PLK5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLK5
Entrez Gene ID	126520
Full Name	polo like kinase 5
Synonyms	PLK-5,PLK5P,SgK384ps
General protein information	Preferred Names polo like kinase 5 Names inactive serine/threonine-protein kinase PLK5 polo-like kinase 5, pseudogene
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001243079.1	NP_001230008.1	inactive serine/threonine-protein kinase PLK5
NM_001243079.2	NP_001230008.1	inactive serine/threonine-protein kinase PLK5

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PLK5	XP_005633301.1
Rattus norvegicus (Norway rat)	Plk5	NP_001164028.1
Pan troglodytes (chimpanzee)	PLK5	XP_003953360.1
Bos taurus (cattle)	PLK5	XP_002689224.2
Homo sapiens (human)	PLK5	NP_001230008.1
Mus musculus (house mouse)	Plk5	NP_898975.2

Gene Ontology
Bibliography

Related articles in PubMed

Genetic mutations associated with metastatic clear cell renal cell carcinoma.
Li Z, Hao P, Wu Q, Li F, Zhao J, Wu K, Qu C, Chen Y, Li M, Chen X, Stucky A, Zhong J, Li L, Zhong JF
Oncotarget7(13)16172-9(2016 Mar)

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
de C?rcer G, Escobar B, Higuero AM, Garc?a L, Ans?n A, P?rez G, Mollejo M, Manning G, Mel?ndez B, Abad-Rodr?guez J, Malumbres M
Molecular and cellular biology31(6)1225-39(2011 Mar)

The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus.
Andrysik Z, Bernstein WZ, Deng L, Myer DL, Li YQ, Tischfield JA, Stambrook PJ, Bahassi el M
Nucleic acids research38(9)2931-43(2010 May)

Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.
Zhang ZD, Frankish A, Hunt T, Harrow J, Gerstein M
Genome biology11(3)R26(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we report a three-nucleotide deletion near the C-region of Plk5 that is specifically associated with the lymphatic metastasis in patients with clear cell renal cell carcinoma
Title: Genetic mutations associated with metastatic clear cell renal cell carcinoma.

The human polo-like kinase 5 gene is significantly silenced in astrocytoma and glioblastoma multiforme by promoter hypermethylation, suggesting a tumor suppressor function for this gene.
Title: Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.

The following PLK5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLK5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08337	NM_001243079.2 Latest version!	Homo sapiens polo like kinase 5 (PLK5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu08337	NM_001243079.1	Homo sapiens polo like kinase 5 (PLK5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLK5 ( NM_001243079.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230008.1 Homo sapiens polo like kinase 5 (PLK5), mRNA.

Price & Availability↑

CloneID	OHu08337
Clone ID Related Accession (Same CDS sequence)	NM_001243079.1 , NM_001243079.2
Accession Version	NM_001243079.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	inactive serine/threonine-protein kinase PLK5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC027307.5, AK054808.1, AI651075.1 and BC100791.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK054808.1, SRR1660803.255346.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END##

