AMER1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AMER1
Entrez Gene ID	139285
Full Name	APC membrane recruitment protein 1
Synonyms	FAM123B,OSCS,WTX
General protein information	Preferred Names APC membrane recruitment protein 1 Names APC membrane recruitment protein 1 RP11-403E24.2 Wilms tumor gene on the X chromosome protein Wilms tumor on the X adenomatous polyposis coli membrane recruitment 1 family with sequence similarity 123B protein FAM123B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq11.2
Summary	The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010].
Disorder MIM:	300647
Disorder Html:	Osteopathia striata with cranial sclerosis, 300373 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011530858.1	XP_011529160.1	APC membrane recruitment protein 1 isoform X1
NM_152424.3	NP_689637.3	APC membrane recruitment protein 1
NM_152424.4	NP_689637.3	APC membrane recruitment protein 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	FAM123B	XP_420290.4
Canis lupus familiaris (dog)	AMER1	XP_005641471.1
Rattus norvegicus (Norway rat)	Amer1	NP_001102790.1
Pan troglodytes (chimpanzee)	FAM123B	XP_003317544.1
Bos taurus (cattle)	FAM123B	XP_005228330.1
Xenopus tropicalis (tropical clawed frog)	amer1	XP_004915814.1
Mus musculus (house mouse)	Amer1	NP_780388.2
Homo sapiens (human)	AMER1	NP_689637.3
	LOC707700	XP_001096922.2

Gene Ontology
Bibliography

Related articles in PubMed

High bone mass due to novel LRP5 and AMER1 mutations.
Costantini A, Kek?l?inen P, M?kitie RE, M?kitie O
European journal of medical genetics60(12)675-679(2017 Dec)

Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation.
Alexandrescu S, Akhavanfard S, Harris MH, Vargas SO
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society20(2)105-111(2017 Mar-Apr)

Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer.
Sanz-Pamplona R, Lopez-Doriga A, Par?-Brunet L, L?zaro K, Bellido F, Alonso MH, Auss? S, Guin? E, Beltr?n S, Castro-Giner F, Gut M, Sanjuan X, Closa A, Cordero D, Mor?n-Duran FD, Soriano A, Salazar R, Valle L, Moreno V
Clinical cancer research : an official journal of the American Association for Cancer Research21(20)4709-18(2015 Oct)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Losses of AMER1 by other mechanisms apart from mutations.
Title: Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer.

A nonsense mutation (c.1045C>T, p.Glu349*) in the WTX gene.
Title: A novel WTX mutation in a female patient with osteopathia striata with cranial sclerosis and hepatoblastoma.

Data show that beta-arrestins regulate Wnt3a-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation by the regulation of the membrane dynamics of Amer1.
Title: ?-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

WTX inactivation occurs in a wider variety of tumor types than previously appreciated and point to shared pathogenic mechanisms between a subset of pediatric malignancies.
Title: Inactivation of the tumor suppressor WTX in a subset of pediatric tumors.

Stat3 inhibits WTX expression through up-regulation of micro RNA-370 in Wilms tumor.
Title: Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor.

The following AMER1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AMER1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19021	NM_152424.4 Latest version!	Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
OHu19021	XM_011530858.1 Latest version!	Homo sapiens APC membrane recruitment protein 1 (AMER1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
View Old Accession Versions >>
OHu19021	NM_152424.3	Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AMER1 ( NM_152424.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689637.3 Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA.

