NOBOX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOBOX
Entrez Gene ID	135935
Full Name	NOBOX oogenesis homeobox
Synonyms	OG-2,OG2,OG2X,POF5,TCAG_12042
General protein information	Preferred Names NOBOX oogenesis homeobox Names homeobox protein NOBOX newborn ovary homeobox-encoding
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q35
Summary	This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.[provided by RefSeq, May 2011].
Disorder MIM:	610934
Disorder Html:	Premature ovarian failure 5, 611548 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017011742.1	XP_016867231.1	homeobox protein NOBOX isoform X1
NM_001080413.3	NP_001073882.3	homeobox protein NOBOX
XM_017011742.2	XP_016867231.1	homeobox protein NOBOX isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NOBOX	NP_001073882.3
	NOBOX	XP_002803549.1
Rattus norvegicus (Norway rat)	Nobox	NP_001178942.1
Mus musculus (house mouse)	Nobox	NP_570939.1
Bos taurus (cattle)	NOBOX	XP_002687182.2
Pan troglodytes (chimpanzee)	NOBOX	XP_003318912.2

Gene Ontology
Bibliography

Related articles in PubMed

A novel homozygous 1-bp deletion in the NOBOX gene in two Brazilian sisters with primary ovarian failure.
Fran?a MM, Funari MFA, Lerario AM, Nishi MY, Pita CC, Fontenele EGP, Mendonca BB
Endocrine58(3)442-447(2017 Dec)

R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.
Bouilly J, Beau I, Barraud S, Bernard V, Delemer B, Young J, Binart N
Journal of ovarian research10(1)51(2017 Jul)

A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency.
Li L, Wang B, Zhang W, Chen B, Luo M, Wang J, Wang X, Cao Y, Kee K
Human reproduction (Oxford, England)32(1)248-255(2017 Jan)

Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency.
Ferrari I, Bouilly J, Beau I, Guizzardi F, Ferlin A, Pollazzon M, Salerno M, Binart N, Persani L, Rossetti R
Human molecular genetics25(23)5223-5233(2016 12)

NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.
Bouali N, Francou B, Bouligand J, Lakhal B, Malek I, Kammoun M, Warszawski J, Mougou S, Saad A, Guiochon-Mantel A
Clinical genetics89(5)608-13(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we report the identification of two novel and two recurrent heterozygous NOBOX variants in 7 out of 107 patients, with a prevalence of 6.5% (upper 95% confidence limit of 11.17%). Several variants conserve the ability to interact with FOXL2 in intracellular aggregates
Title: Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency.

Screening of NOBOX gene indicted three missense mutations (p.Arg117Trp; p.Gly91Trp and p.Pro619Leu) in eight patients with primary ovarian insufficiency.
Title: NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.

High prevalence of the association between the NOBOX rare variants and Primary ovarian insufficiency.
Title: New NOBOX mutations identified in a large cohort of women with primary ovarian insufficiency decrease KIT-L expression.

both NOBOX and FOXL2 are expressed in human follicle granulosa cells and their interaction plays an inhibitory role in the transcriptional response of these promoters.
Title: NOBOX is a key FOXL2 partner involved in ovarian folliculogenesis.

The very high 6.2% prevalence of these new mutations in POI patients suggest considering NOBOX as the first autosomal candidate gene involved in this syndrome.
Title: Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort.

The following NOBOX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOBOX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21293	NM_001080413.3 Latest version!	Homo sapiens NOBOX oogenesis homeobox (NOBOX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu97038	XM_017011742.2 Latest version!	Homo sapiens NOBOX oogenesis homeobox (NOBOX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu97038	XM_017011742.1	Homo sapiens NOBOX oogenesis homeobox (NOBOX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOBOX ( NM_001080413.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001073882.3 Homo sapiens NOBOX oogenesis homeobox (NOBOX), mRNA.

Price & Availability↑

CloneID	OHu21293
Clone ID Related Accession (Same CDS sequence)	NM_001080413.3
Accession Version	NM_001080413.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2076bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	homeobox protein NOBOX
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC004534.1. This sequence is a reference standard in the RefSeqGene project. On May 20, 2011 this sequence version replaced NM_001080413.2. Sequence Note: The RefSeq transcript and protein were assembled by in silico methods based on partial sequence data reported in PMID: 16597639 and additional support from similarity to mouse protein NP_570939.1. The 5' and 3' exons have not been experimentally verified in humans. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2148093, SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000467773.1/ ENSP00000419457.1 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END##