ATGTACACGG TGCTGACTGG CACCCCACCC TTCATGGCCT CACCCCTGTC GGAGATGTAC 
CAAAACATCC GTGAGGGCCA CTACCCCGAA CCCGCTCACC TGTCTGCCAA TGCGCGCCGC 
CTCATCGTGC ACCTCCTAGC ACCCAACCCG GCCGAGCGGC CCAGCCTGGA CCACCTGCTG 
CAGGACGACT TCTTCACACA GGGTTTCACT CCAGACCGGC TGCCGGCCCA CTCCTGCCAC 
AGTCCCCCCA TCTTCGCCAT ACCCCCGCCT CTGGGCAGGA TCTTCCGGAA GGTGGGCCAG 
CGGCTGCTCA CCCAGTGCCG GCCACCCTGC CCCTTCACGC CTAAAGAGGC CTCGGGTCCA 
GGAGAAGGTG GGCCAGACCC TGACTCCATG GAGTGGGACG GCGAGAGCTC CCTGTCTGCG 
AAAGAGGTTC CCTGCCTGGA AGGCCCCATC CACCTGGTCG CACAAGGGAC CCTGCAGAGT 
GACCTGGCCG GGCCCGAGGG GAGCCGGCGG CCAGAGGTGG AGGCGGCCCT CAGACACCTG 
CAGCTGTGCC TGGATGTAGG CCCCCCGGCC ACACAGGACC CCCTGGGAGA GCAGCAGCCC 
ATCCTCTGGG CCCCCAAATG GGTGGATTAT TCCAGCAAAT ACGGCTTTGG CTACCAGCTC 
TTGGACGGGG GGCGCACGGG ACGGCACCCA CATGGCCCTG CGACCCCCCG GAGGGAGGGG 
ACCCTCCCCA CACCTGTGCC ACCTGCTGGA CCCGGCCTCT GCCTCCTGCG CTTCCTGGCC 
TCTGAGCACG CCCTGCTGCT GCTGTTCAGC AATGGGATGG TGCAGGTGAG CTTCAGTGGA 
GTCCCGGCCC AACTGGTGCT GAGTGGCGAG GGTGAGGGTT TGCAGCTCAC CCTCTGGGAG 
CAGGGGTCCC CTGGCACCTC CTACTCCCTG GACGTCCCGC GGAGCCACGG CTGCGCCCCC 
ACCACCGGAC AGCACCTTCA CCACGCCCTC CGCATGCTGC AGAGTATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230008.1
CDS	717..1727
Translation	MYTVLTGTPPFMASPLSEMYQNIREGHYPEPAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFFTQGFTPDRLPAHSCHSPPIFAIPPPLGRIFRKVGQRLLTQCRPPCPFTPKEASGPGEGGPDPDSMEWDGESSLSAKEVPCLEGPIHLVAQGTLQSDLAGPEGSRRPEVEAALRHLQLCLDVGPPATQDPLGEQQPILWAPKWVDYSSKYGFGYQLLDGGRTGRHPHGPATPRREGTLPTPVPPAGPGLCLLRFLASEHALLLLFSNGMVQVSFSGVPAQLVLSGEGEGLQLTLWEQGSPGTSYSLDVPRSHGCAPTTGQHLHHALRMLQSI

Target ORF information:

RefSeq Version	NM_001243079.1
Organism	Homo sapiens(human)
Definition	Homo sapiens polo like kinase 5 (PLK5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243079.1

ORF Insert Sequence:

ATGTACACGG TGCTGACTGG CACCCCACCC TTCATGGCCT CACCCCTGTC GGAGATGTAC 
CAAAACATCC GTGAGGGCCA CTACCCCGAA CCCGCTCACC TGTCTGCCAA TGCGCGCCGC 
CTCATCGTGC ACCTCCTAGC ACCCAACCCG GCCGAGCGGC CCAGCCTGGA CCACCTGCTG 
CAGGACGACT TCTTCACACA GGGTTTCACT CCAGACCGGC TGCCGGCCCA CTCCTGCCAC 
AGTCCCCCCA TCTTCGCCAT ACCCCCGCCT CTGGGCAGGA TCTTCCGGAA GGTGGGCCAG 
CGGCTGCTCA CCCAGTGCCG GCCACCCTGC CCCTTCACGC CTAAAGAGGC CTCGGGTCCA 
GGAGAAGGTG GGCCAGACCC TGACTCCATG GAGTGGGACG GCGAGAGCTC CCTGTCTGCG 
AAAGAGGTTC CCTGCCTGGA AGGCCCCATC CACCTGGTCG CACAAGGGAC CCTGCAGAGT 
GACCTGGCCG GGCCCGAGGG GAGCCGGCGG CCAGAGGTGG AGGCGGCCCT CAGACACCTG 
CAGCTGTGCC TGGATGTAGG CCCCCCGGCC ACACAGGACC CCCTGGGAGA GCAGCAGCCC 
ATCCTCTGGG CCCCCAAATG GGTGGATTAT TCCAGCAAAT ACGGCTTTGG CTACCAGCTC 
TTGGACGGGG GGCGCACGGG ACGGCACCCA CATGGCCCTG CGACCCCCCG GAGGGAGGGG 
ACCCTCCCCA CACCTGTGCC ACCTGCTGGA CCCGGCCTCT GCCTCCTGCG CTTCCTGGCC 
TCTGAGCACG CCCTGCTGCT GCTGTTCAGC AATGGGATGG TGCAGGTGAG CTTCAGTGGA 
GTCCCGGCCC AACTGGTGCT GAGTGGCGAG GGTGAGGGTT TGCAGCTCAC CCTCTGGGAG 
CAGGGGTCCC CTGGCACCTC CTACTCCCTG GACGTCCCGC GGAGCCACGG CTGCGCCCCC 
ACCACCGGAC AGCACCTTCA CCACGCCCTC CGCATGCTGC AGAGTATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLK5 ( NM_001243079.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230008.1 Homo sapiens polo like kinase 5 (PLK5), mRNA.

