MPLKIP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MPLKIP
Entrez Gene ID	136647
Full Name	M-phase specific PLK1 interacting protein
Synonyms	ABHS,C7orf11,ORF20,TTD4
General protein information	Preferred Names M-phase specific PLK1 interacting protein Names M-phase-specific PLK1-interacting protein Russell-Silver syndrome region TTD non-photosensitive 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.1
Summary	The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009].
Disorder MIM:	609188
Disorder Html:	Trichothiodystrophy 4, nonphotosensitive, 234050 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_138701.4	NP_619646.1	M-phase-specific PLK1-interacting protein
NM_138701.3	NP_619646.1	M-phase-specific PLK1-interacting protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MPLKIP	XP_001138964.1
	MPLKIP	XP_001098814.2
Rattus norvegicus (Norway rat)	Mplkip	NP_001102922.1
Bos taurus (cattle)	MPLKIP	NP_001068857.1
Gallus gallus (chicken)	C7ORF11	XP_001236113.3
Canis lupus familiaris (dog)	MPLKIP	XP_003432357.2
Mus musculus (house mouse)	Mplkip	NP_079755.1
Xenopus tropicalis (tropical clawed frog)	mplkip	NP_989025.1
Homo sapiens (human)	MPLKIP	NP_619646.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitral regurgitation as a phenotypic manifestation of nonphotosensitive trichothiodystrophy due to a splice variant in MPLKIP.
Shah K, Ali RH, Ansar M, Lee K, Chishti MS, Abbe I, Li B, , Smith JD, Nickerson DA, Shendure J, Coucke PJ, Steyaert W, Bamshad MJ, Santos-Cortez RLP, Leal SM, Ahmad W
BMC medical genetics1713(2016 Feb)

A novel mutation in the C7orf11 gene causes nonphotosensitive trichothiodystrophy in a multiplex highly consanguineous kindred.
Pode-Shakked B, Marek-Yagel D, Greenberger S, Pode-Shakked N, Pras E, Barzilai A, Yassin S, Sidi Y, Anikster Y
European journal of medical genetics58(12)685-8(2015 Dec)

Mutations in the TTDN1 gene are associated with a distinct trichothiodystrophy phenotype.
Heller ER, Khan SG, Kuschal C, Tamura D, DiGiovanna JJ, Kraemer KH
The Journal of investigative dermatology135(3)734-741(2015 Mar)

TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity.
Zhang Y, Tian Y, Chen Q, Chen D, Zhai Z, Shu HB
Cellular and molecular life sciences : CMLS64(5)632-40(2007 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study extends the allelic and phenotypic spectra of MPLKIP-related trichothiodystrophy, to include a splice variant that causes cardiomyopathy as part of the trichothiodystrophy phenotype.
Title: Mitral regurgitation as a phenotypic manifestation of nonphotosensitive trichothiodystrophy due to a splice variant in MPLKIP.

A novel mutation in the C7orf11 gene causes nonphotosensitive trichothiodystrophy in a multiplex highly consanguineous kindred
Title: A novel mutation in the C7orf11 gene causes nonphotosensitive trichothiodystrophy in a multiplex highly consanguineous kindred.

There is a distinct phenotype relationship in trichothiodystrophy caused by TTDN1 mutations.
Title: Mutations in the TTDN1 gene are associated with a distinct trichothiodystrophy phenotype.

TTDN1 is phosphorylated in mitosis, and this is required for its interaction with polo-like kinase 1.
Title: TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity.

Reported mutations in Trichothiodystrophy do not affect TTDN1 response to ultraviolet (UV) light or the steady state level of the repair/transcription factor IIH (TFIIH), which is central to the onset of the photosensitive form of TTD.
Title: Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships.

The following MPLKIP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MPLKIP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19198	NM_138701.4 Latest version!	Homo sapiens M-phase specific PLK1 interacting protein (MPLKIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19198	NM_138701.3	Homo sapiens M-phase specific PLK1 interacting protein (MPLKIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MPLKIP ( NM_138701.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_619646.1 Homo sapiens M-phase specific PLK1 interacting protein (MPLKIP), mRNA.