ATGGCTCTCC TTTTGACACT AACATCACCA GACCTGGAGG GTACCTGGGA CACCAGAGAC 
AAGGATGGCT TCAAAGCCCA GGAGGGGCCG CCCCTGGCTG TACCTGAATT TCCTGTGTGT 
GGACTGTACC GGATCTACGG AGTCTGTGGC TCTTTCAGCT CCTTCTTCAT CATCCGGTGC 
AGCCTTTGTG CTCTGGAGAC CCTCAAATCA CCCCAACATG ATCCCTTAGA GATACCTGAA 
CAGTCCCTCA AACTCATACC CCTGGTGTCT GGGAAAAGGG AACTCACAAG GGGCCAGAAA 
GCTGGAGAGA AGCCCCTGGC TGCAGGACCC GGGGAGGAGG AACTGCTCCG GGGCTCAGCC 
CCTCATGCTC AGGACACTCA GAGTGAGGAA CTGCCACCCT CCTGCACCAT CTCAGGAGAG 
AAGAAGCCGC CAGCAGTCTC TGGAGAAGCC ACCGGGGCTG ATGCTGGGAG ACTGTGCCCG 
CCCCCCCGCT CCAGGGCTCC CCACAAAGAC AGAACTCTAG CCCGCTCCAG GCCCCAGACT 
CAGGGGGAAG ATTGTTCCCT CCCAGTGGGA GAGGTGAAGA TAGGAAAGAG GTCCTATTCT 
CCAGCCCCCG GGAAGCAGAA AAAGCCTAAT GCCATGGGTC TGGCCCCAAC ATCATCTCCG 
GGTGCCCCTA ACTCAGCCCG TGCCACACAC AACCCAGTGC CCTGTGGGTC AGGCCGGGGG 
CCCTGCCACC TGGCCAATCT CCTCAGTACA TTGGCGCAGA GCAACCAAAA CAGAGACCAC 
AAGCAGGGGC CCCCGGAAGT GACCTGCCAA ATTAGGAAAA AGACACGAAC CCTATACCGC 
TCAGATCAGC TGGAGGAGCT AGAGAAGATA TTCCAAGAAG ACCACTATCC TGACAGTGAT 
AAACGCCGAG AGATTGCCCA GACGGTGGGG GTGACCCCCC AGCGCATCAT GGTAAAGGGG 
GCCGGCTCAC TGGTGGCAGG GTGGAGTGGC GGAGGGCCCA CCATTGAAAC ACTCGAATTG 
CAGAGTGAGC GCTCAGCGGT AGCCTGGGTG TGGTTCCAGA ATCGCCGGGC CAAGTGGCGA 
AAAATGGAGA AACTGAATGG GAAAGAAAGC AAGGACAATC CTGCAGCCCC TGGCCCTGCC 
AGCAGTCAAT GCAGCTCTGC AGCTGAGATC CTACCTGCTG TGCCCATGGA GCCAAAGCCT 
GACCCTTTCC CTCAGGAGTC CCCTCTGGAT ACCTTTCCAG AGCCCCCCAT GCTGCTGACT 
TCTGACCAGA CTTTGGCCCC CACCCAACCC AGTGAGGGTG CTCAGAGGGT GGTGACCCCC 
CCACTCTTCA GCCCCCCACC TGTGCGAAGG GCCGATCTTC CTTTCCCCCT TGGCCCTGTC 
CACACCCCCC AACTGATGCC ACTGCTGATG GATGTTGCTG GCAGTGACAG CAGCCACAAG 
GACGGCCCCT GTGGGTCCTG GGGGACAAGC ATCACCCTGC CACCCCCCTG TTCATATTTG 
GAGGAGCTGG AGCCCCAGGA TTACCAACAG AGCAACCAGC CAGGACCCTT CCAGTTCTCC 
CAGGCTCCAC AGCCCCCGCT TTTCCAGTCC CCTCAGCCCA AGTTGCCCTA CCTCCCCACT 
TTCCCCTTCT CCATGCCCAG TTCACTGACG CTTCCACCGC CCGAAGACTC TCTCTTTATG 
TTTCCCTGTG GCCCCAGCGG GGGCACATCG CAGGGCTATT GCCCAGGTGC CTCCTCAGGA 
CAGATCCTGA TGCAACCACC TGCTGGGAAT ATAGGTACAG CCTCCTGGAG TGACCCCTGT 
TTGCCAGAGC TGCCCTTCCC TGGTCCGTTC TGCCCACAAG CTCTGGGGCA TCCCCCAGGA 
GGGGATGGCT ACTTTCCTGA TCTATTTCCA ACTCCCTGCC CCCAGGCTCT GGGCAGGCAG 
CCTTCGTCAG CTCTCTCATG GATGCCTGAA GGGGCCAGAC CAGGGACTGG GCCCTTACTC 
AGCAAGGCAA AAGAGGAACC ACCAGCTGCT TCCCTGGATC AGCCCTCAGC ACTGGAGGAG 
GCCAGAGGGG ATGACAAGAA TAGCCATGTC CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073882.3
CDS	1..2076
Translation	MALLLTLTSPDLEGTWDTRDKDGFKAQEGPPLAVPEFPVCGLYRIYGVCGSFSSFFIIRCSLCALETLKSPQHDPLEIPEQSLKLIPLVSGKRELTRGQKAGEKPLAAGPGEEELLRGSAPHAQDTQSEELPPSCTISGEKKPPAVSGEATGADAGRLCPPPRSRAPHKDRTLARSRPQTQGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPTSSPGAPNSARATHNPVPCGSGRGPCHLANLLSTLAQSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIMVKGAGSLVAGWSGGGPTIETLELQSERSAVAWVWFQNRRAKWRKMEKLNGKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPFPQESPLDTFPEPPMLLTSDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPLLMDVAGSDSSHKDGPCGSWGTSITLPPPCSYLEELEPQDYQQSNQPGPFQFSQAPQPPLFQSPQPKLPYLPTFPFSMPSSLTLPPPEDSLFMFPCGPSGGTSQGYCPGASSGQILMQPPAGNIGTASWSDPCLPELPFPGPFCPQALGHPPGGDGYFPDLFPTPCPQALGRQPSSALSWMPEGARPGTGPLLSKAKEEPPAASLDQPSALEEARGDDKNSHVP