Price & Availability↑

CloneID	OHu08337
Clone ID Related Accession (Same CDS sequence)	NM_001243079.1 , NM_001243079.2
Accession Version	NM_001243079.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	inactive serine/threonine-protein kinase PLK5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC027307.5, AK054808.1, AI651075.1 and BC100791.2. On May 17, 2019 this sequence version replaced NM_001243079.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.255346.1, SRR3476690.705705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000454744.7/ ENSP00000468376.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTACACGG TGCTGACTGG CACCCCACCC TTCATGGCCT CACCCCTGTC GGAGATGTAC 
CAAAACATCC GTGAGGGCCA CTACCCCGAA CCCGCTCACC TGTCTGCCAA TGCGCGCCGC 
CTCATCGTGC ACCTCCTAGC ACCCAACCCG GCCGAGCGGC CCAGCCTGGA CCACCTGCTG 
CAGGACGACT TCTTCACACA GGGTTTCACT CCAGACCGGC TGCCGGCCCA CTCCTGCCAC 
AGTCCCCCCA TCTTCGCCAT ACCCCCGCCT CTGGGCAGGA TCTTCCGGAA GGTGGGCCAG 
CGGCTGCTCA CCCAGTGCCG GCCACCCTGC CCCTTCACGC CTAAAGAGGC CTCGGGTCCA 
GGAGAAGGTG GGCCAGACCC TGACTCCATG GAGTGGGACG GCGAGAGCTC CCTGTCTGCG 
AAAGAGGTTC CCTGCCTGGA AGGCCCCATC CACCTGGTCG CACAAGGGAC CCTGCAGAGT 
GACCTGGCCG GGCCCGAGGG GAGCCGGCGG CCAGAGGTGG AGGCGGCCCT CAGACACCTG 
CAGCTGTGCC TGGATGTAGG CCCCCCGGCC ACACAGGACC CCCTGGGAGA GCAGCAGCCC 
ATCCTCTGGG CCCCCAAATG GGTGGATTAT TCCAGCAAAT ACGGCTTTGG CTACCAGCTC 
TTGGACGGGG GGCGCACGGG ACGGCACCCA CATGGCCCTG CGACCCCCCG GAGGGAGGGG 
ACCCTCCCCA CACCTGTGCC ACCTGCTGGA CCCGGCCTCT GCCTCCTGCG CTTCCTGGCC 
TCTGAGCACG CCCTGCTGCT GCTGTTCAGC AATGGGATGG TGCAGGTGAG CTTCAGTGGA 
GTCCCGGCCC AACTGGTGCT GAGTGGCGAG GGTGAGGGTT TGCAGCTCAC CCTCTGGGAG 
CAGGGGTCCC CTGGCACCTC CTACTCCCTG GACGTCCCGC GGAGCCACGG CTGCGCCCCC 
ACCACCGGAC AGCACCTTCA CCACGCCCTC CGCATGCTGC AGAGTATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230008.1
CDS	714..1724
Translation	MYTVLTGTPPFMASPLSEMYQNIREGHYPEPAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFFTQGFTPDRLPAHSCHSPPIFAIPPPLGRIFRKVGQRLLTQCRPPCPFTPKEASGPGEGGPDPDSMEWDGESSLSAKEVPCLEGPIHLVAQGTLQSDLAGPEGSRRPEVEAALRHLQLCLDVGPPATQDPLGEQQPILWAPKWVDYSSKYGFGYQLLDGGRTGRHPHGPATPRREGTLPTPVPPAGPGLCLLRFLASEHALLLLFSNGMVQVSFSGVPAQLVLSGEGEGLQLTLWEQGSPGTSYSLDVPRSHGCAPTTGQHLHHALRMLQSI

