CRHBP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRHBP
Entrez Gene ID	1393
Full Name	corticotropin releasing hormone binding protein
Synonyms	CRF-BP,CRFBP
General protein information	Preferred Names corticotropin releasing hormone binding protein Names corticotropin-releasing factor-binding protein CRF-binding protein CRH-BP
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q13.3
Summary	Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008].
Disorder MIM:	122559

mRNA and Protein(s)

mRNA	Protein	Name
NM_001882.3	NP_001873.2	corticotropin-releasing factor-binding protein precursor
NM_001882.4	NP_001873.2	corticotropin-releasing factor-binding protein precursor

Pathways from BioSystems

Homologies

	CRHBP	XP_001106453.1
Mus musculus (house mouse)	Crhbp	NP_940800.1
Gallus gallus (chicken)	CRHBP	XP_424801.3
Danio rerio (zebrafish)	crhbp	NP_001003459.1
Rattus norvegicus (Norway rat)	Crhbp	NP_631922.1
Drosophila melanogaster (fruit fly)	CG15537	NP_001097981.1
Xenopus tropicalis (tropical clawed frog)	crhbp	XP_002940913.1
Bos taurus (cattle)	CRHBP	NP_001094672.1
Homo sapiens (human)	CRHBP	NP_001873.2
Pan troglodytes (chimpanzee)	CRHBP	XP_001144864.1
Canis lupus familiaris (dog)	CRHBP	XP_853211.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000955	XP_309147.5

Gene Ontology
Bibliography

Related articles in PubMed

Genes involved in stress response and alcohol use among high-risk African American youth.
Goyal N, Aliev F, Latendresse SJ, Kertes DA, Bolland JM, Byck GR, Mustanski B, Salvatore JE, Dick DM
Substance abuse37(3)450-458(2016 Jul-Sep)

Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis.
Tezval H, Dubrowinskaja N, Peters I, Reese C, Serth K, Atschekzei F, Hennenlotter J, Stenzl A, Kuczyk MA, Serth J
PloS one11(10)e0163873(2016)

CRHBP polymorphisms predict chronic pain development following motor vehicle collision.
Linnstaedt SD, Bortsov AV, Soward AC, Swor R, Peak DA, Jones J, Rathlev N, Lee DC, Domeier R, Hendry PL, McLean SA
Pain157(1)273-9(2016 Jan)

Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.
Sasaki A, Sato N, Suzuki N, Kano M, Tanaka Y, Kanazawa M, Aoki M, Fukudo S
PloS one11(2)e0149322(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A measure of stressful life events was significantly predictive of alcohol use/misuse. In addition, this association was significantly dependent upon the number of putative risk variants at rs1715749, a single-nucleotide polymorphism (SNP) in CRHBP.
Title: Genes involved in stress response and alcohol use among high-risk African American youth.

We describe for the first time tumor specific epigenetic silencing of CRHBP and statistical association with aggressive tumors thus suggesting the CRH system to contribute to the development of kidney cancer.
Title: Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis.

Genetic polymorphism rs7718461 in the CRHBP gene showed significant association with overall pain severity during the year after motor vehicle collision.
Title: CRHBP polymorphisms predict chronic pain development following motor vehicle collision.

These results suggest that the CRH and CRH-BP genes have no direct effect on Irritable bowel syndrome status.
Title: Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.

Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD and depressive symptoms
Title: A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors.

The following CRHBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRHBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03731	NM_001882.4 Latest version!	Homo sapiens corticotropin releasing hormone binding protein (CRHBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu03731	NM_001882.3	Homo sapiens corticotropin releasing hormone binding protein (CRHBP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRHBP ( NM_001882.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001873.2 Homo sapiens corticotropin releasing hormone binding protein (CRHBP), mRNA.

