GIPC3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GIPC3
Entrez Gene ID	126326
Full Name	GIPC PDZ domain containing family member 3
Synonyms	C19orf64,DFNB15,DFNB72,DFNB95
General protein information	Preferred Names GIPC PDZ domain containing family member 3 Names PDZ domain-containing protein GIPC3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2011].
Disorder MIM:	608792
Disorder Html:	Deafness, autosomal recessive 15, 601869 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_133261.2	NP_573568.1	PDZ domain-containing protein GIPC3
NM_133261.3	NP_573568.1	PDZ domain-containing protein GIPC3
XM_005259492.3	XP_005259549.1	PDZ domain-containing protein GIPC3 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GIPC3	XP_001135295.1
Gallus gallus (chicken)	LOC100857667	XP_004948770.1
Danio rerio (zebrafish)	zgc:136839	NP_001038783.1
Xenopus tropicalis (tropical clawed frog)	gipc3	NP_001096502.1
Canis lupus familiaris (dog)	GIPC3	XP_542175.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007674	XP_001687864.1
Bos taurus (cattle)	GIPC3	NP_001193223.1
Drosophila melanogaster (fruit fly)	kermit	NP_652028.1
Rattus norvegicus (Norway rat)	Gipc3	NP_001102752.1
Homo sapiens (human)	GIPC3	NP_573568.1
	GIPC3	XP_001100669.1
Mus musculus (house mouse)	Gipc3	NP_683753.1

Gene Ontology
Bibliography

Related articles in PubMed

A canonical splice site mutation in GIPC3 causes sensorineural hearing loss in a large Pakistani family.
Siddiqi S, Ismail M, Oostrik J, Munawar S, Mansoor A, Kremer H, Qamar R, Schraders M
Journal of human genetics59(12)683-6(2014 Dec)

Homozygosity mapping identifies a novel GIPC3 mutation causing congenital nonsyndromic hearing loss in a Saudi family.
Ramzan K, Al-Owain M, Allam R, Berhan A, Abuharb G, Taibah K, Imtiaz F
Gene521(1)195-9(2013 May)

Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p.
Rehman AU, Gul K, Morell RJ, Lee K, Ahmed ZM, Riazuddin S, Ali RA, Shahzad M, Jaleel AU, Andrade PB, Khan SN, Khan S, Brewer CC, Ahmad W, Leal SM, Riazuddin S, Friedman TB
Human genetics130(6)759-65(2011 Dec)

Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human.
Charizopoulou N, Lelli A, Schraders M, Ray K, Hildebrand MS, Ramesh A, Srisailapathy CR, Oostrik J, Admiraal RJ, Neely HR, Latoche JR, Smith RJ, Northup JK, Kremer H, Holt JR, Noben-Trauth K
Nature communications2201(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study expands the mutational spectrum of GIPC3 in autosomal recessive nonsyndromic hearing impairment.
Title: A canonical splice site mutation in GIPC3 causes sensorineural hearing loss in a large Pakistani family.

This study identified a novel causative mutation in GIPC3 for congenital nonsyndromic hearing loss in a consanguineous family from Saudi Arabia.
Title: Homozygosity mapping identifies a novel GIPC3 mutation causing congenital nonsyndromic hearing loss in a Saudi family.

Haplotype analysis excluded GIPC3 from the obligate linkage interval in this family and defined a novel locus spanning 4.08 Mb and 104 genes.
Title: Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p.

Gipc3 plays a pivotal role in acoustic signal acquisition and propagation in cochlear hair cells, while mutations are associated with audiogenic seizures and sensorineural hearing loss.
Title: Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human.

Observational study of gene-disease association. (HuGE Navigator)
Title: Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.

The following GIPC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GIPC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22422	NM_133261.3 Latest version!	Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu51428	XM_005259492.3 Latest version!	Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00
View Old Accession Versions >>
OHu22422	NM_133261.2	Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GIPC3 ( NM_133261.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_573568.1 Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), mRNA.

