NUDT16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NUDT16
Entrez Gene ID	131870
Full Name	nudix hydrolase 16
General protein information	Preferred Names nudix hydrolase 16 Names U8 snoRNA-decapping enzyme IDP phosphatase IDPase U8 snoRNA-binding protein H29K inosine diphosphate phosphatase m7GpppN-mRNA hydrolase nucleoside diphosphate-linked moiety X motif 16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 nudix motif 16 testicular tissue protein Li 129
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.1
Disorder MIM:	617381

mRNA and Protein(s)

mRNA	Protein	Name
NM_152395.2	NP_689608.2	U8 snoRNA-decapping enzyme isoform 2
NM_001171905.1	NP_001165376.1	U8 snoRNA-decapping enzyme isoform 3
NM_001171906.1	NP_001165377.1	U8 snoRNA-decapping enzyme isoform 1
NM_152395.3	NP_689608.2	U8 snoRNA-decapping enzyme isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nudt16	NP_083661.2
Pan troglodytes (chimpanzee)	NUDT16	XP_001147228.1
	NUDT16	XP_001115629.1
Danio rerio (zebrafish)	zgc:103759	NP_001006008.1
Xenopus tropicalis (tropical clawed frog)	nudt16	NP_001165006.2
Homo sapiens (human)	NUDT16	NP_689608.2
Rattus norvegicus (Norway rat)	Nudt16	NP_001121026.1
Danio rerio (zebrafish)	LOC100534816	XP_003201242.2

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia.
Anad?n C, van Tetering G, Ferreira HJ, Moutinho C, Mart?nez-Card?s A, Villanueva A, Soler M, Heyn H, Moran S, Castro de Moura M, Setien F, Vidal A, Genesc? E, Ribera JM, Nomdedeu JF, Guil S, Esteller M
Leukemia31(7)1622-1625(2017 Jul)

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection.
Hopkins KC, Tartell MA, Herrmann C, Hackett BA, Taschuk F, Panda D, Menghani SV, Sabin LR, Cherry S
Proceedings of the National Academy of Sciences of the United States of America112(22)E2920-9(2015 Jun)

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
Tr?saugues L, Lundb?ck T, Welin M, Flodin S, Nyman T, Silvander C, Gr?slund S, Nordlund P
PloS one10(6)e0131507(2015)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The RNA decapping enzyme NUDT16 selectively degrades 5'-TOP mRNAs during Rift Valley fever virus infection and this decay is triggered in response to mTOR attenuation via the translational repressor 4EBP1/2 axis.
Title: Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection.

This study details structural and regulatory mechanisms explaining how substrates are selected for hydrolysis by human NUDT16.
Title: Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.

hNUDT16 can also actively cleave the mGDP cap from mRNAs in the presence of Mg(2)(+) or Mn(2)(+).
Title: hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA.

Like Dcp2, Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis.
Title: Multiple mRNA decapping enzymes in mammalian cells.

NUDT16 is a (deoxy)inosine diphosphatase that may function mainly in the nucleus to protect cells from deleterious effects of (d)ITP.
Title: NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.

The following NUDT16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NUDT16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00858	NM_152395.3 Latest version!	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00123	NM_001171905.1 Latest version!	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu00795	NM_001171906.1 Latest version!	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu00858	NM_152395.2	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NUDT16 ( NM_152395.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_689608.2 Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00858
Clone ID Related Accession (Same CDS sequence)	NM_152395.2 , NM_152395.3
Accession Version	NM_152395.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-21
Organism	Homo sapiens(human)
Product	U8 snoRNA-decapping enzyme isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP219080.1, CB121755.1 and AC010210.24. On Feb 2, 2010 this sequence version replaced NM_152395.1. Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP219080.1, SRR1660809.210101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGAG CCCGCAGGCT GGAGCTAGGC GAGGCCCTGG CGCTGGGGTC GGGCTGGCGT 
CATGCGTGCC ACGCTCTCCT CTACGCGCCG GACCCTGGGA TGCTCTTCGG CCGCATCCCG 
CTGCGCTACG CCATACTGAT GCAGATGCGC TTCGATGGAC GCCTGGGCTT CCCCGGCGGA 
TTCGTGGACA CGCAGGACAG AAGCCTAGAG GACGGGCTGA ACCGCGAGCT GCGCGAGGAG 
CTGGGCGAAG CGGCTGCCGC TTTCCGCGTG GAGCGCACTG ACTACCGCAG CTCCCACGTC 
GGGTCAGGGC CACGCGTTGT GGCCCACTTC TATGCCAAGC GTCTGACGCT CGAGGAGCTG 
TTGGCTGTGG AGGCCGGCGC AACACGCGCC AAGGACCACG GGCTGGAGGT GCTGGGCCTG 
GTGCGAGTGC CCCTGTATAC CCTGCGGGAT GGTGTAGGAG GCCTGCCTAC CTTCCTGGAG 
AATTCCTTTA TTGGCTCTGC GCGGGAGCAG TTACTTGAAG CTCTCCAGGA CTTGGGACTG 
CTGCAGTCTG GCTCTATTTC AGGCCTTAAG ATTCCAGCTC ATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689608.2
CDS	41..628
Translation	MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIPLRYAILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGSAREQLLEALQDLGLLQSGSISGLKIPAHH