Price & Availability↑

CloneID	OHu03731
Clone ID Related Accession (Same CDS sequence)	NM_001882.3 , NM_001882.4
Accession Version	NM_001882.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	corticotropin-releasing factor-binding protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB959505.1, BC018038.1 and AW451896.1. On May 7, 2004 this sequence version replaced NM_001882.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.63799.1, SRR1660807.157518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

ATGTCGCCCA ACTTCAAACT TCAGTGTCAC TTCATTCTCA TCTTCCTGAC GGCTCTAAGA 
GGGGAAAGCC GGTACCTAGA GCTGAGGGAA GCGGCGGACT ACGATCCTTT CCTGCTCTTC 
AGCGCCAACC TGAAGCGGGA GCTGGCTGGG GAGCAGCCGT ACCGCCGCGC TCTGCGGTGC 
CTGGACATGC TGAGCCTCCA GGGCCAGTTC ACCTTCACCG CCGACCGGCC GCAGCTGCAC 
TGCGCAGCCT TCTTCATCAG CGAGCCCGAG GAGTTCATTA CCATCCACTA CGACCAGGTC 
TCCATCGACT GTCAGGGCGG CGACTTCCTG AAGGTATTTG ATGGTTGGAT TCTCAAGGGG 
GAGAAGTTCC CCAGTTCCCA GGATCATCCT CTCCCCTCAG CTGAGCGGTA CATAGATTTC 
TGTGAGAGTG GTCTTAGCAG GAGGAGCATC AGATCTTCCC AGAATGTGGC CATGATCTTC 
TTCCGAGTCC ATGAACCAGG AAATGGATTC ACATTAACCA TAAAGACAGA CCCCAACCTC 
TTTCCTTGCA ATGTCATTTC TCAGACTCCA AATGGAAAGT TTACCCTGGT AGTTCCACAC 
CAGCATCGAA ACTGCAGCTT CTCCATAATT TATCCTGTGG TGATCAAAAT ATCTGATCTT 
ACCCTGGGAC ACGTAAATGG TCTTCAGTTA AAGAAATCCT CAGCAGGTTG CGAGGGAATA 
GGAGACTTTG TGGAGCTGCT GGGAGGAACT GGATTGGACC CTTCCAAGAT GACGCCTTTA 
GCTGATCTCT GCTACCCCTT TCATGGCCCG GCCCAGATGA AAGTTGGCTG TGACAACACT 
GTGGTGCGCA TGGTCTCCAG TGGAAAACAC GTAAATCGTG TGACTTTTGA GTATCGTCAG 
CTGGAGCCGT ACGAGCTGGA AAACCCAAAT GGAAACAGTA TCGGGGAATT CTGTTTGTCT 
GGTCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001873.2
CDS	281..1249
Translation	MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL

Target ORF information:

RefSeq Version	NM_001882.3
Organism	Homo sapiens(human)
Definition	Homo sapiens corticotropin releasing hormone binding protein (CRHBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001882.3

ORF Insert Sequence:

