COX6B1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX6B1
Entrez Gene ID	1340
Full Name	cytochrome c oxidase subunit 6B1
Synonyms	COX6B,COXG,COXVIb1
General protein information	Preferred Names cytochrome c oxidase subunit 6B1 Names cytochrome c oxidase subunit 6B1 COX VIb-1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.12
Summary	Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010].
Disorder MIM:	124089
Disorder Html:	Mitochondrial complex IV deficiency, 220110 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001863.4	NP_001854.1	cytochrome c oxidase subunit 6B1
NM_001863.5	NP_001854.1	cytochrome c oxidase subunit 6B1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC612644	XP_855469.1
Danio rerio (zebrafish)	cox6b1	NP_001002695.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP013092	XP_003435734.1
Neurospora crassa	NCU11339	XP_963513.1
Mus musculus (house mouse)	Cox6b1	NP_079904.1
Rattus norvegicus (Norway rat)	LOC688869	NP_001138745.1
Schizosaccharomyces pombe (fission yeast)	cox12	NP_588322.2
Xenopus tropicalis (tropical clawed frog)	cox6b1	NP_001005102.1
	COX6B1	NP_001035371.1
Saccharomyces cerevisiae (baker's yeast)	COX12	NP_013139.1
Eremothecium gossypii	AGOS_ADR240C	NP_984336.1
Arabidopsis thaliana (thale cress)	COX6B	NP_173661.1
Magnaporthe oryzae (rice blast fungus)	MGG_01111	XP_003717823.1
Homo sapiens (human)	COX6B1	NP_001854.1
Pan troglodytes (chimpanzee)	COX6B1	XP_001160605.1
Bos taurus (cattle)	COX6B1	NP_788848.1
Drosophila melanogaster (fruit fly)	CoVIb	NP_728295.1
Kluyveromyces lactis	KLLA0F17281g	XP_455857.1

Gene Ontology
Bibliography

Related articles in PubMed

ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag.
Ogawa M, Takemoto Y, Sumi S, Inoue D, Kishimoto N, Takamune N, Shoji S, Suzu S, Misumi S
Retrovirology1297(2015 Nov)

Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
Abdulhag UN, Soiferman D, Schueler-Furman O, Miller C, Shaag A, Elpeleg O, Edvardson S, Saada A
European journal of human genetics : EJHG23(2)159-64(2015 Feb)

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Chen S, Lu FF, Seeman P, Liu F
Neurochemical research37(12)2805-13(2012 Dec)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
Lazarou M, Smith SM, Thorburn DR, Ryan MT, McKenzie M
The FEBS journal276(22)6701-13(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

p2 peptide from HIV-1 enhances HIV-1 acute infection by increasing intracellular ATP production via the activation of mitochondrial cytochrome c oxidase (MT-CO) involved in the respiratory chain
Title: ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates.
Title: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.

two siblings with severe infantile encephalomyopathy revealed the presence of a missense mutation in the COX6B1 gene
Title: Severe infantile encephalomyopathy caused by a mutation in COX6B1, a nucleus-encoded subunit of cytochrome c oxidase.

The following COX6B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22973	NM_001863.5 Latest version!	Homo sapiens cytochrome c oxidase subunit 6B1 (COX6B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22973	NM_001863.4	Homo sapiens cytochrome c oxidase subunit 6B1 (COX6B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX6B1 ( NM_001863.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001854.1 Homo sapiens cytochrome c oxidase subunit 6B1 (COX6B1), mRNA.

