MTPN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTPN
Entrez Gene ID	136319
Full Name	myotrophin
Synonyms	GCDP,V-1
General protein information	Preferred Names myotrophin Names myotrophin granule cell differentiation protein protein V-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q33
Summary	The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008].
Disorder MIM:	606484

mRNA and Protein(s)

mRNA	Protein	Name
NM_145808.4	NP_665807.1	myotrophin
NM_145808.3	NP_665807.1	myotrophin

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mtpn	NP_998137.1
Drosophila melanogaster (fruit fly)	CG7423	NP_573347.1
Caenorhabditis elegans (roundworm)	C43H6.3	NP_508437.1
Xenopus tropicalis (tropical clawed frog)	mtpn	NP_989406.1
Pan troglodytes (chimpanzee)	MTPN	XP_519405.2
Bos taurus (cattle)	MTPN	NP_976238.2
Mus musculus (house mouse)	Mtpn	NP_032124.1
Gallus gallus (chicken)	MTPN	NP_990217.1
Drosophila melanogaster (fruit fly)	CG31715	NP_723568.1
Homo sapiens (human)	MTPN	NP_665807.1
	MTPN	XP_001106700.1
Canis lupus familiaris (dog)	MTPN	NP_001002989.1
Rattus norvegicus (Norway rat)	Mtpn	NP_077350.1

Gene Ontology
Bibliography

Related articles in PubMed

9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.
Perri M, Caroleo MC, Liu N, Gallelli L, De Sarro G, Kagechika H, Cione E
Experimental cell research354(1)25-30(2017 05)

The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension.
Wang Y, Chen J, Song W, Wang Y, Chen Y, Nie Y, Ye Z, Hui R
PloS one10(8)e0135526(2015)

An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.
Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Chen Y, Verstovsek S, Wang H, Prchal J, Yang XF
Journal of immunology (Baltimore, Md. : 1950)177(7)4907-16(2006 Oct)

Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end.
Bhattacharya N, Ghosh S, Sept D, Cooper JA
The Journal of biological chemistry281(41)31021-30(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In our findings 9cRA emerges has a hormone with a regulatory action on miR-375 that in most cases interfere with Mtpn expression.
Title: 9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.

T allele of rs17168525 in the 3'-UTR of myotrophin influence the level of myotrophin protein by interfering with let-7 binding.The T allele of MTPN rs17168525 is not associated with the left ventricular hypertrophy risk in essential hypertension patients.
Title: The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension.

a novel internal ribosome entry site-mediated mechanism may be responsible for the translation of unconventional self-Ag MPD6 in response to IFN-alpha stimulation.
Title: An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.

myotrophin/V-1 is a regulatory protein for modulating the levels of activated NFkappaB dimers.
Title: Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers.

The following MTPN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTPN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31896	NM_145808.4 Latest version!	Homo sapiens myotrophin (MTPN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31896	NM_145808.3	Homo sapiens myotrophin (MTPN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTPN ( NM_145808.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_665807.1 Homo sapiens myotrophin (MTPN), mRNA.

Price & Availability↑

CloneID	OHu31896
Clone ID Related Accession (Same CDS sequence)	NM_145808.4 , NM_145808.3
Accession Version	NM_145808.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	myotrophin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA325130.1, AL834231.1 and CB530008.1. On Nov 22, 2018 this sequence version replaced NM_145808.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.846398.1, SRR1803615.197334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 16982933 MANE Ensembl match :: ENST00000393085.4/ ENSP00000376800.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGCGACA AGGAGTTCAT GTGGGCCCTG AAAAACGGAG ACTTGGATGA GGTGAAAGAC 
TATGTGGCCA AGGGAGAAGA TGTCAACCGG ACACTAGAAG GTGGAAGGAA ACCTCTTCAT 
TATGCAGCAG ATTGTGGGCA GCTTGAAATC CTGGAATTTC TGCTGCTGAA AGGAGCAGAT 
ATTAATGCTC CAGATAAACA TCATATTACT CCTCTTCTGT CTGCTGTCTA TGAGGGTCAT 
GTTTCCTGTG TGAAATTGCT TCTGTCAAAG GGTGCTGATA AGACTGTGAA AGGCCCAGAT 
GGACTGACCG CCTTTGAAGC CACTGACAAC CAGGCAATCA AAGCTCTTCT CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665807.1
CDS	260..616
Translation	MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ

Target ORF information:

RefSeq Version	NM_145808.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myotrophin (MTPN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145808.4

ORF Insert Sequence:

ATGTGCGACA AGGAGTTCAT GTGGGCCCTG AAAAACGGAG ACTTGGATGA GGTGAAAGAC 
TATGTGGCCA AGGGAGAAGA TGTCAACCGG ACACTAGAAG GTGGAAGGAA ACCTCTTCAT 
TATGCAGCAG ATTGTGGGCA GCTTGAAATC CTGGAATTTC TGCTGCTGAA AGGAGCAGAT 
ATTAATGCTC CAGATAAACA TCATATTACT CCTCTTCTGT CTGCTGTCTA TGAGGGTCAT 
GTTTCCTGTG TGAAATTGCT TCTGTCAAAG GGTGCTGATA AGACTGTGAA AGGCCCAGAT 
GGACTGACCG CCTTTGAAGC CACTGACAAC CAGGCAATCA AAGCTCTTCT CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTPN ( NM_145808.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_665807.1 Homo sapiens myotrophin (MTPN), mRNA.

Price & Availability↑

CloneID	OHu31896
Clone ID Related Accession (Same CDS sequence)	NM_145808.4 , NM_145808.3
Accession Version	NM_145808.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	myotrophin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA325130.1, AL834231.1 and CB530008.1. On Jun 20, 2008 this sequence version replaced NM_145808.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.265605.1, SRR1660803.63476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 16982933 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGCGACA AGGAGTTCAT GTGGGCCCTG AAAAACGGAG ACTTGGATGA GGTGAAAGAC 
TATGTGGCCA AGGGAGAAGA TGTCAACCGG ACACTAGAAG GTGGAAGGAA ACCTCTTCAT 
TATGCAGCAG ATTGTGGGCA GCTTGAAATC CTGGAATTTC TGCTGCTGAA AGGAGCAGAT 
ATTAATGCTC CAGATAAACA TCATATTACT CCTCTTCTGT CTGCTGTCTA TGAGGGTCAT 
GTTTCCTGTG TGAAATTGCT TCTGTCAAAG GGTGCTGATA AGACTGTGAA AGGCCCAGAT 
GGACTGACCG CCTTTGAAGC CACTGACAAC CAGGCAATCA AAGCTCTTCT CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665807.1
CDS	357..713
Translation	MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ

Target ORF information:

RefSeq Version	NM_145808.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myotrophin (MTPN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145808.3

ORF Insert Sequence:

ATGTGCGACA AGGAGTTCAT GTGGGCCCTG AAAAACGGAG ACTTGGATGA GGTGAAAGAC 
TATGTGGCCA AGGGAGAAGA TGTCAACCGG ACACTAGAAG GTGGAAGGAA ACCTCTTCAT 
TATGCAGCAG ATTGTGGGCA GCTTGAAATC CTGGAATTTC TGCTGCTGAA AGGAGCAGAT 
ATTAATGCTC CAGATAAACA TCATATTACT CCTCTTCTGT CTGCTGTCTA TGAGGGTCAT 
GTTTCCTGTG TGAAATTGCT TCTGTCAAAG GGTGCTGATA AGACTGTGAA AGGCCCAGAT 
GGACTGACCG CCTTTGAAGC CACTGACAAC CAGGCAATCA AAGCTCTTCT CCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.
Experimental cell research354(1)25-30(2017 05)
Perri M,Caroleo MC,Liu N,Gallelli L,De Sarro G,Kagechika H,Cione E

The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension.
PloS one10(8)e0135526(2015)
Wang Y,Chen J,Song W,Wang Y,Chen Y,Nie Y,Ye Z,Hui R

An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.
Journal of immunology (Baltimore, Md. : 1950)177(7)4907-16(2006 Oct)
Xiong Z,Liu E,Yan Y,Silver RT,Yang F,Chen IH,Chen Y,Verstovsek S,Wang H,Prchal J,Yang XF

Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end.
The Journal of biological chemistry281(41)31021-30(2006 Oct)
Bhattacharya N,Ghosh S,Sept D,Cooper JA

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MTPN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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