ATGTCGCCCA ACTTCAAACT TCAGTGTCAC TTCATTCTCA TCTTCCTGAC GGCTCTAAGA 
GGGGAAAGCC GGTACCTAGA GCTGAGGGAA GCGGCGGACT ACGATCCTTT CCTGCTCTTC 
AGCGCCAACC TGAAGCGGGA GCTGGCTGGG GAGCAGCCGT ACCGCCGCGC TCTGCGGTGC 
CTGGACATGC TGAGCCTCCA GGGCCAGTTC ACCTTCACCG CCGACCGGCC GCAGCTGCAC 
TGCGCAGCCT TCTTCATCAG CGAGCCCGAG GAGTTCATTA CCATCCACTA CGACCAGGTC 
TCCATCGACT GTCAGGGCGG CGACTTCCTG AAGGTATTTG ATGGTTGGAT TCTCAAGGGG 
GAGAAGTTCC CCAGTTCCCA GGATCATCCT CTCCCCTCAG CTGAGCGGTA CATAGATTTC 
TGTGAGAGTG GTCTTAGCAG GAGGAGCATC AGATCTTCCC AGAATGTGGC CATGATCTTC 
TTCCGAGTCC ATGAACCAGG AAATGGATTC ACATTAACCA TAAAGACAGA CCCCAACCTC 
TTTCCTTGCA ATGTCATTTC TCAGACTCCA AATGGAAAGT TTACCCTGGT AGTTCCACAC 
CAGCATCGAA ACTGCAGCTT CTCCATAATT TATCCTGTGG TGATCAAAAT ATCTGATCTT 
ACCCTGGGAC ACGTAAATGG TCTTCAGTTA AAGAAATCCT CAGCAGGTTG CGAGGGAATA 
GGAGACTTTG TGGAGCTGCT GGGAGGAACT GGATTGGACC CTTCCAAGAT GACGCCTTTA 
GCTGATCTCT GCTACCCCTT TCATGGCCCG GCCCAGATGA AAGTTGGCTG TGACAACACT 
GTGGTGCGCA TGGTCTCCAG TGGAAAACAC GTAAATCGTG TGACTTTTGA GTATCGTCAG 
CTGGAGCCGT ACGAGCTGGA AAACCCAAAT GGAAACAGTA TCGGGGAATT CTGTTTGTCT 
GGTCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRHBP ( NM_001882.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001873.2 Homo sapiens corticotropin releasing hormone binding protein (CRHBP), mRNA.

Price & Availability↑

CloneID	OHu03731
Clone ID Related Accession (Same CDS sequence)	NM_001882.3 , NM_001882.4
Accession Version	NM_001882.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	corticotropin-releasing factor-binding protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB959505.1, BC018038.1 and AW451896.1. On Nov 22, 2018 this sequence version replaced NM_001882.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018038.1, SRR1660809.14523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000274368.9/ ENSP00000274368.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGCCCA ACTTCAAACT TCAGTGTCAC TTCATTCTCA TCTTCCTGAC GGCTCTAAGA 
GGGGAAAGCC GGTACCTAGA GCTGAGGGAA GCGGCGGACT ACGATCCTTT CCTGCTCTTC 
AGCGCCAACC TGAAGCGGGA GCTGGCTGGG GAGCAGCCGT ACCGCCGCGC TCTGCGGTGC 
CTGGACATGC TGAGCCTCCA GGGCCAGTTC ACCTTCACCG CCGACCGGCC GCAGCTGCAC 
TGCGCAGCCT TCTTCATCAG CGAGCCCGAG GAGTTCATTA CCATCCACTA CGACCAGGTC 
TCCATCGACT GTCAGGGCGG CGACTTCCTG AAGGTATTTG ATGGTTGGAT TCTCAAGGGG 
GAGAAGTTCC CCAGTTCCCA GGATCATCCT CTCCCCTCAG CTGAGCGGTA CATAGATTTC 
TGTGAGAGTG GTCTTAGCAG GAGGAGCATC AGATCTTCCC AGAATGTGGC CATGATCTTC 
TTCCGAGTCC ATGAACCAGG AAATGGATTC ACATTAACCA TAAAGACAGA CCCCAACCTC 
TTTCCTTGCA ATGTCATTTC TCAGACTCCA AATGGAAAGT TTACCCTGGT AGTTCCACAC 
CAGCATCGAA ACTGCAGCTT CTCCATAATT TATCCTGTGG TGATCAAAAT ATCTGATCTT 
ACCCTGGGAC ACGTAAATGG TCTTCAGTTA AAGAAATCCT CAGCAGGTTG CGAGGGAATA 
GGAGACTTTG TGGAGCTGCT GGGAGGAACT GGATTGGACC CTTCCAAGAT GACGCCTTTA 
GCTGATCTCT GCTACCCCTT TCATGGCCCG GCCCAGATGA AAGTTGGCTG TGACAACACT 
GTGGTGCGCA TGGTCTCCAG TGGAAAACAC GTAAATCGTG TGACTTTTGA GTATCGTCAG 
CTGGAGCCGT ACGAGCTGGA AAACCCAAAT GGAAACAGTA TCGGGGAATT CTGTTTGTCT 
GGTCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001873.2
CDS	91..1059
Translation	MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL

Target ORF information:

RefSeq Version	NM_001882.4
Organism	Homo sapiens(human)
Definition	Homo sapiens corticotropin releasing hormone binding protein (CRHBP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001882.4

ORF Insert Sequence:

ATGTCGCCCA ACTTCAAACT TCAGTGTCAC TTCATTCTCA TCTTCCTGAC GGCTCTAAGA 
GGGGAAAGCC GGTACCTAGA GCTGAGGGAA GCGGCGGACT ACGATCCTTT CCTGCTCTTC 
AGCGCCAACC TGAAGCGGGA GCTGGCTGGG GAGCAGCCGT ACCGCCGCGC TCTGCGGTGC 
CTGGACATGC TGAGCCTCCA GGGCCAGTTC ACCTTCACCG CCGACCGGCC GCAGCTGCAC 
TGCGCAGCCT TCTTCATCAG CGAGCCCGAG GAGTTCATTA CCATCCACTA CGACCAGGTC 
TCCATCGACT GTCAGGGCGG CGACTTCCTG AAGGTATTTG ATGGTTGGAT TCTCAAGGGG 
GAGAAGTTCC CCAGTTCCCA GGATCATCCT CTCCCCTCAG CTGAGCGGTA CATAGATTTC 
TGTGAGAGTG GTCTTAGCAG GAGGAGCATC AGATCTTCCC AGAATGTGGC CATGATCTTC 
TTCCGAGTCC ATGAACCAGG AAATGGATTC ACATTAACCA TAAAGACAGA CCCCAACCTC 
TTTCCTTGCA ATGTCATTTC TCAGACTCCA AATGGAAAGT TTACCCTGGT AGTTCCACAC 
CAGCATCGAA ACTGCAGCTT CTCCATAATT TATCCTGTGG TGATCAAAAT ATCTGATCTT 
ACCCTGGGAC ACGTAAATGG TCTTCAGTTA AAGAAATCCT CAGCAGGTTG CGAGGGAATA 
GGAGACTTTG TGGAGCTGCT GGGAGGAACT GGATTGGACC CTTCCAAGAT GACGCCTTTA 
GCTGATCTCT GCTACCCCTT TCATGGCCCG GCCCAGATGA AAGTTGGCTG TGACAACACT 
GTGGTGCGCA TGGTCTCCAG TGGAAAACAC GTAAATCGTG TGACTTTTGA GTATCGTCAG 
CTGGAGCCGT ACGAGCTGGA AAACCCAAAT GGAAACAGTA TCGGGGAATT CTGTTTGTCT 
GGTCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genes involved in stress response and alcohol use among high-risk African American youth.
Substance abuse37(3)450-458(2016 Jul-Sep)
Goyal N,Aliev F,Latendresse SJ,Kertes DA,Bolland JM,Byck GR,Mustanski B,Salvatore JE,Dick DM

Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis.
PloS one11(10)e0163873(2016)
Tezval H,Dubrowinskaja N,Peters I,Reese C,Serth K,Atschekzei F,Hennenlotter J,Stenzl A,Kuczyk MA,Serth J

CRHBP polymorphisms predict chronic pain development following motor vehicle collision.
Pain157(1)273-9(2016 Jan)
Linnstaedt SD,Bortsov AV,Soward AC,Swor R,Peak DA,Jones J,Rathlev N,Lee DC,Domeier R,Hendry PL,McLean SA

Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.
PloS one11(2)e0149322(2016)
Sasaki A,Sato N,Suzuki N,Kano M,Tanaka Y,Kanazawa M,Aoki M,Fukudo S

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CRHBP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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