Price & Availability↑

CloneID	OHu19021
Clone ID Related Accession (Same CDS sequence)	XM_011530858.1 , NM_152424.3 , NM_152424.4
Accession Version	NM_152424.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	APC membrane recruitment protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA939151.1, EF186024.1 and AL355852.23. This sequence is a reference standard in the RefSeqGene project. On Jan 26, 2007 this sequence version replaced NM_152424.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA939151.1, EF186024.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACCC AAAAGGATGA AGCTGCTCAG GCCAAGGGAG CTGCAGCCTC TGGGAGTACC 
CGTGAACAAA CAGCAGAAAA AGGAGCCAAG AACAAGGCAG CTGAGGCGAC AGAAGGACCA 
ACCTCAGAGC CATCCTCATC CGGCCCAGGT AGGCTGAAGA AAACTGCCAT GAAACTCTTT 
GGTGGCAAGA AGGGTATCTG TACTCTGCCT AGTTTCTTTG GAGGGGGACG GAGCAAAGGT 
TCTGGGAAAG GCAGCTCCAA GAAAGGTCTC AGCAAGAGCA AGACCCACGA TGGCCTGAGT 
GAAGCAGCCC ATGGCCCTGA AGATGTTGTC AGTGAAGGAA CTGGCTTCTC CCTGCCTTTG 
CCTGAGTTAC CCTGCCAATT TCCCAGCTCT CAGAGTGCCC ATGGGGCTTT GGAGACAGGC 
TCCAGATGTA AGACATCTGT GGCTGGAGCC ACAGAGAAAG CTGTGGCTGA GAAGTTTCCC 
TCTATGCCCA AGCCAAAGAA AGGCCTAAAA GGCTTTTTTA GCAGTATCCG CCGTCACCGG 
AAGAGCAAGG TCACTGGGGC TGAGCAAAGT GAGCCAGGGG CCAAGGGGCC TGAGAGGGTC 
AGAGCCAGGC CTCATGAGCA CGTGAGCTCA GCCCCTCAGG TGCCCTGCTT TGAGGAGACC 
TTCCAAGCCC CTAGAAAGGA AAATGCTAAC CCCCAAGATG CCCCTGGGCC AAAAGTTTCT 
CCAACACCAG AACCTTCTCC ACCAGCTACT GAGAAAATGG CCTGTAAAGA TCCAGAAAAA 
CCCATGGAGG CCTGTGCCTC AGCACATGTG CAACCCAAGC CTGCCCCTGA AGCCAGTAGC 
CTAGAGGAGC CCCATAGCCC AGAAACAGGG GAGAAGGTAG TAGCAGGAGA GGTAAACCCA 
CCCAATGGCC CTGTGGGGGA CCCACTGAGC CTCTTGTTTG GGGATGTGAC ATCCCTGAAA 
AGCTTTGATT CATTGACAGG TTGTGGTGAC ATAATAGCAG AACAGGACAT GGACAGTATG 
ACAGACAGCA TGGCCTCTGG GGGCCAGAGA GCAAACCGAG ATGGGACCAA GCGAAGTTCC 
TGCCTGGTGA CCTACCAAGG AGGTGGGGAG GAGATGGCCT TGCCAGATGA TGATGACGAG 
GAGGAAGAAG AGGAAGAAGA GGTGGAATTA GAGGAGGAAG AAGAGGAGGT TAAGGAGGAG 
GAAGAAGATG ATGACTTAGA ATATCTGTGG GAAACTGCCC AAATGTATCC ACGGCCCAAT 
ATGAACCTGG GCTACCATCC CACCACATCC CCAGGCCACC ACGGCTACAT GCTCCTTGAC 
CCAGTTAGGT CTTATCCTGG CCTAGCCCCT GGGGAACTTT TGACTCCTCA GAGTGACCAG 
CAAGAATCCG CCCCCAATAG TGATGAAGGT TATTATGACT CCACCACACC TGGATTTGAG 
GATGATTCAG GTGAGGCCCT GGGGCTTGTC CGCAGGGATT GTCTACCCCG AGACAGCTAC 
AGTGGAGATG CCCTATATGA GTTCTATGAG CCAGATGACA GCCTTGAGAA CTCTCCACCT 
GGAGATGACT GCCTTTATGA CCTCCATGGT CGAAGCTCTG AGATGTTTGA CCCCTTCTTA 
AACTTTGAGC CCTTTTTGTC CTCCCGGCCA CCTGGGGCAA TGGAGACAGA GGAAGAACGG 
CTAGTGACCA TCCAGAAACA GTTGTTGTAT TGGGAGCTTC GGCGGGAGCA GCTTGAGGCC 
CAGGAGGCAC GTGCCCGAGA AGCTCATGCC AGGGAGGCCC ACGCCAGGGA GGCCTATACT 
CGAGAGGCTT ATGGCAGGGA AGCCTATGCC AGGGAGGCCC ACACTTGGGA AGCTCATGGC 
AGGGAGGCCA GAACCCGAGA AGCCCAGGCC CGAGAGGTTC GTTGTAGAGA GACTCAAGTC 
CGAGAGACCC AGGCCCGGCA GGAGAAGCCC GTCTTAGAGT ATCAGATGAG GCCCTTAGGC 
CCATCAGTGA TGGGCCTGGC AGCAGGGGTA TCAGGGACCT CTCAGATTTC CCACCGGGGA 
