CCTCAGAGTA CCACAGAAAT 
GTCACCTTCC TTTCATGCCA ATTTGTTTCC GTCATGAGAA TGGACTACAT GGTATACTTC 
AGCTTCCTCA CCTGGATTTT CATCCCCCTG GTTGTCATGT GCGCCATCTA TCTTGACATC 
TTTTACATCA TTCGGAACAA ACTCAGTCTG AACTTATCTA ACTCCAAAGA GACAGGTGCA 
TTTTATGGAC GGGAGTTCAA GACGGCTAAG TCCTTGTTTC TGGTTCTTTT CTTGTTTGCT 
CTGTCATGGC TGCCTTTATC TATCATCAAC TGCATCATCT ACTTTAATGG TGAGGTACCA 
CAGCTTGTGC TGTACATGGG CATCCTGCTG TCCCATGCCA ACTCCATGAT GAACCCTATC 
GTCTATGCCT ATAAAATAAA GAAGTTCAAG GAAACCTACC TTTTGATCCT CAAAGCTTGT 
GTGGTCTGCC ATCCCTCTGA TTCTTTGGAC ACAAGCATTG AGAAGAATTC TGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADORA3 ( NM_001302678.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289607.1 Homo sapiens adenosine A3 receptor (ADORA3), transcript variant B, mRNA.

Price & Availability↑

CloneID	OHu56183
Clone ID Related Accession (Same CDS sequence)	NM_001302678.1 , NM_001302678.2
Accession Version	NM_001302678.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	adenosine receptor A3 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390195.10, CD013875.1, JN855714.1, BM675096.1 and BF432324.1. Transcript Variant: This variant (B) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant A. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.186816.1, SRR1660805.382508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146982, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG CTCCATCTCC 
CCTACCCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289607.1
CDS	768..1139
Translation	MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVSSISPTL

Target ORF information:

RefSeq Version	NM_001302678.1
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302678.1

ORF Insert Sequence:

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG CTCCATCTCC 
CCTACCCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADORA3 ( NM_001302678.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289607.1 Homo sapiens adenosine A3 receptor (ADORA3), transcript variant B, mRNA.

Price & Availability↑

CloneID	OHu56183
Clone ID Related Accession (Same CDS sequence)	NM_001302678.1 , NM_001302678.2
Accession Version	NM_001302678.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	adenosine receptor A3 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390195.10, CD013875.1, JN855714.1, BM675096.1 and BF432324.1. On Jun 2, 2019 this sequence version replaced NM_001302678.1. Transcript Variant: This variant (B) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant A. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.186816.1, SRR1660805.382508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146982, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG CTCCATCTCC 
CCTACCCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289607.1
CDS	280..651
Translation	MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVSSISPTL

Target ORF information:

RefSeq Version	NM_001302678.2
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302678.2

ORF Insert Sequence:

ATGCCCAACA ACAGCACTGC TCTGTCATTG GCCAATGTTA CCTACATCAC CATGGAAATT 
TTCATTGGAC TCTGCGCCAT AGTGGGCAAC GTGCTGGTCA TCTGCGTGGT CAAGCTGAAC 
CCCAGCCTGC AGACCACCAC CTTCTATTTC ATTGTCTCTC TAGCCCTGGC TGACATTGCT 
GTTGGGGTGC TGGTCATGCC TTTGGCCATT GTTGTCAGCC TGGGCATCAC AATCCACTTC 
TACAGCTGCC TTTTTATGAC TTGCCTACTG CTTATCTTTA CCCACGCCTC CATCATGTCC 
TTGCTGGCCA TCGCTGTGGA CCGATACTTG CGGGTCAAGC TTACCGTCAG CTCCATCTCC 
CCTACCCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADORA3 ( NM_001302679.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289608.1 Homo sapiens adenosine A3 receptor (ADORA3), transcript variant C, mRNA.

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CloneID	OHu56184
Clone ID Related Accession (Same CDS sequence)	NM_001302679.2 , NM_001302679.1
Accession Version	NM_001302679.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	adenosine receptor A3 isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390195.10, BX283401.1, JN855714.1, BM675096.1 and BF432324.1. On Jun 2, 2019 this sequence version replaced NM_001302679.1. Transcript Variant: This variant (C) uses an alternate splice site in the 5' terminal exon, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant A. The encoded isoform (C) is shorter at the N-terminus, compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG426977.1, BX283401.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTTGGCT GGAACATGAA ACTGACCTCA GAGTACCACA GAAATGTCAC CTTCCTTTCA 
TGCCAATTTG TTTCCGTCAT GAGAATGGAC TACATGGTAT ACTTCAGCTT CCTCACCTGG 
ATTTTCATCC CCCTGGTTGT CATGTGCGCC ATCTATCTTG ACATCTTTTA CATCATTCGG 
AACAAACTCA GTCTGAACTT ATCTAACTCC AAAGAGACAG GTGCATTTTA TGGACGGGAG 
TTCAAGACGG CTAAGTCCTT GTTTCTGGTT CTTTTCTTGT TTGCTCTGTC ATGGCTGCCT 
TTATCTATCA TCAACTGCAT CATCTACTTT AATGGTGAGG TACCACAGCT TGTGCTGTAC 
ATGGGCATCC TGCTGTCCCA TGCCAACTCC ATGATGAACC CTATCGTCTA TGCCTATAAA 
ATAAAGAAGT TCAAGGAAAC CTACCTTTTG ATCCTCAAAG CTTGTGTGGT CTGCCATCCC 
TCTGATTCTT TGGACACAAG CATTGAGAAG AATTCTGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289608.1
CDS	221..742
Translation	MFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE

Target ORF information:

RefSeq Version	NM_001302679.2
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant C, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302679.2

ORF Insert Sequence:

ATGTTTGGCT GGAACATGAA ACTGACCTCA GAGTACCACA GAAATGTCAC CTTCCTTTCA 
TGCCAATTTG TTTCCGTCAT GAGAATGGAC TACATGGTAT ACTTCAGCTT CCTCACCTGG 
ATTTTCATCC CCCTGGTTGT CATGTGCGCC ATCTATCTTG ACATCTTTTA CATCATTCGG 
AACAAACTCA GTCTGAACTT ATCTAACTCC AAAGAGACAG GTGCATTTTA TGGACGGGAG 
TTCAAGACGG CTAAGTCCTT GTTTCTGGTT CTTTTCTTGT TTGCTCTGTC ATGGCTGCCT 
TTATCTATCA TCAACTGCAT CATCTACTTT AATGGTGAGG TACCACAGCT TGTGCTGTAC 
ATGGGCATCC TGCTGTCCCA TGCCAACTCC ATGATGAACC CTATCGTCTA TGCCTATAAA 
ATAAAGAAGT TCAAGGAAAC CTACCTTTTG ATCCTCAAAG CTTGTGTGGT CTGCCATCCC 
TCTGATTCTT TGGACACAAG CATTGAGAAG AATTCTGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADORA3 ( NM_001302679.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289608.1 Homo sapiens adenosine A3 receptor (ADORA3), transcript variant C, mRNA.

Price & Availability↑

CloneID	OHu56184
Clone ID Related Accession (Same CDS sequence)	NM_001302679.2 , NM_001302679.1
Accession Version	NM_001302679.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	adenosine receptor A3 isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390195.10, BX283401.1, JN855714.1, BM675096.1 and BF432324.1. Transcript Variant: This variant (C) uses an alternate splice site in the 5' terminal exon, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant A. The encoded isoform (C) is shorter at the N-terminus, compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG426977.1, BX283401.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTTGGCT GGAACATGAA ACTGACCTCA GAGTACCACA GAAATGTCAC CTTCCTTTCA 
TGCCAATTTG TTTCCGTCAT GAGAATGGAC TACATGGTAT ACTTCAGCTT CCTCACCTGG 
ATTTTCATCC CCCTGGTTGT CATGTGCGCC ATCTATCTTG ACATCTTTTA CATCATTCGG 
AACAAACTCA GTCTGAACTT ATCTAACTCC AAAGAGACAG GTGCATTTTA TGGACGGGAG 
TTCAAGACGG CTAAGTCCTT GTTTCTGGTT CTTTTCTTGT TTGCTCTGTC ATGGCTGCCT 
TTATCTATCA TCAACTGCAT CATCTACTTT AATGGTGAGG TACCACAGCT TGTGCTGTAC 
ATGGGCATCC TGCTGTCCCA TGCCAACTCC ATGATGAACC CTATCGTCTA TGCCTATAAA 
ATAAAGAAGT TCAAGGAAAC CTACCTTTTG ATCCTCAAAG CTTGTGTGGT CTGCCATCCC 
TCTGATTCTT TGGACACAAG CATTGAGAAG AATTCTGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289608.1
CDS	709..1230
Translation	MFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE

Target ORF information:

RefSeq Version	NM_001302679.1
Organism	Homo sapiens(human)
Definition	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant C, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302679.1

ORF Insert Sequence:

ATGTTTGGCT GGAACATGAA ACTGACCTCA GAGTACCACA GAAATGTCAC CTTCCTTTCA 
TGCCAATTTG TTTCCGTCAT GAGAATGGAC TACATGGTAT ACTTCAGCTT CCTCACCTGG 
ATTTTCATCC CCCTGGTTGT CATGTGCGCC ATCTATCTTG ACATCTTTTA CATCATTCGG 
AACAAACTCA GTCTGAACTT ATCTAACTCC AAAGAGACAG GTGCATTTTA TGGACGGGAG 
TTCAAGACGG CTAAGTCCTT GTTTCTGGTT CTTTTCTTGT TTGCTCTGTC ATGGCTGCCT 
TTATCTATCA TCAACTGCAT CATCTACTTT AATGGTGAGG TACCACAGCT TGTGCTGTAC 
ATGGGCATCC TGCTGTCCCA TGCCAACTCC ATGATGAACC CTATCGTCTA TGCCTATAAA 
ATAAAGAAGT TCAAGGAAAC CTACCTTTTG ATCCTCAAAG CTTGTGTGGT CTGCCATCCC 
TCTGATTCTT TGGACACAAG CATTGAGAAG AATTCTGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cordycepin induces apoptosis in human bladder cancer cells via activation of A3 adenosine receptors.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317706915(2017 Jul)
Cao HL,Liu ZJ,Chang Z

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ADORA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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