COX8A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX8A
Entrez Gene ID	1351
Full Name	cytochrome c oxidase subunit 8A
Synonyms	COX,COX8,COX8-2,COX8L,VIII,VIII-L
General protein information	Preferred Names cytochrome c oxidase subunit 8A Names cytochrome c oxidase subunit 8A, mitochondrial cytochrome c oxidase polypeptide VIII-liver/heart cytochrome c oxidase subunit 8-2 cytochrome c oxidase subunit 8A (ubiquitous) cytochrome c oxidase subunit VIII cytochrome c oxidase subunit VIIIA (ubiquitous)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008].
Disorder MIM:	123870
Disorder Html:	?Mitochondrial complex IV deficiency, 220110 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004074.2	NP_004065.1	cytochrome c oxidase subunit 8A, mitochondrial
NM_004074.3	NP_004065.1	cytochrome c oxidase subunit 8A, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	COX8A	NP_004065.1
Pan troglodytes (chimpanzee)	COX8A	NP_001073394.1
Canis lupus familiaris (dog)	COX8A	NP_001239299.1
Bos taurus (cattle)	LOC783202	XP_003587571.2
Rattus norvegicus (Norway rat)	Cox8a	NP_599172.1
	COX8A	XP_001115516.1
Mus musculus (house mouse)	Cox8a	NP_031776.1
Bos taurus (cattle)	COX8A	NP_776449.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.
Hallmann K, Kudin AP, Zsurka G, Kornblum C, Reimann J, St?ve B, Waltz S, Hattingen E, Thiele H, N?rnberg P, R?b C, Voos W, Kopatz J, Neumann H, Kunz WS
Brain : a journal of neurology139(Pt 2)338-45(2016 Feb)

Image-based genome-wide siRNA screen identifies selective autophagy factors.
Orvedahl A, Sumpter R Jr, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B
Nature480(7375)113-7(2011 Dec)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

A third isoform of cytochrome c oxidase subunit VIII is present in mammals.
H?ttemann M, Schmidt TR, Grossman LI
Gene31295-102(2003 Jul)

Peptide nucleic acid delivery to human mitochondria.
Chinnery PF, Taylor RW, Diekert K, Lill R, Turnbull DM, Lightowlers RN
Gene therapy6(12)1919-28(1999 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COX8A is indispensable for function of human complex IV and its mutation causes Leigh-like syndrome and epilepsy.
Title: Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following COX8A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX8A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30792	NM_004074.3 Latest version!	Homo sapiens cytochrome c oxidase subunit 8A (COX8A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30792	NM_004074.2	Homo sapiens cytochrome c oxidase subunit 8A (COX8A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX8A ( NM_004074.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004065.1 Homo sapiens cytochrome c oxidase subunit 8A (COX8A), mRNA.

Price & Availability↑

CloneID	OHu30792
Clone ID Related Accession (Same CDS sequence)	NM_004074.2 , NM_004074.3
Accession Version	NM_004074.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 8A, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC063025.1. This sequence is a reference standard in the RefSeqGene project. On Mar 30, 2004 this sequence version replaced NM_004074.1. ##Evidence-Data-START## Transcript exon combination :: BC063025.1, BM919236.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCGTCC TGACGCCGCT GCTGCTGCGG GGCTTGACAG GCTCGGCCCG GCGGCTCCCA 
GTGCCGCGCG CCAAGATCCA TTCGTTGCCG CCGGAGGGGA AGCTTGGGAT CATGGAATTG 
GCCGTTGGGC TTACCTCCTG CTTCGTGACC TTCCTCCTGC CAGCGGGCTG GATCCTGTCA 
CACCTGGAGA CCTACAGGAG GCCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004065.1
CDS	75..284
Translation	MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE

Target ORF information:

RefSeq Version	NM_004074.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 8A (COX8A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004074.2

ORF Insert Sequence:

ATGTCCGTCC TGACGCCGCT GCTGCTGCGG GGCTTGACAG GCTCGGCCCG GCGGCTCCCA 
GTGCCGCGCG CCAAGATCCA TTCGTTGCCG CCGGAGGGGA AGCTTGGGAT CATGGAATTG 
GCCGTTGGGC TTACCTCCTG CTTCGTGACC TTCCTCCTGC CAGCGGGCTG GATCCTGTCA 
CACCTGGAGA CCTACAGGAG GCCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX8A ( NM_004074.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004065.1 Homo sapiens cytochrome c oxidase subunit 8A (COX8A), mRNA.

Price & Availability↑

CloneID	OHu30792
Clone ID Related Accession (Same CDS sequence)	NM_004074.2 , NM_004074.3
Accession Version	NM_004074.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 210bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 8A, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC063025.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004074.2. ##Evidence-Data-START## Transcript exon combination :: BP271537.1, BP271677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000314133.4/ ENSP00000321260.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCGTCC TGACGCCGCT GCTGCTGCGG GGCTTGACAG GCTCGGCCCG GCGGCTCCCA 
GTGCCGCGCG CCAAGATCCA TTCGTTGCCG CCGGAGGGGA AGCTTGGGAT CATGGAATTG 
GCCGTTGGGC TTACCTCCTG CTTCGTGACC TTCCTCCTGC CAGCGGGCTG GATCCTGTCA 
CACCTGGAGA CCTACAGGAG GCCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004065.1
CDS	62..271
Translation	MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE

Target ORF information:

RefSeq Version	NM_004074.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 8A (COX8A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004074.3

ORF Insert Sequence:

ATGTCCGTCC TGACGCCGCT GCTGCTGCGG GGCTTGACAG GCTCGGCCCG GCGGCTCCCA 
GTGCCGCGCG CCAAGATCCA TTCGTTGCCG CCGGAGGGGA AGCTTGGGAT CATGGAATTG 
GCCGTTGGGC TTACCTCCTG CTTCGTGACC TTCCTCCTGC CAGCGGGCTG GATCCTGTCA 
CACCTGGAGA CCTACAGGAG GCCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.
Brain : a journal of neurology139(Pt 2)338-45(2016 Feb)
Hallmann K,Kudin AP,Zsurka G,Kornblum C,Reimann J,St?ve B,Waltz S,Hattingen E,Thiele H,N?rnberg P,R?b C,Voos W,Kopatz J,Neumann H,Kunz WS

Image-based genome-wide siRNA screen identifies selective autophagy factors.
Nature480(7375)113-7(2011 Dec)
Orvedahl A,Sumpter R Jr,Xiao G,Ng A,Zou Z,Tang Y,Narimatsu M,Gilpin C,Sun Q,Roth M,Forst CV,Wrana JL,Zhang YE,Luby-Phelps K,Xavier RJ,Xie Y,Levine B

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

A third isoform of cytochrome c oxidase subunit VIII is present in mammals.
Gene31295-102(2003 Jul)
H?ttemann M,Schmidt TR,Grossman LI

Peptide nucleic acid delivery to human mitochondria.
Gene therapy6(12)1919-28(1999 Dec)
Chinnery PF,Taylor RW,Diekert K,Lill R,Turnbull DM,Lightowlers RN

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COX8A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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