ATTACCTCAG CTTTCCCCAC CACTGCAAGC AGCGAGCCAG ACTGGAGGGA CTTCCGTCCT 
CTGGAGAAGC GTTATGAAGG AACCTGCTCC AAGAAAGATC AAAGTACCTG CCTGATGCAG 
CTCTTCCAGA GTGATGCCAT GTTTGAGCCA GACATGCAAG AAGCAAATTT TGGAGGATCT 
CCCAGGAGGG CCTACCCTAC TTATTCACCC CCTGAAGATC CAGAGGAAGA GGAGGTTGAG 
AAGGAAGGGA ATGCCACTGT GAGTTTCTCA CAGGCCCTGG TAGAGTTCAC CAGCAATGGG 
AACCTCTTTT CCAGCATGTC CTGCAGCTCT GACTCTGACT CATCTTTCAC TCAAAACCTC 
CCTGAGCTGC CTCCCATGGT GACCTTTGAC ATCGCTGATG TGGAACGGGA TGGGGAAGGC 
AAGTGTGAAG AGAATCCTGA GTTCCACAAT GATGAAGATC TTGCAGCCTC CTTGGAAGCC 
TTTGAGCTGG GCTACTATCA CAAACATGCC TTCAACAACT ACCATAGTCG ATTCTACCAA 
GGCCTGCCCT GGGGTGTGAG CAGCCTCCCT CGATACTTGG GACTGCCTGG CCTGCACCCT 
CGACCTCCAC CTGCTGCTAT GGCCCTCAAC AGGAGAAGCC GCTCTCTCGA CACTGCAGAG 
ACCCTGGAGA TGGAGCTCTC CAATTCCCAC TTGGTCCAGG GCTACCTCGA GTCTGATGAG 
CTGCAGGCCC AGCAGGAAGA TTCAGATGAG GAGGACGAAG AGGAGGAAGA AGGAGAATGG 
AGCCGAGACA GTCCCCTTTC CCTCTATACT GAACCCCCAG GGGCCTATGA TTGGCCTGCT 
TGGGCTCCCT GTCCTCTTCC AGTGGGGCCA GGTCCTGCCT GGATAAGCCC CAACCAGTTG 
GACAGGCCTT CCAGCCAGTC TCCATATAGG CAGGCAACCT GTTGCATACC TCCTATGACC 
ATGTCAATAT CACTATCAGT GCCAGAGTCA AGGGCACCTG GGGAATCTGG GCCTCAACTA 
GCTCGTCCCT CACACCTACA CCTGCCCATG GGCCCTTGCT ATAACCTCCA GCCACAGGCC 
TCCCAGAGCA TGAGGGCCAG GCCTCGAGAT GTGCTGCTGC CTGTTGATGA GCCCAGTTGC 
TCTTCCAGTT CTGGAGGCTT CAGCCCCAGC CCTCTACCAC AGGCCAAGCC TGTGGGCATC 
ACCCATGGCA TTCCTCAGCT GCCCAGGGTC CGGCCTGAGC ACCCCCAGCC TCAGCCCACT 
CACTATGGGC CTTCCAGCCT TGACCTGTCA AAGGAGAGGG CTGAGCAAGG TGCCTCTCTT 
GCCACCAGCT ACTCCTCCAC TGCCATGAAT GGAAACCTAG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689637.3
CDS	274..3681
Translation	METQKDEAAQAKGAAASGSTREQTAEKGAKNKAAEATEGPTSEPSSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAAHGPEDVVSEGTGFSLPLPELPCQFPSSQSAHGALETGSRCKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEPGAKGPERVRARPHEHVSSAPQVPCFEETFQAPRKENANPQDAPGPKVSPTPEPSPPATEKMACKDPEKPMEACASAHVQPKPAPEASSLEEPHSPETGEKVVAGEVNPPNGPVGDPLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEEVELEEEEEEVKEEEEDDDLEYLWETAQMYPRPNMNLGYHPTTSPGHHGYMLLDPVRSYPGLAPGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLVRRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHGRSSEMFDPFLNFEPFLSSRPPGAMETEEERLVTIQKQLLYWELRREQLEAQEARAREAHAREAHAREAYTREAYGREAYAREAHTWEAHGREARTREAQAREVRCRETQVRETQARQEKPVLEYQMRPLGPSVMGLAAGVSGTSQISHRGITSAFPTTASSEPDWRDFRPLEKRYEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEDPEEEEVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYHKHAFNNYHSRFYQGLPWGVSSLPRYLGLPGLHPRPPPAAMALNRRSRSLDTAETLEMELSNSHLVQGYLESDELQAQQEDSDEEDEEEEEGEWSRDSPLSLYTEPPGAYDWPAWAPCPLPVGPGPAWISPNQLDRPSSQSPYRQATCCIPPMTMSISLSVPESRAPGESGPQLARPSHLHLPMGPCYNLQPQASQSMRARPRDVLLPVDEPSCSSSSGGFSPSPLPQAKPVGITHGIPQLPRVRPEHPQPQPTHYGPSSLDLSKERAEQGASLATSYSSTAMNGNLAK

Target ORF information:

RefSeq Version	NM_152424.3
Organism	Homo sapiens(human)
Definition	Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152424.3

ORF Insert Sequence:

