CPN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CPN1
Entrez Gene ID	1369
Full Name	carboxypeptidase N subunit 1
Synonyms	CPN,SCPN
General protein information	Preferred Names carboxypeptidase N subunit 1 Names carboxypeptidase N catalytic chain anaphylatoxin inactivator arginine carboxypeptidase carboxypeptidase K carboxypeptidase N catalytic subunit carboxypeptidase N polypeptide 1 50 kD carboxypeptidase N small subunit carboxypeptidase N, polypeptide 1 kininase I kininase-1 lysine carboxypeptidase plasma carboxypeptidase B serum carboxypeptidase N
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.2
Summary	Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008].
Disorder MIM:	603103
Disorder Html:	Carboxypeptidase N deficiency, 212070 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308.3	NP_001299.1	carboxypeptidase N catalytic chain precursor
NM_001308.2	NP_001299.1	carboxypeptidase N catalytic chain precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CPN1	NP_001299.1
Bos taurus (cattle)	CPN1	NP_001069548.1
Rattus norvegicus (Norway rat)	Cpn1	NP_445978.1
Danio rerio (zebrafish)	cpn1	NP_997935.1
Canis lupus familiaris (dog)	CPN1	XP_534989.3
Mus musculus (house mouse)	Cpn1	NP_109628.1
Gallus gallus (chicken)	CPN1	NP_001264183.1
Xenopus tropicalis (tropical clawed frog)	cpn1	NP_001017266.1

Gene Ontology
Bibliography

Related articles in PubMed

Binding of carboxypeptidase N to fibrinogen and fibrin.
Talens S, Lebbink JH, Malfliet JJ, Demmers JA, Uitte de Willige S, Leebeek FW, Rijken DC
Biochemical and biophysical research communications427(2)421-5(2012 Oct)

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, Gonz?lez-Mac?as J, K?h?nen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren ?, Lorenc RS, Marc J, Mellstr?m D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NL, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg E, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina-G?mez C, Palsson ST, Reppe S, Rotter JI, Sigurdsson G, van Meurs JB, Verlaan D, Williams FM, Wood AR, Zhou Y, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Gudnason V, Hofman A, Jackson RD, Jones G, Jukema JW, Khaw KT, Lehtim?ki T, Liu Y, Lorentzon M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson GC, Oostra BA, Peacock M, Pols HA, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, Shuldiner AR, Tylavsky FA, van Duijn CM, Wareham NJ, Cupples LA, Econs MJ, Evans DM, Harris TB, Kung AW, Psaty BM, Reeve J, Spector TD, Streeten EA, Zillikens MC, Thorsteinsdottir U, Ohlsson C, Karasik D, Richards JB, Brown MA, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F
Nature genetics44(5)491-501(2012 Apr)

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, K?hnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, D?ring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hypp?nen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, K?hn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, W?rtz P, Xu C, Yerges-Armstrong LM, , , , , , , , Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietil?inen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, V?lzke H, Schadt EE, Scott J, J?rvelin MR, Elliott P, Kooner JS
Nature genetics43(11)1131-8(2011 Oct)

Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.
Grilo A, S?ez-Rosas MP, Santos-Morano J, S?nchez E, Moreno-Rey C, Real LM, Ram?rez-Lorca R, S?ez ME
Pharmacogenetics and genomics21(1)10-7(2011 Jan)

Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segr? AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, M?gi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, K?nig IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, M?ller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpel?inen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Par? G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietil?inen KH, Pouta A, Ridderstr?le M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, K?h?nen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtim?ki T, Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, T?njes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Gr?nberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, V?lzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN
Nature467(7317)832-8(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CPN binds to fibrinogen and is present in a fibrin clot prepared from plasma.
Title: Binding of carboxypeptidase N to fibrinogen and fibrin.

Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.

Observational study of gene-disease association. (HuGE Navigator)
Title: PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.

Observational study of gene-disease association. (HuGE Navigator)
Title: Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.

circulating CPN/CPB and platelets may potentially contribute to regulating the bioactivity of leukocyte chemoattractant chemerin
Title: Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets.

The following CPN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CPN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22700	NM_001308.3 Latest version!	Homo sapiens carboxypeptidase N subunit 1 (CPN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu22700	NM_001308.2	Homo sapiens carboxypeptidase N subunit 1 (CPN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CPN1 ( NM_001308.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299.1 Homo sapiens carboxypeptidase N subunit 1 (CPN1), mRNA.