Price & Availability↑

CloneID	OHu22422
Clone ID Related Accession (Same CDS sequence)	NM_133261.2 , NM_133261.3
Accession Version	NM_133261.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-14
Organism	Homo sapiens(human)
Product	PDZ domain-containing protein GIPC3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB073738.1 and AC116968.2. This sequence is a reference standard in the RefSeqGene project. On or before Mar 11, 2009 this sequence version replaced XM_001726165.1, XM_001722785.1, XM_001726185.1, NM_133261.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB073738.1, BC117312.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGAG CAGCGGCCCG GGAGGCCCGG GGGACCGAGA CCCCGCGCGC GTCTGCGCCC 
CCGCCCGCGC CCTCGGAGCC CCCGGCCGCG CCCCGCGCCC GCCCGCGCCT CGTCTTCCGC 
ACGCAGCTGG CGCACGGGAG CCCCACGGGC AAGATCGAGG GCTTCACCAA CGTCCGCGAG 
CTGTACGCCA AGATCGCCGA AGCCTTCGGG ATCGCGCCCA CCGAGATTTT ATTCTGCACC 
CTCAACAGCC ACAAAGTGGA CATGCAGAAG CTCCTGGGGG GTCAGATAGG CCTGGAGGAC 
TTCATCTTTG CCCACGTGCG AGGCGAGACC AAGGAGGTGG AGGTCACTAA GACAGAGGAT 
GCTCTGGGGC TGACCATCAC GGACAACGGG GCTGGCTACG CCTTCATCAA GAGAATCAAG 
GAAGGCAGTA TCATCAACCG GATCGAGGCA GTGTGCGTGG GTGACAGCAT CGAAGCCATC 
AACGACCACT CCATTGTGGG CTGCCGCCAC TACGAGGTGG CCAAGATGCT CCGGGAGCTG 
CCCAAGTCCC AGCCCTTCAC CCTGCGCCTG GTGCAGCCCA AGAGGGCCTT CGATATGATT 
GGCCAGAGAA GTCGGTCCAG CAAATGTCCA GTAGAGGCGA AAGTGACCAG CGGGAGGGAG 
ACCCTGCGGC TTCGTTCTGG GGGGGCTGCC ACAGTGGAGG AAGCGCCCAG TGAGTTTGAG 
GAGGAGGCAT CTCGGAAGGT TGATGACCTG CTGGAAAGCT ACATGGGCAT TCGGGACCCC 
GAGCTGGCGT CCACCATGGT GGAGACGTCC AAGAAGACAG CGAGCGCCCA GGAGTTTGCA 
CGCTGTTTAG ACTCCGTCTT GGGCGAGTTC GCCTTCCCCG ACGAGTTTGT GGTGGAAGTG 
TGGGCCGCCA TCGGCGAGGC CAGAGAGGCC TGTGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573568.1
CDS	28..966
Translation	MEGAAAREARGTETPRASAPPPAPSEPPAAPRARPRLVFRTQLAHGSPTGKIEGFTNVRELYAKIAEAFGIAPTEILFCTLNSHKVDMQKLLGGQIGLEDFIFAHVRGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAKMLRELPKSQPFTLRLVQPKRAFDMIGQRSRSSKCPVEAKVTSGRETLRLRSGGAATVEEAPSEFEEEASRKVDDLLESYMGIRDPELASTMVETSKKTASAQEFARCLDSVLGEFAFPDEFVVEVWAAIGEAREACG

Target ORF information:

RefSeq Version	NM_133261.2
Organism	Homo sapiens(human)
Definition	Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133261.2

ORF Insert Sequence:

ATGGAGGGAG CAGCGGCCCG GGAGGCCCGG GGGACCGAGA CCCCGCGCGC GTCTGCGCCC 
CCGCCCGCGC CCTCGGAGCC CCCGGCCGCG CCCCGCGCCC GCCCGCGCCT CGTCTTCCGC 
ACGCAGCTGG CGCACGGGAG CCCCACGGGC AAGATCGAGG GCTTCACCAA CGTCCGCGAG 
CTGTACGCCA AGATCGCCGA AGCCTTCGGG ATCGCGCCCA CCGAGATTTT ATTCTGCACC 
CTCAACAGCC ACAAAGTGGA CATGCAGAAG CTCCTGGGGG GTCAGATAGG CCTGGAGGAC 
TTCATCTTTG CCCACGTGCG AGGCGAGACC AAGGAGGTGG AGGTCACTAA GACAGAGGAT 
GCTCTGGGGC TGACCATCAC GGACAACGGG GCTGGCTACG CCTTCATCAA GAGAATCAAG 
GAAGGCAGTA TCATCAACCG GATCGAGGCA GTGTGCGTGG GTGACAGCAT CGAAGCCATC 
AACGACCACT CCATTGTGGG CTGCCGCCAC TACGAGGTGG CCAAGATGCT CCGGGAGCTG 
CCCAAGTCCC AGCCCTTCAC CCTGCGCCTG GTGCAGCCCA AGAGGGCCTT CGATATGATT 
GGCCAGAGAA GTCGGTCCAG CAAATGTCCA GTAGAGGCGA AAGTGACCAG CGGGAGGGAG 
ACCCTGCGGC TTCGTTCTGG GGGGGCTGCC ACAGTGGAGG AAGCGCCCAG TGAGTTTGAG 
GAGGAGGCAT CTCGGAAGGT TGATGACCTG CTGGAAAGCT ACATGGGCAT TCGGGACCCC 
GAGCTGGCGT CCACCATGGT GGAGACGTCC AAGAAGACAG CGAGCGCCCA GGAGTTTGCA 
CGCTGTTTAG ACTCCGTCTT GGGCGAGTTC GCCTTCCCCG ACGAGTTTGT GGTGGAAGTG 
TGGGCCGCCA TCGGCGAGGC CAGAGAGGCC TGTGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GIPC3 ( NM_133261.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_573568.1 Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), mRNA.