Price & Availability↑

CloneID	OHu19198
Clone ID Related Accession (Same CDS sequence)	NM_138701.4 , NM_138701.3
Accession Version	NM_138701.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	M-phase-specific PLK1-interacting protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG501110.1, BC026265.1 and AC006023.2. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_138701.3. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.216983.1, SRR1660803.50670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306984.8/ ENSP00000304553.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGAC AGAATTTTCG GCCCCCAACT CCTCCTTACC CTGGTCCGGG TGGAGGAGGT 
TGGGGTAGCG GAAGCAGCTT CCGGGGAACC CCGGGCGGGG GCGGACCACG GCCGCCCTCC 
CCTCGAGACG GGTACGGGAG TCCGCACCAC ACGCCGCCGT ACGGGCCCCG GTCTAGGCCG 
TACGGGAGCA GTCACTCTCC GCGACACGGC GGCAGCTTCC CGGGGGGCCG GTTCGGGTCT 
CCGTCCCCTG GCGGCTACCC TGGCTCCTAC TCCAGGTCCC CCGCGGGGTC CCAGCAGCAA 
TTCGGCTACT CCCCAGGGCA GCAGCAGACC CACCCCCAGG GTTCTCCAAG GACATCTACA 
CCATTTGGAT CAGGGCGTGT TAGAGAAAAA AGAATGTCTA ATGAGTTGGA AAATTATTTC 
AAGCCTTCAA TGCTTGAAGA TCCTTGGGCT GGCCTAGAAC CAGTATCTGT AGTGGATATA 
AGCCAACAAT ACAGCAATAC TCAAACATTC ACAGGCAAAA AAGGAAGATA CTTTTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_619646.1
CDS	56..595
Translation	MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDGYGSPHHTPPYGPRSRPYGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFGYSPGQQQTHPQGSPRTSTPFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFC

Target ORF information:

RefSeq Version	NM_138701.4
Organism	Homo sapiens(human)
Definition	Homo sapiens M-phase specific PLK1 interacting protein (MPLKIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138701.4

ORF Insert Sequence:

ATGCAGCGAC AGAATTTTCG GCCCCCAACT CCTCCTTACC CTGGTCCGGG TGGAGGAGGT 
TGGGGTAGCG GAAGCAGCTT CCGGGGAACC CCGGGCGGGG GCGGACCACG GCCGCCCTCC 
CCTCGAGACG GGTACGGGAG TCCGCACCAC ACGCCGCCGT ACGGGCCCCG GTCTAGGCCG 
TACGGGAGCA GTCACTCTCC GCGACACGGC GGCAGCTTCC CGGGGGGCCG GTTCGGGTCT 
CCGTCCCCTG GCGGCTACCC TGGCTCCTAC TCCAGGTCCC CCGCGGGGTC CCAGCAGCAA 
TTCGGCTACT CCCCAGGGCA GCAGCAGACC CACCCCCAGG GTTCTCCAAG GACATCTACA 
CCATTTGGAT CAGGGCGTGT TAGAGAAAAA AGAATGTCTA ATGAGTTGGA AAATTATTTC 
AAGCCTTCAA TGCTTGAAGA TCCTTGGGCT GGCCTAGAAC CAGTATCTGT AGTGGATATA 
AGCCAACAAT ACAGCAATAC TCAAACATTC ACAGGCAAAA AAGGAAGATA CTTTTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPLKIP ( NM_138701.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_619646.1 Homo sapiens M-phase specific PLK1 interacting protein (MPLKIP), mRNA.