Price & Availability↑

CloneID	OHu22700
Clone ID Related Accession (Same CDS sequence)	NM_001308.3 , NM_001308.2
Accession Version	NM_001308.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	carboxypeptidase N catalytic chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL441886.18, X14329.1 and AW950687.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001308.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027897.1, X14329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465408 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370418.8/ ENSP00000359446.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCAGACC TGCTCTCAGT CTTCCTCCAC CTCCTCCTTC TCTTCAAGTT GGTTGCCCCG 
GTGACCTTTC GCCACCACCG CTATGATGAT CTTGTGCGGA CGCTGTACAA GGTGCAAAAC 
GAATGCCCCG GCATCACGCG GGTCTACAGC ATTGGGCGCA GCGTGGAGGG GAGACACCTC 
TACGTGCTGG AGTTCAGCGA CCACCCTGGA ATCCACGAGC CCTTGGAACC AGAGGTCAAG 
TATGTGGGGA ACATGCACGG CAACGAAGCG TTGGGCCGCG AGCTGATGCT GCAGCTGTCG 
GAGTTTCTGT GCGAGGAGTT CCGGAACAGG AACCAGCGCA TCGTCCAGCT CATCCAGGAC 
ACGCGCATTC ACATCCTGCC ATCCATGAAC CCCGACGGCT ACGAGGTGGC TGCTGCCCAG 
GGCCCAAACA AGCCTGGGTA TCTAGTTGGC AGGAACAATG CAAATGGAGT GGACCTGAAC 
CGCAACTTCC CTGATCTCAA TACCTATATC TACTATAACG AGAAGTACGG AGGCCCCAAC 
CACCACCTGC CCCTTCCAGA CAACTGGAAA AGTCAGGTGG AACCCGAGAC CCGGGCGGTG 
ATCCGGTGGA TGCACTCCTT CAACTTTGTT CTTTCAGCCA ATCTCCACGG AGGGGCGGTG 
GTGGCCAATT ACCCGTATGA CAAGTCCTTT GAGCACCGGG TCCGAGGGGT CCGCCGCACC 
GCCAGCACCC CCACGCCTGA CGACAAGCTC TTCCAGAAGC TGGCCAAGGT CTACTCCTAT 
GCACATGGAT GGATGTTCCA AGGTTGGAAC TGCGGAGATT ACTTCCCAGA TGGCATCACC 
AATGGGGCTT CCTGGTATTC TCTCAGCAAG GGAATGCAAG ACTTTAATTA TCTCCATACC 
AACTGCTTTG AGATCACGCT GGAACTGAGT TGCGACAAGT TTCCCCCCGA AGAGGAGTTA 
CAGCGGGAGT GGCTGGGTAA TCGGGAAGCC CTAATCCAGT TCCTGGAACA GGTTCACCAG 
GGCATCAAGG GAATGGTGCT TGATGAGAAT TACAATAATC TCGCCAATGC TGTCATTTCT 
GTCAGTGGGA TTAACCATGA TGTCACTTCA GGTGACCATG GTGATTACTT CCGGCTGCTG 
CTTCCAGGTA TCTACACTGT TAGTGCCACA GCACCTGGGT ATGACCCAGA GACAGTAACT 
GTGACCGTGG GTCCTGCGGA ACCAACGTTG GTTAACTTCC ACCTCAAAAG AAGCATCCCT 
CAAGTAAGCC CTGTGAGGAG AGCTCCCAGC AGAAGGCACG GAGTCAGAGC CAAAGTGCAG 
CCCCAAGCCA GAAAGAAAGA AATGGAGATG AGGCAGCTGC AGAGAGGCCC TGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299.1
CDS	245..1621
Translation	MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA

Target ORF information:

RefSeq Version	NM_001308.3
Organism	Homo sapiens(human)
Definition	Homo sapiens carboxypeptidase N subunit 1 (CPN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308.3

ORF Insert Sequence:

ATGTCAGACC TGCTCTCAGT CTTCCTCCAC CTCCTCCTTC TCTTCAAGTT GGTTGCCCCG 
GTGACCTTTC GCCACCACCG CTATGATGAT CTTGTGCGGA CGCTGTACAA GGTGCAAAAC 
GAATGCCCCG GCATCACGCG GGTCTACAGC ATTGGGCGCA GCGTGGAGGG GAGACACCTC 
TACGTGCTGG AGTTCAGCGA CCACCCTGGA ATCCACGAGC CCTTGGAACC AGAGGTCAAG 
TATGTGGGGA ACATGCACGG CAACGAAGCG TTGGGCCGCG AGCTGATGCT GCAGCTGTCG 
GAGTTTCTGT GCGAGGAGTT CCGGAACAGG AACCAGCGCA TCGTCCAGCT CATCCAGGAC 
ACGCGCATTC ACATCCTGCC ATCCATGAAC CCCGACGGCT ACGAGGTGGC TGCTGCCCAG 
GGCCCAAACA AGCCTGGGTA TCTAGTTGGC AGGAACAATG CAAATGGAGT GGACCTGAAC 
CGCAACTTCC CTGATCTCAA TACCTATATC TACTATAACG AGAAGTACGG AGGCCCCAAC 
CACCACCTGC CCCTTCCAGA CAACTGGAAA AGTCAGGTGG AACCCGAGAC CCGGGCGGTG 
ATCCGGTGGA TGCACTCCTT CAACTTTGTT CTTTCAGCCA ATCTCCACGG AGGGGCGGTG 
GTGGCCAATT ACCCGTATGA CAAGTCCTTT GAGCACCGGG TCCGAGGGGT CCGCCGCACC 
GCCAGCACCC CCACGCCTGA CGACAAGCTC TTCCAGAAGC TGGCCAAGGT CTACTCCTAT 
GCACATGGAT GGATGTTCCA AGGTTGGAAC TGCGGAGATT ACTTCCCAGA TGGCATCACC 
AATGGGGCTT CCTGGTATTC TCTCAGCAAG GGAATGCAAG ACTTTAATTA TCTCCATACC 
AACTGCTTTG AGATCACGCT GGAACTGAGT TGCGACAAGT TTCCCCCCGA AGAGGAGTTA 
CAGCGGGAGT GGCTGGGTAA TCGGGAAGCC CTAATCCAGT TCCTGGAACA GGTTCACCAG 
GGCATCAAGG GAATGGTGCT TGATGAGAAT TACAATAATC TCGCCAATGC TGTCATTTCT 
GTCAGTGGGA TTAACCATGA TGTCACTTCA GGTGACCATG GTGATTACTT CCGGCTGCTG 
CTTCCAGGTA TCTACACTGT TAGTGCCACA GCACCTGGGT ATGACCCAGA GACAGTAACT 
GTGACCGTGG GTCCTGCGGA ACCAACGTTG GTTAACTTCC ACCTCAAAAG AAGCATCCCT 
CAAGTAAGCC CTGTGAGGAG AGCTCCCAGC AGAAGGCACG GAGTCAGAGC CAAAGTGCAG 
CCCCAAGCCA GAAAGAAAGA AATGGAGATG AGGCAGCTGC AGAGAGGCCC TGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CPN1 ( NM_001308.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299.1 Homo sapiens carboxypeptidase N subunit 1 (CPN1), mRNA.

