EDARADD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EDARADD
Entrez Gene ID	128178
Full Name	EDAR associated death domain
Synonyms	ECTD11A,ECTD11B,ED3,EDA3
General protein information	Preferred Names EDAR associated death domain Names ectodysplasin-A receptor-associated adapter protein EDAR-associated death domain protein crinkled homolog ectodysplasia A receptor associated death domain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.3-q43
Summary	This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Disorder MIM:	606603
Disorder Html:	Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive, 614941 (3); Ectodermal dysplasia 11A, hypohidrotic/hair/tooth type, autosomal dominant, 614940 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_080738.3	NP_542776.1	ectodysplasin-A receptor-associated adapter protein isoform B
NM_080738.4	NP_542776.1	ectodysplasin-A receptor-associated adapter protein isoform B
NM_145861.3	NP_665860.2	ectodysplasin-A receptor-associated adapter protein isoform A
NM_145861.2	NP_665860.2	ectodysplasin-A receptor-associated adapter protein isoform A
NM_145861.4	NP_665860.2	ectodysplasin-A receptor-associated adapter protein isoform A

Pathways from BioSystems

Homologies

Homo sapiens (human)	EDARADD	NP_665860.2
Danio rerio (zebrafish)	edaradd	XP_695138.4
Xenopus tropicalis (tropical clawed frog)	LOC100490133	XP_002933922.2
	EDARADD	XP_001099801.1
Bos taurus (cattle)	EDARADD	XP_002698858.2
Rattus norvegicus (Norway rat)	Edaradd	XP_574055.4
Canis lupus familiaris (dog)	EDARADD	XP_005618853.1
Gallus gallus (chicken)	EDARADD	NP_001012405.2
Mus musculus (house mouse)	Edaradd	NP_598398.3

Gene Ontology
Bibliography

Related articles in PubMed

A novel missense mutation in the gene EDARADD associated with an unusual phenotype of hypohidrotic ectodermal dysplasia.
Wohlfart S, S?der S, Smahi A, Schneider H
American journal of medical genetics. Part A170A(1)249-53(2016 Jan)

A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population.
Liu H, Zhang J, Song S, Zhao H, Han D, Feng H
European journal of oral sciences120(5)378-85(2012 Oct)

Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes.
Bergendal B, Klar J, Stecks?n-Blicks C, Norderyd J, Dahl N
American journal of medical genetics. Part A155A(7)1616-22(2011 Jul)

Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases.
Cluzeau C, Hadj-Rabia S, Jambou M, Mansour S, Guigue P, Masmoudi S, Bal E, Chassaing N, Vincent MC, Viot G, Clauss F, Mani?re MC, Toupenay S, Le Merrer M, Lyonnet S, Cormier-Daire V, Amiel J, Faivre L, de Prost Y, Munnich A, Bonnefont JP, Bodemer C, Smahi A
Human mutation32(1)70-2(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

detected a novel missense mutation c.367G>A (p.Asp123Asn) in the death domain of the gene EDARADD, which co-segregated with hypohidrotic ectodermal dysplasia in the affected family. This mutation led to an impaired ability of EDARADD to activate NF-kappaB signaling.
Title: A novel missense mutation in the gene EDARADD associated with an unusual phenotype of hypohidrotic ectodermal dysplasia.

The study data demonstrate an association between SNP rs3916983 of the EDARADD gene and non-syndromic hypodontia in Chinese Han individuals.
Title: A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population.

a cohort of 93 Swedish probands with non-syndromic, isolated oligodontia, mutations were identified in the EDARADD), AXIN2, MSX1, and PAX9 genes
Title: Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes.

The phenotypes associated with EDA1, EDAR, and EDARADD mutations were indistinguishable
Title: Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases.

Results demonstrate that EDARADD mutations are not a frequent cause of hypohidrotic ectodermal dysplasia, while mutations in TRAF6, TAB2 and TAK1 may not be implicated in this disease.
Title: Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases.