Target ORF information:

RefSeq Version	NM_001080413.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NOBOX oogenesis homeobox (NOBOX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080413.3

ORF Insert Sequence:

ATGGCTCTCC TTTTGACACT AACATCACCA GACCTGGAGG GTACCTGGGA CACCAGAGAC 
AAGGATGGCT TCAAAGCCCA GGAGGGGCCG CCCCTGGCTG TACCTGAATT TCCTGTGTGT 
GGACTGTACC GGATCTACGG AGTCTGTGGC TCTTTCAGCT CCTTCTTCAT CATCCGGTGC 
AGCCTTTGTG CTCTGGAGAC CCTCAAATCA CCCCAACATG ATCCCTTAGA GATACCTGAA 
CAGTCCCTCA AACTCATACC CCTGGTGTCT GGGAAAAGGG AACTCACAAG GGGCCAGAAA 
GCTGGAGAGA AGCCCCTGGC TGCAGGACCC GGGGAGGAGG AACTGCTCCG GGGCTCAGCC 
CCTCATGCTC AGGACACTCA GAGTGAGGAA CTGCCACCCT CCTGCACCAT CTCAGGAGAG 
AAGAAGCCGC CAGCAGTCTC TGGAGAAGCC ACCGGGGCTG ATGCTGGGAG ACTGTGCCCG 
CCCCCCCGCT CCAGGGCTCC CCACAAAGAC AGAACTCTAG CCCGCTCCAG GCCCCAGACT 
CAGGGGGAAG ATTGTTCCCT CCCAGTGGGA GAGGTGAAGA TAGGAAAGAG GTCCTATTCT 
CCAGCCCCCG GGAAGCAGAA AAAGCCTAAT GCCATGGGTC TGGCCCCAAC ATCATCTCCG 
GGTGCCCCTA ACTCAGCCCG TGCCACACAC AACCCAGTGC CCTGTGGGTC AGGCCGGGGG 
CCCTGCCACC TGGCCAATCT CCTCAGTACA TTGGCGCAGA GCAACCAAAA CAGAGACCAC 
AAGCAGGGGC CCCCGGAAGT GACCTGCCAA ATTAGGAAAA AGACACGAAC CCTATACCGC 
TCAGATCAGC TGGAGGAGCT AGAGAAGATA TTCCAAGAAG ACCACTATCC TGACAGTGAT 
AAACGCCGAG AGATTGCCCA GACGGTGGGG GTGACCCCCC AGCGCATCAT GGTAAAGGGG 
GCCGGCTCAC TGGTGGCAGG GTGGAGTGGC GGAGGGCCCA CCATTGAAAC ACTCGAATTG 
CAGAGTGAGC GCTCAGCGGT AGCCTGGGTG TGGTTCCAGA ATCGCCGGGC CAAGTGGCGA 
AAAATGGAGA AACTGAATGG GAAAGAAAGC AAGGACAATC CTGCAGCCCC TGGCCCTGCC 
AGCAGTCAAT GCAGCTCTGC AGCTGAGATC CTACCTGCTG TGCCCATGGA GCCAAAGCCT 
GACCCTTTCC CTCAGGAGTC CCCTCTGGAT ACCTTTCCAG AGCCCCCCAT GCTGCTGACT 
TCTGACCAGA CTTTGGCCCC CACCCAACCC AGTGAGGGTG CTCAGAGGGT GGTGACCCCC 
CCACTCTTCA GCCCCCCACC TGTGCGAAGG GCCGATCTTC CTTTCCCCCT TGGCCCTGTC 
CACACCCCCC AACTGATGCC ACTGCTGATG GATGTTGCTG GCAGTGACAG CAGCCACAAG 
GACGGCCCCT GTGGGTCCTG GGGGACAAGC ATCACCCTGC CACCCCCCTG TTCATATTTG 
GAGGAGCTGG AGCCCCAGGA TTACCAACAG AGCAACCAGC CAGGACCCTT CCAGTTCTCC 
CAGGCTCCAC AGCCCCCGCT TTTCCAGTCC CCTCAGCCCA AGTTGCCCTA CCTCCCCACT 