Price & Availability↑

CloneID	OHu22700
Clone ID Related Accession (Same CDS sequence)	NM_001308.3 , NM_001308.2
Accession Version	NM_001308.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	carboxypeptidase N catalytic chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL441886.18, X14329.1 and AW950687.1. This sequence is a reference standard in the RefSeqGene project. On Mar 2, 2007 this sequence version replaced NM_001308.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027897.1, X14329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465408 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGACC TGCTCTCAGT CTTCCTCCAC CTCCTCCTTC TCTTCAAGTT GGTTGCCCCG 
GTGACCTTTC GCCACCACCG CTATGATGAT CTTGTGCGGA CGCTGTACAA GGTGCAAAAC 
GAATGCCCCG GCATCACGCG GGTCTACAGC ATTGGGCGCA GCGTGGAGGG GAGACACCTC 
TACGTGCTGG AGTTCAGCGA CCACCCTGGA ATCCACGAGC CCTTGGAACC AGAGGTCAAG 
TATGTGGGGA ACATGCACGG CAACGAAGCG TTGGGCCGCG AGCTGATGCT GCAGCTGTCG 
GAGTTTCTGT GCGAGGAGTT CCGGAACAGG AACCAGCGCA TCGTCCAGCT CATCCAGGAC 
ACGCGCATTC ACATCCTGCC ATCCATGAAC CCCGACGGCT ACGAGGTGGC TGCTGCCCAG 
GGCCCAAACA AGCCTGGGTA TCTAGTTGGC AGGAACAATG CAAATGGAGT GGACCTGAAC 
CGCAACTTCC CTGATCTCAA TACCTATATC TACTATAACG AGAAGTACGG AGGCCCCAAC 
CACCACCTGC CCCTTCCAGA CAACTGGAAA AGTCAGGTGG AACCCGAGAC CCGGGCGGTG 
ATCCGGTGGA TGCACTCCTT CAACTTTGTT CTTTCAGCCA ATCTCCACGG AGGGGCGGTG 
GTGGCCAATT ACCCGTATGA CAAGTCCTTT GAGCACCGGG TCCGAGGGGT CCGCCGCACC 
GCCAGCACCC CCACGCCTGA CGACAAGCTC TTCCAGAAGC TGGCCAAGGT CTACTCCTAT 
GCACATGGAT GGATGTTCCA AGGTTGGAAC TGCGGAGATT ACTTCCCAGA TGGCATCACC 
AATGGGGCTT CCTGGTATTC TCTCAGCAAG GGAATGCAAG ACTTTAATTA TCTCCATACC 
AACTGCTTTG AGATCACGCT GGAACTGAGT TGCGACAAGT TTCCCCCCGA AGAGGAGTTA 
CAGCGGGAGT GGCTGGGTAA TCGGGAAGCC CTAATCCAGT TCCTGGAACA GGTTCACCAG 
GGCATCAAGG GAATGGTGCT TGATGAGAAT TACAATAATC TCGCCAATGC TGTCATTTCT 
GTCAGTGGGA TTAACCATGA TGTCACTTCA GGTGACCATG GTGATTACTT CCGGCTGCTG 
CTTCCAGGTA TCTACACTGT TAGTGCCACA GCACCTGGGT ATGACCCAGA GACAGTAACT 
GTGACCGTGG GTCCTGCGGA ACCAACGTTG GTTAACTTCC ACCTCAAAAG AAGCATCCCT 
CAAGTAAGCC CTGTGAGGAG AGCTCCCAGC AGAAGGCACG GAGTCAGAGC CAAAGTGCAG 
CCCCAAGCCA GAAAGAAAGA AATGGAGATG AGGCAGCTGC AGAGAGGCCC TGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299.1
CDS	261..1637
Translation	MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA

Target ORF information:

RefSeq Version	NM_001308.2
Organism	Homo sapiens(human)
Definition	Homo sapiens carboxypeptidase N subunit 1 (CPN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308.2

ORF Insert Sequence:

ATGTCAGACC TGCTCTCAGT CTTCCTCCAC CTCCTCCTTC TCTTCAAGTT GGTTGCCCCG 
GTGACCTTTC GCCACCACCG CTATGATGAT CTTGTGCGGA CGCTGTACAA GGTGCAAAAC 
GAATGCCCCG GCATCACGCG GGTCTACAGC ATTGGGCGCA GCGTGGAGGG GAGACACCTC 
TACGTGCTGG AGTTCAGCGA CCACCCTGGA ATCCACGAGC CCTTGGAACC AGAGGTCAAG 
TATGTGGGGA ACATGCACGG CAACGAAGCG TTGGGCCGCG AGCTGATGCT GCAGCTGTCG 
GAGTTTCTGT GCGAGGAGTT CCGGAACAGG AACCAGCGCA TCGTCCAGCT CATCCAGGAC 
ACGCGCATTC ACATCCTGCC ATCCATGAAC CCCGACGGCT ACGAGGTGGC TGCTGCCCAG 
GGCCCAAACA AGCCTGGGTA TCTAGTTGGC AGGAACAATG CAAATGGAGT GGACCTGAAC 
CGCAACTTCC CTGATCTCAA TACCTATATC TACTATAACG AGAAGTACGG AGGCCCCAAC 
CACCACCTGC CCCTTCCAGA CAACTGGAAA AGTCAGGTGG AACCCGAGAC CCGGGCGGTG 
ATCCGGTGGA TGCACTCCTT CAACTTTGTT CTTTCAGCCA ATCTCCACGG AGGGGCGGTG 
GTGGCCAATT ACCCGTATGA CAAGTCCTTT GAGCACCGGG TCCGAGGGGT CCGCCGCACC 
GCCAGCACCC CCACGCCTGA CGACAAGCTC TTCCAGAAGC TGGCCAAGGT CTACTCCTAT 
GCACATGGAT GGATGTTCCA AGGTTGGAAC TGCGGAGATT ACTTCCCAGA TGGCATCACC 
AATGGGGCTT CCTGGTATTC TCTCAGCAAG GGAATGCAAG ACTTTAATTA TCTCCATACC 
AACTGCTTTG AGATCACGCT GGAACTGAGT TGCGACAAGT TTCCCCCCGA AGAGGAGTTA 
CAGCGGGAGT GGCTGGGTAA TCGGGAAGCC CTAATCCAGT TCCTGGAACA GGTTCACCAG 
GGCATCAAGG GAATGGTGCT TGATGAGAAT TACAATAATC TCGCCAATGC TGTCATTTCT 
GTCAGTGGGA TTAACCATGA TGTCACTTCA GGTGACCATG GTGATTACTT CCGGCTGCTG 
CTTCCAGGTA TCTACACTGT TAGTGCCACA GCACCTGGGT ATGACCCAGA GACAGTAACT 
GTGACCGTGG GTCCTGCGGA ACCAACGTTG GTTAACTTCC ACCTCAAAAG AAGCATCCCT 
CAAGTAAGCC CTGTGAGGAG AGCTCCCAGC AGAAGGCACG GAGTCAGAGC CAAAGTGCAG 
CCCCAAGCCA GAAAGAAAGA AATGGAGATG AGGCAGCTGC AGAGAGGCCC TGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Binding of carboxypeptidase N to fibrinogen and fibrin.
Biochemical and biophysical research communications427(2)421-5(2012 Oct)
Talens S,Lebbink JH,Malfliet JJ,Demmers JA,Uitte de Willige S,Leebeek FW,Rijken DC