Target ORF information:

RefSeq Version	NM_001243079.2
Organism	Homo sapiens(human)
Definition	Homo sapiens polo like kinase 5 (PLK5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243079.2

ORF Insert Sequence:

ATGTACACGG TGCTGACTGG CACCCCACCC TTCATGGCCT CACCCCTGTC GGAGATGTAC 
CAAAACATCC GTGAGGGCCA CTACCCCGAA CCCGCTCACC TGTCTGCCAA TGCGCGCCGC 
CTCATCGTGC ACCTCCTAGC ACCCAACCCG GCCGAGCGGC CCAGCCTGGA CCACCTGCTG 
CAGGACGACT TCTTCACACA GGGTTTCACT CCAGACCGGC TGCCGGCCCA CTCCTGCCAC 
AGTCCCCCCA TCTTCGCCAT ACCCCCGCCT CTGGGCAGGA TCTTCCGGAA GGTGGGCCAG 
CGGCTGCTCA CCCAGTGCCG GCCACCCTGC CCCTTCACGC CTAAAGAGGC CTCGGGTCCA 
GGAGAAGGTG GGCCAGACCC TGACTCCATG GAGTGGGACG GCGAGAGCTC CCTGTCTGCG 
AAAGAGGTTC CCTGCCTGGA AGGCCCCATC CACCTGGTCG CACAAGGGAC CCTGCAGAGT 
GACCTGGCCG GGCCCGAGGG GAGCCGGCGG CCAGAGGTGG AGGCGGCCCT CAGACACCTG 
CAGCTGTGCC TGGATGTAGG CCCCCCGGCC ACACAGGACC CCCTGGGAGA GCAGCAGCCC 
ATCCTCTGGG CCCCCAAATG GGTGGATTAT TCCAGCAAAT ACGGCTTTGG CTACCAGCTC 
TTGGACGGGG GGCGCACGGG ACGGCACCCA CATGGCCCTG CGACCCCCCG GAGGGAGGGG 
ACCCTCCCCA CACCTGTGCC ACCTGCTGGA CCCGGCCTCT GCCTCCTGCG CTTCCTGGCC 
TCTGAGCACG CCCTGCTGCT GCTGTTCAGC AATGGGATGG TGCAGGTGAG CTTCAGTGGA 
GTCCCGGCCC AACTGGTGCT GAGTGGCGAG GGTGAGGGTT TGCAGCTCAC CCTCTGGGAG 
CAGGGGTCCC CTGGCACCTC CTACTCCCTG GACGTCCCGC GGAGCCACGG CTGCGCCCCC 
ACCACCGGAC AGCACCTTCA CCACGCCCTC CGCATGCTGC AGAGTATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic mutations associated with metastatic clear cell renal cell carcinoma.
Oncotarget7(13)16172-9(2016 Mar)
Li Z,Hao P,Wu Q,Li F,Zhao J,Wu K,Qu C,Chen Y,Li M,Chen X,Stucky A,Zhong J,Li L,Zhong JF

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
Molecular and cellular biology31(6)1225-39(2011 Mar)
de C?rcer G,Escobar B,Higuero AM,Garc?a L,Ans?n A,P?rez G,Mollejo M,Manning G,Mel?ndez B,Abad-Rodr?guez J,Malumbres M

The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus.
Nucleic acids research38(9)2931-43(2010 May)
Andrysik Z,Bernstein WZ,Deng L,Myer DL,Li YQ,Tischfield JA,Stambrook PJ,Bahassi el M

Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.
Genome biology11(3)R26(2010)
Zhang ZD,Frankish A,Hunt T,Harrow J,Gerstein M

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PLK5 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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