Price & Availability↑

CloneID	OHu19198
Clone ID Related Accession (Same CDS sequence)	NM_138701.4 , NM_138701.3
Accession Version	NM_138701.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	M-phase-specific PLK1-interacting protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG501110.1 and BC026265.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2010 this sequence version replaced NM_138701.2. ##Evidence-Data-START## Transcript exon combination :: ERR279825.8363.1, SRR1803611.56240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGAC AGAATTTTCG GCCCCCAACT CCTCCTTACC CTGGTCCGGG TGGAGGAGGT 
TGGGGTAGCG GAAGCAGCTT CCGGGGAACC CCGGGCGGGG GCGGACCACG GCCGCCCTCC 
CCTCGAGACG GGTACGGGAG TCCGCACCAC ACGCCGCCGT ACGGGCCCCG GTCTAGGCCG 
TACGGGAGCA GTCACTCTCC GCGACACGGC GGCAGCTTCC CGGGGGGCCG GTTCGGGTCT 
CCGTCCCCTG GCGGCTACCC TGGCTCCTAC TCCAGGTCCC CCGCGGGGTC CCAGCAGCAA 
TTCGGCTACT CCCCAGGGCA GCAGCAGACC CACCCCCAGG GTTCTCCAAG GACATCTACA 
CCATTTGGAT CAGGGCGTGT TAGAGAAAAA AGAATGTCTA ATGAGTTGGA AAATTATTTC 
AAGCCTTCAA TGCTTGAAGA TCCTTGGGCT GGCCTAGAAC CAGTATCTGT AGTGGATATA 
AGCCAACAAT ACAGCAATAC TCAAACATTC ACAGGCAAAA AAGGAAGATA CTTTTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_619646.1
CDS	86..625
Translation	MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDGYGSPHHTPPYGPRSRPYGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFGYSPGQQQTHPQGSPRTSTPFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFC

Target ORF information:

RefSeq Version	NM_138701.3
Organism	Homo sapiens(human)
Definition	Homo sapiens M-phase specific PLK1 interacting protein (MPLKIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138701.3

ORF Insert Sequence:

ATGCAGCGAC AGAATTTTCG GCCCCCAACT CCTCCTTACC CTGGTCCGGG TGGAGGAGGT 
TGGGGTAGCG GAAGCAGCTT CCGGGGAACC CCGGGCGGGG GCGGACCACG GCCGCCCTCC 
CCTCGAGACG GGTACGGGAG TCCGCACCAC ACGCCGCCGT ACGGGCCCCG GTCTAGGCCG 
TACGGGAGCA GTCACTCTCC GCGACACGGC GGCAGCTTCC CGGGGGGCCG GTTCGGGTCT 
CCGTCCCCTG GCGGCTACCC TGGCTCCTAC TCCAGGTCCC CCGCGGGGTC CCAGCAGCAA 
TTCGGCTACT CCCCAGGGCA GCAGCAGACC CACCCCCAGG GTTCTCCAAG GACATCTACA 
CCATTTGGAT CAGGGCGTGT TAGAGAAAAA AGAATGTCTA ATGAGTTGGA AAATTATTTC 
AAGCCTTCAA TGCTTGAAGA TCCTTGGGCT GGCCTAGAAC CAGTATCTGT AGTGGATATA 
AGCCAACAAT ACAGCAATAC TCAAACATTC ACAGGCAAAA AAGGAAGATA CTTTTGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitral regurgitation as a phenotypic manifestation of nonphotosensitive trichothiodystrophy due to a splice variant in MPLKIP.
BMC medical genetics1713(2016 Feb)
Shah K,Ali RH,Ansar M,Lee K,Chishti MS,Abbe I,Li B,,Smith JD,Nickerson DA,Shendure J,Coucke PJ,Steyaert W,Bamshad MJ,Santos-Cortez RLP,Leal SM,Ahmad W

A novel mutation in the C7orf11 gene causes nonphotosensitive trichothiodystrophy in a multiplex highly consanguineous kindred.
European journal of medical genetics58(12)685-8(2015 Dec)
Pode-Shakked B,Marek-Yagel D,Greenberger S,Pode-Shakked N,Pras E,Barzilai A,Yassin S,Sidi Y,Anikster Y

Mutations in the TTDN1 gene are associated with a distinct trichothiodystrophy phenotype.
The Journal of investigative dermatology135(3)734-741(2015 Mar)
Heller ER,Khan SG,Kuschal C,Tamura D,DiGiovanna JJ,Kraemer KH

TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity.
Cellular and molecular life sciences : CMLS64(5)632-40(2007 Mar)
Zhang Y,Tian Y,Chen Q,Chen D,Zhai Z,Shu HB

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MPLKIP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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