ATGGAGACCC AAAAGGATGA AGCTGCTCAG GCCAAGGGAG CTGCAGCCTC TGGGAGTACC 
CGTGAACAAA CAGCAGAAAA AGGAGCCAAG AACAAGGCAG CTGAGGCGAC AGAAGGACCA 
ACCTCAGAGC CATCCTCATC CGGCCCAGGT AGGCTGAAGA AAACTGCCAT GAAACTCTTT 
GGTGGCAAGA AGGGTATCTG TACTCTGCCT AGTTTCTTTG GAGGGGGACG GAGCAAAGGT 
TCTGGGAAAG GCAGCTCCAA GAAAGGTCTC AGCAAGAGCA AGACCCACGA TGGCCTGAGT 
GAAGCAGCCC ATGGCCCTGA AGATGTTGTC AGTGAAGGAA CTGGCTTCTC CCTGCCTTTG 
CCTGAGTTAC CCTGCCAATT TCCCAGCTCT CAGAGTGCCC ATGGGGCTTT GGAGACAGGC 
TCCAGATGTA AGACATCTGT GGCTGGAGCC ACAGAGAAAG CTGTGGCTGA GAAGTTTCCC 
TCTATGCCCA AGCCAAAGAA AGGCCTAAAA GGCTTTTTTA GCAGTATCCG CCGTCACCGG 
AAGAGCAAGG TCACTGGGGC TGAGCAAAGT GAGCCAGGGG CCAAGGGGCC TGAGAGGGTC 
AGAGCCAGGC CTCATGAGCA CGTGAGCTCA GCCCCTCAGG TGCCCTGCTT TGAGGAGACC 
TTCCAAGCCC CTAGAAAGGA AAATGCTAAC CCCCAAGATG CCCCTGGGCC AAAAGTTTCT 
CCAACACCAG AACCTTCTCC ACCAGCTACT GAGAAAATGG CCTGTAAAGA TCCAGAAAAA 
CCCATGGAGG CCTGTGCCTC AGCACATGTG CAACCCAAGC CTGCCCCTGA AGCCAGTAGC 
CTAGAGGAGC CCCATAGCCC AGAAACAGGG GAGAAGGTAG TAGCAGGAGA GGTAAACCCA 
CCCAATGGCC CTGTGGGGGA CCCACTGAGC CTCTTGTTTG GGGATGTGAC ATCCCTGAAA 
AGCTTTGATT CATTGACAGG TTGTGGTGAC ATAATAGCAG AACAGGACAT GGACAGTATG 
ACAGACAGCA TGGCCTCTGG GGGCCAGAGA GCAAACCGAG ATGGGACCAA GCGAAGTTCC 
TGCCTGGTGA CCTACCAAGG AGGTGGGGAG GAGATGGCCT TGCCAGATGA TGATGACGAG 
GAGGAAGAAG AGGAAGAAGA GGTGGAATTA GAGGAGGAAG AAGAGGAGGT TAAGGAGGAG 
GAAGAAGATG ATGACTTAGA ATATCTGTGG GAAACTGCCC AAATGTATCC ACGGCCCAAT 
ATGAACCTGG GCTACCATCC CACCACATCC CCAGGCCACC ACGGCTACAT GCTCCTTGAC 
CCAGTTAGGT CTTATCCTGG CCTAGCCCCT GGGGAACTTT TGACTCCTCA GAGTGACCAG 
CAAGAATCCG CCCCCAATAG TGATGAAGGT TATTATGACT CCACCACACC TGGATTTGAG 
GATGATTCAG GTGAGGCCCT GGGGCTTGTC CGCAGGGATT GTCTACCCCG AGACAGCTAC 
AGTGGAGATG CCCTATATGA GTTCTATGAG CCAGATGACA GCCTTGAGAA CTCTCCACCT 
GGAGATGACT GCCTTTATGA CCTCCATGGT CGAAGCTCTG AGATGTTTGA CCCCTTCTTA 
AACTTTGAGC CCTTTTTGTC CTCCCGGCCA CCTGGGGCAA TGGAGACAGA GGAAGAACGG 
CTAGTGACCA TCCAGAAACA GTTGTTGTAT TGGGAGCTTC GGCGGGAGCA GCTTGAGGCC 
CAGGAGGCAC GTGCCCGAGA AGCTCATGCC AGGGAGGCCC ACGCCAGGGA GGCCTATACT 
CGAGAGGCTT ATGGCAGGGA AGCCTATGCC AGGGAGGCCC ACACTTGGGA AGCTCATGGC 
AGGGAGGCCA GAACCCGAGA AGCCCAGGCC CGAGAGGTTC GTTGTAGAGA GACTCAAGTC 
CGAGAGACCC AGGCCCGGCA GGAGAAGCCC GTCTTAGAGT ATCAGATGAG GCCCTTAGGC 
CCATCAGTGA TGGGCCTGGC AGCAGGGGTA TCAGGGACCT CTCAGATTTC CCACCGGGGA 
ATTACCTCAG CTTTCCCCAC CACTGCAAGC AGCGAGCCAG ACTGGAGGGA CTTCCGTCCT 
CTGGAGAAGC GTTATGAAGG AACCTGCTCC AAGAAAGATC AAAGTACCTG CCTGATGCAG 
CTCTTCCAGA GTGATGCCAT GTTTGAGCCA GACATGCAAG AAGCAAATTT TGGAGGATCT 
CCCAGGAGGG CCTACCCTAC TTATTCACCC CCTGAAGATC CAGAGGAAGA GGAGGTTGAG 
AAGGAAGGGA ATGCCACTGT GAGTTTCTCA CAGGCCCTGG TAGAGTTCAC CAGCAATGGG 
AACCTCTTTT CCAGCATGTC CTGCAGCTCT GACTCTGACT CATCTTTCAC TCAAAACCTC 
CCTGAGCTGC CTCCCATGGT GACCTTTGAC ATCGCTGATG TGGAACGGGA TGGGGAAGGC 
AAGTGTGAAG AGAATCCTGA GTTCCACAAT GATGAAGATC TTGCAGCCTC CTTGGAAGCC 
TTTGAGCTGG GCTACTATCA CAAACATGCC TTCAACAACT ACCATAGTCG ATTCTACCAA 
GGCCTGCCCT GGGGTGTGAG CAGCCTCCCT CGATACTTGG GACTGCCTGG CCTGCACCCT 
CGACCTCCAC CTGCTGCTAT GGCCCTCAAC AGGAGAAGCC GCTCTCTCGA CACTGCAGAG 
ACCCTGGAGA TGGAGCTCTC CAATTCCCAC TTGGTCCAGG GCTACCTCGA GTCTGATGAG 
CTGCAGGCCC AGCAGGAAGA TTCAGATGAG GAGGACGAAG AGGAGGAAGA AGGAGAATGG 
AGCCGAGACA GTCCCCTTTC CCTCTATACT GAACCCCCAG GGGCCTATGA TTGGCCTGCT 
TGGGCTCCCT GTCCTCTTCC AGTGGGGCCA GGTCCTGCCT GGATAAGCCC CAACCAGTTG 
GACAGGCCTT CCAGCCAGTC TCCATATAGG CAGGCAACCT GTTGCATACC TCCTATGACC 
ATGTCAATAT CACTATCAGT GCCAGAGTCA AGGGCACCTG GGGAATCTGG GCCTCAACTA 
GCTCGTCCCT CACACCTACA CCTGCCCATG GGCCCTTGCT ATAACCTCCA GCCACAGGCC 
TCCCAGAGCA TGAGGGCCAG GCCTCGAGAT GTGCTGCTGC CTGTTGATGA GCCCAGTTGC 
TCTTCCAGTT CTGGAGGCTT CAGCCCCAGC CCTCTACCAC AGGCCAAGCC TGTGGGCATC 
ACCCATGGCA TTCCTCAGCT GCCCAGGGTC CGGCCTGAGC ACCCCCAGCC TCAGCCCACT 
CACTATGGGC CTTCCAGCCT TGACCTGTCA AAGGAGAGGG CTGAGCAAGG TGCCTCTCTT 
GCCACCAGCT ACTCCTCCAC TGCCATGAAT GGAAACCTAG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AMER1 ( NM_152424.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689637.3 Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA.