Target ORF information:

RefSeq Version	NM_152395.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152395.2

ORF Insert Sequence:

ATGGCCGGAG CCCGCAGGCT GGAGCTAGGC GAGGCCCTGG CGCTGGGGTC GGGCTGGCGT 
CATGCGTGCC ACGCTCTCCT CTACGCGCCG GACCCTGGGA TGCTCTTCGG CCGCATCCCG 
CTGCGCTACG CCATACTGAT GCAGATGCGC TTCGATGGAC GCCTGGGCTT CCCCGGCGGA 
TTCGTGGACA CGCAGGACAG AAGCCTAGAG GACGGGCTGA ACCGCGAGCT GCGCGAGGAG 
CTGGGCGAAG CGGCTGCCGC TTTCCGCGTG GAGCGCACTG ACTACCGCAG CTCCCACGTC 
GGGTCAGGGC CACGCGTTGT GGCCCACTTC TATGCCAAGC GTCTGACGCT CGAGGAGCTG 
TTGGCTGTGG AGGCCGGCGC AACACGCGCC AAGGACCACG GGCTGGAGGT GCTGGGCCTG 
GTGCGAGTGC CCCTGTATAC CCTGCGGGAT GGTGTAGGAG GCCTGCCTAC CTTCCTGGAG 
AATTCCTTTA TTGGCTCTGC GCGGGAGCAG TTACTTGAAG CTCTCCAGGA CTTGGGACTG 
CTGCAGTCTG GCTCTATTTC AGGCCTTAAG ATTCCAGCTC ATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUDT16 ( NM_152395.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689608.2 Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00858
Clone ID Related Accession (Same CDS sequence)	NM_152395.2 , NM_152395.3
Accession Version	NM_152395.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	U8 snoRNA-decapping enzyme isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB121755.1 and AC010210.24. On Jun 2, 2019 this sequence version replaced NM_152395.2. Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.47038.1, SRR1803611.92930.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGAG CCCGCAGGCT GGAGCTAGGC GAGGCCCTGG CGCTGGGGTC GGGCTGGCGT 
CATGCGTGCC ACGCTCTCCT CTACGCGCCG GACCCTGGGA TGCTCTTCGG CCGCATCCCG 
CTGCGCTACG CCATACTGAT GCAGATGCGC TTCGATGGAC GCCTGGGCTT CCCCGGCGGA 
TTCGTGGACA CGCAGGACAG AAGCCTAGAG GACGGGCTGA ACCGCGAGCT GCGCGAGGAG 
CTGGGCGAAG CGGCTGCCGC TTTCCGCGTG GAGCGCACTG ACTACCGCAG CTCCCACGTC 
GGGTCAGGGC CACGCGTTGT GGCCCACTTC TATGCCAAGC GTCTGACGCT CGAGGAGCTG 
TTGGCTGTGG AGGCCGGCGC AACACGCGCC AAGGACCACG GGCTGGAGGT GCTGGGCCTG 
GTGCGAGTGC CCCTGTATAC CCTGCGGGAT GGTGTAGGAG GCCTGCCTAC CTTCCTGGAG 
AATTCCTTTA TTGGCTCTGC GCGGGAGCAG TTACTTGAAG CTCTCCAGGA CTTGGGACTG 
CTGCAGTCTG GCTCTATTTC AGGCCTTAAG ATTCCAGCTC ATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689608.2
CDS	32..619
Translation	MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIPLRYAILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGSAREQLLEALQDLGLLQSGSISGLKIPAHH

Target ORF information:

RefSeq Version	NM_152395.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152395.3

ORF Insert Sequence:

ATGGCCGGAG CCCGCAGGCT GGAGCTAGGC GAGGCCCTGG CGCTGGGGTC GGGCTGGCGT 
CATGCGTGCC ACGCTCTCCT CTACGCGCCG GACCCTGGGA TGCTCTTCGG CCGCATCCCG 
CTGCGCTACG CCATACTGAT GCAGATGCGC TTCGATGGAC GCCTGGGCTT CCCCGGCGGA 
TTCGTGGACA CGCAGGACAG AAGCCTAGAG GACGGGCTGA ACCGCGAGCT GCGCGAGGAG 
CTGGGCGAAG CGGCTGCCGC TTTCCGCGTG GAGCGCACTG ACTACCGCAG CTCCCACGTC 
GGGTCAGGGC CACGCGTTGT GGCCCACTTC TATGCCAAGC GTCTGACGCT CGAGGAGCTG 
TTGGCTGTGG AGGCCGGCGC AACACGCGCC AAGGACCACG GGCTGGAGGT GCTGGGCCTG 
GTGCGAGTGC CCCTGTATAC CCTGCGGGAT GGTGTAGGAG GCCTGCCTAC CTTCCTGGAG 
AATTCCTTTA TTGGCTCTGC GCGGGAGCAG TTACTTGAAG CTCTCCAGGA CTTGGGACTG 
CTGCAGTCTG GCTCTATTTC AGGCCTTAAG ATTCCAGCTC ATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUDT16 ( NM_001171905.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001165376.1 Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00123
Clone ID Related Accession (Same CDS sequence)	NM_001171905.1
Accession Version	NM_001171905.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	U8 snoRNA-decapping enzyme isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP199028.1 and AC010210.24. Transcript Variant: This variant (3) has multiple differences, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCAGATGC GCTTCGATGG ACGCCTGGGC TTCCCCGGCG GATTCGTGGA CACGCAGGAC 
AGAAGCCTAG AGGACGGGCT GAACCGCGAG CTGCGCGAGG AGCTGGGCGA AGCGGCTGCC 
GCTTTCCGCG TGGAGCGCAC TGACTACCGC AGCTCCCACG TCGGGTCAGG GCCACGCGTT 
GTGGCCCACT TCTATGCCAA GCGTCTGACG CTCGAGGAGC TGTTGGCTGT GGAGGCCGGC 
GCAACACGCG CCAAGGACCA CGGGCTGGAG GTGCTGGGCC TGGTGCGAGT GCCCCTGTAT 
ACCCTGCGGG ATGGTGTAGG AGGCCTGCCT ACCTTCCTGG AGAATTCCTT TATTGGCTCT 
GCGCGGGAGC AGTTACTTGA AGCAGCCCTC CATGGACCCA TGAAAACTGA GATGAGGACC 
TTGGTACTAG GGAGGGAGGG AAGGACGTGG GAATGTTTTC TTATTGGATC TGAGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165376.1
CDS	76..555
Translation	MQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGSAREQLLEAALHGPMKTEMRTLVLGREGRTWECFLIGSER

Target ORF information:

RefSeq Version	NM_001171905.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171905.1

ORF Insert Sequence:

ATGCAGATGC GCTTCGATGG ACGCCTGGGC TTCCCCGGCG GATTCGTGGA CACGCAGGAC 
AGAAGCCTAG AGGACGGGCT GAACCGCGAG CTGCGCGAGG AGCTGGGCGA AGCGGCTGCC 
GCTTTCCGCG TGGAGCGCAC TGACTACCGC AGCTCCCACG TCGGGTCAGG GCCACGCGTT 
GTGGCCCACT TCTATGCCAA GCGTCTGACG CTCGAGGAGC TGTTGGCTGT GGAGGCCGGC 
GCAACACGCG CCAAGGACCA CGGGCTGGAG GTGCTGGGCC TGGTGCGAGT GCCCCTGTAT 
ACCCTGCGGG ATGGTGTAGG AGGCCTGCCT ACCTTCCTGG AGAATTCCTT TATTGGCTCT 
GCGCGGGAGC AGTTACTTGA AGCAGCCCTC CATGGACCCA TGAAAACTGA GATGAGGACC 
TTGGTACTAG GGAGGGAGGG AAGGACGTGG GAATGTTTTC TTATTGGATC TGAGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUDT16 ( NM_001171906.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001165377.1 Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00795
Clone ID Related Accession (Same CDS sequence)	NM_001171906.1
Accession Version	NM_001171906.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	U8 snoRNA-decapping enzyme isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP219080.1, AK304650.1 and AC010210.24. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304650.1, SRR1803616.180601.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGAG CCCGCAGGCT GGAGCTAGGC GAGGCCCTGG CGCTGGGGTC GGGCTGGCGT 
CATGCGTGCC ACGCTCTCCT CTACGCGCCG GACCCTGGGA TGCTCTTCGG CCGCATCCCG 
CTGCGCTACG CCATACTGAT GCAGATGCGC TTCGATGGAC GCCTGGGCTT CCCCGGCGGA 
TTCGTGGACA CGCAGGACAG AAGCCTAGAG GACGGGCTGA ACCGCGAGCT GCGCGAGGAG 
CTGGGCGAAG CGGCTGCCGC TTTCCGCGTG GAGCGCACTG ACTACCGCAG CTCCCACGTC 
GGGTCAGGGC CACGCGTTGT GGCCCACTTC TATGCCAAGC GTCTGACGCT CGAGGAGCTG 
TTGGCTGTGG AGGCCGGCGC AACACGCGCC AAGGACCACG GGCTGGAGGT GGGACCAGCC 
TGGGACTCTG TCCCTTTCCC AATTTCCTCT TCTCCCAAAG CTTTCTCTCC CCCAAGAAAG 
CATCCCTGGA GAAAAGTCTT TGCCCCTCTG ACCTTGCCCT CTCCCCAGCT TTCTTGGTGG 
AGTTGGGATC GTGATCATCT ATACTCTGAA TTAGTACTGC CAACCTGGGC TTTCTGTAAA 
GGTCTTTCCC ACCCTTTACC AGGAGAGATC CTTTCTAGAA CACACTCATC CATGTCTCTC 
TGCTGTTCCC TATTGACAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165377.1
CDS	41..724
Translation	MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIPLRYAILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAVEAGATRAKDHGLEVGPAWDSVPFPISSSPKAFSPPRKHPWRKVFAPLTLPSPQLSWWSWDRDHLYSELVLPTWAFCKGLSHPLPGEILSRTHSSMSLCCSLLTV

Target ORF information:

RefSeq Version	NM_001171906.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nudix hydrolase 16 (NUDT16), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171906.1

ORF Insert Sequence:

ATGGCCGGAG CCCGCAGGCT GGAGCTAGGC GAGGCCCTGG CGCTGGGGTC GGGCTGGCGT 
CATGCGTGCC ACGCTCTCCT CTACGCGCCG GACCCTGGGA TGCTCTTCGG CCGCATCCCG 
CTGCGCTACG CCATACTGAT GCAGATGCGC TTCGATGGAC GCCTGGGCTT CCCCGGCGGA 
TTCGTGGACA CGCAGGACAG AAGCCTAGAG GACGGGCTGA ACCGCGAGCT GCGCGAGGAG 
CTGGGCGAAG CGGCTGCCGC TTTCCGCGTG GAGCGCACTG ACTACCGCAG CTCCCACGTC 
GGGTCAGGGC CACGCGTTGT GGCCCACTTC TATGCCAAGC GTCTGACGCT CGAGGAGCTG 
TTGGCTGTGG AGGCCGGCGC AACACGCGCC AAGGACCACG GGCTGGAGGT GGGACCAGCC 
TGGGACTCTG TCCCTTTCCC AATTTCCTCT TCTCCCAAAG CTTTCTCTCC CCCAAGAAAG 
CATCCCTGGA GAAAAGTCTT TGCCCCTCTG ACCTTGCCCT CTCCCCAGCT TTCTTGGTGG 
AGTTGGGATC GTGATCATCT ATACTCTGAA TTAGTACTGC CAACCTGGGC TTTCTGTAAA 
GGTCTTTCCC ACCCTTTACC AGGAGAGATC CTTTCTAGAA CACACTCATC CATGTCTCTC 
TGCTGTTCCC TATTGACAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia.
Leukemia31(7)1622-1625(2017 Jul)
Anad?n C,van Tetering G,Ferreira HJ,Moutinho C,Mart?nez-Card?s A,Villanueva A,Soler M,Heyn H,Moran S,Castro de Moura M,Setien F,Vidal A,Genesc? E,Ribera JM,Nomdedeu JF,Guil S,Esteller M

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection.
Proceedings of the National Academy of Sciences of the United States of America112(22)E2920-9(2015 Jun)
Hopkins KC,Tartell MA,Herrmann C,Hackett BA,Taschuk F,Panda D,Menghani SV,Sabin LR,Cherry S

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
PloS one10(6)e0131507(2015)
Tr?saugues L,Lundb?ck T,Welin M,Flodin S,Nyman T,Silvander C,Gr?slund S,Nordlund P

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

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NUDT16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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