RIPPLY2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RIPPLY2
Entrez Gene ID	134701
Full Name	ripply transcriptional repressor 2
Synonyms	C6orf159,SCDO6,dJ237I15.1
General protein information	Preferred Names ripply transcriptional repressor 2 Names protein ripply2 ripply2 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q14.2
Summary	This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Disorder MIM:	609891
Disorder Html:	?Spondylocostal dysostosis 6, 616566 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001009994.2	NP_001009994.1	protein ripply2

Pathways from BioSystems

Homologies

Homo sapiens (human)	RIPPLY2	NP_001009994.1
Pan troglodytes (chimpanzee)	RIPPLY2	XP_003311415.1
Rattus norvegicus (Norway rat)	Ripply2	XP_343445.2
Bos taurus (cattle)	LOC781965	XP_002690259.2
	RIPPLY2	XP_001085600.1
Mus musculus (house mouse)	Ripply2	NP_001032996.1

Gene Ontology
Bibliography

Related articles in PubMed

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel-Feil syndrome.
Karaca E, Yuregir OO, Bozdogan ST, Aslan H, Pehlivan D, Jhangiani SN, Akdemir ZC, Gambin T, Bayram Y, Atik MM, Erdin S, Muzny D, Gibbs RA, Lupski JR,
American journal of medical genetics. Part A167A(11)2795-9(2015 Nov)

Compound heterozygous mutations in RIPPLY2 associated with vertebral segmentation defects.
McInerney-Leo AM, Sparrow DB, Harris JE, Gardiner BB, Marshall MS, O'Reilly VC, Shi H, Brown MA, Leo PJ, Zankl A, Dunwoodie SL, Duncan EL
Human molecular genetics24(5)1234-42(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Novel cleft susceptibility genes in chromosome 6q.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Functional analysis of the mouse Ripply2 ortholog.
Title: Ripply2 is essential for precise somite formation during mouse early development.

Compares Ripply proteins in zebrafish, mouse, human, and amphioxus.
Title: Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites.

The following RIPPLY2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RIPPLY2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu00192	NM_001009994.2 Latest version!	Homo sapiens ripply transcriptional repressor 2 (RIPPLY2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RIPPLY2 ( NM_001009994.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001009994.1 Homo sapiens ripply transcriptional repressor 2 (RIPPLY2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00192
Clone ID Related Accession (Same CDS sequence)	NM_001009994.2
Accession Version	NM_001009994.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	protein ripply2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW511485.1, AL139232.13, BC130460.1 and AI279191.1. This sequence is a reference standard in the RefSeqGene project. On Jun 4, 2013 this sequence version replaced NM_001009994.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. ##Evidence-Data-START## Transcript exon combination :: AW511485.1, BC130460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMEA2158188 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGAACG CGGGAGGCGC AGAGGGTACA GAGAGTGGAG CTGCGGCGTG CGCGGCCACC 
GACGGCCCTA CGCGGCGCGC GGGCGCGGAC TCCGGATACG CAGGCTTCTG GAGACCCTGG 
GTGGACGCCG GAGGCAAGAA AGAAGAGGAG ACGCCGAACC ACGCCGCGGA GGCGATGCCC 
GATGGCCCTG GAATGACCGC AGCCTCAGGA AAGCTTTACC AATTCAGGCA CCCAGTCAGA 
CTATTTTGGC CAAAATCAAA ATGTTATGAT TACTTATATC AAGAAGCAGA AGCTCTTCTG 
AAAAATTTTC CAATTCAAGC CACAATTTCA TTTTATGAAG ATTCTGATAG CGAAGATGAA 
ATTGAGGATC TGACCTGTGA AAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009994.1
CDS	152..538
Translation	MENAGGAEGTESGAAACAATDGPTRRAGADSGYAGFWRPWVDAGGKKEEETPNHAAEAMPDGPGMTAASGKLYQFRHPVRLFWPKSKCYDYLYQEAEALLKNFPIQATISFYEDSDSEDEIEDLTCEN

Target ORF information:

RefSeq Version	NM_001009994.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ripply transcriptional repressor 2 (RIPPLY2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009994.2

ORF Insert Sequence:

ATGGAGAACG CGGGAGGCGC AGAGGGTACA GAGAGTGGAG CTGCGGCGTG CGCGGCCACC 
GACGGCCCTA CGCGGCGCGC GGGCGCGGAC TCCGGATACG CAGGCTTCTG GAGACCCTGG 
GTGGACGCCG GAGGCAAGAA AGAAGAGGAG ACGCCGAACC ACGCCGCGGA GGCGATGCCC 
GATGGCCCTG GAATGACCGC AGCCTCAGGA AAGCTTTACC AATTCAGGCA CCCAGTCAGA 
CTATTTTGGC CAAAATCAAA ATGTTATGAT TACTTATATC AAGAAGCAGA AGCTCTTCTG 
AAAAATTTTC CAATTCAAGC CACAATTTCA TTTTATGAAG ATTCTGATAG CGAAGATGAA 
ATTGAGGATC TGACCTGTGA AAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel-Feil syndrome.
American journal of medical genetics. Part A167A(11)2795-9(2015 Nov)
Karaca E,Yuregir OO,Bozdogan ST,Aslan H,Pehlivan D,Jhangiani SN,Akdemir ZC,Gambin T,Bayram Y,Atik MM,Erdin S,Muzny D,Gibbs RA,Lupski JR,

Compound heterozygous mutations in RIPPLY2 associated with vertebral segmentation defects.
Human molecular genetics24(5)1234-42(2015 Mar)
McInerney-Leo AM,Sparrow DB,Harris JE,Gardiner BB,Marshall MS,O'Reilly VC,Shi H,Brown MA,Leo PJ,Zankl A,Dunwoodie SL,Duncan EL

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RIPPLY2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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