NIPA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NIPA1
Entrez Gene ID	123606
Full Name	non imprinted in Prader-Willi/Angelman syndrome 1
Synonyms	FSP3,SLC57A1,SPG6
General protein information	Preferred Names non imprinted in Prader-Willi/Angelman syndrome 1 Names magnesium transporter NIPA1 non-imprinted in Prader-Willi/Angelman syndrome region protein 1 spastic paraplegia 6 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q11.2
Summary	This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008].
Disorder MIM:	608145
Disorder Html:	Spastic paraplegia 6, autosomal dominant, 600363 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_144599.4	NP_653200.2	magnesium transporter NIPA1 isoform 1
NM_001142275.1	NP_001135747.1	magnesium transporter NIPA1 isoform 2
NM_144599.5	NP_653200.2	magnesium transporter NIPA1 isoform 1

Pathways from BioSystems

Homologies

	LOC710236	XP_001106326.1
Danio rerio (zebrafish)	nipa1	NP_001006062.1
Homo sapiens (human)	NIPA1	NP_653200.2
Mus musculus (house mouse)	Nipa1	NP_705806.1
Rattus norvegicus (Norway rat)	Nipa1	NP_001100989.1
Gallus gallus (chicken)	NIPA1	XP_003640574.2
Xenopus tropicalis (tropical clawed frog)	nipa1	XP_002937031.1
Canis lupus familiaris (dog)	NIPA1	XP_545798.2
Bos taurus (cattle)	NIPA1	XP_002685238.3

Gene Ontology
Bibliography

Related articles in PubMed

Genetic background of the hereditary spastic paraplegia phenotypes in Hungary - An analysis of 58 probands.
Balicza P, Grosz Z, Gonzalez MA, Bencsik R, Pentelenyi K, Gal A, Varga E, Klivenyi P, Koller J, Z?chner S, Molnar JM
Journal of the neurological sciences364116-21(2016 May)

Large-scale screening in sporadic amyotrophic lateral sclerosis identifies genetic modifiers in C9orf72 repeat carriers.
Dekker AM, Seelen M, van Doormaal PT, van Rheenen W, Bothof RJ, van Riessen T, Brands WJ, van der Kooi AJ, de Visser M, Voermans NC, Pasterkamp RJ, Veldink JH, van den Berg LH, van Es MA
Neurobiology of aging39220.e9-15(2016 Mar)

Pure hereditary spastic paraplegia due to a de novo mutation in the NIPA1 gene.
Arkadir D, Noreau A, Goldman JS, Rouleau GA, Alcvalay RN
European journal of neurology21(1)e2(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study showed that the mutations of were detected in SPG11, ATL1, NIPA1, and ABCD1 in patient with hereditary spastic paraplegia.
Title: Genetic background of the hereditary spastic paraplegia phenotypes in Hungary - An analysis of 58 probands.

NIPA1 repeat expansion in the context of a C9orf72 repeat expansion would drive toward a motor neuron disease phenotype.
Title: Large-scale screening in sporadic amyotrophic lateral sclerosis identifies genetic modifiers in C9orf72 repeat carriers.

We report here a family with a pure form of Hereditary spastic paraplegia due to a de novo transition mutation in the NIPA1 gene.
Title: Pure hereditary spastic paraplegia due to a de novo mutation in the NIPA1 gene.

study reports direct evidence of de novo c.316G>A mutation in the same hotspot of the gene in two unrelated patients who had otherwise a prototypical NIPA1-associated phenotype with a severe form of uncomplicated spastic paraplegia
Title: Recurrent de novo c.316G>A mutation in NIPA1 hotspot.

NIPA1 polyalanine repeat expansions are a common risk factor for ALS and modulate disease course
Title: NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis.