TTCCCCTTCT CCATGCCCAG TTCACTGACG CTTCCACCGC CCGAAGACTC TCTCTTTATG 
TTTCCCTGTG GCCCCAGCGG GGGCACATCG CAGGGCTATT GCCCAGGTGC CTCCTCAGGA 
CAGATCCTGA TGCAACCACC TGCTGGGAAT ATAGGTACAG CCTCCTGGAG TGACCCCTGT 
TTGCCAGAGC TGCCCTTCCC TGGTCCGTTC TGCCCACAAG CTCTGGGGCA TCCCCCAGGA 
GGGGATGGCT ACTTTCCTGA TCTATTTCCA ACTCCCTGCC CCCAGGCTCT GGGCAGGCAG 
CCTTCGTCAG CTCTCTCATG GATGCCTGAA GGGGCCAGAC CAGGGACTGG GCCCTTACTC 
AGCAAGGCAA AAGAGGAACC ACCAGCTGCT TCCCTGGATC AGCCCTCAGC ACTGGAGGAG 
GCCAGAGGGG ATGACAAGAA TAGCCATGTC CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOBOX ( XM_017011742.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867231.1 Homo sapiens NOBOX oogenesis homeobox (NOBOX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu97038
Clone ID Related Accession (Same CDS sequence)	XM_017011742.1 , XM_017011742.2
Accession Version	XM_017011742.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	homeobox protein NOBOX isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTCC TTTTGACACT AACATCACCA GACCTGGAGG GTACCTGGGA CACCAGAGAC 
AAGGATGGCT TCAAAGCCCA GGAGGGGCCG CCCCTGGCTG TACCTGAATT TCCTGTGTGT 
GGACTGTACC GGATCTACGG AGTCTGTGGC TCTTTCAGCT CCTTCTTCAT CATCCGGTGC 
AGCCTTTGTG CTCTGGAGAC CCTCAAATCA CCCCAACATG ATCCCTTAGA GATACCTGAA 
CAGTCCCTCA AACTCATACC CCTGGTGTCT GGGAAAAGGG AACTCACAAG GGGCCAGAAA 
GCTGGAGAGA AGCCCCTGGC TGCAGGACCC GGGGAGGAGG AACTGCTCCG GGGCTCAGCC 
CCTCATGCTC AGGACACTCA GAGTGAGGAA CTGCCACCCT CCTGCACCAT CTCAGGAGAG 
AAGAAGCCGC CAGCAGTCTC TGGAGAAGCC ACCGGGGCTG ATGCTGGGAG ACTGTGCCCG 
CCCCCCCGCT CCAGGGCTCC CCACAAAGAC AGAACTCTAG CCCGCTCCAG GCCCCAGACT 
CAGGGGGAAG ATTGTTCCCT CCCAGTGGGA GAGGTGAAGA TAGGAAAGAG GTCCTATTCT 
CCAGCCCCCG GGAAGCAGAA AAAGCCTAAT GCCATGGGTC TGGCCCCAAC ATCATCTCCG 
GGTGCCCCTA ACTCAGCCCG TGCCACACAC AACCCAGTGC CCTGTGGGTC AGGCCGGGGG 
CCCTGCCACC TGGCCAATCT CCTCAGTACA TTGGCGCAGA GCAACCAAAA CAGAGACCAC 
AAGCAGGGGC CCCCGGAAGT GACCTGCCAA ATTAGGAAAA AGACACGAAC CCTATACCGC 
TCAGATCAGC TGGAGGAGCT AGAGAAGATA TTCCAAGAAG ACCACTATCC TGACAGTGAT 