Price & Availability↑

CloneID	OHu19021
Clone ID Related Accession (Same CDS sequence)	XM_011530858.1 , NM_152424.3 , NM_152424.4
Accession Version	NM_152424.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	APC membrane recruitment protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA939151.1, EF186024.1 and AL355852.23. This sequence is a reference standard in the RefSeqGene project. On Jul 30, 2018 this sequence version replaced NM_152424.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF186024.1, DRR138518.370883.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374869.8/ ENSP00000364003.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGACCC AAAAGGATGA AGCTGCTCAG GCCAAGGGAG CTGCAGCCTC TGGGAGTACC 
CGTGAACAAA CAGCAGAAAA AGGAGCCAAG AACAAGGCAG CTGAGGCGAC AGAAGGACCA 
ACCTCAGAGC CATCCTCATC CGGCCCAGGT AGGCTGAAGA AAACTGCCAT GAAACTCTTT 
GGTGGCAAGA AGGGTATCTG TACTCTGCCT AGTTTCTTTG GAGGGGGACG GAGCAAAGGT 
TCTGGGAAAG GCAGCTCCAA GAAAGGTCTC AGCAAGAGCA AGACCCACGA TGGCCTGAGT 
GAAGCAGCCC ATGGCCCTGA AGATGTTGTC AGTGAAGGAA CTGGCTTCTC CCTGCCTTTG 
CCTGAGTTAC CCTGCCAATT TCCCAGCTCT CAGAGTGCCC ATGGGGCTTT GGAGACAGGC 
TCCAGATGTA AGACATCTGT GGCTGGAGCC ACAGAGAAAG CTGTGGCTGA GAAGTTTCCC 
TCTATGCCCA AGCCAAAGAA AGGCCTAAAA GGCTTTTTTA GCAGTATCCG CCGTCACCGG 
AAGAGCAAGG TCACTGGGGC TGAGCAAAGT GAGCCAGGGG CCAAGGGGCC TGAGAGGGTC 
AGAGCCAGGC CTCATGAGCA CGTGAGCTCA GCCCCTCAGG TGCCCTGCTT TGAGGAGACC 
TTCCAAGCCC CTAGAAAGGA AAATGCTAAC CCCCAAGATG CCCCTGGGCC AAAAGTTTCT 
CCAACACCAG AACCTTCTCC ACCAGCTACT GAGAAAATGG CCTGTAAAGA TCCAGAAAAA 
CCCATGGAGG CCTGTGCCTC AGCACATGTG CAACCCAAGC CTGCCCCTGA AGCCAGTAGC 
CTAGAGGAGC CCCATAGCCC AGAAACAGGG GAGAAGGTAG TAGCAGGAGA GGTAAACCCA 
CCCAATGGCC CTGTGGGGGA CCCACTGAGC CTCTTGTTTG GGGATGTGAC ATCCCTGAAA 
AGCTTTGATT CATTGACAGG TTGTGGTGAC ATAATAGCAG AACAGGACAT GGACAGTATG 
ACAGACAGCA TGGCCTCTGG GGGCCAGAGA GCAAACCGAG ATGGGACCAA GCGAAGTTCC 
TGCCTGGTGA CCTACCAAGG AGGTGGGGAG GAGATGGCCT TGCCAGATGA TGATGACGAG 
GAGGAAGAAG AGGAAGAAGA GGTGGAATTA GAGGAGGAAG AAGAGGAGGT TAAGGAGGAG 
GAAGAAGATG ATGACTTAGA ATATCTGTGG GAAACTGCCC AAATGTATCC ACGGCCCAAT 
ATGAACCTGG GCTACCATCC CACCACATCC CCAGGCCACC ACGGCTACAT GCTCCTTGAC 
CCAGTTAGGT CTTATCCTGG CCTAGCCCCT GGGGAACTTT TGACTCCTCA GAGTGACCAG 
CAAGAATCCG CCCCCAATAG TGATGAAGGT TATTATGACT CCACCACACC TGGATTTGAG 
GATGATTCAG GTGAGGCCCT GGGGCTTGTC CGCAGGGATT GTCTACCCCG AGACAGCTAC 
AGTGGAGATG CCCTATATGA GTTCTATGAG CCAGATGACA GCCTTGAGAA CTCTCCACCT 
GGAGATGACT GCCTTTATGA CCTCCATGGT CGAAGCTCTG AGATGTTTGA CCCCTTCTTA 
AACTTTGAGC CCTTTTTGTC CTCCCGGCCA CCTGGGGCAA TGGAGACAGA GGAAGAACGG 
CTAGTGACCA TCCAGAAACA GTTGTTGTAT TGGGAGCTTC GGCGGGAGCA GCTTGAGGCC 
CAGGAGGCAC GTGCCCGAGA AGCTCATGCC AGGGAGGCCC ACGCCAGGGA GGCCTATACT 
CGAGAGGCTT ATGGCAGGGA AGCCTATGCC AGGGAGGCCC ACACTTGGGA AGCTCATGGC 
AGGGAGGCCA GAACCCGAGA AGCCCAGGCC CGAGAGGTTC GTTGTAGAGA GACTCAAGTC 
CGAGAGACCC AGGCCCGGCA GGAGAAGCCC GTCTTAGAGT ATCAGATGAG GCCCTTAGGC 
CCATCAGTGA TGGGCCTGGC AGCAGGGGTA TCAGGGACCT CTCAGATTTC CCACCGGGGA 
ATTACCTCAG CTTTCCCCAC CACTGCAAGC AGCGAGCCAG ACTGGAGGGA CTTCCGTCCT 
CTGGAGAAGC GTTATGAAGG AACCTGCTCC AAGAAAGATC AAAGTACCTG CCTGATGCAG 
CTCTTCCAGA GTGATGCCAT GTTTGAGCCA GACATGCAAG AAGCAAATTT TGGAGGATCT 
CCCAGGAGGG CCTACCCTAC TTATTCACCC CCTGAAGATC CAGAGGAAGA GGAGGTTGAG 
AAGGAAGGGA ATGCCACTGT GAGTTTCTCA CAGGCCCTGG TAGAGTTCAC CAGCAATGGG 
AACCTCTTTT CCAGCATGTC CTGCAGCTCT GACTCTGACT CATCTTTCAC TCAAAACCTC 
CCTGAGCTGC CTCCCATGGT GACCTTTGAC ATCGCTGATG TGGAACGGGA TGGGGAAGGC 
AAGTGTGAAG AGAATCCTGA GTTCCACAAT GATGAAGATC TTGCAGCCTC CTTGGAAGCC 
TTTGAGCTGG GCTACTATCA CAAACATGCC TTCAACAACT ACCATAGTCG ATTCTACCAA 
GGCCTGCCCT GGGGTGTGAG CAGCCTCCCT CGATACTTGG GACTGCCTGG CCTGCACCCT 
CGACCTCCAC CTGCTGCTAT GGCCCTCAAC AGGAGAAGCC GCTCTCTCGA CACTGCAGAG 
ACCCTGGAGA TGGAGCTCTC CAATTCCCAC TTGGTCCAGG GCTACCTCGA GTCTGATGAG 
CTGCAGGCCC AGCAGGAAGA TTCAGATGAG GAGGACGAAG AGGAGGAAGA AGGAGAATGG 
AGCCGAGACA GTCCCCTTTC CCTCTATACT GAACCCCCAG GGGCCTATGA TTGGCCTGCT 
TGGGCTCCCT GTCCTCTTCC AGTGGGGCCA GGTCCTGCCT GGATAAGCCC CAACCAGTTG 
GACAGGCCTT CCAGCCAGTC TCCATATAGG CAGGCAACCT GTTGCATACC TCCTATGACC 
ATGTCAATAT CACTATCAGT GCCAGAGTCA AGGGCACCTG GGGAATCTGG GCCTCAACTA 
GCTCGTCCCT CACACCTACA CCTGCCCATG GGCCCTTGCT ATAACCTCCA GCCACAGGCC 
TCCCAGAGCA TGAGGGCCAG GCCTCGAGAT GTGCTGCTGC CTGTTGATGA GCCCAGTTGC 
TCTTCCAGTT CTGGAGGCTT CAGCCCCAGC CCTCTACCAC AGGCCAAGCC TGTGGGCATC 
ACCCATGGCA TTCCTCAGCT GCCCAGGGTC CGGCCTGAGC ACCCCCAGCC TCAGCCCACT 
CACTATGGGC CTTCCAGCCT TGACCTGTCA AAGGAGAGGG CTGAGCAAGG TGCCTCTCTT 
GCCACCAGCT ACTCCTCCAC TGCCATGAAT GGAAACCTAG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689637.3
CDS	238..3645
Translation	METQKDEAAQAKGAAASGSTREQTAEKGAKNKAAEATEGPTSEPSSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAAHGPEDVVSEGTGFSLPLPELPCQFPSSQSAHGALETGSRCKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEPGAKGPERVRARPHEHVSSAPQVPCFEETFQAPRKENANPQDAPGPKVSPTPEPSPPATEKMACKDPEKPMEACASAHVQPKPAPEASSLEEPHSPETGEKVVAGEVNPPNGPVGDPLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEEVELEEEEEEVKEEEEDDDLEYLWETAQMYPRPNMNLGYHPTTSPGHHGYMLLDPVRSYPGLAPGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLVRRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHGRSSEMFDPFLNFEPFLSSRPPGAMETEEERLVTIQKQLLYWELRREQLEAQEARAREAHAREAHAREAYTREAYGREAYAREAHTWEAHGREARTREAQAREVRCRETQVRETQARQEKPVLEYQMRPLGPSVMGLAAGVSGTSQISHRGITSAFPTTASSEPDWRDFRPLEKRYEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEDPEEEEVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYHKHAFNNYHSRFYQGLPWGVSSLPRYLGLPGLHPRPPPAAMALNRRSRSLDTAETLEMELSNSHLVQGYLESDELQAQQEDSDEEDEEEEEGEWSRDSPLSLYTEPPGAYDWPAWAPCPLPVGPGPAWISPNQLDRPSSQSPYRQATCCIPPMTMSISLSVPESRAPGESGPQLARPSHLHLPMGPCYNLQPQASQSMRARPRDVLLPVDEPSCSSSSGGFSPSPLPQAKPVGITHGIPQLPRVRPEHPQPQPTHYGPSSLDLSKERAEQGASLATSYSSTAMNGNLAK