Price & Availability↑

CloneID	OHu22973
Clone ID Related Accession (Same CDS sequence)	NM_001863.4 , NM_001863.5
Accession Version	NM_001863.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 261bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6B1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB443544.1, BC001015.2 and AC002115.1. This sequence is a reference standard in the RefSeqGene project. On Jan 14, 2010 this sequence version replaced NM_001863.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM906938.1, BU567375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAAG ACATGGAGAC CAAAATCAAG AACTACAAGA CCGCCCCTTT TGACAGCCGC 
TTCCCCAACC AGAACCAGAC TAGAAACTGC TGGCAGAACT ACCTGGACTT CCACCGCTGT 
CAGAAGGCAA TGACCGCTAA AGGAGGCGAT ATCTCTGTGT GCGAATGGTA CCAGCGTGTG 
TACCAGTCCC TCTGCCCCAC ATCCTGGGTC ACAGACTGGG ATGAGCAACG GGCTGAAGGC 
ACGTTTCCCG GGAAGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001854.1
CDS	193..453
Translation	MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPTSWVTDWDEQRAEGTFPGKI

Target ORF information:

RefSeq Version	NM_001863.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6B1 (COX6B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001863.4

ORF Insert Sequence:

ATGGCGGAAG ACATGGAGAC CAAAATCAAG AACTACAAGA CCGCCCCTTT TGACAGCCGC 
TTCCCCAACC AGAACCAGAC TAGAAACTGC TGGCAGAACT ACCTGGACTT CCACCGCTGT 
CAGAAGGCAA TGACCGCTAA AGGAGGCGAT ATCTCTGTGT GCGAATGGTA CCAGCGTGTG 
TACCAGTCCC TCTGCCCCAC ATCCTGGGTC ACAGACTGGG ATGAGCAACG GGCTGAAGGC 
ACGTTTCCCG GGAAGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX6B1 ( NM_001863.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001854.1 Homo sapiens cytochrome c oxidase subunit 6B1 (COX6B1), mRNA.

Price & Availability↑

CloneID	OHu22973
Clone ID Related Accession (Same CDS sequence)	NM_001863.4 , NM_001863.5
Accession Version	NM_001863.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 261bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6B1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001015.2. This sequence is a reference standard in the RefSeqGene project. On Jul 11, 2018 this sequence version replaced NM_001863.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001015.2, BF971969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000649813.2/ ENSP00000497926.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAAG ACATGGAGAC CAAAATCAAG AACTACAAGA CCGCCCCTTT TGACAGCCGC 
TTCCCCAACC AGAACCAGAC TAGAAACTGC TGGCAGAACT ACCTGGACTT CCACCGCTGT 
CAGAAGGCAA TGACCGCTAA AGGAGGCGAT ATCTCTGTGT GCGAATGGTA CCAGCGTGTG 
TACCAGTCCC TCTGCCCCAC ATCCTGGGTC ACAGACTGGG ATGAGCAACG GGCTGAAGGC 
ACGTTTCCCG GGAAGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001854.1
CDS	93..353
Translation	MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPTSWVTDWDEQRAEGTFPGKI

Target ORF information:

RefSeq Version	NM_001863.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6B1 (COX6B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001863.5

ORF Insert Sequence:

ATGGCGGAAG ACATGGAGAC CAAAATCAAG AACTACAAGA CCGCCCCTTT TGACAGCCGC 
TTCCCCAACC AGAACCAGAC TAGAAACTGC TGGCAGAACT ACCTGGACTT CCACCGCTGT 
CAGAAGGCAA TGACCGCTAA AGGAGGCGAT ATCTCTGTGT GCGAATGGTA CCAGCGTGTG 
TACCAGTCCC TCTGCCCCAC ATCCTGGGTC ACAGACTGGG ATGAGCAACG GGCTGAAGGC 
ACGTTTCCCG GGAAGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag.
Retrovirology1297(2015 Nov)
Ogawa M,Takemoto Y,Sumi S,Inoue D,Kishimoto N,Takamune N,Shoji S,Suzu S,Misumi S

Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy.
European journal of human genetics : EJHG23(2)159-64(2015 Feb)
Abdulhag UN,Soiferman D,Schueler-Furman O,Miller C,Shaag A,Elpeleg O,Edvardson S,Saada A

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Neurochemical research37(12)2805-13(2012 Dec)
Chen S,Lu FF,Seeman P,Liu F

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
The FEBS journal276(22)6701-13(2009 Nov)
Lazarou M,Smith SM,Thorburn DR,Ryan MT,McKenzie M

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COX6B1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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