AAACGCCGAG AGATTGCCCA GACGGTGGGG GTGACCCCCC AGCGCATCAT GGTGTGGTTC 
CAGAATCGCC GGGCCAAGTG GCGAAAAATG GAGAAACTGA ATGGGAAAGA AAGCAAGGAC 
AATCCTGCAG CCCCTGGCCC TGCCAGCAGT CAATGCAGCT CTGCAGCTGA GATCCTACCT 
GCTGTGCCCA TGGAGCCAAA GCCTGACCCT TTCCCTCAGG AGTCCCCTCT GGATACCTTT 
CCAGAGCCCC CCATGCTGCT GACTTCTGAC CAGACTTTGG CCCCCACCCA ACCCAGTGAG 
GGTGCTCAGA GGGTGGTGAC CCCCCCACTC TTCAGCCCCC CACCTGTGCG AAGGGCCGAT 
CTTCCTTTCC CCCTTGGCCC TGTCCACACC CCCCAACTGA TGCCACTGCT GATGGATGTT 
GCTGGCAGTG ACAGCAGCCA CAAGGACGGC CCCTGTGGGT CCTGGGGGAC AAGCATCACC 
CTGCCACCCC CCTGTTCATA TTTGGAGGAG CTGGAGCCCC AGGATTACCA ACAGAGCAAC 
CAGCCAGGAC CCTTCCAGTT CTCCCAGGCT CCACAGCCCC CGCTTTTCCA GTCCCCTCAG 
CCCAAGTTGC CCTACCTCCC CACTTTCCCC TTCTCCATGC CCAGTTCACT GACGCTTCCA 
CCGCCCGAAG ACTCTCTCTT TATGTTTCCC TGTGGCCCCA GCGGGGGCAC ATCGCAGGGC 
TATTGCCCAG GTGCCTCCTC AGGACAGATC CTGATGCAAC CACCTGCTGG GAATATAGGT 
ACAGCCTCCT GGAGTGACCC CTGTTTGCCA GAGCTGCCCT TCCCTGGTCC GTTCTGCCCA 
CAAGCTCTGG GGCATCCCCC AGGAGGGGAT GGCTACTTTC CTGATCTATT TCCAACTCCC 
TGCCCCCAGG CTCTGGGCAG GCAGCCTTCG TCAGCTCTCT CATGGATGCC TGAAGGGGCC 
AGACCAGGGA CTGGGCCCTT ACTCAGCAAG GCAAAAGAGG AACCACCAGC TGCTTCCCTG 
GATCAGCCCT CAGCACTGGA GGAGGCCAGA GGGGATGACA AGAATAGCCA TGTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867231.1
CDS	212..2191
Translation	MALLLTLTSPDLEGTWDTRDKDGFKAQEGPPLAVPEFPVCGLYRIYGVCGSFSSFFIIRCSLCALETLKSPQHDPLEIPEQSLKLIPLVSGKRELTRGQKAGEKPLAAGPGEEELLRGSAPHAQDTQSEELPPSCTISGEKKPPAVSGEATGADAGRLCPPPRSRAPHKDRTLARSRPQTQGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPTSSPGAPNSARATHNPVPCGSGRGPCHLANLLSTLAQSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIMVWFQNRRAKWRKMEKLNGKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPFPQESPLDTFPEPPMLLTSDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPLLMDVAGSDSSHKDGPCGSWGTSITLPPPCSYLEELEPQDYQQSNQPGPFQFSQAPQPPLFQSPQPKLPYLPTFPFSMPSSLTLPPPEDSLFMFPCGPSGGTSQGYCPGASSGQILMQPPAGNIGTASWSDPCLPELPFPGPFCPQALGHPPGGDGYFPDLFPTPCPQALGRQPSSALSWMPEGARPGTGPLLSKAKEEPPAASLDQPSALEEARGDDKNSHVP