Price & Availability↑

CloneID	OHu22422
Clone ID Related Accession (Same CDS sequence)	NM_133261.2 , NM_133261.3
Accession Version	NM_133261.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	PDZ domain-containing protein GIPC3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC116968.2 and AB073738.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_133261.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB073738.1, BC117314.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGAG CAGCGGCCCG GGAGGCCCGG GGGACCGAGA CCCCGCGCGC GTCTGCGCCC 
CCGCCCGCGC CCTCGGAGCC CCCGGCCGCG CCCCGCGCCC GCCCGCGCCT CGTCTTCCGC 
ACGCAGCTGG CGCACGGGAG CCCCACGGGC AAGATCGAGG GCTTCACCAA CGTCCGCGAG 
CTGTACGCCA AGATCGCCGA AGCCTTCGGG ATCGCGCCCA CCGAGATTTT ATTCTGCACC 
CTCAACAGCC ACAAAGTGGA CATGCAGAAG CTCCTGGGGG GTCAGATAGG CCTGGAGGAC 
TTCATCTTTG CCCACGTGCG AGGCGAGACC AAGGAGGTGG AGGTCACTAA GACAGAGGAT 
GCTCTGGGGC TGACCATCAC GGACAACGGG GCTGGCTACG CCTTCATCAA GAGAATCAAG 
GAAGGCAGTA TCATCAACCG GATCGAGGCA GTGTGCGTGG GTGACAGCAT CGAAGCCATC 
AACGACCACT CCATTGTGGG CTGCCGCCAC TACGAGGTGG CCAAGATGCT CCGGGAGCTG 
CCCAAGTCCC AGCCCTTCAC CCTGCGCCTG GTGCAGCCCA AGAGGGCCTT CGATATGATT 
GGCCAGAGAA GTCGGTCCAG CAAATGTCCA GTAGAGGCGA AAGTGACCAG CGGGAGGGAG 
ACCCTGCGGC TTCGTTCTGG GGGGGCTGCC ACAGTGGAGG AAGCGCCCAG TGAGTTTGAG 
GAGGAGGCAT CTCGGAAGGT TGATGACCTG CTGGAAAGCT ACATGGGCAT TCGGGACCCC 
GAGCTGGCGT CCACCATGGT GGAGACGTCC AAGAAGACAG CGAGCGCCCA GGAGTTTGCA 
CGCTGTTTAG ACTCCGTCTT GGGCGAGTTC GCCTTCCCCG ACGAGTTTGT GGTGGAAGTG 
TGGGCCGCCA TCGGCGAGGC CAGAGAGGCC TGTGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573568.1
CDS	121..1059
Translation	MEGAAAREARGTETPRASAPPPAPSEPPAAPRARPRLVFRTQLAHGSPTGKIEGFTNVRELYAKIAEAFGIAPTEILFCTLNSHKVDMQKLLGGQIGLEDFIFAHVRGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAKMLRELPKSQPFTLRLVQPKRAFDMIGQRSRSSKCPVEAKVTSGRETLRLRSGGAATVEEAPSEFEEEASRKVDDLLESYMGIRDPELASTMVETSKKTASAQEFARCLDSVLGEFAFPDEFVVEVWAAIGEAREACG

Target ORF information:

RefSeq Version	NM_133261.3
Organism	Homo sapiens(human)
Definition	Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133261.3

ORF Insert Sequence:

ATGGAGGGAG CAGCGGCCCG GGAGGCCCGG GGGACCGAGA CCCCGCGCGC GTCTGCGCCC 
CCGCCCGCGC CCTCGGAGCC CCCGGCCGCG CCCCGCGCCC GCCCGCGCCT CGTCTTCCGC 
ACGCAGCTGG CGCACGGGAG CCCCACGGGC AAGATCGAGG GCTTCACCAA CGTCCGCGAG 
CTGTACGCCA AGATCGCCGA AGCCTTCGGG ATCGCGCCCA CCGAGATTTT ATTCTGCACC 
CTCAACAGCC ACAAAGTGGA CATGCAGAAG CTCCTGGGGG GTCAGATAGG CCTGGAGGAC 
TTCATCTTTG CCCACGTGCG AGGCGAGACC AAGGAGGTGG AGGTCACTAA GACAGAGGAT 
GCTCTGGGGC TGACCATCAC GGACAACGGG GCTGGCTACG CCTTCATCAA GAGAATCAAG 
GAAGGCAGTA TCATCAACCG GATCGAGGCA GTGTGCGTGG GTGACAGCAT CGAAGCCATC 
AACGACCACT CCATTGTGGG CTGCCGCCAC TACGAGGTGG CCAAGATGCT CCGGGAGCTG 
CCCAAGTCCC AGCCCTTCAC CCTGCGCCTG GTGCAGCCCA AGAGGGCCTT CGATATGATT 
GGCCAGAGAA GTCGGTCCAG CAAATGTCCA GTAGAGGCGA AAGTGACCAG CGGGAGGGAG 
ACCCTGCGGC TTCGTTCTGG GGGGGCTGCC ACAGTGGAGG AAGCGCCCAG TGAGTTTGAG 
GAGGAGGCAT CTCGGAAGGT TGATGACCTG CTGGAAAGCT ACATGGGCAT TCGGGACCCC 
GAGCTGGCGT CCACCATGGT GGAGACGTCC AAGAAGACAG CGAGCGCCCA GGAGTTTGCA 
CGCTGTTTAG ACTCCGTCTT GGGCGAGTTC GCCTTCCCCG ACGAGTTTGT GGTGGAAGTG 
TGGGCCGCCA TCGGCGAGGC CAGAGAGGCC TGTGGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GIPC3 ( XM_005259492.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259549.1 Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu51428
Clone ID Related Accession (Same CDS sequence)	XM_005259492.3
Accession Version	XM_005259492.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	PDZ domain-containing protein GIPC3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259492.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGGAG CAGCGGCCCG GGAGGCCCGG GGGACCGAGA CCCCGCGCGC GTCTGCGCCC 
CCGCCCGCGC CCTCGGAGCC CCCGGCCGCG CCCCGCGCCC GCCCGCGCCT CGTCTTCCGC 
ACGCAGCTGG CGCACGGGAG CCCCACGGGC AAGATCGAGG GCTTCACCAA CGTCCGCGAG 
CTGTACGCCA AGATCGCCGA AGCCTTCGGG ATCGCGCCCA CCGAGATTTT ATTCTGCACC 
CTCAACAGCC ACAAAGTGGA CATGCAGAAG CTCCTGGGGG GTCAGATAGG CCTGGAGGAC 
TTCATCTTTG CCCACGTGCG AGGCGAGACC AAGGAGGTGG AGGTCACTAA GACAGAGGAT 
GCTCTGGGGC TGACCATCAC GGACAACGGG GCTGGCTACG CCTTCATCAA GAGAATCAAG 
GAAGGCAGTA TCATCAACCG GATCGAGGCA GTGTGCGTGG GTGACAGCAT CGAAGCCATC 
AACGACCACT CCATTGTGGG CTGCCGCCAC TACGAGGTGG CCAAGATGCT CCGGGAGCTG 
CCCAAGTCCC AGCCCTTCAC CCTGCGCCTG GTGCAGCCCA AGAGGGCCTT CGATATGATT 
GGCCAGAGAA GTCGGTCCAG CAAATGTCCA GTAGAGGCGA AAGTGACCAG CGGGAGGGAG 
ACCCTGCGGC TTCGTTCTGG GGGGGCTGCC ACAGTGGAGG AAGCGCCCAG TGAGTTTGAG 
GAGGAGGCAT CTCGGAAGGT TGATGACCTG CTGGAAAGCT ACATGGGCAT TCGGGACCCC 
GAGCTGGGTA AGGGGCCAGG CGTCCACCAT GGTGGAGACG TCCAAGAAGA CAGCGAGCGC 