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Nature genetics44(5)491-501(2012 Apr)
Estrada K,Styrkarsdottir U,Evangelou E,Hsu YH,Duncan EL,Ntzani EE,Oei L,Albagha OM,Amin N,Kemp JP,Koller DL,Li G,Liu CT,Minster RL,Moayyeri A,Vandenput L,Willner D,Xiao SM,Yerges-Armstrong LM,Zheng HF,Alonso N,Eriksson J,Kammerer CM,Kaptoge SK,Leo PJ,Thorleifsson G,Wilson SG,Wilson JF,Aalto V,Alen M,Aragaki AK,Aspelund T,Center JR,Dailiana Z,Duggan DJ,Garcia M,Garcia-Giralt N,Giroux S,Hallmans G,Hocking LJ,Husted LB,Jameson KA,Khusainova R,Kim GS,Kooperberg C,Koromila T,Kruk M,Laaksonen M,Lacroix AZ,Lee SH,Leung PC,Lewis JR,Masi L,Mencej-Bedrac S,Nguyen TV,Nogues X,Patel MS,Prezelj J,Rose LM,Scollen S,Siggeirsdottir K,Smith AV,Svensson O,Trompet S,Trummer O,van Schoor NM,Woo J,Zhu K,Balcells S,Brandi ML,Buckley BM,Cheng S,Christiansen C,Cooper C,Dedoussis G,Ford I,Frost M,Goltzman D,Gonz?lez-Mac?as J,K?h?nen M,Karlsson M,Khusnutdinova E,Koh JM,Kollia P,Langdahl BL,Leslie WD,Lips P,Ljunggren ?,Lorenc RS,Marc J,Mellstr?m D,Obermayer-Pietsch B,Olmos JM,Pettersson-Kymmer U,Reid DM,Riancho JA,Ridker PM,Rousseau F,Slagboom PE,Tang NL,Urreizti R,Van Hul W,Viikari J,Zarrabeitia MT,Aulchenko YS,Castano-Betancourt M,Grundberg E,Herrera L,Ingvarsson T,Johannsdottir H,Kwan T,Li R,Luben R,Medina-G?mez C,Palsson ST,Reppe S,Rotter JI,Sigurdsson G,van Meurs JB,Verlaan D,Williams FM,Wood AR,Zhou Y,Gautvik KM,Pastinen T,Raychaudhuri S,Cauley JA,Chasman DI,Clark GR,Cummings SR,Danoy P,Dennison EM,Eastell R,Eisman JA,Gudnason V,Hofman A,Jackson RD,Jones G,Jukema JW,Khaw KT,Lehtim?ki T,Liu Y,Lorentzon M,McCloskey E,Mitchell BD,Nandakumar K,Nicholson GC,Oostra BA,Peacock M,Pols HA,Prince RL,Raitakari O,Reid IR,Robbins J,Sambrook PN,Sham PC,Shuldiner AR,Tylavsky FA,van Duijn CM,Wareham NJ,Cupples LA,Econs MJ,Evans DM,Harris TB,Kung AW,Psaty BM,Reeve J,Spector TD,Streeten EA,Zillikens MC,Thorsteinsdottir U,Ohlsson C,Karasik D,Richards JB,Brown MA,Stefansson K,Uitterlinden AG,Ralston SH,Ioannidis JP,Kiel DP,Rivadeneira F

