CRABP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRABP1
Entrez Gene ID	1381
Full Name	cellular retinoic acid binding protein 1
Synonyms	CRABP,CRABP-I,CRABPI,RBP5
General protein information	Preferred Names cellular retinoic acid binding protein 1 Names cellular retinoic acid-binding protein 1 cellular retinoic acid-binding protein I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q25.1
Summary	This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008].
Disorder MIM:	180230

mRNA and Protein(s)

mRNA	Protein	Name
NM_004378.2	NP_004369.1	cellular retinoic acid-binding protein 1
NM_004378.3	NP_004369.1	cellular retinoic acid-binding protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CRABP1	NP_004369.1
Bos taurus (cattle)	CRABP1	NP_851371.1
Mus musculus (house mouse)	Crabp1	NP_038524.1
Pan troglodytes (chimpanzee)	CRABP1	XP_001142851.2
	CRABP1	XP_001107715.1
Rattus norvegicus (Norway rat)	Crabp1	NP_001099186.1
Gallus gallus (chicken)	CRABP1	NP_001025710.1
Xenopus tropicalis (tropical clawed frog)	crabp1	XP_002934613.1
Danio rerio (zebrafish)	crabp1b	NP_001001842.1
Danio rerio (zebrafish)	crabp1a	NP_878278.1

Gene Ontology
Bibliography

Related articles in PubMed

CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension.
Celestino R, Nome T, Pestana A, Hoff AM, Gon?alves AP, Pereira L, Cavadas B, Eloy C, Bj?ro T, Sobrinho-Sim?es M, Skotheim RI, Soares P
BMC cancer18(1)68(2018 Jan)

Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.
Nelson CH, Peng CC, Lutz JD, Yeung CK, Zelter A, Isoherranen N
FEBS letters590(16)2527-35(2016 08)

Cell Line-Dependent Variability of Coordinate Expression of p75NTR and CRABP1 and Modulation of Effects of Fenretinide on Neuroblastoma Cells.
Yang YP, Wang S, Li X, Schor NF
Oxidative medicine and cellular longevity20167568287(2016)

CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.
Liu RZ, Garcia E, Glubrecht DD, Poon HY, Mackey JR, Godbout R
Molecular cancer14129(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Holo-CRABPs had higher affinity for CYP26B1 than free atRA, but both apo-CRABPs(CRABP-I and CRABP-II ) inhibited the formation of 4-OH-RA by CYP26B1.
Title: Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.

p75NTR and CRABP1 modulate the effect of fenretinide on neuroblastoma cells
Title: Cell Line-Dependent Variability of Coordinate Expression of p75NTR and CRABP1 and Modulation of Effects of Fenretinide on Neuroblastoma Cells.

miR-93/miR-106b/miR-375-CIC-CRABP1 is a novel key regulatory axis in prostate cancer progression
Title: miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression.

CRABP1 expression is maintained in ER- and triple-negative breast tumors, and that elevated levels of CRABP1 is a significant indicator of high tumor grade, Ki67 immunoreactivity, and poor prognosis.
Title: CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.

we demonstrated significant changes in CRABP1 and CRABP2 expression in non-small cell lung cancer samples
Title: Expression and clinical significance of CRABP1 and CRABP2 in non-small cell lung cancer.

The following CRABP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRABP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31643	NM_004378.3 Latest version!	Homo sapiens cellular retinoic acid binding protein 1 (CRABP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31643	NM_004378.2	Homo sapiens cellular retinoic acid binding protein 1 (CRABP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRABP1 ( NM_004378.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004369.1 Homo sapiens cellular retinoic acid binding protein 1 (CRABP1), mRNA.

Price & Availability↑

CloneID	OHu31643
Clone ID Related Accession (Same CDS sequence)	NM_004378.2 , NM_004378.3
Accession Version	NM_004378.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cellular retinoic acid-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU132726.1, BC022069.1 and AI863257.1. On Jun 27, 2008 this sequence version replaced NM_004378.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AU132726.1, BU558224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAACT TCGCCGGCAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTGCTC 
AAGGCACTGG GTGTGAACGC CATGCTGAGG AAAGTGGCCG TAGCGGCTGC GTCCAAGCCG 
CACGTGGAGA TCCGCCAGGA CGGGGATCAG TTCTACATCA AGACATCCAC CACGGTGCGC 
ACCACTGAGA TCAACTTCAA GGTCGGAGAA GGCTTTGAGG AGGAGACCGT GGACGGACGC 
AAGTGCAGGA GTTTAGCCAC TTGGGAGAAT GAGAACAAGA TCCACTGCAC GCAAACTCTT 
CTTGAAGGGG ACGGCCCCAA AACCTACTGG ACCCGTGAGC TGGCCAACGA TGAACTTATC 
CTGACGTTTG GCGCCGATGA CGTGGTCTGC ACCAGAATTT ATGTCCGAGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004369.1
CDS	106..519
Translation	MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLATWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE

Target ORF information:

RefSeq Version	NM_004378.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cellular retinoic acid binding protein 1 (CRABP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004378.2

ORF Insert Sequence:

ATGCCCAACT TCGCCGGCAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTGCTC 
AAGGCACTGG GTGTGAACGC CATGCTGAGG AAAGTGGCCG TAGCGGCTGC GTCCAAGCCG 
CACGTGGAGA TCCGCCAGGA CGGGGATCAG TTCTACATCA AGACATCCAC CACGGTGCGC 
ACCACTGAGA TCAACTTCAA GGTCGGAGAA GGCTTTGAGG AGGAGACCGT GGACGGACGC 
AAGTGCAGGA GTTTAGCCAC TTGGGAGAAT GAGAACAAGA TCCACTGCAC GCAAACTCTT 
CTTGAAGGGG ACGGCCCCAA AACCTACTGG ACCCGTGAGC TGGCCAACGA TGAACTTATC 
CTGACGTTTG GCGCCGATGA CGTGGTCTGC ACCAGAATTT ATGTCCGAGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRABP1 ( NM_004378.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004369.1 Homo sapiens cellular retinoic acid binding protein 1 (CRABP1), mRNA.

Price & Availability↑

CloneID	OHu31643
Clone ID Related Accession (Same CDS sequence)	NM_004378.2 , NM_004378.3
Accession Version	NM_004378.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	cellular retinoic acid-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU132726.1, BC022069.1 and AI863257.1. On Nov 23, 2018 this sequence version replaced NM_004378.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.48515.1, BC022069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299529.7/ ENSP00000299529.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAACT TCGCCGGCAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTGCTC 
AAGGCACTGG GTGTGAACGC CATGCTGAGG AAAGTGGCCG TAGCGGCTGC GTCCAAGCCG 
CACGTGGAGA TCCGCCAGGA CGGGGATCAG TTCTACATCA AGACATCCAC CACGGTGCGC 
ACCACTGAGA TCAACTTCAA GGTCGGAGAA GGCTTTGAGG AGGAGACCGT GGACGGACGC 
AAGTGCAGGA GTTTAGCCAC TTGGGAGAAT GAGAACAAGA TCCACTGCAC GCAAACTCTT 
CTTGAAGGGG ACGGCCCCAA AACCTACTGG ACCCGTGAGC TGGCCAACGA TGAACTTATC 
CTGACGTTTG GCGCCGATGA CGTGGTCTGC ACCAGAATTT ATGTCCGAGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004369.1
CDS	77..490
Translation	MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLATWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE

Target ORF information:

RefSeq Version	NM_004378.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cellular retinoic acid binding protein 1 (CRABP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004378.3

ORF Insert Sequence:

ATGCCCAACT TCGCCGGCAC CTGGAAGATG CGCAGCAGCG AGAATTTCGA CGAGCTGCTC 
AAGGCACTGG GTGTGAACGC CATGCTGAGG AAAGTGGCCG TAGCGGCTGC GTCCAAGCCG 
CACGTGGAGA TCCGCCAGGA CGGGGATCAG TTCTACATCA AGACATCCAC CACGGTGCGC 
ACCACTGAGA TCAACTTCAA GGTCGGAGAA GGCTTTGAGG AGGAGACCGT GGACGGACGC 
AAGTGCAGGA GTTTAGCCAC TTGGGAGAAT GAGAACAAGA TCCACTGCAC GCAAACTCTT 
CTTGAAGGGG ACGGCCCCAA AACCTACTGG ACCCGTGAGC TGGCCAACGA TGAACTTATC 
CTGACGTTTG GCGCCGATGA CGTGGTCTGC ACCAGAATTT ATGTCCGAGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension.
BMC cancer18(1)68(2018 Jan)
Celestino R,Nome T,Pestana A,Hoff AM,Gon?alves AP,Pereira L,Cavadas B,Eloy C,Bj?ro T,Sobrinho-Sim?es M,Skotheim RI,Soares P

Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.
FEBS letters590(16)2527-35(2016 08)
Nelson CH,Peng CC,Lutz JD,Yeung CK,Zelter A,Isoherranen N

Cell Line-Dependent Variability of Coordinate Expression of p75NTR and CRABP1 and Modulation of Effects of Fenretinide on Neuroblastoma Cells.
Oxidative medicine and cellular longevity20167568287(2016)
Yang YP,Wang S,Li X,Schor NF

CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.
Molecular cancer14129(2015 Jul)
Liu RZ,Garcia E,Glubrecht DD,Poon HY,Mackey JR,Godbout R

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CRABP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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