CCAGGAGTTT GCACGCTGTT TAGACTCCGT CTTGGGCGAG TTCGCCTTCC CCGACGAGTT 
TGTGGTGGAA GTGTGGGCCG CCATCGGCGA GGCCAGAGAG GCCTGTGGCT AGTTTGCCCT 
GGGGGGGCCC AGCACAGCCC CAGCCCGGAG CCCAGCCCCC TGCCCCGGCC CTGCTCCAGA 
ACCCAGCCCA GATCGGAGGA CAAGTTCCTC TCTAGAACCC AATCCAATTT GGAGCCCCAG 
CCCAACTCCA GAACCCAACC CTTCTCTAGA ATCCAGCCCA GATCTGAGGC CAAGCTATGT 
GCTAGAGCCC AGGCCAGCTC TGAGACCAAG CCCAGCATTG AGAATAAGCT CTGTTCTAAA 
ACTCAGGCCA GCCCTGAGAC CAAGCCCAGC TCTAGAACTC AGATGAGCTT TGAGACCATG 
CCCAGCACTG AGACCAAGCC CTGTTCTAGA ACTCAGGCCT GCTCTGAGGC CAAGCCCAGC 
TCTAGAACCC AGATGAGCTC TGAGACCATG CCCAGCTCTA GAACTCAGAT GGGCTCTGAG 
ACCATGCCCA GCTCTAGAAC TCAGATGGGC TCTGAGACCG AGCCCAGCTC TAGAACTCAG 
ATGGGCTCTG AGACCGAGCC CAGCTCTAAA ACTCAGATGG GCTCTGAGAC CATGCCCAGC 
TCTAGAACTC AGATGGGCTC TGAGACCGAG CCCAGCTCTA GAACTCAGAT GGGCTCTGAG 
ACCGAGCCCA GCTCTAGAAC TCAGATGGGC TCTGAGACCA TGCCCAGCTC TAGAACTCAG 
ATGGGCTCCG AGACCAAGCC CAGCTCTAGA ACCCAGATGA GCTCTGAGAC CATGCCCAGC 
TCTAGAACTC AGATGAGCTC TGAGACAGAG CCCAGTATTG AGACCAAGCC CTGTTCTAGA 
GTCCAGGCCA GCTCCGAGAC CAAGCCCAGC TCTAGAACCC AGATAAGCTC TGAAACCAAG 
CCCAGCATAG AGACCAAGCC GTGTTCTAGA ATTCAGGCCA CATCTGAAGC CAAGCCCAGC 
TCTAGAACTC AGGTCAGCCC TGAGACCAAG CCCAGCTCTA GAACCCAGAT AAGCTCTGAA 
ACCAATCCCA GCATTGAGAC CAAGCCCTGT TCTAGAACTC AGGCCACCTC TGAGGCCAAA 
CCCAGCTCTA GAACCCAGAT AAGATCTGAG ACCAAGCCCT GCTCTGAAGC CCAGGCCAGC 
TCTGAGACGA AGCACATCTC TAGAATCCAG CTGAGCCCTG ACAACAAGCC AAACTCTGGA 
ACCCAGACAC ATTTTAAGAC CCAGACCAGC TTGGAGACCA ATCCCAGTTC CAGAATCCAG 
GCTAGCTCGG AGACCAAGCC CTGCTGGAAA ACTCAAGCTG ACTCTGGAAC TCTGGACAGC 
TCCACGATGC AGCCACACCT GGACACTCGG TCTAGCTCCG GAACCCCAGT TAATTTTGGA 
ACCCATGTGA GATTCATGAA GCAGCCCAGC TCTGGAACCC CAGTCAGCTC AGGATTCAGA 
GACAGCTCCC AAATCAAATC CTATTCAAGA ACTCAGACCA GCTCAGAAAC CCAGGTCCAC 
ACGGCTGCCC AGTCCAGATC CCAACCCCAG TTGCATCCAA GTGCCCATCC CCATCCTGCA 
GCCCAGTCCA GCTCCAGTGA TGATTCCAGC TCTGAGACTG AGCCCAGCTC TAGAACCTCG 
CCTAGTGCTA CAACCAGGCC CAACTCCAGG ATTCAGACCA GCTCTGGAAC CCCATCCATC 
TTGGAAGCAA GACCCAGCTC CAGCACACAG CTTGGTGCCA AGCCCCACTC TCCTTGCACA 
ATGCAGCTCA GCTCTAGAAT GCAGTTTACT TCCAGGACCC AGACCAATTT CAAGGCCTGG 
CCAAGCTCCA GAGCTCAATC CAGCCCAAGC ACCGCACCCA GCTCTGGAAC TCAGCTCAGT 
TCTGGAGCAC AGGCTGGTTC TGAAATCCCA GCCAGCTCCA AAACACAGAC AGCAGCTGAG 
ACCCAGCCAA GTTCCAGAAT CCAGCTAAGC TCTGGAGTCC AATCTAGTCC TGGGACCCAG 
GCCATCGCAG CAATAGAATT AAGCTCCACA GCCCTGTCTA GTTCCGACAG CAGGTCCAGC 
TCCAGGACCC AGCGCTGCCC AGGAGCTCGA CCAGCCTCTG GGACTCAATT CGCCTCTAAA 
ACCCTGCCAG GTTCTAGATA CCAGCTCCAG ACCACAGCCC CAGACAGCTC TGGTATTCAA 
CTGGACTTTG GGAAGCAGAG CAGTTCTGAA AGTCAGCTTA GCTTTGGAAC TCAGCCCAGC 
