COPA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COPA
Entrez Gene ID	1314
Full Name	coatomer protein complex subunit alpha
Synonyms	AILJK,HEP-COP
General protein information	Preferred Names coatomer protein complex subunit alpha Names coatomer subunit alpha HEPCOP alpha coat protein alpha-COP proxenin xenin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.2
Summary	In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	601924
Disorder Html:	{Autoimmune interstitial lung, joint, and kidney disease}, 616414 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001098398.2	NP_001091868.1	coatomer subunit alpha isoform 1
NM_001098398.1	NP_001091868.1	coatomer subunit alpha isoform 1
NM_004371.3	NP_004362.2	coatomer subunit alpha isoform 2
NM_004371.4	NP_004362.2	coatomer subunit alpha isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	COPA	NP_001091868.1
Mus musculus (house mouse)	Copa	NP_034068.3
Caenorhabditis elegans (roundworm)	Y71F9AL.17	NP_491069.1
Saccharomyces cerevisiae (baker's yeast)	COP1	NP_010136.1
Kluyveromyces lactis	KLLA0F04884g	XP_455301.1
Danio rerio (zebrafish)	copa	NP_001001941.2
Xenopus tropicalis (tropical clawed frog)	copa	NP_001121466.1
Bos taurus (cattle)	COPA	NP_001099115.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010251	XP_319442.1
Magnaporthe oryzae (rice blast fungus)	MGG_03511	XP_003716408.1
Arabidopsis thaliana (thale cress)	AT1G62020	NP_176393.1
Rattus norvegicus (Norway rat)	Copa	NP_001128012.1
Gallus gallus (chicken)	COPA	NP_001026576.1
Drosophila melanogaster (fruit fly)	alphaCop	NP_477395.1
Eremothecium gossypii	AGOS_ADR077C	NP_984173.1
Schizosaccharomyces pombe (fission yeast)	SPBPJ4664.04	NP_595279.1
Oryza sativa (rice)	Os09g0127800	NP_001062612.1
Oryza sativa (rice)	Os03g0711400	NP_001051056.1
Pan troglodytes (chimpanzee)	COPA	XP_001171563.1
	COPA	XP_002801923.1
Canis lupus familiaris (dog)	COPA	XP_005640952.1
Neurospora crassa	NCU10066	XP_957881.1
Arabidopsis thaliana (thale cress)	AT2G21390	NP_179734.1

Gene Ontology
Bibliography

Related articles in PubMed

COPA syndrome in an Icelandic family caused by a recurrent missense mutation in COPA.
Jensson BO, Hansdottir S, Arnadottir GA, Sulem G, Kristjansson RP, Oddsson A, Benonisdottir S, Jonsson H, Helgason A, Saemundsdottir J, Magnusson OT, Masson G, Thorisson GA, Jonasdottir A, Jonasdottir A, Sigurdsson A, Jonsdottir I, Petursdottir V, Kristinsson JR, Gudbjartsson DF, Thorsteinsdottir U, Arngrimsson R, Sulem P, Gudmundsson G, Stefansson K
BMC medical genetics18(1)129(2017 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the second report of a pathogenic mutation in COPA. The p.Glu241Lys mutation detected in the current Icelandic pedigree is a de novo mutation. The fact that the mutation is absent from 176,040 unrelated individuals but present in two families with affected individuals confirms its role in the pathogenesis of COPA syndrome.
Title: COPA syndrome in an Icelandic family caused by a recurrent missense mutation in COPA.

COPA variants impair binding to proteins targeted for retrograde Golgi-to-ER transport.
Title: COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.

Serum xenin levels of obese patients were higher than in control groups.
Title: Evaluation of serum xenin and ghrelin levels and their relationship with nonalcoholic fatty liver disease and insulin resistance in obese adolescents.

The cell membrane gene SLC4A4 and the trafficking regulator gene COPA, which also plays an important role in early endosome maturation, were identified for the cellular entry of poly-arginine peptide.
Title: COPA and SLC4A4 are required for cellular entry of arginine-rich peptides.

Results show that the interaction between SMN and alpha-COP serves an important function in the growth and maintenance of motor neuron processes and may play a significant role in the pathogenesis of Spinal muscular atrophy.
Title: Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle protein ?-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy.