Target ORF information:

RefSeq Version	XM_017011742.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NOBOX oogenesis homeobox (NOBOX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011742.1

ORF Insert Sequence:

ATGGCTCTCC TTTTGACACT AACATCACCA GACCTGGAGG GTACCTGGGA CACCAGAGAC 
AAGGATGGCT TCAAAGCCCA GGAGGGGCCG CCCCTGGCTG TACCTGAATT TCCTGTGTGT 
GGACTGTACC GGATCTACGG AGTCTGTGGC TCTTTCAGCT CCTTCTTCAT CATCCGGTGC 
AGCCTTTGTG CTCTGGAGAC CCTCAAATCA CCCCAACATG ATCCCTTAGA GATACCTGAA 
CAGTCCCTCA AACTCATACC CCTGGTGTCT GGGAAAAGGG AACTCACAAG GGGCCAGAAA 
GCTGGAGAGA AGCCCCTGGC TGCAGGACCC GGGGAGGAGG AACTGCTCCG GGGCTCAGCC 
CCTCATGCTC AGGACACTCA GAGTGAGGAA CTGCCACCCT CCTGCACCAT CTCAGGAGAG 
AAGAAGCCGC CAGCAGTCTC TGGAGAAGCC ACCGGGGCTG ATGCTGGGAG ACTGTGCCCG 
CCCCCCCGCT CCAGGGCTCC CCACAAAGAC AGAACTCTAG CCCGCTCCAG GCCCCAGACT 
CAGGGGGAAG ATTGTTCCCT CCCAGTGGGA GAGGTGAAGA TAGGAAAGAG GTCCTATTCT 
CCAGCCCCCG GGAAGCAGAA AAAGCCTAAT GCCATGGGTC TGGCCCCAAC ATCATCTCCG 
GGTGCCCCTA ACTCAGCCCG TGCCACACAC AACCCAGTGC CCTGTGGGTC AGGCCGGGGG 
CCCTGCCACC TGGCCAATCT CCTCAGTACA TTGGCGCAGA GCAACCAAAA CAGAGACCAC 
AAGCAGGGGC CCCCGGAAGT GACCTGCCAA ATTAGGAAAA AGACACGAAC CCTATACCGC 
TCAGATCAGC TGGAGGAGCT AGAGAAGATA TTCCAAGAAG ACCACTATCC TGACAGTGAT 
AAACGCCGAG AGATTGCCCA GACGGTGGGG GTGACCCCCC AGCGCATCAT GGTGTGGTTC 
CAGAATCGCC GGGCCAAGTG GCGAAAAATG GAGAAACTGA ATGGGAAAGA AAGCAAGGAC 
AATCCTGCAG CCCCTGGCCC TGCCAGCAGT CAATGCAGCT CTGCAGCTGA GATCCTACCT 
GCTGTGCCCA TGGAGCCAAA GCCTGACCCT TTCCCTCAGG AGTCCCCTCT GGATACCTTT 
CCAGAGCCCC CCATGCTGCT GACTTCTGAC CAGACTTTGG CCCCCACCCA ACCCAGTGAG 
GGTGCTCAGA GGGTGGTGAC CCCCCCACTC TTCAGCCCCC CACCTGTGCG AAGGGCCGAT 
CTTCCTTTCC CCCTTGGCCC TGTCCACACC CCCCAACTGA TGCCACTGCT GATGGATGTT 
GCTGGCAGTG ACAGCAGCCA CAAGGACGGC CCCTGTGGGT CCTGGGGGAC AAGCATCACC 
CTGCCACCCC CCTGTTCATA TTTGGAGGAG CTGGAGCCCC AGGATTACCA ACAGAGCAAC 
CAGCCAGGAC CCTTCCAGTT CTCCCAGGCT CCACAGCCCC CGCTTTTCCA GTCCCCTCAG 
CCCAAGTTGC CCTACCTCCC CACTTTCCCC TTCTCCATGC CCAGTTCACT GACGCTTCCA 
CCGCCCGAAG ACTCTCTCTT TATGTTTCCC TGTGGCCCCA GCGGGGGCAC ATCGCAGGGC 
TATTGCCCAG GTGCCTCCTC AGGACAGATC CTGATGCAAC CACCTGCTGG GAATATAGGT 
ACAGCCTCCT GGAGTGACCC CTGTTTGCCA GAGCTGCCCT TCCCTGGTCC GTTCTGCCCA 
CAAGCTCTGG GGCATCCCCC AGGAGGGGAT GGCTACTTTC CTGATCTATT TCCAACTCCC 
TGCCCCCAGG CTCTGGGCAG GCAGCCTTCG TCAGCTCTCT CATGGATGCC TGAAGGGGCC 
AGACCAGGGA CTGGGCCCTT ACTCAGCAAG GCAAAAGAGG AACCACCAGC TGCTTCCCTG 
GATCAGCCCT CAGCACTGGA GGAGGCCAGA GGGGATGACA AGAATAGCCA TGTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOBOX ( XM_017011742.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867231.1 Homo sapiens NOBOX oogenesis homeobox (NOBOX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu97038
Clone ID Related Accession (Same CDS sequence)	XM_017011742.1 , XM_017011742.2
Accession Version	XM_017011742.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	homeobox protein NOBOX isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017011742.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTCC TTTTGACACT AACATCACCA GACCTGGAGG GTACCTGGGA CACCAGAGAC 