TCTGGGACCC AGATAAGCTC AAGAATTCAA GCCAGCTCTG GAAGTCAGCT TAGTTCGGGA 
ACCCAGCTGA TTTCCGGAGC CCAACCCAGC TCCAGAACTC AGACTAGTTC TGGAAACCAG 
CTCAGCTCCG GGACCCAGAC CACTGCAAGA ATTCAGCTCA GCCCTGGAGC TCATCTTAGC 
TCCAGAACCC AGTCCAGTCC TGAGACCAGG CTCAGCTCTG AGGCTCAGTC CAGCTCTGGA 
ACCCAGTTCA GTTCTGGGAT TCAGTTTGGC TCTGAAACCC AGACCGGCTC AAGAATTCAG 
CCCGACTCTG GAGCCCAACT TAGTTCCAGA ACCCAGTCCA GCTCTGAGAC CGGGCTCAGC 
TCTGAAACCC AGACCGGCTC AAGAATTCAG CCCAGCCCTG GAGCCCACCT TAGTTCTGGA 
ACCCAGCCTG TTTCTGGAAC CCAATCCAGT TCCAGAACTC ACACCAGTTC AAGAATCTGG 
CTGAGCCCTG GAAATGGAAT CTGCCCACAG ACCCCTGGCC TTGACCCTAG AATCCAGCTT 
GAGGCCCCTG CCCCAGCCCA ACCTCAGCCC CCAGGCCCAT CCCCCAGAGA CCCCACCCCA 
GCCCCTAGCA AAGACCCCCA GCCTCTGCCT CAGCCCCATG ATCAGGTATG TGGCATCCAG 
GCCAGCCTTG GCCCCATCCC AGGCTTACCC CAAGCCTCCT ACCTGGCCCC ACAGTCACAG 
GTCTCCTCAA CCCCCCAGAA GCCAGCCGTC TCTCCCAAGC CCCGGGTGGG ACCCCAGAAG 
TCCACCCCAC CCACCATATC TGTCACTCCT AGTCCTGCCC CTAGGGCAGC CCTCCTGAGT 
TCCCAGCTGT CTGAGTCCCC AGCTTTGGCG CCAGCCCTTT GCCCCACTCT GGGGGAGCCA 
GGAGCCCGCC CTTACCGCGG GGGGCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259549.1
CDS	68..4117
Translation	MEGAAAREARGTETPRASAPPPAPSEPPAAPRARPRLVFRTQLAHGSPTGKIEGFTNVRELYAKIAEAFGIAPTEILFCTLNSHKVDMQKLLGGQIGLEDFIFAHVRGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAKMLRELPKSQPFTLRLVQPKRAFDMIGQRSRSSKCPVEAKVTSGRETLRLRSGGAATVEEAPSEFEEEASRKVDDLLESYMGIRDPELGKGPGVHHGGDVQEDSERPGVCTLFRLRLGRVRLPRRVCGGSVGRHRRGQRGLWLVCPGGAQHSPSPEPSPLPRPCSRTQPRSEDKFLSRTQSNLEPQPNSRTQPFSRIQPRSEAKLCARAQASSETKPSIENKLCSKTQASPETKPSSRTQMSFETMPSTETKPCSRTQACSEAKPSSRTQMSSETMPSSRTQMGSETMPSSRTQMGSETEPSSRTQMGSETEPSSKTQMGSETMPSSRTQMGSETEPSSRTQMGSETEPSSRTQMGSETMPSSRTQMGSETKPSSRTQMSSETMPSSRTQMSSETEPSIETKPCSRVQASSETKPSSRTQISSETKPSIETKPCSRIQATSEAKPSSRTQVSPETKPSSRTQISSETNPSIETKPCSRTQATSEAKPSSRTQIRSETKPCSEAQASSETKHISRIQLSPDNKPNSGTQTHFKTQTSLETNPSSRIQASSETKPCWKTQADSGTLDSSTMQPHLDTRSSSGTPVNFGTHVRFMKQPSSGTPVSSGFRDSSQIKSYSRTQTSSETQVHTAAQSRSQPQLHPSAHPHPAAQSSSSDDSSSETEPSSRTSPSATTRPNSRIQTSSGTPSILEARPSSSTQLGAKPHSPCTMQLSSRMQFTSRTQTNFKAWPSSRAQSSPSTAPSSGTQLSSGAQAGSEIPASSKTQTAAETQPSSRIQLSSGVQSSPGTQAIAAIELSSTALSSSDSRSSSRTQRCPGARPASGTQFASKTLPGSRYQLQTTAPDSSGIQLDFGKQSSSESQLSFGTQPSSGTQISSRIQASSGSQLSSGTQLISGAQPSSRTQTSSGNQLSSGTQTTARIQLSPGAHLSSRTQSSPETRLSSEAQSSSGTQFSSGIQFGSETQTGSRIQPDSGAQLSSRTQSSSETGLSSETQTGSRIQPSPGAHLSSGTQPVSGTQSSSRTHTSSRIWLSPGNGICPQTPGLDPRIQLEAPAPAQPQPPGPSPRDPTPAPSKDPQPLPQPHDQVCGIQASLGPIPGLPQASYLAPQSQVSSTPQKPAVSPKPRVGPQKSTPPTISVTPSPAPRAALLSSQLSESPALAPALCPTLGEPGARPYRGGP