The following EDARADD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EDARADD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19463	NM_145861.4 Latest version!	Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu16488	NM_080738.4 Latest version!	Homo sapiens EDAR associated death domain (EDARADD), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu16488	NM_080738.3	Homo sapiens EDAR associated death domain (EDARADD), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu19463	NM_145861.2	Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu19463	NM_145861.3	Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EDARADD ( NM_145861.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_665860.2 Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu19463
Clone ID Related Accession (Same CDS sequence)	NM_145861.3 , NM_145861.2 , NM_145861.4
Accession Version	NM_145861.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	ectodysplasin-A receptor-associated adapter protein isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL354693.6, AY028913.1 and AL136105.9. On Jun 2, 2019 this sequence version replaced NM_145861.2. Transcript Variant: This variant (A) encodes a longer isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC114557.1, SRR6380199.41564.23 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCTCA GGACGACTAA ACAGATGGGG AGAGGCACTA AAGCTCCTGG TCACCAAGAG 
GATCATATGG TAAAGGAACC AGTGGAAGAC ACAGACCCTA GCACTTTATC CTTTAATATG 
TCAGACAAAT ATCCCATTCA AGATACGGAA CTCCCTAAAG CTGAAGAATG TGATACAATT 
ACTTTGAACT GCCCACGAAA TTCAGATATG AAAAATCAGG GAGAAGAAAA TGGCTTTCCA 
GATAGCACTG GAGATCCTCT TCCAGAGATC AGCAAGGACA ACTCCTGCAA AGAAAACTGT 
ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC ACCATAAGTG ACTTGCTCAA TGATCAGGAC 
TTACTAGACG TGATCAGGAT AAAGCTGGAT CCGTGTCACC CAACGGTGAA AAACTGGAGG 
AATTTTGCAA GCAAATGGGG GATGTCCTAT GACGAATTGT GCTTCCTGGA GCAGAGGCCA 
CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG AACAGTCAGA GGACGGTGGG CCAGCTGATG 
GAGCTCTGCA GGCTCTACCA CAGGGCCGAC GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC 
GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665860.2
CDS	160..807
Translation	MGLRTTKQMGRGTKAPGHQEDHMVKEPVEDTDPSTLSFNMSDKYPIQDTELPKAEECDTITLNCPRNSDMKNQGEENGFPDSTGDPLPEISKDNSCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLMELCRLYHRADVEKVLRRWVDEEWPKRERGDPSRHF

Target ORF information:

RefSeq Version	NM_145861.3
Organism	Homo sapiens(human)
Definition	Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145861.3

ORF Insert Sequence:

ATGGGCCTCA GGACGACTAA ACAGATGGGG AGAGGCACTA AAGCTCCTGG TCACCAAGAG 
GATCATATGG TAAAGGAACC AGTGGAAGAC ACAGACCCTA GCACTTTATC CTTTAATATG 
TCAGACAAAT ATCCCATTCA AGATACGGAA CTCCCTAAAG CTGAAGAATG TGATACAATT 
ACTTTGAACT GCCCACGAAA TTCAGATATG AAAAATCAGG GAGAAGAAAA TGGCTTTCCA 
GATAGCACTG GAGATCCTCT TCCAGAGATC AGCAAGGACA ACTCCTGCAA AGAAAACTGT 
ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC ACCATAAGTG ACTTGCTCAA TGATCAGGAC 
TTACTAGACG TGATCAGGAT AAAGCTGGAT CCGTGTCACC CAACGGTGAA AAACTGGAGG 
AATTTTGCAA GCAAATGGGG GATGTCCTAT GACGAATTGT GCTTCCTGGA GCAGAGGCCA 
CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG AACAGTCAGA GGACGGTGGG CCAGCTGATG 
GAGCTCTGCA GGCTCTACCA CAGGGCCGAC GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC 
GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EDARADD ( NM_145861.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_665860.2 Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu19463
Clone ID Related Accession (Same CDS sequence)	NM_145861.3 , NM_145861.2 , NM_145861.4
Accession Version	NM_145861.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	ectodysplasin-A receptor-associated adapter protein isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL354693.6, AY028913.1 and AL136105.9. This sequence is a reference standard in the RefSeqGene project. On Jul 24, 2007 this sequence version replaced NM_145861.1. Transcript Variant: This variant (A) encodes a longer isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY028913.1, BC128082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCTCA GGACGACTAA ACAGATGGGG AGAGGCACTA AAGCTCCTGG TCACCAAGAG 
GATCATATGG TAAAGGAACC AGTGGAAGAC ACAGACCCTA GCACTTTATC CTTTAATATG 
TCAGACAAAT ATCCCATTCA AGATACGGAA CTCCCTAAAG CTGAAGAATG TGATACAATT 
ACTTTGAACT GCCCACGAAA TTCAGATATG AAAAATCAGG GAGAAGAAAA TGGCTTTCCA 
GATAGCACTG GAGATCCTCT TCCAGAGATC AGCAAGGACA ACTCCTGCAA AGAAAACTGT 
ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC ACCATAAGTG ACTTGCTCAA TGATCAGGAC 
TTACTAGACG TGATCAGGAT AAAGCTGGAT CCGTGTCACC CAACGGTGAA AAACTGGAGG 
AATTTTGCAA GCAAATGGGG GATGTCCTAT GACGAATTGT GCTTCCTGGA GCAGAGGCCA 
CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG AACAGTCAGA GGACGGTGGG CCAGCTGATG 
GAGCTCTGCA GGCTCTACCA CAGGGCCGAC GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC 
GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665860.2
CDS	66..713
Translation	MGLRTTKQMGRGTKAPGHQEDHMVKEPVEDTDPSTLSFNMSDKYPIQDTELPKAEECDTITLNCPRNSDMKNQGEENGFPDSTGDPLPEISKDNSCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLMELCRLYHRADVEKVLRRWVDEEWPKRERGDPSRHF