AAGGATGGCT TCAAAGCCCA GGAGGGGCCG CCCCTGGCTG TACCTGAATT TCCTGTGTGT 
GGACTGTACC GGATCTACGG AGTCTGTGGC TCTTTCAGCT CCTTCTTCAT CATCCGGTGC 
AGCCTTTGTG CTCTGGAGAC CCTCAAATCA CCCCAACATG ATCCCTTAGA GATACCTGAA 
CAGTCCCTCA AACTCATACC CCTGGTGTCT GGGAAAAGGG AACTCACAAG GGGCCAGAAA 
GCTGGAGAGA AGCCCCTGGC TGCAGGACCC GGGGAGGAGG AACTGCTCCG GGGCTCAGCC 
CCTCATGCTC AGGACACTCA GAGTGAGGAA CTGCCACCCT CCTGCACCAT CTCAGGAGAG 
AAGAAGCCGC CAGCAGTCTC TGGAGAAGCC ACCGGGGCTG ATGCTGGGAG ACTGTGCCCG 
CCCCCCCGCT CCAGGGCTCC CCACAAAGAC AGAACTCTAG CCCGCTCCAG GCCCCAGACT 
CAGGGGGAAG ATTGTTCCCT CCCAGTGGGA GAGGTGAAGA TAGGAAAGAG GTCCTATTCT 
CCAGCCCCCG GGAAGCAGAA AAAGCCTAAT GCCATGGGTC TGGCCCCAAC ATCATCTCCG 
GGTGCCCCTA ACTCAGCCCG TGCCACACAC AACCCAGTGC CCTGTGGGTC AGGCCGGGGG 
CCCTGCCACC TGGCCAATCT CCTCAGTACA TTGGCGCAGA GCAACCAAAA CAGAGACCAC 
AAGCAGGGGC CCCCGGAAGT GACCTGCCAA ATTAGGAAAA AGACACGAAC CCTATACCGC 
TCAGATCAGC TGGAGGAGCT AGAGAAGATA TTCCAAGAAG ACCACTATCC TGACAGTGAT 
AAACGCCGAG AGATTGCCCA GACGGTGGGG GTGACCCCCC AGCGCATCAT GGTGTGGTTC 
CAGAATCGCC GGGCCAAGTG GCGAAAAATG GAGAAACTGA ATGGGAAAGA AAGCAAGGAC 
AATCCTGCAG CCCCTGGCCC TGCCAGCAGT CAATGCAGCT CTGCAGCTGA GATCCTACCT 
GCTGTGCCCA TGGAGCCAAA GCCTGACCCT TTCCCTCAGG AGTCCCCTCT GGATACCTTT 
CCAGAGCCCC CCATGCTGCT GACTTCTGAC CAGACTTTGG CCCCCACCCA ACCCAGTGAG 
GGTGCTCAGA GGGTGGTGAC CCCCCCACTC TTCAGCCCCC CACCTGTGCG AAGGGCCGAT 
CTTCCTTTCC CCCTTGGCCC TGTCCACACC CCCCAACTGA TGCCACTGCT GATGGATGTT 
GCTGGCAGTG ACAGCAGCCA CAAGGACGGC CCCTGTGGGT CCTGGGGGAC AAGCATCACC 
CTGCCACCCC CCTGTTCATA TTTGGAGGAG CTGGAGCCCC AGGATTACCA ACAGAGCAAC 
CAGCCAGGAC CCTTCCAGTT CTCCCAGGCT CCACAGCCCC CGCTTTTCCA GTCCCCTCAG 
CCCAAGTTGC CCTACCTCCC CACTTTCCCC TTCTCCATGC CCAGTTCACT GACGCTTCCA 
CCGCCCGAAG ACTCTCTCTT TATGTTTCCC TGTGGCCCCA GCGGGGGCAC ATCGCAGGGC 
TATTGCCCAG GTGCCTCCTC AGGACAGATC CTGATGCAAC CACCTGCTGG GAATATAGGT 
ACAGCCTCCT GGAGTGACCC CTGTTTGCCA GAGCTGCCCT TCCCTGGTCC GTTCTGCCCA 
CAAGCTCTGG GGCATCCCCC AGGAGGGGAT GGCTACTTTC CTGATCTATT TCCAACTCCC 
TGCCCCCAGG CTCTGGGCAG GCAGCCTTCG TCAGCTCTCT CATGGATGCC TGAAGGGGCC 
AGACCAGGGA CTGGGCCCTT ACTCAGCAAG GCAAAAGAGG AACCACCAGC TGCTTCCCTG 
GATCAGCCCT CAGCACTGGA GGAGGCCAGA GGGGATGACA AGAATAGCCA TGTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867231.1
CDS	196..2175
Translation	MALLLTLTSPDLEGTWDTRDKDGFKAQEGPPLAVPEFPVCGLYRIYGVCGSFSSFFIIRCSLCALETLKSPQHDPLEIPEQSLKLIPLVSGKRELTRGQKAGEKPLAAGPGEEELLRGSAPHAQDTQSEELPPSCTISGEKKPPAVSGEATGADAGRLCPPPRSRAPHKDRTLARSRPQTQGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPTSSPGAPNSARATHNPVPCGSGRGPCHLANLLSTLAQSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIMVWFQNRRAKWRKMEKLNGKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPFPQESPLDTFPEPPMLLTSDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPLLMDVAGSDSSHKDGPCGSWGTSITLPPPCSYLEELEPQDYQQSNQPGPFQFSQAPQPPLFQSPQPKLPYLPTFPFSMPSSLTLPPPEDSLFMFPCGPSGGTSQGYCPGASSGQILMQPPAGNIGTASWSDPCLPELPFPGPFCPQALGHPPGGDGYFPDLFPTPCPQALGRQPSSALSWMPEGARPGTGPLLSKAKEEPPAASLDQPSALEEARGDDKNSHVP

