MICOS13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MICOS13
Entrez Gene ID	125988
Full Name	chromosome 19 open reading frame 70
Synonyms	MIC13,P117,QIL1
General protein information	Preferred Names chromosome 19 open reading frame 70 Names MICOS complex subunit MIC13 protein QIL1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Disorder MIM:	616658

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308240.1	NP_001295169.1	MICOS complex subunit MIC13 isoform 1
NM_001365761.1	NP_001352690.1	MICOS complex subunit MIC13 isoform 1
XM_011527675.2	XP_011525977.1	MICOS complex subunit MIC13 isoform X2
XM_017026248.1	XP_016881737.1	MICOS complex subunit MIC13 isoform X1
NM_205767.2	NP_991330.1	MICOS complex subunit MIC13 isoform 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	C19orf70	NP_991330.1
Xenopus tropicalis (tropical clawed frog)	LOC100489521	XP_002936370.1
Canis lupus familiaris (dog)	C20H19orf70	XP_533944.2
Mus musculus (house mouse)	2410015M20Rik	NP_694792.1
Gallus gallus (chicken)	LOC100858091	XP_003642891.2
Danio rerio (zebrafish)	si:dkey-78l4.14	NP_001038338.1
Pan troglodytes (chimpanzee)	C19H19orf70	XP_512299.1
	LOC702052	XP_001094526.1
Bos taurus (cattle)	C7H19orf70	XP_002688935.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.
Zeharia A, Friedman JR, Tobar A, Saada A, Konen O, Fellig Y, Shaag A, Nunnari J, Elpeleg O
European journal of human genetics : EJHG24(12)1778-1782(2016 12)

QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease.
Guarani V, Jardel C, Chr?tien D, Lomb?s A, B?nit P, Labasse C, Lac?ne E, Bourillon A, Imbard A, Benoist JF, Dorboz I, Gilleron M, Goetzman ES, Gaignard P, Slama A, Elmaleh-Berg?s M, Romero NB, Rustin P, Ogier de Baulny H, Paulo JA, Harper JW, Schiff M
eLife5(2016 09)

Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.
Anand R, Strecker V, Urbach J, Wittig I, Reichert AS
PloS one11(8)e0160258(2016)

Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex.
Huynen MA, M?hlmeister M, Gotthardt K, Guerrero-Castillo S, Brandt U
Biochimica et biophysica acta1863(1)91-101(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mitochondrial hepato-encephalopathy patients were found to be homozygous for the p.(Gly15Glufs*75) variant in the QIL1 . QIL1 deficiency is associated with disassembly of the MICOS complex, aberration of cristae morphology and mitochondrial respiratory dysfunction.
Title: Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.

Taken together, these data provide the first evidence of altered mitochondrial contact site assembly linked with a human mitochondrial disease and confirm a central role for QIL1 in stable mitochondrial contact site complex formation.
Title: QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease.

MIC13 has a fundamental role in crista junction formation and that assembly of respiratory chain supercomplexes is independent of mitochondrial cristae shape.
Title: Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.

we identified QIL1 (C19orf70) as a novel conserved MICOS subunit.
Title: QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.

The following MICOS13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MICOS13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02997	NM_205767.2 Latest version!	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu75368	NM_001308240.1 Latest version!	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu75368	NM_001365761.1 Latest version!	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu75368	XM_017026248.1 Latest version!	Homo sapiens chromosome 19 open reading frame 70 (C19orf70), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu75369	XM_011527675.2 Latest version!	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MICOS13 ( NM_205767.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_991330.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02997
Clone ID Related Accession (Same CDS sequence)	NM_205767.2
Accession Version	NM_205767.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC13 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI827162.1, CR748109.1, BC009557.1 and AI004554.1. On Apr 28, 2015 this sequence version replaced NM_205767.1. Transcript Variant: This variant (2) lacks an alternate 5' exon, which results in a difference in the 5' UTR and use of an alternate start codon compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI827162.1, ERR279870.620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCCC GGGTGTGGTC GCTGATGAGG TTCCTCATCA AGGGAAGTGT GGCTGGGGGC 
GCCGTCTACC TGGTGTACGA CCAGGAGCTG CTGGGGCCCA GCGACAAGAG CCAGGCAGCC 
CTACAGAAGG CTGGGGAGGT GGTCCCCCCC GCCATGTACC AGTTCAGCCA GTACGTGTGT 
CAGCAGACAG GCCTGCAGAT ACCCCAGCTC CCAGCCCCTC CAAAGATTTA CTTTCCCATC 
CGTGACTCCT GGAATGCAGG CATCATGACG GTGATGTCAG CTCTGTCGGT GGCCCCCTCC 
AAGGCCCGCG AGTACTCCAA GGAGGGCTGG GAGTATGTGA AGGCGCGCAC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_991330.1
CDS	411..767
Translation	MVARVWSLMRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK

Target ORF information:

RefSeq Version	NM_205767.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205767.2

ORF Insert Sequence:

ATGGTGGCCC GGGTGTGGTC GCTGATGAGG TTCCTCATCA AGGGAAGTGT GGCTGGGGGC 
GCCGTCTACC TGGTGTACGA CCAGGAGCTG CTGGGGCCCA GCGACAAGAG CCAGGCAGCC 
CTACAGAAGG CTGGGGAGGT GGTCCCCCCC GCCATGTACC AGTTCAGCCA GTACGTGTGT 
CAGCAGACAG GCCTGCAGAT ACCCCAGCTC CCAGCCCCTC CAAAGATTTA CTTTCCCATC 
CGTGACTCCT GGAATGCAGG CATCATGACG GTGATGTCAG CTCTGTCGGT GGCCCCCTCC 
AAGGCCCGCG AGTACTCCAA GGAGGGCTGG GAGTATGTGA AGGCGCGCAC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS13 ( NM_001308240.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001295169.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu75368
Clone ID Related Accession (Same CDS sequence)	NM_001308240.1 , NM_001365761.1 , XM_017026248.1
Accession Version	NM_001308240.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC13 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI827162.1, CR748109.1, AA292888.1, AC011499.5, AJ707830.1, AI300708.1 and AI004554.1. On Apr 28, 2015 this sequence version replaced XM_011527674.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AA292888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGCATC ATGACGGTGA TGTCAGCTCT GTCGGTGGCC 
CCCTCCAAGG CCCGCGAGTA CTCCAAGGAG GGCTGGGAGT ATGTGAAGGC GCGCACCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295169.1
CDS	541..963
Translation	MRSECVLGAASDSGQEAPRDTWFLQGWKASRRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK

Target ORF information:

RefSeq Version	NM_001308240.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308240.1

ORF Insert Sequence:

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGCATC ATGACGGTGA TGTCAGCTCT GTCGGTGGCC 
CCCTCCAAGG CCCGCGAGTA CTCCAAGGAG GGCTGGGAGT ATGTGAAGGC GCGCACCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS13 ( NM_001365761.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001352690.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu75368
Clone ID Related Accession (Same CDS sequence)	NM_001308240.1 , NM_001365761.1 , XM_017026248.1
Accession Version	NM_001365761.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC13 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011499.5. On Sep 12, 2018 this sequence version replaced XM_017026248.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.179154.1, SRR7410571.175630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGCATC ATGACGGTGA TGTCAGCTCT GTCGGTGGCC 
CCCTCCAAGG CCCGCGAGTA CTCCAAGGAG GGCTGGGAGT ATGTGAAGGC GCGCACCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001352690.1
CDS	90..512
Translation	MRSECVLGAASDSGQEAPRDTWFLQGWKASRRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK

Target ORF information:

RefSeq Version	NM_001365761.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001365761.1

ORF Insert Sequence:

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGCATC ATGACGGTGA TGTCAGCTCT GTCGGTGGCC 
CCCTCCAAGG CCCGCGAGTA CTCCAAGGAG GGCTGGGAGT ATGTGAAGGC GCGCACCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS13 ( XM_017026248.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881737.1 Homo sapiens chromosome 19 open reading frame 70 (C19orf70), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu75368
Clone ID Related Accession (Same CDS sequence)	NM_001308240.1 , NM_001365761.1 , XM_017026248.1
Accession Version	XM_017026248.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC13 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGCATC ATGACGGTGA TGTCAGCTCT GTCGGTGGCC 
CCCTCCAAGG CCCGCGAGTA CTCCAAGGAG GGCTGGGAGT ATGTGAAGGC GCGCACCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881737.1
CDS	286..708
Translation	MRSECVLGAASDSGQEAPRDTWFLQGWKASRRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK

Target ORF information:

RefSeq Version	XM_017026248.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 19 open reading frame 70 (C19orf70), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026248.1

ORF Insert Sequence:

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGCATC ATGACGGTGA TGTCAGCTCT GTCGGTGGCC 
CCCTCCAAGG CCCGCGAGTA CTCCAAGGAG GGCTGGGAGT ATGTGAAGGC GCGCACCAAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MICOS13 ( XM_011527675.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525977.1 Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu75369
Clone ID Related Accession (Same CDS sequence)	XM_011527675.2
Accession Version	XM_011527675.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	MICOS complex subunit MIC13 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527675.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGGATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525977.1
CDS	294..626
Translation	MRSECVLGAASDSGQEAPRDTWFLQGWKASRRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGI

Target ORF information:

RefSeq Version	XM_011527675.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial contact site and cristae organizing system subunit 13 (MICOS13), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527675.2

ORF Insert Sequence:

ATGAGAAGTG AATGCGTGCT CGGAGCTGCG AGTGACAGCG GGCAGGAGGC GCCCAGGGAC 
ACTTGGTTTC TCCAGGGCTG GAAGGCTTCT AGAAGGTTCC TCATCAAGGG AAGTGTGGCT 
GGGGGCGCCG TCTACCTGGT GTACGACCAG GAGCTGCTGG GGCCCAGCGA CAAGAGCCAG 
GCAGCCCTAC AGAAGGCTGG GGAGGTGGTC CCCCCCGCCA TGTACCAGTT CAGCCAGTAC 
GTGTGTCAGC AGACAGGCCT GCAGATACCC CAGCTCCCAG CCCCTCCAAA GATTTACTTT 
CCCATCCGTG ACTCCTGGAA TGCAGGGATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.
European journal of human genetics : EJHG24(12)1778-1782(2016 12)
Zeharia A,Friedman JR,Tobar A,Saada A,Konen O,Fellig Y,Shaag A,Nunnari J,Elpeleg O

QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease.
eLife5(2016 09)
Guarani V,Jardel C,Chr?tien D,Lomb?s A,B?nit P,Labasse C,Lac?ne E,Bourillon A,Imbard A,Benoist JF,Dorboz I,Gilleron M,Goetzman ES,Gaignard P,Slama A,Elmaleh-Berg?s M,Romero NB,Rustin P,Ogier de Baulny H,Paulo JA,Harper JW,Schiff M

Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.
PloS one11(8)e0160258(2016)
Anand R,Strecker V,Urbach J,Wittig I,Reichert AS

Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex.
Biochimica et biophysica acta1863(1)91-101(2016 Jan)
Huynen MA,M?hlmeister M,Gotthardt K,Guerrero-Castillo S,Brandt U

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MICOS13 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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