Target ORF information:

RefSeq Version	NM_145861.2
Organism	Homo sapiens(human)
Definition	Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145861.2

ORF Insert Sequence:

ATGGGCCTCA GGACGACTAA ACAGATGGGG AGAGGCACTA AAGCTCCTGG TCACCAAGAG 
GATCATATGG TAAAGGAACC AGTGGAAGAC ACAGACCCTA GCACTTTATC CTTTAATATG 
TCAGACAAAT ATCCCATTCA AGATACGGAA CTCCCTAAAG CTGAAGAATG TGATACAATT 
ACTTTGAACT GCCCACGAAA TTCAGATATG AAAAATCAGG GAGAAGAAAA TGGCTTTCCA 
GATAGCACTG GAGATCCTCT TCCAGAGATC AGCAAGGACA ACTCCTGCAA AGAAAACTGT 
ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC ACCATAAGTG ACTTGCTCAA TGATCAGGAC 
TTACTAGACG TGATCAGGAT AAAGCTGGAT CCGTGTCACC CAACGGTGAA AAACTGGAGG 
AATTTTGCAA GCAAATGGGG GATGTCCTAT GACGAATTGT GCTTCCTGGA GCAGAGGCCA 
CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG AACAGTCAGA GGACGGTGGG CCAGCTGATG 
GAGCTCTGCA GGCTCTACCA CAGGGCCGAC GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC 
GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EDARADD ( NM_145861.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_665860.2 Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu19463
Clone ID Related Accession (Same CDS sequence)	NM_145861.3 , NM_145861.2 , NM_145861.4
Accession Version	NM_145861.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	ectodysplasin-A receptor-associated adapter protein isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL354693.6 and AL136105.9. On Oct 1, 2019 this sequence version replaced NM_145861.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC114557.1, AK290862.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END##

ATGGGCCTCA GGACGACTAA ACAGATGGGG AGAGGCACTA AAGCTCCTGG TCACCAAGAG 
GATCATATGG TAAAGGAACC AGTGGAAGAC ACAGACCCTA GCACTTTATC CTTTAATATG 
TCAGACAAAT ATCCCATTCA AGATACGGAA CTCCCTAAAG CTGAAGAATG TGATACAATT 
ACTTTGAACT GCCCACGAAA TTCAGATATG AAAAATCAGG GAGAAGAAAA TGGCTTTCCA 
GATAGCACTG GAGATCCTCT TCCAGAGATC AGCAAGGACA ACTCCTGCAA AGAAAACTGT 
ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC ACCATAAGTG ACTTGCTCAA TGATCAGGAC 
TTACTAGACG TGATCAGGAT AAAGCTGGAT CCGTGTCACC CAACGGTGAA AAACTGGAGG 
AATTTTGCAA GCAAATGGGG GATGTCCTAT GACGAATTGT GCTTCCTGGA GCAGAGGCCA 
CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG AACAGTCAGA GGACGGTGGG CCAGCTGATG 
GAGCTCTGCA GGCTCTACCA CAGGGCCGAC GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC 
GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665860.2
CDS	160..807
Translation	MGLRTTKQMGRGTKAPGHQEDHMVKEPVEDTDPSTLSFNMSDKYPIQDTELPKAEECDTITLNCPRNSDMKNQGEENGFPDSTGDPLPEISKDNSCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLMELCRLYHRADVEKVLRRWVDEEWPKRERGDPSRHF

Target ORF information:

RefSeq Version	NM_145861.4
Organism	Homo sapiens(human)
Definition	Homo sapiens EDAR associated death domain (EDARADD), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145861.4

ORF Insert Sequence:

ATGGGCCTCA GGACGACTAA ACAGATGGGG AGAGGCACTA AAGCTCCTGG TCACCAAGAG 
GATCATATGG TAAAGGAACC AGTGGAAGAC ACAGACCCTA GCACTTTATC CTTTAATATG 
TCAGACAAAT ATCCCATTCA AGATACGGAA CTCCCTAAAG CTGAAGAATG TGATACAATT 
ACTTTGAACT GCCCACGAAA TTCAGATATG AAAAATCAGG GAGAAGAAAA TGGCTTTCCA 
GATAGCACTG GAGATCCTCT TCCAGAGATC AGCAAGGACA ACTCCTGCAA AGAAAACTGT 
ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC ACCATAAGTG ACTTGCTCAA TGATCAGGAC 
TTACTAGACG TGATCAGGAT AAAGCTGGAT CCGTGTCACC CAACGGTGAA AAACTGGAGG 
AATTTTGCAA GCAAATGGGG GATGTCCTAT GACGAATTGT GCTTCCTGGA GCAGAGGCCA 
CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG AACAGTCAGA GGACGGTGGG CCAGCTGATG 
GAGCTCTGCA GGCTCTACCA CAGGGCCGAC GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC 
GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EDARADD ( NM_080738.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542776.1 Homo sapiens EDAR associated death domain (EDARADD), transcript variant B, mRNA.

Price & Availability↑

CloneID	OHu16488
Clone ID Related Accession (Same CDS sequence)	NM_080738.3 , NM_080738.4
Accession Version	NM_080738.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	ectodysplasin-A receptor-associated adapter protein isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK096339.1 and BC006533.2. On Jul 24, 2007 this sequence version replaced NM_080738.2. Transcript Variant: This variant (B) differs in the 5' region compared to variant A. It encodes an isoform (B) that contains a distinct and shorter N-terminus, as compared to isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK096339.1, BC006533.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCAC CGGACGACCC TCTGCGCGCA GATCATATGG TAAAGGAACC AGTGGAAGAC 
ACAGACCCTA GCACTTTATC CTTTAATATG TCAGACAAAT ATCCCATTCA AGATACGGAA 
CTCCCTAAAG CTGAAGAATG TGATACAATT ACTTTGAACT GCCCACGAAA TTCAGATATG 
AAAAATCAGG GAGAAGAAAA TGGCTTTCCA GATAGCACTG GAGATCCTCT TCCAGAGATC 
AGCAAGGACA ACTCCTGCAA AGAAAACTGT ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC 
ACCATAAGTG ACTTGCTCAA TGATCAGGAC TTACTAGACG TGATCAGGAT AAAGCTGGAT 
CCGTGTCACC CAACGGTGAA AAACTGGAGG AATTTTGCAA GCAAATGGGG GATGTCCTAT 
GACGAATTGT GCTTCCTGGA GCAGAGGCCA CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG 
AACAGTCAGA GGACGGTGGG CCAGCTGATG GAGCTCTGCA GGCTCTACCA CAGGGCCGAC 
GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC 
CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542776.1
CDS	215..832
Translation	MASPDDPLRADHMVKEPVEDTDPSTLSFNMSDKYPIQDTELPKAEECDTITLNCPRNSDMKNQGEENGFPDSTGDPLPEISKDNSCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLMELCRLYHRADVEKVLRRWVDEEWPKRERGDPSRHF

Target ORF information:

RefSeq Version	NM_080738.3
Organism	Homo sapiens(human)
Definition	Homo sapiens EDAR associated death domain (EDARADD), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080738.3

ORF Insert Sequence:

ATGGCTTCAC CGGACGACCC TCTGCGCGCA GATCATATGG TAAAGGAACC AGTGGAAGAC 
ACAGACCCTA GCACTTTATC CTTTAATATG TCAGACAAAT ATCCCATTCA AGATACGGAA 
CTCCCTAAAG CTGAAGAATG TGATACAATT ACTTTGAACT GCCCACGAAA TTCAGATATG 
AAAAATCAGG GAGAAGAAAA TGGCTTTCCA GATAGCACTG GAGATCCTCT TCCAGAGATC 
AGCAAGGACA ACTCCTGCAA AGAAAACTGT ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC 
ACCATAAGTG ACTTGCTCAA TGATCAGGAC TTACTAGACG TGATCAGGAT AAAGCTGGAT 
CCGTGTCACC CAACGGTGAA AAACTGGAGG AATTTTGCAA GCAAATGGGG GATGTCCTAT 
GACGAATTGT GCTTCCTGGA GCAGAGGCCA CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG 
AACAGTCAGA GGACGGTGGG CCAGCTGATG GAGCTCTGCA GGCTCTACCA CAGGGCCGAC 
GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC 
CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EDARADD ( NM_080738.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_542776.1 Homo sapiens EDAR associated death domain (EDARADD), transcript variant B, mRNA.