Target ORF information:

RefSeq Version	XM_017011742.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NOBOX oogenesis homeobox (NOBOX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011742.2

ORF Insert Sequence:

ATGGCTCTCC TTTTGACACT AACATCACCA GACCTGGAGG GTACCTGGGA CACCAGAGAC 
AAGGATGGCT TCAAAGCCCA GGAGGGGCCG CCCCTGGCTG TACCTGAATT TCCTGTGTGT 
GGACTGTACC GGATCTACGG AGTCTGTGGC TCTTTCAGCT CCTTCTTCAT CATCCGGTGC 
AGCCTTTGTG CTCTGGAGAC CCTCAAATCA CCCCAACATG ATCCCTTAGA GATACCTGAA 
CAGTCCCTCA AACTCATACC CCTGGTGTCT GGGAAAAGGG AACTCACAAG GGGCCAGAAA 
GCTGGAGAGA AGCCCCTGGC TGCAGGACCC GGGGAGGAGG AACTGCTCCG GGGCTCAGCC 
CCTCATGCTC AGGACACTCA GAGTGAGGAA CTGCCACCCT CCTGCACCAT CTCAGGAGAG 
AAGAAGCCGC CAGCAGTCTC TGGAGAAGCC ACCGGGGCTG ATGCTGGGAG ACTGTGCCCG 
CCCCCCCGCT CCAGGGCTCC CCACAAAGAC AGAACTCTAG CCCGCTCCAG GCCCCAGACT 
CAGGGGGAAG ATTGTTCCCT CCCAGTGGGA GAGGTGAAGA TAGGAAAGAG GTCCTATTCT 
CCAGCCCCCG GGAAGCAGAA AAAGCCTAAT GCCATGGGTC TGGCCCCAAC ATCATCTCCG 
GGTGCCCCTA ACTCAGCCCG TGCCACACAC AACCCAGTGC CCTGTGGGTC AGGCCGGGGG 
CCCTGCCACC TGGCCAATCT CCTCAGTACA TTGGCGCAGA GCAACCAAAA CAGAGACCAC 
AAGCAGGGGC CCCCGGAAGT GACCTGCCAA ATTAGGAAAA AGACACGAAC CCTATACCGC 
TCAGATCAGC TGGAGGAGCT AGAGAAGATA TTCCAAGAAG ACCACTATCC TGACAGTGAT 
AAACGCCGAG AGATTGCCCA GACGGTGGGG GTGACCCCCC AGCGCATCAT GGTGTGGTTC 
CAGAATCGCC GGGCCAAGTG GCGAAAAATG GAGAAACTGA ATGGGAAAGA AAGCAAGGAC 
AATCCTGCAG CCCCTGGCCC TGCCAGCAGT CAATGCAGCT CTGCAGCTGA GATCCTACCT 
GCTGTGCCCA TGGAGCCAAA GCCTGACCCT TTCCCTCAGG AGTCCCCTCT GGATACCTTT 
CCAGAGCCCC CCATGCTGCT GACTTCTGAC CAGACTTTGG CCCCCACCCA ACCCAGTGAG 
GGTGCTCAGA GGGTGGTGAC CCCCCCACTC TTCAGCCCCC CACCTGTGCG AAGGGCCGAT 
CTTCCTTTCC CCCTTGGCCC TGTCCACACC CCCCAACTGA TGCCACTGCT GATGGATGTT 
GCTGGCAGTG ACAGCAGCCA CAAGGACGGC CCCTGTGGGT CCTGGGGGAC AAGCATCACC 
CTGCCACCCC CCTGTTCATA TTTGGAGGAG CTGGAGCCCC AGGATTACCA ACAGAGCAAC 
CAGCCAGGAC CCTTCCAGTT CTCCCAGGCT CCACAGCCCC CGCTTTTCCA GTCCCCTCAG 
CCCAAGTTGC CCTACCTCCC CACTTTCCCC TTCTCCATGC CCAGTTCACT GACGCTTCCA 
CCGCCCGAAG ACTCTCTCTT TATGTTTCCC TGTGGCCCCA GCGGGGGCAC ATCGCAGGGC 
TATTGCCCAG GTGCCTCCTC AGGACAGATC CTGATGCAAC CACCTGCTGG GAATATAGGT 
ACAGCCTCCT GGAGTGACCC CTGTTTGCCA GAGCTGCCCT TCCCTGGTCC GTTCTGCCCA 
CAAGCTCTGG GGCATCCCCC AGGAGGGGAT GGCTACTTTC CTGATCTATT TCCAACTCCC 
TGCCCCCAGG CTCTGGGCAG GCAGCCTTCG TCAGCTCTCT CATGGATGCC TGAAGGGGCC 
AGACCAGGGA CTGGGCCCTT ACTCAGCAAG GCAAAAGAGG AACCACCAGC TGCTTCCCTG 
GATCAGCCCT CAGCACTGGA GGAGGCCAGA GGGGATGACA AGAATAGCCA TGTCCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel homozygous 1-bp deletion in the NOBOX gene in two Brazilian sisters with primary ovarian failure.
Endocrine58(3)442-447(2017 Dec)
Fran?a MM,Funari MFA,Lerario AM,Nishi MY,Pita CC,Fontenele EGP,Mendonca BB

R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.
Journal of ovarian research10(1)51(2017 Jul)
Bouilly J,Beau I,Barraud S,Bernard V,Delemer B,Young J,Binart N

A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency.
Human reproduction (Oxford, England)32(1)248-255(2017 Jan)
Li L,Wang B,Zhang W,Chen B,Luo M,Wang J,Wang X,Cao Y,Kee K

Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency.
Human molecular genetics25(23)5223-5233(2016 12)
Ferrari I,Bouilly J,Beau I,Guizzardi F,Ferlin A,Pollazzon M,Salerno M,Binart N,Persani L,Rossetti R

NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.
Clinical genetics89(5)608-13(2016 May)
Bouali N,Francou B,Bouligand J,Lakhal B,Malek I,Kammoun M,Warszawski J,Mougou S,Saad A,Guiochon-Mantel A

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NOBOX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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