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Nature genetics43(11)1131-8(2011 Oct)
Chambers JC,Zhang W,Sehmi J,Li X,Wass MN,Van der Harst P,Holm H,Sanna S,Kavousi M,Baumeister SE,Coin LJ,Deng G,Gieger C,Heard-Costa NL,Hottenga JJ,K?hnel B,Kumar V,Lagou V,Liang L,Luan J,Vidal PM,Mateo Leach I,O'Reilly PF,Peden JF,Rahmioglu N,Soininen P,Speliotes EK,Yuan X,Thorleifsson G,Alizadeh BZ,Atwood LD,Borecki IB,Brown MJ,Charoen P,Cucca F,Das D,de Geus EJ,Dixon AL,D?ring A,Ehret G,Eyjolfsson GI,Farrall M,Forouhi NG,Friedrich N,Goessling W,Gudbjartsson DF,Harris TB,Hartikainen AL,Heath S,Hirschfield GM,Hofman A,Homuth G,Hypp?nen E,Janssen HL,Johnson T,Kangas AJ,Kema IP,K?hn JP,Lai S,Lathrop M,Lerch MM,Li Y,Liang TJ,Lin JP,Loos RJ,Martin NG,Moffatt MF,Montgomery GW,Munroe PB,Musunuru K,Nakamura Y,O'Donnell CJ,Olafsson I,Penninx BW,Pouta A,Prins BP,Prokopenko I,Puls R,Ruokonen A,Savolainen MJ,Schlessinger D,Schouten JN,Seedorf U,Sen-Chowdhry S,Siminovitch KA,Smit JH,Spector TD,Tan W,Teslovich TM,Tukiainen T,Uitterlinden AG,Van der Klauw MM,Vasan RS,Wallace C,Wallaschofski H,Wichmann HE,Willemsen G,W?rtz P,Xu C,Yerges-Armstrong LM,,,,,,,,Abecasis GR,Ahmadi KR,Boomsma DI,Caulfield M,Cookson WO,van Duijn CM,Froguel P,Matsuda K,McCarthy MI,Meisinger C,Mooser V,Pietil?inen KH,Schumann G,Snieder H,Sternberg MJ,Stolk RP,Thomas HC,Thorsteinsdottir U,Uda M,Waeber G,Wareham NJ,Waterworth DM,Watkins H,Whitfield JB,Witteman JC,Wolffenbuttel BH,Fox CS,Ala-Korpela M,Stefansson K,Vollenweider P,V?lzke H,Schadt EE,Scott J,J?rvelin MR,Elliott P,Kooner JS

Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.
Pharmacogenetics and genomics21(1)10-7(2011 Jan)
Grilo A,S?ez-Rosas MP,Santos-Morano J,S?nchez E,Moreno-Rey C,Real LM,Ram?rez-Lorca R,S?ez ME

Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Nature467(7317)832-8(2010 Oct)
Lango Allen H,Estrada K,Lettre G,Berndt SI,Weedon MN,Rivadeneira F,Willer CJ,Jackson AU,Vedantam S,Raychaudhuri S,Ferreira T,Wood AR,Weyant RJ,Segr? AV,Speliotes EK,Wheeler E,Soranzo N,Park JH,Yang J,Gudbjartsson D,Heard-Costa NL,Randall JC,Qi L,Vernon Smith A,M?gi R,Pastinen T,Liang L,Heid IM,Luan J,Thorleifsson G,Winkler TW,Goddard ME,Sin Lo K,Palmer C,Workalemahu T,Aulchenko YS,Johansson A,Zillikens MC,Feitosa MF,Esko T,Johnson T,Ketkar S,Kraft P,Mangino M,Prokopenko I,Absher D,Albrecht E,Ernst F,Glazer NL,Hayward C,Hottenga JJ,Jacobs KB,Knowles JW,Kutalik Z,Monda KL,Polasek O,Preuss M,Rayner NW,Robertson NR,Steinthorsdottir V,Tyrer JP,Voight BF,Wiklund F,Xu J,Zhao JH,Nyholt DR,Pellikka N,Perola M,Perry JR,Surakka I,Tammesoo ML,Altmaier EL,Amin N,Aspelund T,Bhangale T,Boucher G,Chasman DI,Chen C,Coin L,Cooper MN,Dixon AL,Gibson Q,Grundberg E,Hao K,Juhani Junttila M,Kaplan LM,Kettunen J,K?nig IR,Kwan T,Lawrence RW,Levinson DF,Lorentzon M,McKnight B,Morris AP,M?ller M,Suh Ngwa J,Purcell S,Rafelt S,Salem RM,Salvi E,Sanna S,Shi J,Sovio U,Thompson JR,Turchin MC,Vandenput L,Verlaan DJ,Vitart V,White CC,Ziegler A,Almgren P,Balmforth AJ,Campbell H,Citterio L,De Grandi A,Dominiczak A,Duan J,Elliott P,Elosua R,Eriksson JG,Freimer NB,Geus EJ,Glorioso N,Haiqing S,Hartikainen AL,Havulinna AS,Hicks AA,Hui J,Igl W,Illig T,Jula A,Kajantie E,Kilpel?inen TO,Koiranen M,Kolcic I,Koskinen S,Kovacs P,Laitinen J,Liu J,Lokki ML,Marusic A,Maschio A,Meitinger T,Mulas A,Par? G,Parker AN,Peden JF,Petersmann A,Pichler I,Pietil?inen KH,Pouta A,Ridderstr?le M,Rotter JI,Sambrook JG,Sanders AR,Schmidt CO,Sinisalo J,Smit JH,Stringham HM,Bragi Walters G,Widen E,Wild SH,Willemsen G,Zagato L,Zgaga L,Zitting P,Alavere H,Farrall M,McArdle WL,Nelis M,Peters MJ,Ripatti S,van Meurs JB,Aben KK,Ardlie KG,Beckmann JS,Beilby JP,Bergman RN,Bergmann S,Collins FS,Cusi D,den Heijer M,Eiriksdottir G,Gejman PV,Hall AS,Hamsten A,Huikuri HV,Iribarren C,K?h?nen M,Kaprio J,Kathiresan S,Kiemeney L,Kocher T,Launer LJ,Lehtim?ki T,Melander O,Mosley TH Jr,Musk AW,Nieminen MS,O'Donnell CJ,Ohlsson C,Oostra B,Palmer LJ,Raitakari O,Ridker PM,Rioux JD,Rissanen A,Rivolta C,Schunkert H,Shuldiner AR,Siscovick DS,Stumvoll M,T?njes A,Tuomilehto J,van Ommen GJ,Viikari J,Heath AC,Martin NG,Montgomery GW,Province MA,Kayser M,Arnold AM,Atwood LD,Boerwinkle E,Chanock SJ,Deloukas P,Gieger C,Gr?nberg H,Hall P,Hattersley AT,Hengstenberg C,Hoffman W,Lathrop GM,Salomaa V,Schreiber S,Uda M,Waterworth D,Wright AF,Assimes TL,Barroso I,Hofman A,Mohlke KL,Boomsma DI,Caulfield MJ,Cupples LA,Erdmann J,Fox CS,Gudnason V,Gyllensten U,Harris TB,Hayes RB,Jarvelin MR,Mooser V,Munroe PB,Ouwehand WH,Penninx BW,Pramstaller PP,Quertermous T,Rudan I,Samani NJ,Spector TD,V?lzke H,Watkins H,Wilson JF,Groop LC,Haritunians T,Hu FB,Kaplan RC,Metspalu A,North KE,Schlessinger D,Wareham NJ,Hunter DJ,O'Connell JR,Strachan DP,Wichmann HE,Borecki IB,van Duijn CM,Schadt EE,Thorsteinsdottir U,Peltonen L,Uitterlinden AG,Visscher PM,Chatterjee N,Loos RJ,Boehnke M,McCarthy MI,Ingelsson E,Lindgren CM,Abecasis GR,Stefansson K,Frayling TM,Hirschhorn JN

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CPN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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