CREBL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CREBL2
Entrez Gene ID	1389
Full Name	cAMP responsive element binding protein like 2
General protein information	Preferred Names cAMP responsive element binding protein like 2 Names cAMP-responsive element-binding protein-like 2 MHBs-binding protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.1
Summary	cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	603476

mRNA and Protein(s)

mRNA	Protein	Name
NM_001310.3	NP_001301.1	cAMP-responsive element-binding protein-like 2
NM_001310.4	NP_001301.1	cAMP-responsive element-binding protein-like 2

Pathways from BioSystems

Homologies

	CREBL2	XP_001085204.1
Canis lupus familiaris (dog)	CREBL2	XP_853938.1
Bos taurus (cattle)	CREBL2	NP_001069556.1
Mus musculus (house mouse)	Crebl2	NP_808355.1
Rattus norvegicus (Norway rat)	Crebl2	NP_001015027.1
Xenopus tropicalis (tropical clawed frog)	crebl2	NP_001090852.1
Homo sapiens (human)	CREBL2	NP_001301.1
Pan troglodytes (chimpanzee)	CREBL2	XP_001153386.1
Gallus gallus (chicken)	CREBL2	NP_001265039.1
Danio rerio (zebrafish)	crebl2	NP_001002702.2
Drosophila melanogaster (fruit fly)	CG18619	NP_609363.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008762	XP_314882.4

Gene Ontology
Bibliography

Related articles in PubMed

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.
Al-Shehhi H, Konn ZJ, Schwab CJ, Erhorn A, Barber KE, Wright SL, Gabriel AS, Harrison CJ, Moorman AV
Genes, chromosomes & cancer52(2)202-13(2013 Feb)

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, Yang J, Cui Y, Zhang L, Hirankarn N, Cheng H, Pan HF, Gao J, Lee TL, Sheng Y, Lau CS, Li Y, Chan TM, Yin X, Ying D, Lu Q, Leung AM, Zuo X, Chen X, Tong KL, Zhou F, Diao Q, Tse NK, Xie H, Mok CC, Hao F, Wong SN, Shi B, Lee KW, Hui Y, Ho MH, Liang B, Lee PP, Cui H, Guo Q, Chung BH, Pu X, Liu Q, Zhang X, Zhang C, Chong CY, Fang H, Wong RW, Sun Y, Mok MY, Li XP, Avihingsanon Y, Zhai Z, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Gao F, Shotelersuk V, Kang X, Ying SK, Zhang L, Wong WH, Zhu D, Fung SK, Zeng F, Lai WM, Wong CM, Ng IO, Garcia-Barcel? MM, Cherny SS, Shen N, Tam PK, Sham PC, Ye DQ, Yang S, Zhang X, Lau YL
American journal of human genetics92(1)41-51(2013 Jan)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.
Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP
Physiological genomics25(1)9-15(2006 Mar)

CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B.
Hoornaert I, Marynen P, Baens M
Genomics51(1)154-7(1998 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that LRP6, BCL2L14, DUSP16, CREBL2, and CDKN1B were involed in centromeric (12p11.21-12p13.2) deletion in ETV6-RUNX1 B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
Title: Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.

The following CREBL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CREBL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12259	NM_001310.4 Latest version!	Homo sapiens cAMP responsive element binding protein like 2 (CREBL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12259	NM_001310.3	Homo sapiens cAMP responsive element binding protein like 2 (CREBL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CREBL2 ( NM_001310.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001301.1 Homo sapiens cAMP responsive element binding protein like 2 (CREBL2), mRNA.

Price & Availability↑

CloneID	OHu12259
Clone ID Related Accession (Same CDS sequence)	NM_001310.3 , NM_001310.4
Accession Version	NM_001310.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	cAMP-responsive element-binding protein-like 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY795169.2, BC106052.1, AC008115.4 and AI375846.1. On Sep 7, 2013 this sequence version replaced NM_001310.2. ##Evidence-Data-START## Transcript exon combination :: BC106052.1, AF039081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGACA GTAAGGTGGT TGGAGGCAAA GTAAAGAAGC CCGGTAAACG TGGTCGGAAG 
CCAGCCAAAA TTGACTTGAA AGCAAAACTT GAGAGGAGCC GGCAGAGTGC AAGAGAATGC 
CGAGCCCGAA AAAAGCTGAG ATATCAGTAT TTGGAAGAGT TGGTATCCAG TCGAGAAAGA 
GCTATATGTG CCCTCAGAGA GGAACTGGAA ATGTACAAGC AGTGGTGCAT GGCAATGGAC 
CAAGGAAAAA TCCCTTCTGA AATAAAGGCC CTACTCACTG GAGAAGAGCA GAACAAATCT 
CAGCAGAACT CAAGCAGGCA TACCAAGGCT GGGAAGACAG ATGCTAATAG CAATTCCTGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001301.1
CDS	341..703
Translation	MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW

Target ORF information:

RefSeq Version	NM_001310.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cAMP responsive element binding protein like 2 (CREBL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310.3

ORF Insert Sequence:

ATGGATGACA GTAAGGTGGT TGGAGGCAAA GTAAAGAAGC CCGGTAAACG TGGTCGGAAG 
CCAGCCAAAA TTGACTTGAA AGCAAAACTT GAGAGGAGCC GGCAGAGTGC AAGAGAATGC 
CGAGCCCGAA AAAAGCTGAG ATATCAGTAT TTGGAAGAGT TGGTATCCAG TCGAGAAAGA 
GCTATATGTG CCCTCAGAGA GGAACTGGAA ATGTACAAGC AGTGGTGCAT GGCAATGGAC 
CAAGGAAAAA TCCCTTCTGA AATAAAGGCC CTACTCACTG GAGAAGAGCA GAACAAATCT 
CAGCAGAACT CAAGCAGGCA TACCAAGGCT GGGAAGACAG ATGCTAATAG CAATTCCTGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CREBL2 ( NM_001310.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001301.1 Homo sapiens cAMP responsive element binding protein like 2 (CREBL2), mRNA.

Price & Availability↑

CloneID	OHu12259
Clone ID Related Accession (Same CDS sequence)	NM_001310.3 , NM_001310.4
Accession Version	NM_001310.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cAMP-responsive element-binding protein-like 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY795169.2, BC106052.1, AC008115.4 and AI375846.1. On Nov 22, 2018 this sequence version replaced NM_001310.3. ##Evidence-Data-START## Transcript exon combination :: BC106052.1, AF039081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000228865.3/ ENSP00000228865.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATGACA GTAAGGTGGT TGGAGGCAAA GTAAAGAAGC CCGGTAAACG TGGTCGGAAG 
CCAGCCAAAA TTGACTTGAA AGCAAAACTT GAGAGGAGCC GGCAGAGTGC AAGAGAATGC 
CGAGCCCGAA AAAAGCTGAG ATATCAGTAT TTGGAAGAGT TGGTATCCAG TCGAGAAAGA 
GCTATATGTG CCCTCAGAGA GGAACTGGAA ATGTACAAGC AGTGGTGCAT GGCAATGGAC 
CAAGGAAAAA TCCCTTCTGA AATAAAGGCC CTACTCACTG GAGAAGAGCA GAACAAATCT 
CAGCAGAACT CAAGCAGGCA TACCAAGGCT GGGAAGACAG ATGCTAATAG CAATTCCTGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001301.1
CDS	298..660
Translation	MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW

Target ORF information:

RefSeq Version	NM_001310.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cAMP responsive element binding protein like 2 (CREBL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310.4

ORF Insert Sequence:

ATGGATGACA GTAAGGTGGT TGGAGGCAAA GTAAAGAAGC CCGGTAAACG TGGTCGGAAG 
CCAGCCAAAA TTGACTTGAA AGCAAAACTT GAGAGGAGCC GGCAGAGTGC AAGAGAATGC 
CGAGCCCGAA AAAAGCTGAG ATATCAGTAT TTGGAAGAGT TGGTATCCAG TCGAGAAAGA 
GCTATATGTG CCCTCAGAGA GGAACTGGAA ATGTACAAGC AGTGGTGCAT GGCAATGGAC 
CAAGGAAAAA TCCCTTCTGA AATAAAGGCC CTACTCACTG GAGAAGAGCA GAACAAATCT 
CAGCAGAACT CAAGCAGGCA TACCAAGGCT GGGAAGACAG ATGCTAATAG CAATTCCTGG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.
Genes, chromosomes & cancer52(2)202-13(2013 Feb)
Al-Shehhi H,Konn ZJ,Schwab CJ,Erhorn A,Barber KE,Wright SL,Gabriel AS,Harrison CJ,Moorman AV

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
American journal of human genetics92(1)41-51(2013 Jan)
Yang W,Tang H,Zhang Y,Tang X,Zhang J,Sun L,Yang J,Cui Y,Zhang L,Hirankarn N,Cheng H,Pan HF,Gao J,Lee TL,Sheng Y,Lau CS,Li Y,Chan TM,Yin X,Ying D,Lu Q,Leung AM,Zuo X,Chen X,Tong KL,Zhou F,Diao Q,Tse NK,Xie H,Mok CC,Hao F,Wong SN,Shi B,Lee KW,Hui Y,Ho MH,Liang B,Lee PP,Cui H,Guo Q,Chung BH,Pu X,Liu Q,Zhang X,Zhang C,Chong CY,Fang H,Wong RW,Sun Y,Mok MY,Li XP,Avihingsanon Y,Zhai Z,Rianthavorn P,Deekajorndej T,Suphapeetiporn K,Gao F,Shotelersuk V,Kang X,Ying SK,Zhang L,Wong WH,Zhu D,Fung SK,Zeng F,Lai WM,Wong CM,Ng IO,Garcia-Barcel? MM,Cherny SS,Shen N,Tam PK,Sham PC,Ye DQ,Yang S,Zhang X,Lau YL

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.
Physiological genomics25(1)9-15(2006 Mar)
Choy KW,Wang CC,Ogura A,Lau TK,Rogers MS,Ikeo K,Gojobori T,Lam DS,Pang CP

CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B.
Genomics51(1)154-7(1998 Jul)
Hoornaert I,Marynen P,Baens M

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CREBL2 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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