The following COPA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COPA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17236	NM_004371.4 Latest version!	Homo sapiens COPI coat complex subunit alpha (COPA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
OHu17387	NM_001098398.2 Latest version!	Homo sapiens COPI coat complex subunit alpha (COPA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
View Old Accession Versions >>
OHu17387	NM_001098398.1	Homo sapiens coatomer protein complex subunit alpha (COPA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
OHu17236	NM_004371.3	Homo sapiens coatomer protein complex subunit alpha (COPA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COPA ( NM_004371.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004362.2 Homo sapiens coatomer protein complex subunit alpha (COPA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17236
Clone ID Related Accession (Same CDS sequence)	NM_004371.3 , NM_004371.4
Accession Version	NM_004371.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	coatomer subunit alpha isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308331.1, U24105.1 and AL513282.10. On Jun 1, 2007 this sequence version replaced NM_004371.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.76889.1, SRR1803616.271524.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGCC ATTGTGATCT GTAACCGCAA ACTGGATGCT 
TTATGTAACA TTCATGAGAA CATTCGTGTC AAGAGTGGGG CCTGGGATGA GAGTGGGGTA 
TTTATCTATA CCACAAGCAA CCACATCAAA TATGCTGTCA CCACTGGGGA CCACGGGATC 
ATTCGAACTC TGGATTTACC CATCTATGTC ACACGGGTGA AGGGCAACAA TGTATACTGC 
CTAGACAGGG AGTGTCGTCC CCGGGTACTC ACCATTGATC CCACTGAGTT CAAATTCAAG 
CTGGCCCTGA TCAACAGAAA ATATGATGAG GTACTGCACA TGGTGAGGAA TGCCAAACTA 
GTTGGCCAGT CTATTATTGC TTATCTCCAG AAGAAGGGCT ATCCTGAAGT GGCACTGCAT 
TTTGTCAAGG ATGAGAAAAC TCGCTTTAGT CTGGCACTGG AGTGTGGAAA CATTGAGATT 
GCTCTGGAAG CAGCCAAAGC ACTGGATGAC AAGAACTGCT GGGAAAAGCT GGGAGAAGTG 
GCCCTGCTGC AGGGGAACCA CCAGATTGTG GAAATGTGCT ATCAGCGTAC CAAAAACTTT 
GACAAACTTT CCTTCCTGTA TCTTATCACT GGCAACTTAG AAAAACTTCG CAAGATGATG 
AAGATTGCTG AGATCAGAAA GGACATGAGT GGCCACTATC AGAATGCCCT ATACCTGGGT 
GATGTGTCAG AGCGTGTGCG GATCCTGAAG AACTGTGGAC AGAAGTCCCT GGCCTATCTC 
ACAGCTGCTA CCCATGGCTT AGATGAAGAA GCTGAGAGCC TAAAGGAGAC ATTTGACCCA 
GAGAAGGAGA CAATCCCAGA CATTGACCCT AATGCCAAGC TGCTCCAGCC ACCTGCACCT 
ATCATGCCAT TGGATACCAA TTGGCCTTTA TTGACTGTAT CCAAAGGATT TTTTGAAGGC 
ACCATTGCCA GCAAAGGGAA GGGAGGAGCA CTGGCTGCTG ACATTGACAT TGACACTGTT 
GGTACAGAGG GCTGGGGAGA GGATGCAGAG CTGCAGTTGG ATGAAGATGG GTTTGTGGAG 
GCTACAGAAG GTTTGGGGGA TGATGCTCTT GGCAAGGGAC AGGAAGAAGG AGGTGGCTGG 
GATGTAGAAG AAGATCTGGA GCTCCCTCCT GAGCTGGATA TATCCCCTGG GGCAGCTGGT 
GGGGCTGAAG ATGGTTTCTT TGTGCCCCCA ACCAAGGGAA CAAGTCCAAC TCAGATCTGG 
TGTAATAACT CTCAGCTTCC AGTTGATCAC ATCCTGGCAG GCTCTTTCGA AACAGCCATG 
CGGCTCCTTC ATGACCAAGT AGGGGTAATC CAGTTTGGCC CCTACAAGCA ACTGTTCCTA 
CAGACATACG CCCGAGGCCG CACAACCTAT CAGGCTCTGC CCTGCCTACC CTCCATGTAT 
GGCTATCCTA ATCGCAACTG GAAGGATGCA GGGCTGAAGA ATGGTGTACC AGCTGTGGGC 
CTGAAGCTTA ATGACCTCAT CCAACGGTTG CAGCTGTGCT ACCAGCTCAC CACAGTTGGC 
AAATTTGAGG AGGCTGTGGA AAAATTCCGT TCCATCCTTC TCAGTGTGCC ACTTCTTGTT 
GTGGACAATA AACAAGAGAT TGCAGAGGCC CAGCAGCTCA TCACCATTTG CCGTGAGTAC 
ATTGTGGGTT TGTCCGTGGA GACAGAAAGG AAGAAGCTGC CCAAAGAGAC TCTAGAACAG 
CAGAAGCGCA TCTGTGAGAT GGCAGCCTAT TTCACCCACT CAAACCTGCA GCCTGTGCAC 
ATGATCCTGG TGCTGCGTAC AGCCCTCAAT CTGTTCTTCA AGCTCAAGAA CTTCAAGACA 
GCTGCCACCT TTGCTCGGCG CCTACTAGAA CTCGGGCCCA AGCCTGAGGT GGCCCAACAG 
ACCCGAAAAA TCCTGTCTGC CTGTGAGAAG AATCCCACAG ATGCCTACCA GCTCAATTAT 
GACATGCACA ACCCCTTTGA CATTTGTGCT GCATCATATC GGCCCATCTA CCGTGGAAAG 
CCAGTAGAAA AGTGTCCACT CAGTGGGGCC TGCTATTCCC CTGAGTTCAA AGGTCAAATC 
TGCAGGGTCA CCACAGTGAC AGAGATTGGC AAAGATGTGA TTGGTTTAAG GATCAGTCCT 
CTGCAGTTTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004362.2
CDS	395..4069
Translation	MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEIGKDVIGLRISPLQFR

Target ORF information:

RefSeq Version	NM_004371.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coatomer protein complex subunit alpha (COPA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004371.3

ORF Insert Sequence:

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGCC ATTGTGATCT GTAACCGCAA ACTGGATGCT 
TTATGTAACA TTCATGAGAA CATTCGTGTC AAGAGTGGGG CCTGGGATGA GAGTGGGGTA 
TTTATCTATA CCACAAGCAA CCACATCAAA TATGCTGTCA CCACTGGGGA CCACGGGATC 
ATTCGAACTC TGGATTTACC CATCTATGTC ACACGGGTGA AGGGCAACAA TGTATACTGC 
CTAGACAGGG AGTGTCGTCC CCGGGTACTC ACCATTGATC CCACTGAGTT CAAATTCAAG 
CTGGCCCTGA TCAACAGAAA ATATGATGAG GTACTGCACA TGGTGAGGAA TGCCAAACTA 
GTTGGCCAGT CTATTATTGC TTATCTCCAG AAGAAGGGCT ATCCTGAAGT GGCACTGCAT 
TTTGTCAAGG ATGAGAAAAC TCGCTTTAGT CTGGCACTGG AGTGTGGAAA CATTGAGATT 
GCTCTGGAAG CAGCCAAAGC ACTGGATGAC AAGAACTGCT GGGAAAAGCT GGGAGAAGTG 
GCCCTGCTGC AGGGGAACCA CCAGATTGTG GAAATGTGCT ATCAGCGTAC CAAAAACTTT 
GACAAACTTT CCTTCCTGTA TCTTATCACT GGCAACTTAG AAAAACTTCG CAAGATGATG 
AAGATTGCTG AGATCAGAAA GGACATGAGT GGCCACTATC AGAATGCCCT ATACCTGGGT 
GATGTGTCAG AGCGTGTGCG GATCCTGAAG AACTGTGGAC AGAAGTCCCT GGCCTATCTC 
ACAGCTGCTA CCCATGGCTT AGATGAAGAA GCTGAGAGCC TAAAGGAGAC ATTTGACCCA 
GAGAAGGAGA CAATCCCAGA CATTGACCCT AATGCCAAGC TGCTCCAGCC ACCTGCACCT 
ATCATGCCAT TGGATACCAA TTGGCCTTTA TTGACTGTAT CCAAAGGATT TTTTGAAGGC 
ACCATTGCCA GCAAAGGGAA GGGAGGAGCA CTGGCTGCTG ACATTGACAT TGACACTGTT 
GGTACAGAGG GCTGGGGAGA GGATGCAGAG CTGCAGTTGG ATGAAGATGG GTTTGTGGAG 
GCTACAGAAG GTTTGGGGGA TGATGCTCTT GGCAAGGGAC AGGAAGAAGG AGGTGGCTGG 
GATGTAGAAG AAGATCTGGA GCTCCCTCCT GAGCTGGATA TATCCCCTGG GGCAGCTGGT 
GGGGCTGAAG ATGGTTTCTT TGTGCCCCCA ACCAAGGGAA CAAGTCCAAC TCAGATCTGG 
TGTAATAACT CTCAGCTTCC AGTTGATCAC ATCCTGGCAG GCTCTTTCGA AACAGCCATG 
CGGCTCCTTC ATGACCAAGT AGGGGTAATC CAGTTTGGCC CCTACAAGCA ACTGTTCCTA 
CAGACATACG CCCGAGGCCG CACAACCTAT CAGGCTCTGC CCTGCCTACC CTCCATGTAT 
GGCTATCCTA ATCGCAACTG GAAGGATGCA GGGCTGAAGA ATGGTGTACC AGCTGTGGGC 
CTGAAGCTTA ATGACCTCAT CCAACGGTTG CAGCTGTGCT ACCAGCTCAC CACAGTTGGC 
AAATTTGAGG AGGCTGTGGA AAAATTCCGT TCCATCCTTC TCAGTGTGCC ACTTCTTGTT 
GTGGACAATA AACAAGAGAT TGCAGAGGCC CAGCAGCTCA TCACCATTTG CCGTGAGTAC 
ATTGTGGGTT TGTCCGTGGA GACAGAAAGG AAGAAGCTGC CCAAAGAGAC TCTAGAACAG 
CAGAAGCGCA TCTGTGAGAT GGCAGCCTAT TTCACCCACT CAAACCTGCA GCCTGTGCAC 
ATGATCCTGG TGCTGCGTAC AGCCCTCAAT CTGTTCTTCA AGCTCAAGAA CTTCAAGACA 
GCTGCCACCT TTGCTCGGCG CCTACTAGAA CTCGGGCCCA AGCCTGAGGT GGCCCAACAG 
ACCCGAAAAA TCCTGTCTGC CTGTGAGAAG AATCCCACAG ATGCCTACCA GCTCAATTAT 
GACATGCACA ACCCCTTTGA CATTTGTGCT GCATCATATC GGCCCATCTA CCGTGGAAAG 
CCAGTAGAAA AGTGTCCACT CAGTGGGGCC TGCTATTCCC CTGAGTTCAA AGGTCAAATC 
TGCAGGGTCA CCACAGTGAC AGAGATTGGC AAAGATGTGA TTGGTTTAAG GATCAGTCCT 
CTGCAGTTTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COPA ( NM_004371.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004362.2 Homo sapiens COPI coat complex subunit alpha (COPA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17236
Clone ID Related Accession (Same CDS sequence)	NM_004371.3 , NM_004371.4
Accession Version	NM_004371.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	coatomer subunit alpha isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308331.1, U24105.1 and AL513282.10. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2018 this sequence version replaced NM_004371.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.172274.1, SRR1803616.271524.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000241704.8/ ENSP00000241704.7 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGCC ATTGTGATCT GTAACCGCAA ACTGGATGCT 
TTATGTAACA TTCATGAGAA CATTCGTGTC AAGAGTGGGG CCTGGGATGA GAGTGGGGTA 
TTTATCTATA CCACAAGCAA CCACATCAAA TATGCTGTCA CCACTGGGGA CCACGGGATC 
ATTCGAACTC TGGATTTACC CATCTATGTC ACACGGGTGA AGGGCAACAA TGTATACTGC 
CTAGACAGGG AGTGTCGTCC CCGGGTACTC ACCATTGATC CCACTGAGTT CAAATTCAAG 
CTGGCCCTGA TCAACAGAAA ATATGATGAG GTACTGCACA TGGTGAGGAA TGCCAAACTA 
GTTGGCCAGT CTATTATTGC TTATCTCCAG AAGAAGGGCT ATCCTGAAGT GGCACTGCAT 
TTTGTCAAGG ATGAGAAAAC TCGCTTTAGT CTGGCACTGG AGTGTGGAAA CATTGAGATT 
GCTCTGGAAG CAGCCAAAGC ACTGGATGAC AAGAACTGCT GGGAAAAGCT GGGAGAAGTG 
GCCCTGCTGC AGGGGAACCA CCAGATTGTG GAAATGTGCT ATCAGCGTAC CAAAAACTTT 
GACAAACTTT CCTTCCTGTA TCTTATCACT GGCAACTTAG AAAAACTTCG CAAGATGATG 
AAGATTGCTG AGATCAGAAA GGACATGAGT GGCCACTATC AGAATGCCCT ATACCTGGGT 
GATGTGTCAG AGCGTGTGCG GATCCTGAAG AACTGTGGAC AGAAGTCCCT GGCCTATCTC 
ACAGCTGCTA CCCATGGCTT AGATGAAGAA GCTGAGAGCC TAAAGGAGAC ATTTGACCCA 
GAGAAGGAGA CAATCCCAGA CATTGACCCT AATGCCAAGC TGCTCCAGCC ACCTGCACCT 
ATCATGCCAT TGGATACCAA TTGGCCTTTA TTGACTGTAT CCAAAGGATT TTTTGAAGGC 
ACCATTGCCA GCAAAGGGAA GGGAGGAGCA CTGGCTGCTG ACATTGACAT TGACACTGTT 
GGTACAGAGG GCTGGGGAGA GGATGCAGAG CTGCAGTTGG ATGAAGATGG GTTTGTGGAG 
GCTACAGAAG GTTTGGGGGA TGATGCTCTT GGCAAGGGAC AGGAAGAAGG AGGTGGCTGG 
GATGTAGAAG AAGATCTGGA GCTCCCTCCT GAGCTGGATA TATCCCCTGG GGCAGCTGGT 
GGGGCTGAAG ATGGTTTCTT TGTGCCCCCA ACCAAGGGAA CAAGTCCAAC TCAGATCTGG 
TGTAATAACT CTCAGCTTCC AGTTGATCAC ATCCTGGCAG GCTCTTTCGA AACAGCCATG 
CGGCTCCTTC ATGACCAAGT AGGGGTAATC CAGTTTGGCC CCTACAAGCA ACTGTTCCTA 
CAGACATACG CCCGAGGCCG CACAACCTAT CAGGCTCTGC CCTGCCTACC CTCCATGTAT 
GGCTATCCTA ATCGCAACTG GAAGGATGCA GGGCTGAAGA ATGGTGTACC AGCTGTGGGC 
CTGAAGCTTA ATGACCTCAT CCAACGGTTG CAGCTGTGCT ACCAGCTCAC CACAGTTGGC 
AAATTTGAGG AGGCTGTGGA AAAATTCCGT TCCATCCTTC TCAGTGTGCC ACTTCTTGTT 
GTGGACAATA AACAAGAGAT TGCAGAGGCC CAGCAGCTCA TCACCATTTG CCGTGAGTAC 
ATTGTGGGTT TGTCCGTGGA GACAGAAAGG AAGAAGCTGC CCAAAGAGAC TCTAGAACAG 
CAGAAGCGCA TCTGTGAGAT GGCAGCCTAT TTCACCCACT CAAACCTGCA GCCTGTGCAC 
ATGATCCTGG TGCTGCGTAC AGCCCTCAAT CTGTTCTTCA AGCTCAAGAA CTTCAAGACA 
GCTGCCACCT TTGCTCGGCG CCTACTAGAA CTCGGGCCCA AGCCTGAGGT GGCCCAACAG 
ACCCGAAAAA TCCTGTCTGC CTGTGAGAAG AATCCCACAG ATGCCTACCA GCTCAATTAT 
GACATGCACA ACCCCTTTGA CATTTGTGCT GCATCATATC GGCCCATCTA CCGTGGAAAG 
CCAGTAGAAA AGTGTCCACT CAGTGGGGCC TGCTATTCCC CTGAGTTCAA AGGTCAAATC 
TGCAGGGTCA CCACAGTGAC AGAGATTGGC AAAGATGTGA TTGGTTTAAG GATCAGTCCT 
CTGCAGTTTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004362.2
CDS	81..3755
Translation	MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEIGKDVIGLRISPLQFR

Target ORF information:

RefSeq Version	NM_004371.4
Organism	Homo sapiens(human)
Definition	Homo sapiens COPI coat complex subunit alpha (COPA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004371.4

ORF Insert Sequence:

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGCC ATTGTGATCT GTAACCGCAA ACTGGATGCT 
TTATGTAACA TTCATGAGAA CATTCGTGTC AAGAGTGGGG CCTGGGATGA GAGTGGGGTA 
TTTATCTATA CCACAAGCAA CCACATCAAA TATGCTGTCA CCACTGGGGA CCACGGGATC 
ATTCGAACTC TGGATTTACC CATCTATGTC ACACGGGTGA AGGGCAACAA TGTATACTGC 
CTAGACAGGG AGTGTCGTCC CCGGGTACTC ACCATTGATC CCACTGAGTT CAAATTCAAG 
CTGGCCCTGA TCAACAGAAA ATATGATGAG GTACTGCACA TGGTGAGGAA TGCCAAACTA 
GTTGGCCAGT CTATTATTGC TTATCTCCAG AAGAAGGGCT ATCCTGAAGT GGCACTGCAT 
TTTGTCAAGG ATGAGAAAAC TCGCTTTAGT CTGGCACTGG AGTGTGGAAA CATTGAGATT 
GCTCTGGAAG CAGCCAAAGC ACTGGATGAC AAGAACTGCT GGGAAAAGCT GGGAGAAGTG 
GCCCTGCTGC AGGGGAACCA CCAGATTGTG GAAATGTGCT ATCAGCGTAC CAAAAACTTT 
GACAAACTTT CCTTCCTGTA TCTTATCACT GGCAACTTAG AAAAACTTCG CAAGATGATG 
AAGATTGCTG AGATCAGAAA GGACATGAGT GGCCACTATC AGAATGCCCT ATACCTGGGT 
GATGTGTCAG AGCGTGTGCG GATCCTGAAG AACTGTGGAC AGAAGTCCCT GGCCTATCTC 
ACAGCTGCTA CCCATGGCTT AGATGAAGAA GCTGAGAGCC TAAAGGAGAC ATTTGACCCA 
GAGAAGGAGA CAATCCCAGA CATTGACCCT AATGCCAAGC TGCTCCAGCC ACCTGCACCT 
ATCATGCCAT TGGATACCAA TTGGCCTTTA TTGACTGTAT CCAAAGGATT TTTTGAAGGC 
ACCATTGCCA GCAAAGGGAA GGGAGGAGCA CTGGCTGCTG ACATTGACAT TGACACTGTT 
GGTACAGAGG GCTGGGGAGA GGATGCAGAG CTGCAGTTGG ATGAAGATGG GTTTGTGGAG 
GCTACAGAAG GTTTGGGGGA TGATGCTCTT GGCAAGGGAC AGGAAGAAGG AGGTGGCTGG 
GATGTAGAAG AAGATCTGGA GCTCCCTCCT GAGCTGGATA TATCCCCTGG GGCAGCTGGT 
GGGGCTGAAG ATGGTTTCTT TGTGCCCCCA ACCAAGGGAA CAAGTCCAAC TCAGATCTGG 
TGTAATAACT CTCAGCTTCC AGTTGATCAC ATCCTGGCAG GCTCTTTCGA AACAGCCATG 
CGGCTCCTTC ATGACCAAGT AGGGGTAATC CAGTTTGGCC CCTACAAGCA ACTGTTCCTA 
CAGACATACG CCCGAGGCCG CACAACCTAT CAGGCTCTGC CCTGCCTACC CTCCATGTAT 
GGCTATCCTA ATCGCAACTG GAAGGATGCA GGGCTGAAGA ATGGTGTACC AGCTGTGGGC 
CTGAAGCTTA ATGACCTCAT CCAACGGTTG CAGCTGTGCT ACCAGCTCAC CACAGTTGGC 
AAATTTGAGG AGGCTGTGGA AAAATTCCGT TCCATCCTTC TCAGTGTGCC ACTTCTTGTT 
GTGGACAATA AACAAGAGAT TGCAGAGGCC CAGCAGCTCA TCACCATTTG CCGTGAGTAC 
ATTGTGGGTT TGTCCGTGGA GACAGAAAGG AAGAAGCTGC CCAAAGAGAC TCTAGAACAG 
CAGAAGCGCA TCTGTGAGAT GGCAGCCTAT TTCACCCACT CAAACCTGCA GCCTGTGCAC 
ATGATCCTGG TGCTGCGTAC AGCCCTCAAT CTGTTCTTCA AGCTCAAGAA CTTCAAGACA 
GCTGCCACCT TTGCTCGGCG CCTACTAGAA CTCGGGCCCA AGCCTGAGGT GGCCCAACAG 
ACCCGAAAAA TCCTGTCTGC CTGTGAGAAG AATCCCACAG ATGCCTACCA GCTCAATTAT 
GACATGCACA ACCCCTTTGA CATTTGTGCT GCATCATATC GGCCCATCTA CCGTGGAAAG 
CCAGTAGAAA AGTGTCCACT CAGTGGGGCC TGCTATTCCC CTGAGTTCAA AGGTCAAATC 
TGCAGGGTCA CCACAGTGAC AGAGATTGGC AAAGATGTGA TTGGTTTAAG GATCAGTCCT 
CTGCAGTTTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COPA ( NM_001098398.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001091868.1 Homo sapiens COPI coat complex subunit alpha (COPA), transcript variant 1, mRNA.