Target ORF information:

RefSeq Version	XM_005259492.3
Organism	Homo sapiens(human)
Definition	Homo sapiens GIPC PDZ domain containing family member 3 (GIPC3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259492.3

ORF Insert Sequence:

ATGGAGGGAG CAGCGGCCCG GGAGGCCCGG GGGACCGAGA CCCCGCGCGC GTCTGCGCCC 
CCGCCCGCGC CCTCGGAGCC CCCGGCCGCG CCCCGCGCCC GCCCGCGCCT CGTCTTCCGC 
ACGCAGCTGG CGCACGGGAG CCCCACGGGC AAGATCGAGG GCTTCACCAA CGTCCGCGAG 
CTGTACGCCA AGATCGCCGA AGCCTTCGGG ATCGCGCCCA CCGAGATTTT ATTCTGCACC 
CTCAACAGCC ACAAAGTGGA CATGCAGAAG CTCCTGGGGG GTCAGATAGG CCTGGAGGAC 
TTCATCTTTG CCCACGTGCG AGGCGAGACC AAGGAGGTGG AGGTCACTAA GACAGAGGAT 
GCTCTGGGGC TGACCATCAC GGACAACGGG GCTGGCTACG CCTTCATCAA GAGAATCAAG 
GAAGGCAGTA TCATCAACCG GATCGAGGCA GTGTGCGTGG GTGACAGCAT CGAAGCCATC 
AACGACCACT CCATTGTGGG CTGCCGCCAC TACGAGGTGG CCAAGATGCT CCGGGAGCTG 
CCCAAGTCCC AGCCCTTCAC CCTGCGCCTG GTGCAGCCCA AGAGGGCCTT CGATATGATT 
GGCCAGAGAA GTCGGTCCAG CAAATGTCCA GTAGAGGCGA AAGTGACCAG CGGGAGGGAG 
ACCCTGCGGC TTCGTTCTGG GGGGGCTGCC ACAGTGGAGG AAGCGCCCAG TGAGTTTGAG 
GAGGAGGCAT CTCGGAAGGT TGATGACCTG CTGGAAAGCT ACATGGGCAT TCGGGACCCC 
GAGCTGGGTA AGGGGCCAGG CGTCCACCAT GGTGGAGACG TCCAAGAAGA CAGCGAGCGC 
CCAGGAGTTT GCACGCTGTT TAGACTCCGT CTTGGGCGAG TTCGCCTTCC CCGACGAGTT 
TGTGGTGGAA GTGTGGGCCG CCATCGGCGA GGCCAGAGAG GCCTGTGGCT AGTTTGCCCT 
GGGGGGGCCC AGCACAGCCC CAGCCCGGAG CCCAGCCCCC TGCCCCGGCC CTGCTCCAGA 
ACCCAGCCCA GATCGGAGGA CAAGTTCCTC TCTAGAACCC AATCCAATTT GGAGCCCCAG 
CCCAACTCCA GAACCCAACC CTTCTCTAGA ATCCAGCCCA GATCTGAGGC CAAGCTATGT 
GCTAGAGCCC AGGCCAGCTC TGAGACCAAG CCCAGCATTG AGAATAAGCT CTGTTCTAAA 
ACTCAGGCCA GCCCTGAGAC CAAGCCCAGC TCTAGAACTC AGATGAGCTT TGAGACCATG 
CCCAGCACTG AGACCAAGCC CTGTTCTAGA ACTCAGGCCT GCTCTGAGGC CAAGCCCAGC 
TCTAGAACCC AGATGAGCTC TGAGACCATG CCCAGCTCTA GAACTCAGAT GGGCTCTGAG 
ACCATGCCCA GCTCTAGAAC TCAGATGGGC TCTGAGACCG AGCCCAGCTC TAGAACTCAG 
ATGGGCTCTG AGACCGAGCC CAGCTCTAAA ACTCAGATGG GCTCTGAGAC CATGCCCAGC 
TCTAGAACTC AGATGGGCTC TGAGACCGAG CCCAGCTCTA GAACTCAGAT GGGCTCTGAG 
ACCGAGCCCA GCTCTAGAAC TCAGATGGGC TCTGAGACCA TGCCCAGCTC TAGAACTCAG 
ATGGGCTCCG AGACCAAGCC CAGCTCTAGA ACCCAGATGA GCTCTGAGAC CATGCCCAGC 
TCTAGAACTC AGATGAGCTC TGAGACAGAG CCCAGTATTG AGACCAAGCC CTGTTCTAGA 
GTCCAGGCCA GCTCCGAGAC CAAGCCCAGC TCTAGAACCC AGATAAGCTC TGAAACCAAG 
CCCAGCATAG AGACCAAGCC GTGTTCTAGA ATTCAGGCCA CATCTGAAGC CAAGCCCAGC 
TCTAGAACTC AGGTCAGCCC TGAGACCAAG CCCAGCTCTA GAACCCAGAT AAGCTCTGAA 
ACCAATCCCA GCATTGAGAC CAAGCCCTGT TCTAGAACTC AGGCCACCTC TGAGGCCAAA 
CCCAGCTCTA GAACCCAGAT AAGATCTGAG ACCAAGCCCT GCTCTGAAGC CCAGGCCAGC 
TCTGAGACGA AGCACATCTC TAGAATCCAG CTGAGCCCTG ACAACAAGCC AAACTCTGGA 
ACCCAGACAC ATTTTAAGAC CCAGACCAGC TTGGAGACCA ATCCCAGTTC CAGAATCCAG 
GCTAGCTCGG AGACCAAGCC CTGCTGGAAA ACTCAAGCTG ACTCTGGAAC TCTGGACAGC 
TCCACGATGC AGCCACACCT GGACACTCGG TCTAGCTCCG GAACCCCAGT TAATTTTGGA 
ACCCATGTGA GATTCATGAA GCAGCCCAGC TCTGGAACCC CAGTCAGCTC AGGATTCAGA 
GACAGCTCCC AAATCAAATC CTATTCAAGA ACTCAGACCA GCTCAGAAAC CCAGGTCCAC 
ACGGCTGCCC AGTCCAGATC CCAACCCCAG TTGCATCCAA GTGCCCATCC CCATCCTGCA 