The following NIPA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NIPA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07472	NM_001142275.1 Latest version!	Homo sapiens NIPA magnesium transporter 1 (NIPA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu18589	NM_144599.5 Latest version!	Homo sapiens NIPA magnesium transporter 1 (NIPA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu18589	NM_144599.4	Homo sapiens non imprinted in Prader-Willi/Angelman syndrome 1 (NIPA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NIPA1 ( NM_001142275.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135747.1 Homo sapiens NIPA magnesium transporter 1 (NIPA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07472
Clone ID Related Accession (Same CDS sequence)	NM_001142275.1
Accession Version	NM_001142275.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	magnesium transporter NIPA1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025678.1 and BK001020.1. Transcript Variant: This variant (2) uses an alternate 5' exon and downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025678.1, SRR1660805.153000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTTG GCCAGATTGG AAACTTCCTG GCTTACACGG CGGTCCCCAC GGTCCTGGTA 
ACCCCCCTGG GCGCCCTTGG AGTACCGTTC GGGTCCATTT TAGCTTCCTA TCTCCTGAAG 
GAAAAGCTCA ACATCTTGGG CAAGTTGGGG TGCCTGCTAA GCTGTGCAGG CTCCGTCGTG 
CTGATTATCC ACTCCCCAAA GTCTGAGAGT GTGACAACTC AGGCTGAGCT GGAGGAAAAG 
CTGACCAATC CAGTGTTTGT GGGCTACCTG TGCATCGTGC TGCTCATGCT GCTGCTGCTC 
ATCTTCTGGA TCGCGCCGGC CCATGGGCCC ACCAACATCA TGGTCTACAT CAGCATCTGC 
TCCTTGCTGG GCAGTTTCAC CGTGCCTTCC ACCAAGGGCA TCGGGCTGGC GGCCCAAGAC 
ATCTTGCATA ACAACCCGTC CAGTCAGAGA GCCCTCTGCC TGTGCCTGGT ACTCCTGGCC 
GTGCTCGGCT GCAGCATCAT CGTCCAGTTC AGGTACATCA ACAAGGCGCT GGAGTGCTTC 
GACTCCTCGG TGTTCGGGGC CATCTACTAC GTCGTGTTTA CCACGCTGGT CCTGCTGGCC 
TCAGCCATCC TCTTCCGGGA GTGGAGCAAC GTGGGCCTGG TGGACTTCTT GGGGATGGCC 
TGTGGATTCA CGACCGTCTC CGTGGGGATT GTCCTTATAC AGGTGTTCAA AGAGTTCAAT 
TTCAACCTTG GGGAGATGAA CAAATCTAAT ATGAAAACAG ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135747.1
CDS	72..836
Translation	MAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD

Target ORF information:

RefSeq Version	NM_001142275.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NIPA magnesium transporter 1 (NIPA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142275.1

ORF Insert Sequence:

ATGGCTGTTG GCCAGATTGG AAACTTCCTG GCTTACACGG CGGTCCCCAC GGTCCTGGTA 
ACCCCCCTGG GCGCCCTTGG AGTACCGTTC GGGTCCATTT TAGCTTCCTA TCTCCTGAAG 
GAAAAGCTCA ACATCTTGGG CAAGTTGGGG TGCCTGCTAA GCTGTGCAGG CTCCGTCGTG 
CTGATTATCC ACTCCCCAAA GTCTGAGAGT GTGACAACTC AGGCTGAGCT GGAGGAAAAG 
CTGACCAATC CAGTGTTTGT GGGCTACCTG TGCATCGTGC TGCTCATGCT GCTGCTGCTC 
ATCTTCTGGA TCGCGCCGGC CCATGGGCCC ACCAACATCA TGGTCTACAT CAGCATCTGC 
TCCTTGCTGG GCAGTTTCAC CGTGCCTTCC ACCAAGGGCA TCGGGCTGGC GGCCCAAGAC 
ATCTTGCATA ACAACCCGTC CAGTCAGAGA GCCCTCTGCC TGTGCCTGGT ACTCCTGGCC 
GTGCTCGGCT GCAGCATCAT CGTCCAGTTC AGGTACATCA ACAAGGCGCT GGAGTGCTTC 
GACTCCTCGG TGTTCGGGGC CATCTACTAC GTCGTGTTTA CCACGCTGGT CCTGCTGGCC 
TCAGCCATCC TCTTCCGGGA GTGGAGCAAC GTGGGCCTGG TGGACTTCTT GGGGATGGCC 
TGTGGATTCA CGACCGTCTC CGTGGGGATT GTCCTTATAC AGGTGTTCAA AGAGTTCAAT 
TTCAACCTTG GGGAGATGAA CAAATCTAAT ATGAAAACAG ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NIPA1 ( NM_144599.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_653200.2 Homo sapiens NIPA magnesium transporter 1 (NIPA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18589
Clone ID Related Accession (Same CDS sequence)	NM_144599.4 , NM_144599.5
Accession Version	NM_144599.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	magnesium transporter NIPA1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001020.1 and AK314073.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_144599.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK001020.1, SRR1660805.34307.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000337435.9/ ENSP00000337452.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGACTG CAGCTGCGGC AGCGGCGGCG GCGGCGGCGG CGGCGGCCGG GGAGGGGGCG 
CGTAGCCCGA GCCCCGCCGC CGTGTCGCTC GGCCTGGGCG TGGCCGTCGT GTCGAGCCTG 
GTGAACGGGT CCACGTTCGT GCTACAGAAG AAGGGCATCG TGCGTGCCAA GCGGCGAGGT 
ACTTCCTATT TAACAGACAT TGTGTGGTGG GCTGGCACAA TCGCAATGGC TGTTGGCCAG 
ATTGGAAACT TCCTGGCTTA CACGGCGGTC CCCACGGTCC TGGTAACCCC CCTGGGCGCC 
CTTGGAGTAC CGTTCGGGTC CATTTTAGCT TCCTATCTCC TGAAGGAAAA GCTCAACATC 
TTGGGCAAGT TGGGGTGCCT GCTAAGCTGT GCAGGCTCCG TCGTGCTGAT TATCCACTCC 
CCAAAGTCTG AGAGTGTGAC AACTCAGGCT GAGCTGGAGG AAAAGCTGAC CAATCCAGTG 
TTTGTGGGCT ACCTGTGCAT CGTGCTGCTC ATGCTGCTGC TGCTCATCTT CTGGATCGCG 
CCGGCCCATG GGCCCACCAA CATCATGGTC TACATCAGCA TCTGCTCCTT GCTGGGCAGT 
TTCACCGTGC CTTCCACCAA GGGCATCGGG CTGGCGGCCC AAGACATCTT GCATAACAAC 
CCGTCCAGTC AGAGAGCCCT CTGCCTGTGC CTGGTACTCC TGGCCGTGCT CGGCTGCAGC 
ATCATCGTCC AGTTCAGGTA CATCAACAAG GCGCTGGAGT GCTTCGACTC CTCGGTGTTC 
GGGGCCATCT ACTACGTCGT GTTTACCACG CTGGTCCTGC TGGCCTCAGC CATCCTCTTC 
CGGGAGTGGA GCAACGTGGG CCTGGTGGAC TTCTTGGGGA TGGCCTGTGG ATTCACGACC 
GTCTCCGTGG GGATTGTCCT TATACAGGTG TTCAAAGAGT TCAATTTCAA CCTTGGGGAG 
ATGAACAAAT CTAATATGAA AACAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653200.2
CDS	14..1003
Translation	MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD

Target ORF information:

RefSeq Version	NM_144599.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NIPA magnesium transporter 1 (NIPA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144599.5

ORF Insert Sequence:

ATGGGGACTG CAGCTGCGGC AGCGGCGGCG GCGGCGGCGG CGGCGGCCGG GGAGGGGGCG 
CGTAGCCCGA GCCCCGCCGC CGTGTCGCTC GGCCTGGGCG TGGCCGTCGT GTCGAGCCTG 
GTGAACGGGT CCACGTTCGT GCTACAGAAG AAGGGCATCG TGCGTGCCAA GCGGCGAGGT 
ACTTCCTATT TAACAGACAT TGTGTGGTGG GCTGGCACAA TCGCAATGGC TGTTGGCCAG 
ATTGGAAACT TCCTGGCTTA CACGGCGGTC CCCACGGTCC TGGTAACCCC CCTGGGCGCC 
CTTGGAGTAC CGTTCGGGTC CATTTTAGCT TCCTATCTCC TGAAGGAAAA GCTCAACATC 
TTGGGCAAGT TGGGGTGCCT GCTAAGCTGT GCAGGCTCCG TCGTGCTGAT TATCCACTCC 
CCAAAGTCTG AGAGTGTGAC AACTCAGGCT GAGCTGGAGG AAAAGCTGAC CAATCCAGTG 
TTTGTGGGCT ACCTGTGCAT CGTGCTGCTC ATGCTGCTGC TGCTCATCTT CTGGATCGCG 
CCGGCCCATG GGCCCACCAA CATCATGGTC TACATCAGCA TCTGCTCCTT GCTGGGCAGT 
TTCACCGTGC CTTCCACCAA GGGCATCGGG CTGGCGGCCC AAGACATCTT GCATAACAAC 
CCGTCCAGTC AGAGAGCCCT CTGCCTGTGC CTGGTACTCC TGGCCGTGCT CGGCTGCAGC 
ATCATCGTCC AGTTCAGGTA CATCAACAAG GCGCTGGAGT GCTTCGACTC CTCGGTGTTC 
GGGGCCATCT ACTACGTCGT GTTTACCACG CTGGTCCTGC TGGCCTCAGC CATCCTCTTC 
CGGGAGTGGA GCAACGTGGG CCTGGTGGAC TTCTTGGGGA TGGCCTGTGG ATTCACGACC 
GTCTCCGTGG GGATTGTCCT TATACAGGTG TTCAAAGAGT TCAATTTCAA CCTTGGGGAG 
ATGAACAAAT CTAATATGAA AACAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NIPA1 ( NM_144599.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_653200.2 Homo sapiens non imprinted in Prader-Willi/Angelman syndrome 1 (NIPA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18589
Clone ID Related Accession (Same CDS sequence)	NM_144599.4 , NM_144599.5
Accession Version	NM_144599.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	magnesium transporter NIPA1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK001020.1 and AK314073.1. This sequence is a reference standard in the RefSeqGene project. On Apr 29, 2008 this sequence version replaced NM_144599.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK001020.1, SRR1660805.34307.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGACTG CAGCTGCGGC AGCGGCGGCG GCGGCGGCGG CGGCGGCCGG GGAGGGGGCG 
CGTAGCCCGA GCCCCGCCGC CGTGTCGCTC GGCCTGGGCG TGGCCGTCGT GTCGAGCCTG 
GTGAACGGGT CCACGTTCGT GCTACAGAAG AAGGGCATCG TGCGTGCCAA GCGGCGAGGT 
ACTTCCTATT TAACAGACAT TGTGTGGTGG GCTGGCACAA TCGCAATGGC TGTTGGCCAG 
ATTGGAAACT TCCTGGCTTA CACGGCGGTC CCCACGGTCC TGGTAACCCC CCTGGGCGCC 
CTTGGAGTAC CGTTCGGGTC CATTTTAGCT TCCTATCTCC TGAAGGAAAA GCTCAACATC 
TTGGGCAAGT TGGGGTGCCT GCTAAGCTGT GCAGGCTCCG TCGTGCTGAT TATCCACTCC 
CCAAAGTCTG AGAGTGTGAC AACTCAGGCT GAGCTGGAGG AAAAGCTGAC CAATCCAGTG 
TTTGTGGGCT ACCTGTGCAT CGTGCTGCTC ATGCTGCTGC TGCTCATCTT CTGGATCGCG 
CCGGCCCATG GGCCCACCAA CATCATGGTC TACATCAGCA TCTGCTCCTT GCTGGGCAGT 
TTCACCGTGC CTTCCACCAA GGGCATCGGG CTGGCGGCCC AAGACATCTT GCATAACAAC 
CCGTCCAGTC AGAGAGCCCT CTGCCTGTGC CTGGTACTCC TGGCCGTGCT CGGCTGCAGC 
ATCATCGTCC AGTTCAGGTA CATCAACAAG GCGCTGGAGT GCTTCGACTC CTCGGTGTTC 
GGGGCCATCT ACTACGTCGT GTTTACCACG CTGGTCCTGC TGGCCTCAGC CATCCTCTTC 
CGGGAGTGGA GCAACGTGGG CCTGGTGGAC TTCTTGGGGA TGGCCTGTGG ATTCACGACC 
GTCTCCGTGG GGATTGTCCT TATACAGGTG TTCAAAGAGT TCAATTTCAA CCTTGGGGAG 
ATGAACAAAT CTAATATGAA AACAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653200.2
CDS	26..1015
Translation	MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD

Target ORF information:

RefSeq Version	NM_144599.4
Organism	Homo sapiens(human)
Definition	Homo sapiens non imprinted in Prader-Willi/Angelman syndrome 1 (NIPA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144599.4

ORF Insert Sequence:

ATGGGGACTG CAGCTGCGGC AGCGGCGGCG GCGGCGGCGG CGGCGGCCGG GGAGGGGGCG 
CGTAGCCCGA GCCCCGCCGC CGTGTCGCTC GGCCTGGGCG TGGCCGTCGT GTCGAGCCTG 
GTGAACGGGT CCACGTTCGT GCTACAGAAG AAGGGCATCG TGCGTGCCAA GCGGCGAGGT 
ACTTCCTATT TAACAGACAT TGTGTGGTGG GCTGGCACAA TCGCAATGGC TGTTGGCCAG 
ATTGGAAACT TCCTGGCTTA CACGGCGGTC CCCACGGTCC TGGTAACCCC CCTGGGCGCC 
CTTGGAGTAC CGTTCGGGTC CATTTTAGCT TCCTATCTCC TGAAGGAAAA GCTCAACATC 
TTGGGCAAGT TGGGGTGCCT GCTAAGCTGT GCAGGCTCCG TCGTGCTGAT TATCCACTCC 
CCAAAGTCTG AGAGTGTGAC AACTCAGGCT GAGCTGGAGG AAAAGCTGAC CAATCCAGTG 
TTTGTGGGCT ACCTGTGCAT CGTGCTGCTC ATGCTGCTGC TGCTCATCTT CTGGATCGCG 
CCGGCCCATG GGCCCACCAA CATCATGGTC TACATCAGCA TCTGCTCCTT GCTGGGCAGT 
TTCACCGTGC CTTCCACCAA GGGCATCGGG CTGGCGGCCC AAGACATCTT GCATAACAAC 
CCGTCCAGTC AGAGAGCCCT CTGCCTGTGC CTGGTACTCC TGGCCGTGCT CGGCTGCAGC 
ATCATCGTCC AGTTCAGGTA CATCAACAAG GCGCTGGAGT GCTTCGACTC CTCGGTGTTC 
GGGGCCATCT ACTACGTCGT GTTTACCACG CTGGTCCTGC TGGCCTCAGC CATCCTCTTC 
CGGGAGTGGA GCAACGTGGG CCTGGTGGAC TTCTTGGGGA TGGCCTGTGG ATTCACGACC 
GTCTCCGTGG GGATTGTCCT TATACAGGTG TTCAAAGAGT TCAATTTCAA CCTTGGGGAG 
ATGAACAAAT CTAATATGAA AACAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic background of the hereditary spastic paraplegia phenotypes in Hungary - An analysis of 58 probands.
Journal of the neurological sciences364116-21(2016 May)
Balicza P,Grosz Z,Gonzalez MA,Bencsik R,Pentelenyi K,Gal A,Varga E,Klivenyi P,Koller J,Z?chner S,Molnar JM

Large-scale screening in sporadic amyotrophic lateral sclerosis identifies genetic modifiers in C9orf72 repeat carriers.
Neurobiology of aging39220.e9-15(2016 Mar)
Dekker AM,Seelen M,van Doormaal PT,van Rheenen W,Bothof RJ,van Riessen T,Brands WJ,van der Kooi AJ,de Visser M,Voermans NC,Pasterkamp RJ,Veldink JH,van den Berg LH,van Es MA

Pure hereditary spastic paraplegia due to a de novo mutation in the NIPA1 gene.
European journal of neurology21(1)e2(2014)
Arkadir D,Noreau A,Goldman JS,Rouleau GA,Alcvalay RN

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NIPA1 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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