Target ORF information:

RefSeq Version	NM_152424.4
Organism	Homo sapiens(human)
Definition	Homo sapiens APC membrane recruitment protein 1 (AMER1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152424.4

ORF Insert Sequence:

ATGGAGACCC AAAAGGATGA AGCTGCTCAG GCCAAGGGAG CTGCAGCCTC TGGGAGTACC 
CGTGAACAAA CAGCAGAAAA AGGAGCCAAG AACAAGGCAG CTGAGGCGAC AGAAGGACCA 
ACCTCAGAGC CATCCTCATC CGGCCCAGGT AGGCTGAAGA AAACTGCCAT GAAACTCTTT 
GGTGGCAAGA AGGGTATCTG TACTCTGCCT AGTTTCTTTG GAGGGGGACG GAGCAAAGGT 
TCTGGGAAAG GCAGCTCCAA GAAAGGTCTC AGCAAGAGCA AGACCCACGA TGGCCTGAGT 
GAAGCAGCCC ATGGCCCTGA AGATGTTGTC AGTGAAGGAA CTGGCTTCTC CCTGCCTTTG 
CCTGAGTTAC CCTGCCAATT TCCCAGCTCT CAGAGTGCCC ATGGGGCTTT GGAGACAGGC 
TCCAGATGTA AGACATCTGT GGCTGGAGCC ACAGAGAAAG CTGTGGCTGA GAAGTTTCCC 
TCTATGCCCA AGCCAAAGAA AGGCCTAAAA GGCTTTTTTA GCAGTATCCG CCGTCACCGG 
AAGAGCAAGG TCACTGGGGC TGAGCAAAGT GAGCCAGGGG CCAAGGGGCC TGAGAGGGTC 
AGAGCCAGGC CTCATGAGCA CGTGAGCTCA GCCCCTCAGG TGCCCTGCTT TGAGGAGACC 
TTCCAAGCCC CTAGAAAGGA AAATGCTAAC CCCCAAGATG CCCCTGGGCC AAAAGTTTCT 
CCAACACCAG AACCTTCTCC ACCAGCTACT GAGAAAATGG CCTGTAAAGA TCCAGAAAAA 
CCCATGGAGG CCTGTGCCTC AGCACATGTG CAACCCAAGC CTGCCCCTGA AGCCAGTAGC 
CTAGAGGAGC CCCATAGCCC AGAAACAGGG GAGAAGGTAG TAGCAGGAGA GGTAAACCCA 
CCCAATGGCC CTGTGGGGGA CCCACTGAGC CTCTTGTTTG GGGATGTGAC ATCCCTGAAA 
AGCTTTGATT CATTGACAGG TTGTGGTGAC ATAATAGCAG AACAGGACAT GGACAGTATG 
ACAGACAGCA TGGCCTCTGG GGGCCAGAGA GCAAACCGAG ATGGGACCAA GCGAAGTTCC 
TGCCTGGTGA CCTACCAAGG AGGTGGGGAG GAGATGGCCT TGCCAGATGA TGATGACGAG 
GAGGAAGAAG AGGAAGAAGA GGTGGAATTA GAGGAGGAAG AAGAGGAGGT TAAGGAGGAG 
GAAGAAGATG ATGACTTAGA ATATCTGTGG GAAACTGCCC AAATGTATCC ACGGCCCAAT 
ATGAACCTGG GCTACCATCC CACCACATCC CCAGGCCACC ACGGCTACAT GCTCCTTGAC 
CCAGTTAGGT CTTATCCTGG CCTAGCCCCT GGGGAACTTT TGACTCCTCA GAGTGACCAG 
CAAGAATCCG CCCCCAATAG TGATGAAGGT TATTATGACT CCACCACACC TGGATTTGAG 
GATGATTCAG GTGAGGCCCT GGGGCTTGTC CGCAGGGATT GTCTACCCCG AGACAGCTAC 
AGTGGAGATG CCCTATATGA GTTCTATGAG CCAGATGACA GCCTTGAGAA CTCTCCACCT 
GGAGATGACT GCCTTTATGA CCTCCATGGT CGAAGCTCTG AGATGTTTGA CCCCTTCTTA 
AACTTTGAGC CCTTTTTGTC CTCCCGGCCA CCTGGGGCAA TGGAGACAGA GGAAGAACGG 
CTAGTGACCA TCCAGAAACA GTTGTTGTAT TGGGAGCTTC GGCGGGAGCA GCTTGAGGCC 
CAGGAGGCAC GTGCCCGAGA AGCTCATGCC AGGGAGGCCC ACGCCAGGGA GGCCTATACT 
CGAGAGGCTT ATGGCAGGGA AGCCTATGCC AGGGAGGCCC ACACTTGGGA AGCTCATGGC 
AGGGAGGCCA GAACCCGAGA AGCCCAGGCC CGAGAGGTTC GTTGTAGAGA GACTCAAGTC 
CGAGAGACCC AGGCCCGGCA GGAGAAGCCC GTCTTAGAGT ATCAGATGAG GCCCTTAGGC 
CCATCAGTGA TGGGCCTGGC AGCAGGGGTA TCAGGGACCT CTCAGATTTC CCACCGGGGA 
ATTACCTCAG CTTTCCCCAC CACTGCAAGC AGCGAGCCAG ACTGGAGGGA CTTCCGTCCT 
CTGGAGAAGC GTTATGAAGG AACCTGCTCC AAGAAAGATC AAAGTACCTG CCTGATGCAG 
CTCTTCCAGA GTGATGCCAT GTTTGAGCCA GACATGCAAG AAGCAAATTT TGGAGGATCT 
CCCAGGAGGG CCTACCCTAC TTATTCACCC CCTGAAGATC CAGAGGAAGA GGAGGTTGAG 
AAGGAAGGGA ATGCCACTGT GAGTTTCTCA CAGGCCCTGG TAGAGTTCAC CAGCAATGGG 
AACCTCTTTT CCAGCATGTC CTGCAGCTCT GACTCTGACT CATCTTTCAC TCAAAACCTC 
CCTGAGCTGC CTCCCATGGT GACCTTTGAC ATCGCTGATG TGGAACGGGA TGGGGAAGGC 
AAGTGTGAAG AGAATCCTGA GTTCCACAAT GATGAAGATC TTGCAGCCTC CTTGGAAGCC 
TTTGAGCTGG GCTACTATCA CAAACATGCC TTCAACAACT ACCATAGTCG ATTCTACCAA 
GGCCTGCCCT GGGGTGTGAG CAGCCTCCCT CGATACTTGG GACTGCCTGG CCTGCACCCT 
CGACCTCCAC CTGCTGCTAT GGCCCTCAAC AGGAGAAGCC GCTCTCTCGA CACTGCAGAG 
ACCCTGGAGA TGGAGCTCTC CAATTCCCAC TTGGTCCAGG GCTACCTCGA GTCTGATGAG 
CTGCAGGCCC AGCAGGAAGA TTCAGATGAG GAGGACGAAG AGGAGGAAGA AGGAGAATGG 
AGCCGAGACA GTCCCCTTTC CCTCTATACT GAACCCCCAG GGGCCTATGA TTGGCCTGCT 
TGGGCTCCCT GTCCTCTTCC AGTGGGGCCA GGTCCTGCCT GGATAAGCCC CAACCAGTTG 
GACAGGCCTT CCAGCCAGTC TCCATATAGG CAGGCAACCT GTTGCATACC TCCTATGACC 
ATGTCAATAT CACTATCAGT GCCAGAGTCA AGGGCACCTG GGGAATCTGG GCCTCAACTA 
GCTCGTCCCT CACACCTACA CCTGCCCATG GGCCCTTGCT ATAACCTCCA GCCACAGGCC 
TCCCAGAGCA TGAGGGCCAG GCCTCGAGAT GTGCTGCTGC CTGTTGATGA GCCCAGTTGC 
TCTTCCAGTT CTGGAGGCTT CAGCCCCAGC CCTCTACCAC AGGCCAAGCC TGTGGGCATC 
ACCCATGGCA TTCCTCAGCT GCCCAGGGTC CGGCCTGAGC ACCCCCAGCC TCAGCCCACT 
CACTATGGGC CTTCCAGCCT TGACCTGTCA AAGGAGAGGG CTGAGCAAGG TGCCTCTCTT 
GCCACCAGCT ACTCCTCCAC TGCCATGAAT GGAAACCTAG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AMER1 ( XM_011530858.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529160.1 Homo sapiens APC membrane recruitment protein 1 (AMER1), transcript variant X1, mRNA.