GCCCAGTCCA GCTCCAGTGA TGATTCCAGC TCTGAGACTG AGCCCAGCTC TAGAACCTCG 
CCTAGTGCTA CAACCAGGCC CAACTCCAGG ATTCAGACCA GCTCTGGAAC CCCATCCATC 
TTGGAAGCAA GACCCAGCTC CAGCACACAG CTTGGTGCCA AGCCCCACTC TCCTTGCACA 
ATGCAGCTCA GCTCTAGAAT GCAGTTTACT TCCAGGACCC AGACCAATTT CAAGGCCTGG 
CCAAGCTCCA GAGCTCAATC CAGCCCAAGC ACCGCACCCA GCTCTGGAAC TCAGCTCAGT 
TCTGGAGCAC AGGCTGGTTC TGAAATCCCA GCCAGCTCCA AAACACAGAC AGCAGCTGAG 
ACCCAGCCAA GTTCCAGAAT CCAGCTAAGC TCTGGAGTCC AATCTAGTCC TGGGACCCAG 
GCCATCGCAG CAATAGAATT AAGCTCCACA GCCCTGTCTA GTTCCGACAG CAGGTCCAGC 
TCCAGGACCC AGCGCTGCCC AGGAGCTCGA CCAGCCTCTG GGACTCAATT CGCCTCTAAA 
ACCCTGCCAG GTTCTAGATA CCAGCTCCAG ACCACAGCCC CAGACAGCTC TGGTATTCAA 
CTGGACTTTG GGAAGCAGAG CAGTTCTGAA AGTCAGCTTA GCTTTGGAAC TCAGCCCAGC 
TCTGGGACCC AGATAAGCTC AAGAATTCAA GCCAGCTCTG GAAGTCAGCT TAGTTCGGGA 
ACCCAGCTGA TTTCCGGAGC CCAACCCAGC TCCAGAACTC AGACTAGTTC TGGAAACCAG 
CTCAGCTCCG GGACCCAGAC CACTGCAAGA ATTCAGCTCA GCCCTGGAGC TCATCTTAGC 
TCCAGAACCC AGTCCAGTCC TGAGACCAGG CTCAGCTCTG AGGCTCAGTC CAGCTCTGGA 
ACCCAGTTCA GTTCTGGGAT TCAGTTTGGC TCTGAAACCC AGACCGGCTC AAGAATTCAG 
CCCGACTCTG GAGCCCAACT TAGTTCCAGA ACCCAGTCCA GCTCTGAGAC CGGGCTCAGC 
TCTGAAACCC AGACCGGCTC AAGAATTCAG CCCAGCCCTG GAGCCCACCT TAGTTCTGGA 
ACCCAGCCTG TTTCTGGAAC CCAATCCAGT TCCAGAACTC ACACCAGTTC AAGAATCTGG 
CTGAGCCCTG GAAATGGAAT CTGCCCACAG ACCCCTGGCC TTGACCCTAG AATCCAGCTT 
GAGGCCCCTG CCCCAGCCCA ACCTCAGCCC CCAGGCCCAT CCCCCAGAGA CCCCACCCCA 
GCCCCTAGCA AAGACCCCCA GCCTCTGCCT CAGCCCCATG ATCAGGTATG TGGCATCCAG 
GCCAGCCTTG GCCCCATCCC AGGCTTACCC CAAGCCTCCT ACCTGGCCCC ACAGTCACAG 
GTCTCCTCAA CCCCCCAGAA GCCAGCCGTC TCTCCCAAGC CCCGGGTGGG ACCCCAGAAG 
TCCACCCCAC CCACCATATC TGTCACTCCT AGTCCTGCCC CTAGGGCAGC CCTCCTGAGT 
TCCCAGCTGT CTGAGTCCCC AGCTTTGGCG CCAGCCCTTT GCCCCACTCT GGGGGAGCCA 
GGAGCCCGCC CTTACCGCGG GGGGCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A canonical splice site mutation in GIPC3 causes sensorineural hearing loss in a large Pakistani family.
Journal of human genetics59(12)683-6(2014 Dec)
Siddiqi S,Ismail M,Oostrik J,Munawar S,Mansoor A,Kremer H,Qamar R,Schraders M

Homozygosity mapping identifies a novel GIPC3 mutation causing congenital nonsyndromic hearing loss in a Saudi family.
Gene521(1)195-9(2013 May)
Ramzan K,Al-Owain M,Allam R,Berhan A,Abuharb G,Taibah K,Imtiaz F

Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p.
Human genetics130(6)759-65(2011 Dec)
Rehman AU,Gul K,Morell RJ,Lee K,Ahmed ZM,Riazuddin S,Ali RA,Shahzad M,Jaleel AU,Andrade PB,Khan SN,Khan S,Brewer CC,Ahmad W,Leal SM,Riazuddin S,Friedman TB

Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human.
Nature communications2201(2011 Feb)
Charizopoulou N,Lelli A,Schraders M,Ray K,Hildebrand MS,Ramesh A,Srisailapathy CR,Oostrik J,Admiraal RJ,Neely HR,Latoche JR,Smith RJ,Northup JK,Kremer H,Holt JR,Noben-Trauth K

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GIPC3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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