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CloneID	OHu17387
Clone ID Related Accession (Same CDS sequence)	NM_001098398.2 , NM_001098398.1
Accession Version	NM_001098398.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	coatomer subunit alpha isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308331.1, BC038447.1 and AL513282.10. On Dec 14, 2018 this sequence version replaced NM_001098398.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.130559.1, SRR1803614.264750.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGAA CACTCATGCC CTTTGCCTCT TACAGCCATT 
GTGATCTGTA ACCGCAAACT GGATGCTTTA TGTAACATTC ATGAGAACAT TCGTGTCAAG 
AGTGGGGCCT GGGATGAGAG TGGGGTATTT ATCTATACCA CAAGCAACCA CATCAAATAT 
GCTGTCACCA CTGGGGACCA CGGGATCATT CGAACTCTGG ATTTACCCAT CTATGTCACA 
CGGGTGAAGG GCAACAATGT ATACTGCCTA GACAGGGAGT GTCGTCCCCG GGTACTCACC 
ATTGATCCCA CTGAGTTCAA ATTCAAGCTG GCCCTGATCA ACAGAAAATA TGATGAGGTA 
CTGCACATGG TGAGGAATGC CAAACTAGTT GGCCAGTCTA TTATTGCTTA TCTCCAGAAG 
AAGGGCTATC CTGAAGTGGC ACTGCATTTT GTCAAGGATG AGAAAACTCG CTTTAGTCTG 
GCACTGGAGT GTGGAAACAT TGAGATTGCT CTGGAAGCAG CCAAAGCACT GGATGACAAG 
AACTGCTGGG AAAAGCTGGG AGAAGTGGCC CTGCTGCAGG GGAACCACCA GATTGTGGAA 
ATGTGCTATC AGCGTACCAA AAACTTTGAC AAACTTTCCT TCCTGTATCT TATCACTGGC 
AACTTAGAAA AACTTCGCAA GATGATGAAG ATTGCTGAGA TCAGAAAGGA CATGAGTGGC 
CACTATCAGA ATGCCCTATA CCTGGGTGAT GTGTCAGAGC GTGTGCGGAT CCTGAAGAAC 
TGTGGACAGA AGTCCCTGGC CTATCTCACA GCTGCTACCC ATGGCTTAGA TGAAGAAGCT 
GAGAGCCTAA AGGAGACATT TGACCCAGAG AAGGAGACAA TCCCAGACAT TGACCCTAAT 
GCCAAGCTGC TCCAGCCACC TGCACCTATC ATGCCATTGG ATACCAATTG GCCTTTATTG 
ACTGTATCCA AAGGATTTTT TGAAGGCACC ATTGCCAGCA AAGGGAAGGG AGGAGCACTG 
GCTGCTGACA TTGACATTGA CACTGTTGGT ACAGAGGGCT GGGGAGAGGA TGCAGAGCTG 
CAGTTGGATG AAGATGGGTT TGTGGAGGCT ACAGAAGGTT TGGGGGATGA TGCTCTTGGC 
AAGGGACAGG AAGAAGGAGG TGGCTGGGAT GTAGAAGAAG ATCTGGAGCT CCCTCCTGAG 
CTGGATATAT CCCCTGGGGC AGCTGGTGGG GCTGAAGATG GTTTCTTTGT GCCCCCAACC 
AAGGGAACAA GTCCAACTCA GATCTGGTGT AATAACTCTC AGCTTCCAGT TGATCACATC 
CTGGCAGGCT CTTTCGAAAC AGCCATGCGG CTCCTTCATG ACCAAGTAGG GGTAATCCAG 
TTTGGCCCCT ACAAGCAACT GTTCCTACAG ACATACGCCC GAGGCCGCAC AACCTATCAG 
GCTCTGCCCT GCCTACCCTC CATGTATGGC TATCCTAATC GCAACTGGAA GGATGCAGGG 
CTGAAGAATG GTGTACCAGC TGTGGGCCTG AAGCTTAATG ACCTCATCCA ACGGTTGCAG 
CTGTGCTACC AGCTCACCAC AGTTGGCAAA TTTGAGGAGG CTGTGGAAAA ATTCCGTTCC 
ATCCTTCTCA GTGTGCCACT TCTTGTTGTG GACAATAAAC AAGAGATTGC AGAGGCCCAG 
CAGCTCATCA CCATTTGCCG TGAGTACATT GTGGGTTTGT CCGTGGAGAC AGAAAGGAAG 
AAGCTGCCCA AAGAGACTCT AGAACAGCAG AAGCGCATCT GTGAGATGGC AGCCTATTTC 
ACCCACTCAA ACCTGCAGCC TGTGCACATG ATCCTGGTGC TGCGTACAGC CCTCAATCTG 
TTCTTCAAGC TCAAGAACTT CAAGACAGCT GCCACCTTTG CTCGGCGCCT ACTAGAACTC 
GGGCCCAAGC CTGAGGTGGC CCAACAGACC CGAAAAATCC TGTCTGCCTG TGAGAAGAAT 
CCCACAGATG CCTACCAGCT CAATTATGAC ATGCACAACC CCTTTGACAT TTGTGCTGCA 
TCATATCGGC CCATCTACCG TGGAAAGCCA GTAGAAAAGT GTCCACTCAG TGGGGCCTGC 
TATTCCCCTG AGTTCAAAGG TCAAATCTGC AGGGTCACCA CAGTGACAGA GATTGGCAAA 
GATGTGATTG GTTTAAGGAT CAGTCCTCTG CAGTTTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001091868.1
CDS	81..3782
Translation	MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHEHSCPLPLTAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEIGKDVIGLRISPLQFR

Target ORF information:

RefSeq Version	NM_001098398.2
Organism	Homo sapiens(human)
Definition	Homo sapiens COPI coat complex subunit alpha (COPA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098398.2

ORF Insert Sequence:

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGAA CACTCATGCC CTTTGCCTCT TACAGCCATT 
GTGATCTGTA ACCGCAAACT GGATGCTTTA TGTAACATTC ATGAGAACAT TCGTGTCAAG 
AGTGGGGCCT GGGATGAGAG TGGGGTATTT ATCTATACCA CAAGCAACCA CATCAAATAT 
GCTGTCACCA CTGGGGACCA CGGGATCATT CGAACTCTGG ATTTACCCAT CTATGTCACA 
CGGGTGAAGG GCAACAATGT ATACTGCCTA GACAGGGAGT GTCGTCCCCG GGTACTCACC 
ATTGATCCCA CTGAGTTCAA ATTCAAGCTG GCCCTGATCA ACAGAAAATA TGATGAGGTA 
CTGCACATGG TGAGGAATGC CAAACTAGTT GGCCAGTCTA TTATTGCTTA TCTCCAGAAG 
AAGGGCTATC CTGAAGTGGC ACTGCATTTT GTCAAGGATG AGAAAACTCG CTTTAGTCTG 
GCACTGGAGT GTGGAAACAT TGAGATTGCT CTGGAAGCAG CCAAAGCACT GGATGACAAG 
AACTGCTGGG AAAAGCTGGG AGAAGTGGCC CTGCTGCAGG GGAACCACCA GATTGTGGAA 
ATGTGCTATC AGCGTACCAA AAACTTTGAC AAACTTTCCT TCCTGTATCT TATCACTGGC 
AACTTAGAAA AACTTCGCAA GATGATGAAG ATTGCTGAGA TCAGAAAGGA CATGAGTGGC 
CACTATCAGA ATGCCCTATA CCTGGGTGAT GTGTCAGAGC GTGTGCGGAT CCTGAAGAAC 
TGTGGACAGA AGTCCCTGGC CTATCTCACA GCTGCTACCC ATGGCTTAGA TGAAGAAGCT 
GAGAGCCTAA AGGAGACATT TGACCCAGAG AAGGAGACAA TCCCAGACAT TGACCCTAAT 
GCCAAGCTGC TCCAGCCACC TGCACCTATC ATGCCATTGG ATACCAATTG GCCTTTATTG 
ACTGTATCCA AAGGATTTTT TGAAGGCACC ATTGCCAGCA AAGGGAAGGG AGGAGCACTG 
GCTGCTGACA TTGACATTGA CACTGTTGGT ACAGAGGGCT GGGGAGAGGA TGCAGAGCTG 
CAGTTGGATG AAGATGGGTT TGTGGAGGCT ACAGAAGGTT TGGGGGATGA TGCTCTTGGC 
AAGGGACAGG AAGAAGGAGG TGGCTGGGAT GTAGAAGAAG ATCTGGAGCT CCCTCCTGAG 
CTGGATATAT CCCCTGGGGC AGCTGGTGGG GCTGAAGATG GTTTCTTTGT GCCCCCAACC 
AAGGGAACAA GTCCAACTCA GATCTGGTGT AATAACTCTC AGCTTCCAGT TGATCACATC 
CTGGCAGGCT CTTTCGAAAC AGCCATGCGG CTCCTTCATG ACCAAGTAGG GGTAATCCAG 
TTTGGCCCCT ACAAGCAACT GTTCCTACAG ACATACGCCC GAGGCCGCAC AACCTATCAG 
GCTCTGCCCT GCCTACCCTC CATGTATGGC TATCCTAATC GCAACTGGAA GGATGCAGGG 
CTGAAGAATG GTGTACCAGC TGTGGGCCTG AAGCTTAATG ACCTCATCCA ACGGTTGCAG 
CTGTGCTACC AGCTCACCAC AGTTGGCAAA TTTGAGGAGG CTGTGGAAAA ATTCCGTTCC 
ATCCTTCTCA GTGTGCCACT TCTTGTTGTG GACAATAAAC AAGAGATTGC AGAGGCCCAG 
CAGCTCATCA CCATTTGCCG TGAGTACATT GTGGGTTTGT CCGTGGAGAC AGAAAGGAAG 
AAGCTGCCCA AAGAGACTCT AGAACAGCAG AAGCGCATCT GTGAGATGGC AGCCTATTTC 
ACCCACTCAA ACCTGCAGCC TGTGCACATG ATCCTGGTGC TGCGTACAGC CCTCAATCTG 
TTCTTCAAGC TCAAGAACTT CAAGACAGCT GCCACCTTTG CTCGGCGCCT ACTAGAACTC 
GGGCCCAAGC CTGAGGTGGC CCAACAGACC CGAAAAATCC TGTCTGCCTG TGAGAAGAAT 
CCCACAGATG CCTACCAGCT CAATTATGAC ATGCACAACC CCTTTGACAT TTGTGCTGCA 
TCATATCGGC CCATCTACCG TGGAAAGCCA GTAGAAAAGT GTCCACTCAG TGGGGCCTGC 
TATTCCCCTG AGTTCAAAGG TCAAATCTGC AGGGTCACCA CAGTGACAGA GATTGGCAAA 
GATGTGATTG GTTTAAGGAT CAGTCCTCTG CAGTTTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COPA ( NM_001098398.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001091868.1 Homo sapiens coatomer protein complex subunit alpha (COPA), transcript variant 1, mRNA.