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CloneID	OHu16488
Clone ID Related Accession (Same CDS sequence)	NM_080738.3 , NM_080738.4
Accession Version	NM_080738.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Homo sapiens(human)
Product	ectodysplasin-A receptor-associated adapter protein isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL354693.6, AK096339.1, BC006533.2 and AL136105.9. On Jun 2, 2019 this sequence version replaced NM_080738.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK096339.1, BC006533.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCAC CGGACGACCC TCTGCGCGCA GATCATATGG TAAAGGAACC AGTGGAAGAC 
ACAGACCCTA GCACTTTATC CTTTAATATG TCAGACAAAT ATCCCATTCA AGATACGGAA 
CTCCCTAAAG CTGAAGAATG TGATACAATT ACTTTGAACT GCCCACGAAA TTCAGATATG 
AAAAATCAGG GAGAAGAAAA TGGCTTTCCA GATAGCACTG GAGATCCTCT TCCAGAGATC 
AGCAAGGACA ACTCCTGCAA AGAAAACTGT ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC 
ACCATAAGTG ACTTGCTCAA TGATCAGGAC TTACTAGACG TGATCAGGAT AAAGCTGGAT 
CCGTGTCACC CAACGGTGAA AAACTGGAGG AATTTTGCAA GCAAATGGGG GATGTCCTAT 
GACGAATTGT GCTTCCTGGA GCAGAGGCCA CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG 
AACAGTCAGA GGACGGTGGG CCAGCTGATG GAGCTCTGCA GGCTCTACCA CAGGGCCGAC 
GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC 
CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542776.1
CDS	218..835
Translation	MASPDDPLRADHMVKEPVEDTDPSTLSFNMSDKYPIQDTELPKAEECDTITLNCPRNSDMKNQGEENGFPDSTGDPLPEISKDNSCKENCTCSSCLLRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLMELCRLYHRADVEKVLRRWVDEEWPKRERGDPSRHF

Target ORF information:

RefSeq Version	NM_080738.4
Organism	Homo sapiens(human)
Definition	Homo sapiens EDAR associated death domain (EDARADD), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080738.4

ORF Insert Sequence:

ATGGCTTCAC CGGACGACCC TCTGCGCGCA GATCATATGG TAAAGGAACC AGTGGAAGAC 
ACAGACCCTA GCACTTTATC CTTTAATATG TCAGACAAAT ATCCCATTCA AGATACGGAA 
CTCCCTAAAG CTGAAGAATG TGATACAATT ACTTTGAACT GCCCACGAAA TTCAGATATG 
AAAAATCAGG GAGAAGAAAA TGGCTTTCCA GATAGCACTG GAGATCCTCT TCCAGAGATC 
AGCAAGGACA ACTCCTGCAA AGAAAACTGT ACTTGTTCCT CCTGCTTGCT CCGGGCCCCC 
ACCATAAGTG ACTTGCTCAA TGATCAGGAC TTACTAGACG TGATCAGGAT AAAGCTGGAT 
CCGTGTCACC CAACGGTGAA AAACTGGAGG AATTTTGCAA GCAAATGGGG GATGTCCTAT 
GACGAATTGT GCTTCCTGGA GCAGAGGCCA CAGAGCCCCA CCTTGGAGTT CTTGCTCCGG 
AACAGTCAGA GGACGGTGGG CCAGCTGATG GAGCTCTGCA GGCTCTACCA CAGGGCCGAC 
GTGGAGAAGG TTCTGCGCAG GTGGGTGGAC GAGGAGTGGC CCAAGCGGGA GCGTGGAGAC 
CCCTCCAGGC ACTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel missense mutation in the gene EDARADD associated with an unusual phenotype of hypohidrotic ectodermal dysplasia.
American journal of medical genetics. Part A170A(1)249-53(2016 Jan)
Wohlfart S,S?der S,Smahi A,Schneider H

A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population.
European journal of oral sciences120(5)378-85(2012 Oct)
Liu H,Zhang J,Song S,Zhao H,Han D,Feng H

Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes.
American journal of medical genetics. Part A155A(7)1616-22(2011 Jul)
Bergendal B,Klar J,Stecks?n-Blicks C,Norderyd J,Dahl N

Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases.
Human mutation32(1)70-2(2011 Jan)
Cluzeau C,Hadj-Rabia S,Jambou M,Mansour S,Guigue P,Masmoudi S,Bal E,Chassaing N,Vincent MC,Viot G,Clauss F,Mani?re MC,Toupenay S,Le Merrer M,Lyonnet S,Cormier-Daire V,Amiel J,Faivre L,de Prost Y,Munnich A,Bonnefont JP,Bodemer C,Smahi A

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EDARADD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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