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CloneID	OHu19021
Clone ID Related Accession (Same CDS sequence)	XM_011530858.1 , NM_152424.3 , NM_152424.4
Accession Version	XM_011530858.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	APC membrane recruitment protein 1 isoform X1
Comment

ATGGAGACCC AAAAGGATGA AGCTGCTCAG GCCAAGGGAG CTGCAGCCTC TGGGAGTACC 
CGTGAACAAA CAGCAGAAAA AGGAGCCAAG AACAAGGCAG CTGAGGCGAC AGAAGGACCA 
ACCTCAGAGC CATCCTCATC CGGCCCAGGT AGGCTGAAGA AAACTGCCAT GAAACTCTTT 
GGTGGCAAGA AGGGTATCTG TACTCTGCCT AGTTTCTTTG GAGGGGGACG GAGCAAAGGT 
TCTGGGAAAG GCAGCTCCAA GAAAGGTCTC AGCAAGAGCA AGACCCACGA TGGCCTGAGT 
GAAGCAGCCC ATGGCCCTGA AGATGTTGTC AGTGAAGGAA CTGGCTTCTC CCTGCCTTTG 
CCTGAGTTAC CCTGCCAATT TCCCAGCTCT CAGAGTGCCC ATGGGGCTTT GGAGACAGGC 
TCCAGATGTA AGACATCTGT GGCTGGAGCC ACAGAGAAAG CTGTGGCTGA GAAGTTTCCC 
TCTATGCCCA AGCCAAAGAA AGGCCTAAAA GGCTTTTTTA GCAGTATCCG CCGTCACCGG 
AAGAGCAAGG TCACTGGGGC TGAGCAAAGT GAGCCAGGGG CCAAGGGGCC TGAGAGGGTC 
AGAGCCAGGC CTCATGAGCA CGTGAGCTCA GCCCCTCAGG TGCCCTGCTT TGAGGAGACC 
TTCCAAGCCC CTAGAAAGGA AAATGCTAAC CCCCAAGATG CCCCTGGGCC AAAAGTTTCT 
CCAACACCAG AACCTTCTCC ACCAGCTACT GAGAAAATGG CCTGTAAAGA TCCAGAAAAA 
CCCATGGAGG CCTGTGCCTC AGCACATGTG CAACCCAAGC CTGCCCCTGA AGCCAGTAGC 
CTAGAGGAGC CCCATAGCCC AGAAACAGGG GAGAAGGTAG TAGCAGGAGA GGTAAACCCA 
CCCAATGGCC CTGTGGGGGA CCCACTGAGC CTCTTGTTTG GGGATGTGAC ATCCCTGAAA 
AGCTTTGATT CATTGACAGG TTGTGGTGAC ATAATAGCAG AACAGGACAT GGACAGTATG 
ACAGACAGCA TGGCCTCTGG GGGCCAGAGA GCAAACCGAG ATGGGACCAA GCGAAGTTCC 
TGCCTGGTGA CCTACCAAGG AGGTGGGGAG GAGATGGCCT TGCCAGATGA TGATGACGAG 
GAGGAAGAAG AGGAAGAAGA GGTGGAATTA GAGGAGGAAG AAGAGGAGGT TAAGGAGGAG 
GAAGAAGATG ATGACTTAGA ATATCTGTGG GAAACTGCCC AAATGTATCC ACGGCCCAAT 
ATGAACCTGG GCTACCATCC CACCACATCC CCAGGCCACC ACGGCTACAT GCTCCTTGAC 
CCAGTTAGGT CTTATCCTGG CCTAGCCCCT GGGGAACTTT TGACTCCTCA GAGTGACCAG 
CAAGAATCCG CCCCCAATAG TGATGAAGGT TATTATGACT CCACCACACC TGGATTTGAG 
GATGATTCAG GTGAGGCCCT GGGGCTTGTC CGCAGGGATT GTCTACCCCG AGACAGCTAC 
AGTGGAGATG CCCTATATGA GTTCTATGAG CCAGATGACA GCCTTGAGAA CTCTCCACCT 
GGAGATGACT GCCTTTATGA CCTCCATGGT CGAAGCTCTG AGATGTTTGA CCCCTTCTTA 
AACTTTGAGC CCTTTTTGTC CTCCCGGCCA CCTGGGGCAA TGGAGACAGA GGAAGAACGG 
CTAGTGACCA TCCAGAAACA GTTGTTGTAT TGGGAGCTTC GGCGGGAGCA GCTTGAGGCC 
CAGGAGGCAC GTGCCCGAGA AGCTCATGCC AGGGAGGCCC ACGCCAGGGA GGCCTATACT 
CGAGAGGCTT ATGGCAGGGA AGCCTATGCC AGGGAGGCCC ACACTTGGGA AGCTCATGGC 
AGGGAGGCCA GAACCCGAGA AGCCCAGGCC CGAGAGGTTC GTTGTAGAGA GACTCAAGTC 
CGAGAGACCC AGGCCCGGCA GGAGAAGCCC GTCTTAGAGT ATCAGATGAG GCCCTTAGGC 
CCATCAGTGA TGGGCCTGGC AGCAGGGGTA TCAGGGACCT CTCAGATTTC CCACCGGGGA 
ATTACCTCAG CTTTCCCCAC CACTGCAAGC AGCGAGCCAG ACTGGAGGGA CTTCCGTCCT 
CTGGAGAAGC GTTATGAAGG AACCTGCTCC AAGAAAGATC AAAGTACCTG CCTGATGCAG 
CTCTTCCAGA GTGATGCCAT GTTTGAGCCA GACATGCAAG AAGCAAATTT TGGAGGATCT 
CCCAGGAGGG CCTACCCTAC TTATTCACCC CCTGAAGATC CAGAGGAAGA GGAGGTTGAG 
AAGGAAGGGA ATGCCACTGT GAGTTTCTCA CAGGCCCTGG TAGAGTTCAC CAGCAATGGG 
AACCTCTTTT CCAGCATGTC CTGCAGCTCT GACTCTGACT CATCTTTCAC TCAAAACCTC 
CCTGAGCTGC CTCCCATGGT GACCTTTGAC ATCGCTGATG TGGAACGGGA TGGGGAAGGC 
AAGTGTGAAG AGAATCCTGA GTTCCACAAT GATGAAGATC TTGCAGCCTC CTTGGAAGCC 
TTTGAGCTGG GCTACTATCA CAAACATGCC TTCAACAACT ACCATAGTCG ATTCTACCAA 
GGCCTGCCCT GGGGTGTGAG CAGCCTCCCT CGATACTTGG GACTGCCTGG CCTGCACCCT 
CGACCTCCAC CTGCTGCTAT GGCCCTCAAC AGGAGAAGCC GCTCTCTCGA CACTGCAGAG 
ACCCTGGAGA TGGAGCTCTC CAATTCCCAC TTGGTCCAGG GCTACCTCGA GTCTGATGAG 
CTGCAGGCCC AGCAGGAAGA TTCAGATGAG GAGGACGAAG AGGAGGAAGA AGGAGAATGG 
AGCCGAGACA GTCCCCTTTC CCTCTATACT GAACCCCCAG GGGCCTATGA TTGGCCTGCT 
TGGGCTCCCT GTCCTCTTCC AGTGGGGCCA GGTCCTGCCT GGATAAGCCC CAACCAGTTG 
GACAGGCCTT CCAGCCAGTC TCCATATAGG CAGGCAACCT GTTGCATACC TCCTATGACC 
ATGTCAATAT CACTATCAGT GCCAGAGTCA AGGGCACCTG GGGAATCTGG GCCTCAACTA 
GCTCGTCCCT CACACCTACA CCTGCCCATG GGCCCTTGCT ATAACCTCCA GCCACAGGCC 
TCCCAGAGCA TGAGGGCCAG GCCTCGAGAT GTGCTGCTGC CTGTTGATGA GCCCAGTTGC 
TCTTCCAGTT CTGGAGGCTT CAGCCCCAGC CCTCTACCAC AGGCCAAGCC TGTGGGCATC 
ACCCATGGCA TTCCTCAGCT GCCCAGGGTC CGGCCTGAGC ACCCCCAGCC TCAGCCCACT 
CACTATGGGC CTTCCAGCCT TGACCTGTCA AAGGAGAGGG CTGAGCAAGG TGCCTCTCTT 
GCCACCAGCT ACTCCTCCAC TGCCATGAAT GGAAACCTAG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011529160.1

Translation

METQKDEAAQAKGAAASGSTREQTAEKGAKNKAAEATEGPTSEPSSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAAHGPEDVVSEGTGFSLPLPELPCQFPSSQSAHGALETGSRCKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEPGAKGPERVRARPHEHVSSAPQVPCFEETFQAPRKENANPQDAPGPKVSPTPEPSPPATEKMACKDPEKPMEACASAHVQPKPAPEASSLEEPHSPETGEKVVAGEVNPPNGPVGDPLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEEVELEEEEEEVKEEEEDDDLEYLWETAQMYPRPNMNLGYHPTTSPGHHGYMLLDPVRSYPGLAPGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLVRRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHGRSSEMFDPFLNFEPFLSSRPPGAMETEEERLVTIQKQLLYWELRREQLEAQEARAREAHAREAHAREAYTREAYGREAYAREAHTWEAHGREARTREAQAREVRCRETQVRETQARQEKPVLEYQMRPLGPSVMGLAAGVSGTSQISHRGITSAFPTTASSEPDWRDFRPLEKRYEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEDPEEEEVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYHKHAFNNYHSRFYQGLPWGVSSLPRYLGLPGLHPRPPPAAMALNRRSRSLDTAETLEMELSNSHLVQGYLESDELQAQQEDSDEEDEEEEEGEWSRDSPLSLYTEPPGAYDWPAWAPCPLPVGPGPAWISPNQLDRPSSQSPYRQATCCIPPMTMSISLSVPESRAPGESGPQLARPSHLHLPMGPCYNLQPQASQSMRARPRDVLLPVDEPSCSSSSGGFSPSPLPQAKPVGITHGIPQLPRVRPEHPQPQPTHYGPSSLDLSKERAEQGASLATSYSSTAMNGNLAK

Target ORF information:

RefSeq Version	XM_011530858.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens APC membrane recruitment protein 1 (AMER1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530858.1

ORF Insert Sequence:

ATGGAGACCC AAAAGGATGA AGCTGCTCAG GCCAAGGGAG CTGCAGCCTC TGGGAGTACC 
CGTGAACAAA CAGCAGAAAA AGGAGCCAAG AACAAGGCAG CTGAGGCGAC AGAAGGACCA 
ACCTCAGAGC CATCCTCATC CGGCCCAGGT AGGCTGAAGA AAACTGCCAT GAAACTCTTT 
GGTGGCAAGA AGGGTATCTG TACTCTGCCT AGTTTCTTTG GAGGGGGACG GAGCAAAGGT 
TCTGGGAAAG GCAGCTCCAA GAAAGGTCTC AGCAAGAGCA AGACCCACGA TGGCCTGAGT 
GAAGCAGCCC ATGGCCCTGA AGATGTTGTC AGTGAAGGAA CTGGCTTCTC CCTGCCTTTG 
CCTGAGTTAC CCTGCCAATT TCCCAGCTCT CAGAGTGCCC ATGGGGCTTT GGAGACAGGC 
TCCAGATGTA AGACATCTGT GGCTGGAGCC ACAGAGAAAG CTGTGGCTGA GAAGTTTCCC 
TCTATGCCCA AGCCAAAGAA AGGCCTAAAA GGCTTTTTTA GCAGTATCCG CCGTCACCGG 
AAGAGCAAGG TCACTGGGGC TGAGCAAAGT GAGCCAGGGG CCAAGGGGCC TGAGAGGGTC 
AGAGCCAGGC CTCATGAGCA CGTGAGCTCA GCCCCTCAGG TGCCCTGCTT TGAGGAGACC 
TTCCAAGCCC CTAGAAAGGA AAATGCTAAC CCCCAAGATG CCCCTGGGCC AAAAGTTTCT 
CCAACACCAG AACCTTCTCC ACCAGCTACT GAGAAAATGG CCTGTAAAGA TCCAGAAAAA 
CCCATGGAGG CCTGTGCCTC AGCACATGTG CAACCCAAGC CTGCCCCTGA AGCCAGTAGC 
CTAGAGGAGC CCCATAGCCC AGAAACAGGG GAGAAGGTAG TAGCAGGAGA GGTAAACCCA 
CCCAATGGCC CTGTGGGGGA CCCACTGAGC CTCTTGTTTG GGGATGTGAC ATCCCTGAAA 
AGCTTTGATT CATTGACAGG TTGTGGTGAC ATAATAGCAG AACAGGACAT GGACAGTATG 
ACAGACAGCA TGGCCTCTGG GGGCCAGAGA GCAAACCGAG ATGGGACCAA GCGAAGTTCC 
TGCCTGGTGA CCTACCAAGG AGGTGGGGAG GAGATGGCCT TGCCAGATGA TGATGACGAG 
GAGGAAGAAG AGGAAGAAGA GGTGGAATTA GAGGAGGAAG AAGAGGAGGT TAAGGAGGAG 
GAAGAAGATG ATGACTTAGA ATATCTGTGG GAAACTGCCC AAATGTATCC ACGGCCCAAT 
ATGAACCTGG GCTACCATCC CACCACATCC CCAGGCCACC ACGGCTACAT GCTCCTTGAC 
CCAGTTAGGT CTTATCCTGG CCTAGCCCCT GGGGAACTTT TGACTCCTCA GAGTGACCAG 
CAAGAATCCG CCCCCAATAG TGATGAAGGT TATTATGACT CCACCACACC TGGATTTGAG 
GATGATTCAG GTGAGGCCCT GGGGCTTGTC CGCAGGGATT GTCTACCCCG AGACAGCTAC 
AGTGGAGATG CCCTATATGA GTTCTATGAG CCAGATGACA GCCTTGAGAA CTCTCCACCT 
GGAGATGACT GCCTTTATGA CCTCCATGGT CGAAGCTCTG AGATGTTTGA CCCCTTCTTA 
AACTTTGAGC CCTTTTTGTC CTCCCGGCCA CCTGGGGCAA TGGAGACAGA GGAAGAACGG 
CTAGTGACCA TCCAGAAACA GTTGTTGTAT TGGGAGCTTC GGCGGGAGCA GCTTGAGGCC 
CAGGAGGCAC GTGCCCGAGA AGCTCATGCC AGGGAGGCCC ACGCCAGGGA GGCCTATACT 
CGAGAGGCTT ATGGCAGGGA AGCCTATGCC AGGGAGGCCC ACACTTGGGA AGCTCATGGC 
AGGGAGGCCA GAACCCGAGA AGCCCAGGCC CGAGAGGTTC GTTGTAGAGA GACTCAAGTC 
CGAGAGACCC AGGCCCGGCA GGAGAAGCCC GTCTTAGAGT ATCAGATGAG GCCCTTAGGC 
CCATCAGTGA TGGGCCTGGC AGCAGGGGTA TCAGGGACCT CTCAGATTTC CCACCGGGGA 
ATTACCTCAG CTTTCCCCAC CACTGCAAGC AGCGAGCCAG ACTGGAGGGA CTTCCGTCCT 
CTGGAGAAGC GTTATGAAGG AACCTGCTCC AAGAAAGATC AAAGTACCTG CCTGATGCAG 
CTCTTCCAGA GTGATGCCAT GTTTGAGCCA GACATGCAAG AAGCAAATTT TGGAGGATCT 
CCCAGGAGGG CCTACCCTAC TTATTCACCC CCTGAAGATC CAGAGGAAGA GGAGGTTGAG 
AAGGAAGGGA ATGCCACTGT GAGTTTCTCA CAGGCCCTGG TAGAGTTCAC CAGCAATGGG 
AACCTCTTTT CCAGCATGTC CTGCAGCTCT GACTCTGACT CATCTTTCAC TCAAAACCTC 
CCTGAGCTGC CTCCCATGGT GACCTTTGAC ATCGCTGATG TGGAACGGGA TGGGGAAGGC 
AAGTGTGAAG AGAATCCTGA GTTCCACAAT GATGAAGATC TTGCAGCCTC CTTGGAAGCC 
TTTGAGCTGG GCTACTATCA CAAACATGCC TTCAACAACT ACCATAGTCG ATTCTACCAA 
GGCCTGCCCT GGGGTGTGAG CAGCCTCCCT CGATACTTGG GACTGCCTGG CCTGCACCCT 
CGACCTCCAC CTGCTGCTAT GGCCCTCAAC AGGAGAAGCC GCTCTCTCGA CACTGCAGAG 
ACCCTGGAGA TGGAGCTCTC CAATTCCCAC TTGGTCCAGG GCTACCTCGA GTCTGATGAG 
CTGCAGGCCC AGCAGGAAGA TTCAGATGAG GAGGACGAAG AGGAGGAAGA AGGAGAATGG 
AGCCGAGACA GTCCCCTTTC CCTCTATACT GAACCCCCAG GGGCCTATGA TTGGCCTGCT 
TGGGCTCCCT GTCCTCTTCC AGTGGGGCCA GGTCCTGCCT GGATAAGCCC CAACCAGTTG 
GACAGGCCTT CCAGCCAGTC TCCATATAGG CAGGCAACCT GTTGCATACC TCCTATGACC 
ATGTCAATAT CACTATCAGT GCCAGAGTCA AGGGCACCTG GGGAATCTGG GCCTCAACTA 
GCTCGTCCCT CACACCTACA CCTGCCCATG GGCCCTTGCT ATAACCTCCA GCCACAGGCC 
TCCCAGAGCA TGAGGGCCAG GCCTCGAGAT GTGCTGCTGC CTGTTGATGA GCCCAGTTGC 
TCTTCCAGTT CTGGAGGCTT CAGCCCCAGC CCTCTACCAC AGGCCAAGCC TGTGGGCATC 
ACCCATGGCA TTCCTCAGCT GCCCAGGGTC CGGCCTGAGC ACCCCCAGCC TCAGCCCACT 
CACTATGGGC CTTCCAGCCT TGACCTGTCA AAGGAGAGGG CTGAGCAAGG TGCCTCTCTT 
GCCACCAGCT ACTCCTCCAC TGCCATGAAT GGAAACCTAG CCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High bone mass due to novel LRP5 and AMER1 mutations.
European journal of medical genetics60(12)675-679(2017 Dec)
Costantini A,Kek?l?inen P,M?kitie RE,M?kitie O

Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society20(2)105-111(2017 Mar-Apr)
Alexandrescu S,Akhavanfard S,Harris MH,Vargas SO

Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research21(20)4709-18(2015 Oct)
Sanz-Pamplona R,Lopez-Doriga A,Par?-Brunet L,L?zaro K,Bellido F,Alonso MH,Auss? S,Guin? E,Beltr?n S,Castro-Giner F,Gut M,Sanjuan X,Closa A,Cordero D,Mor?n-Duran FD,Soriano A,Salazar R,Valle L,Moreno V

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

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AMER1 cDNA ORF clone, Homo sapiens(human)

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