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CloneID	OHu17387
Clone ID Related Accession (Same CDS sequence)	NM_001098398.2 , NM_001098398.1
Accession Version	NM_001098398.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	coatomer subunit alpha isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC308331.1, BC038447.1 and AL513282.10. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.130559.1, SRR1803614.264750.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGAA CACTCATGCC CTTTGCCTCT TACAGCCATT 
GTGATCTGTA ACCGCAAACT GGATGCTTTA TGTAACATTC ATGAGAACAT TCGTGTCAAG 
AGTGGGGCCT GGGATGAGAG TGGGGTATTT ATCTATACCA CAAGCAACCA CATCAAATAT 
GCTGTCACCA CTGGGGACCA CGGGATCATT CGAACTCTGG ATTTACCCAT CTATGTCACA 
CGGGTGAAGG GCAACAATGT ATACTGCCTA GACAGGGAGT GTCGTCCCCG GGTACTCACC 
ATTGATCCCA CTGAGTTCAA ATTCAAGCTG GCCCTGATCA ACAGAAAATA TGATGAGGTA 
CTGCACATGG TGAGGAATGC CAAACTAGTT GGCCAGTCTA TTATTGCTTA TCTCCAGAAG 
AAGGGCTATC CTGAAGTGGC ACTGCATTTT GTCAAGGATG AGAAAACTCG CTTTAGTCTG 
GCACTGGAGT GTGGAAACAT TGAGATTGCT CTGGAAGCAG CCAAAGCACT GGATGACAAG 
AACTGCTGGG AAAAGCTGGG AGAAGTGGCC CTGCTGCAGG GGAACCACCA GATTGTGGAA 
ATGTGCTATC AGCGTACCAA AAACTTTGAC AAACTTTCCT TCCTGTATCT TATCACTGGC 
AACTTAGAAA AACTTCGCAA GATGATGAAG ATTGCTGAGA TCAGAAAGGA CATGAGTGGC 
CACTATCAGA ATGCCCTATA CCTGGGTGAT GTGTCAGAGC GTGTGCGGAT CCTGAAGAAC 
TGTGGACAGA AGTCCCTGGC CTATCTCACA GCTGCTACCC ATGGCTTAGA TGAAGAAGCT 
GAGAGCCTAA AGGAGACATT TGACCCAGAG AAGGAGACAA TCCCAGACAT TGACCCTAAT 
GCCAAGCTGC TCCAGCCACC TGCACCTATC ATGCCATTGG ATACCAATTG GCCTTTATTG 
ACTGTATCCA AAGGATTTTT TGAAGGCACC ATTGCCAGCA AAGGGAAGGG AGGAGCACTG 
GCTGCTGACA TTGACATTGA CACTGTTGGT ACAGAGGGCT GGGGAGAGGA TGCAGAGCTG 
CAGTTGGATG AAGATGGGTT TGTGGAGGCT ACAGAAGGTT TGGGGGATGA TGCTCTTGGC 
AAGGGACAGG AAGAAGGAGG TGGCTGGGAT GTAGAAGAAG ATCTGGAGCT CCCTCCTGAG 
CTGGATATAT CCCCTGGGGC AGCTGGTGGG GCTGAAGATG GTTTCTTTGT GCCCCCAACC 
AAGGGAACAA GTCCAACTCA GATCTGGTGT AATAACTCTC AGCTTCCAGT TGATCACATC 
CTGGCAGGCT CTTTCGAAAC AGCCATGCGG CTCCTTCATG ACCAAGTAGG GGTAATCCAG 
TTTGGCCCCT ACAAGCAACT GTTCCTACAG ACATACGCCC GAGGCCGCAC AACCTATCAG 
GCTCTGCCCT GCCTACCCTC CATGTATGGC TATCCTAATC GCAACTGGAA GGATGCAGGG 
CTGAAGAATG GTGTACCAGC TGTGGGCCTG AAGCTTAATG ACCTCATCCA ACGGTTGCAG 
CTGTGCTACC AGCTCACCAC AGTTGGCAAA TTTGAGGAGG CTGTGGAAAA ATTCCGTTCC 
ATCCTTCTCA GTGTGCCACT TCTTGTTGTG GACAATAAAC AAGAGATTGC AGAGGCCCAG 
CAGCTCATCA CCATTTGCCG TGAGTACATT GTGGGTTTGT CCGTGGAGAC AGAAAGGAAG 
AAGCTGCCCA AAGAGACTCT AGAACAGCAG AAGCGCATCT GTGAGATGGC AGCCTATTTC 
ACCCACTCAA ACCTGCAGCC TGTGCACATG ATCCTGGTGC TGCGTACAGC CCTCAATCTG 
TTCTTCAAGC TCAAGAACTT CAAGACAGCT GCCACCTTTG CTCGGCGCCT ACTAGAACTC 
GGGCCCAAGC CTGAGGTGGC CCAACAGACC CGAAAAATCC TGTCTGCCTG TGAGAAGAAT 
CCCACAGATG CCTACCAGCT CAATTATGAC ATGCACAACC CCTTTGACAT TTGTGCTGCA 
TCATATCGGC CCATCTACCG TGGAAAGCCA GTAGAAAAGT GTCCACTCAG TGGGGCCTGC 
TATTCCCCTG AGTTCAAAGG TCAAATCTGC AGGGTCACCA CAGTGACAGA GATTGGCAAA 
GATGTGATTG GTTTAAGGAT CAGTCCTCTG CAGTTTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001091868.1
CDS	395..4096
Translation	MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHEHSCPLPLTAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEIGKDVIGLRISPLQFR

Target ORF information:

RefSeq Version	NM_001098398.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coatomer protein complex subunit alpha (COPA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098398.1

ORF Insert Sequence:

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTCAAAG GGCTCAGCTT TCACCCCAAA 
AGACCTTGGA TCCTGACTAG TTTACATAAT GGGGTCATCC AGTTATGGGA CTATCGGATG 
TGCACTCTCA TTGACAAGTT TGATGAACAT GATGGTCCAG TGCGAGGCAT TGACTTCCAT 
AAGCAGCAGC CACTGTTCGT CTCTGGAGGA GATGACTATA AGATTAAGGT TTGGAATTAC 
AAGCTTCGGC GCTGTCTTTT CACATTGCTT GGGCACTTAG ATTATATTCG CACCACGTTT 
TTTCATCATG AATATCCCTG GATTCTGAGT GCCTCCGATG ATCAGACCAT CCGAGTGTGG 
AACTGGCAAT CTAGAACCTG TGTTTGTGTG TTAACAGGGC ACAACCATTA TGTGATGTGT 
GCTCAGTTCC ACCCCACAGA AGACTTGGTA GTATCAGCCA GCCTGGACCA GACTGTGCGC 
GTTTGGGATA TTTCTGGTCT GAGGAAAAAA AACCTGTCCC CTGGTGCGGT GGAATCGGAT 
GTGAGAGGAA TAACTGGGGT TGATCTATTT GGAACTACAG ATGCAGTGGT GAAGCATGTA 
CTAGAGGGTC ACGATCGTGG AGTAAACTGG GCTGCCTTCC ACCCCACTAT GCCCCTTATT 
GTATCTGGGG CAGATGATCG TCAAGTGAAG ATCTGGCGCA TGAATGAATC AAAGGCATGG 
GAGGTTGATA CCTGCCGGGG CCATTACAAC AATGTATCTT GTGCCGTCTT CCACCCTCGC 
CAAGAGTTGA TCCTCAGCAA TTCTGAGGAC AAGAGTATTC GAGTCTGGGA TATGTCTAAG 
CGGACTGGGG TTCAGACTTT CCGCAGAGAC CATGATCGTT TCTGGGTCCT AGCTGCTCAC 
CCTAACCTTA ACCTCTTTGC AGCAGGCCAT GATGGTGGTA TGATTGTGTT TAAGCTGGAA 
CGGGAACGGC CAGCCTATGC TGTTCATGGC AATATGCTAC ACTATGTCAA GGACCGATTC 
TTACGACAGC TGGATTTCAA CAGCTCCAAA GATGTAGCTG TGATGCAGTT GCGGAGTGGT 
TCCAAGTTTC CAGTATTCAA TATGTCATAC AATCCAGCAG AAAATGCAGT CCTGCTTTGT 
ACAAGAGCTA GCAATCTAGA GAATAGTACC TATGACCTGT ACACCATCCC TAAAGATGCT 
GACTCCCAGA ATCCTGATGC GCCTGAAGGG AAACGATCCT CAGGCCTGAC AGCCGTTTGG 
GTCGCTCGAA ATCGGTTTGC TGTCCTAGAT CGGATGCATT CGCTTCTGAT CAAGAATCTG 
AAGAATGAGA TCACCAAAAA GGTACAGGTG CCCAACTGTG ATGAGATCTT CTATGCTGGC 
ACAGGCAATC TCCTGCTTCG AGATGCGGAC TCTATCACAC TCTTTGACGT ACAGCAGAAG 
CGGACTCTGG CATCTGTGAA GATTTCTAAA GTGAAATACG TTATCTGGTC AGCAGACATG 
TCACATGTAG CACTACTAGC CAAACACGAA CACTCATGCC CTTTGCCTCT TACAGCCATT 
GTGATCTGTA ACCGCAAACT GGATGCTTTA TGTAACATTC ATGAGAACAT TCGTGTCAAG 
AGTGGGGCCT GGGATGAGAG TGGGGTATTT ATCTATACCA CAAGCAACCA CATCAAATAT 
GCTGTCACCA CTGGGGACCA CGGGATCATT CGAACTCTGG ATTTACCCAT CTATGTCACA 
CGGGTGAAGG GCAACAATGT ATACTGCCTA GACAGGGAGT GTCGTCCCCG GGTACTCACC 
ATTGATCCCA CTGAGTTCAA ATTCAAGCTG GCCCTGATCA ACAGAAAATA TGATGAGGTA 
CTGCACATGG TGAGGAATGC CAAACTAGTT GGCCAGTCTA TTATTGCTTA TCTCCAGAAG 
AAGGGCTATC CTGAAGTGGC ACTGCATTTT GTCAAGGATG AGAAAACTCG CTTTAGTCTG 
GCACTGGAGT GTGGAAACAT TGAGATTGCT CTGGAAGCAG CCAAAGCACT GGATGACAAG 
AACTGCTGGG AAAAGCTGGG AGAAGTGGCC CTGCTGCAGG GGAACCACCA GATTGTGGAA 
ATGTGCTATC AGCGTACCAA AAACTTTGAC AAACTTTCCT TCCTGTATCT TATCACTGGC 
AACTTAGAAA AACTTCGCAA GATGATGAAG ATTGCTGAGA TCAGAAAGGA CATGAGTGGC 
CACTATCAGA ATGCCCTATA CCTGGGTGAT GTGTCAGAGC GTGTGCGGAT CCTGAAGAAC 
TGTGGACAGA AGTCCCTGGC CTATCTCACA GCTGCTACCC ATGGCTTAGA TGAAGAAGCT 
GAGAGCCTAA AGGAGACATT TGACCCAGAG AAGGAGACAA TCCCAGACAT TGACCCTAAT 
GCCAAGCTGC TCCAGCCACC TGCACCTATC ATGCCATTGG ATACCAATTG GCCTTTATTG 
ACTGTATCCA AAGGATTTTT TGAAGGCACC ATTGCCAGCA AAGGGAAGGG AGGAGCACTG 
GCTGCTGACA TTGACATTGA CACTGTTGGT ACAGAGGGCT GGGGAGAGGA TGCAGAGCTG 
CAGTTGGATG AAGATGGGTT TGTGGAGGCT ACAGAAGGTT TGGGGGATGA TGCTCTTGGC 
AAGGGACAGG AAGAAGGAGG TGGCTGGGAT GTAGAAGAAG ATCTGGAGCT CCCTCCTGAG 
CTGGATATAT CCCCTGGGGC AGCTGGTGGG GCTGAAGATG GTTTCTTTGT GCCCCCAACC 
AAGGGAACAA GTCCAACTCA GATCTGGTGT AATAACTCTC AGCTTCCAGT TGATCACATC 
CTGGCAGGCT CTTTCGAAAC AGCCATGCGG CTCCTTCATG ACCAAGTAGG GGTAATCCAG 
TTTGGCCCCT ACAAGCAACT GTTCCTACAG ACATACGCCC GAGGCCGCAC AACCTATCAG 
GCTCTGCCCT GCCTACCCTC CATGTATGGC TATCCTAATC GCAACTGGAA GGATGCAGGG 
CTGAAGAATG GTGTACCAGC TGTGGGCCTG AAGCTTAATG ACCTCATCCA ACGGTTGCAG 
CTGTGCTACC AGCTCACCAC AGTTGGCAAA TTTGAGGAGG CTGTGGAAAA ATTCCGTTCC 
ATCCTTCTCA GTGTGCCACT TCTTGTTGTG GACAATAAAC AAGAGATTGC AGAGGCCCAG 
CAGCTCATCA CCATTTGCCG TGAGTACATT GTGGGTTTGT CCGTGGAGAC AGAAAGGAAG 
AAGCTGCCCA AAGAGACTCT AGAACAGCAG AAGCGCATCT GTGAGATGGC AGCCTATTTC 
ACCCACTCAA ACCTGCAGCC TGTGCACATG ATCCTGGTGC TGCGTACAGC CCTCAATCTG 
TTCTTCAAGC TCAAGAACTT CAAGACAGCT GCCACCTTTG CTCGGCGCCT ACTAGAACTC 
GGGCCCAAGC CTGAGGTGGC CCAACAGACC CGAAAAATCC TGTCTGCCTG TGAGAAGAAT 
CCCACAGATG CCTACCAGCT CAATTATGAC ATGCACAACC CCTTTGACAT TTGTGCTGCA 
TCATATCGGC CCATCTACCG TGGAAAGCCA GTAGAAAAGT GTCCACTCAG TGGGGCCTGC 
TATTCCCCTG AGTTCAAAGG TCAAATCTGC AGGGTCACCA CAGTGACAGA GATTGGCAAA 
GATGTGATTG GTTTAAGGAT CAGTCCTCTG CAGTTTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

COPA syndrome in an Icelandic family caused by a recurrent missense mutation in COPA.
BMC medical genetics18(1)129(2017 11)
Jensson BO,Hansdottir S,Arnadottir GA,Sulem G,Kristjansson RP,Oddsson A,Benonisdottir S,Jonsson H,Helgason A,Saemundsdottir J,Magnusson OT,Masson G,Thorisson GA,Jonasdottir A,Jonasdottir A,Sigurdsson A,Jonsdottir I,Petursdottir V,Kristinsson JR,Gudbjartsson DF,Thorsteinsdottir U,Arngrimsson R,Sulem P,Gudmundsson G,Stefansson K

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COPA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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