LEO1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LEO1
Entrez Gene ID	123169
Full Name	LEO1 homolog, Paf1/RNA polymerase II complex component
Synonyms	RDL
General protein information	Preferred Names LEO1 homolog, Paf1/RNA polymerase II complex component Names RNA polymerase-associated protein LEO1 Leo1 Paf1/RNA polymerase II complex component Leo1, Paf1/RNA polymerase II complex component, homolog replicative senescence down-regulated leo1-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q21.2
Summary	LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610507

mRNA and Protein(s)

mRNA	Protein	Name
NM_001286430.1	NP_001273359.1	RNA polymerase-associated protein LEO1 isoform 2
NM_001323904.1	NP_001310833.1	RNA polymerase-associated protein LEO1 isoform 4
NM_138792.3	NP_620147.1	RNA polymerase-associated protein LEO1 isoform 1
NM_001323903.1	NP_001310832.1	RNA polymerase-associated protein LEO1 isoform 3
NM_138792.4	NP_620147.1	RNA polymerase-associated protein LEO1 isoform 1
NM_001323904.2	NP_001310833.1	RNA polymerase-associated protein LEO1 isoform 4
XM_017021911.1	XP_016877400.1	RNA polymerase-associated protein LEO1 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LEO1	XP_535485.2
Rattus norvegicus (Norway rat)	Leo1	NP_001005548.1
Pan troglodytes (chimpanzee)	LEO1	NP_001233372.1
Gallus gallus (chicken)	LEO1	XP_004943851.1
Bos taurus (cattle)	LEO1	NP_001076073.1
Mus musculus (house mouse)	Leo1	NP_001034611.1
Danio rerio (zebrafish)	leo1	NP_996950.1
Homo sapiens (human)	LEO1	NP_620147.1
Xenopus tropicalis (tropical clawed frog)	leo1	XP_002936391.2

Gene Ontology
Bibliography

Related articles in PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.
Chong PS, Zhou J, Cheong LL, Liu SC, Qian J, Guo T, Sze SK, Zeng Q, Chng WJ
Cancer research74(11)3043-53(2014 Jun)

Structural insights into Paf1 complex assembly and histone binding.
Chu X, Qin X, Xu H, Li L, Wang Z, Li F, Xie X, Zhou H, Shen Y, Long J
Nucleic acids research41(22)10619-29(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PRL-3 and Leo1 levels were positively associated in AML patient samples.
Title: LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.

The results show that the Paf1/Leo1 heterodimer is necessary for its binding to histone H3, the histone octamer, and nucleosome in vitro.
Title: Structural insights into Paf1 complex assembly and histone binding.

Screened glioblastomas and oligodendrogliomas for fusion genes by identifying aberrant 5'-3' expression of genes that lie over regions of a copy number change. A fusion gene between exon 11 of LEO1 and exon 10 of SLC12A1 was identified.
Title: Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.

The following LEO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LEO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00971	NM_138792.4 Latest version!	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00995	NM_001286430.1 Latest version!	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OHu82896	NM_001323903.1 Latest version!	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OHu82899	NM_001323904.2 Latest version!	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OHu85256	XM_017021911.1 Latest version!	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu00971	NM_138792.3	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu82899	NM_001323904.1	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LEO1 ( NM_138792.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620147.1 Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00971
Clone ID Related Accession (Same CDS sequence)	NM_138792.3 , NM_138792.4
Accession Version	NM_138792.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	RNA polymerase-associated protein LEO1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090971.3 and BC018147.2. On Nov 5, 2013 this sequence version replaced NM_138792.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY302186.1, SRR1803615.160968.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAAG GTGAACCTTC CGGAAAGAGA 
AAAGCAGAAG ATGATGATAA AGCAAATAAA AAGCATAAGA AGTATGTGAT CAGCGATGAA 
GAGGAAGAAG ATGATGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620147.1
CDS	57..2057
Translation	MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD

Target ORF information:

RefSeq Version	NM_138792.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138792.3

ORF Insert Sequence:

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAAG GTGAACCTTC CGGAAAGAGA 
AAAGCAGAAG ATGATGATAA AGCAAATAAA AAGCATAAGA AGTATGTGAT CAGCGATGAA 
GAGGAAGAAG ATGATGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEO1 ( NM_138792.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_620147.1 Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00971
Clone ID Related Accession (Same CDS sequence)	NM_138792.3 , NM_138792.4
Accession Version	NM_138792.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	RNA polymerase-associated protein LEO1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090971.3 and BC018147.2. On Nov 23, 2018 this sequence version replaced NM_138792.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY302186.1, SRR1660807.83920.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299601.10/ ENSP00000299601.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAAG GTGAACCTTC CGGAAAGAGA 
AAAGCAGAAG ATGATGATAA AGCAAATAAA AAGCATAAGA AGTATGTGAT CAGCGATGAA 
GAGGAAGAAG ATGATGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620147.1
CDS	34..2034
Translation	MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD

Target ORF information:

RefSeq Version	NM_138792.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138792.4

ORF Insert Sequence:

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAAG GTGAACCTTC CGGAAAGAGA 
AAAGCAGAAG ATGATGATAA AGCAAATAAA AAGCATAAGA AGTATGTGAT CAGCGATGAA 
GAGGAAGAAG ATGATGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEO1 ( NM_001286430.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001273359.1 Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00995
Clone ID Related Accession (Same CDS sequence)	NM_001286430.1
Accession Version	NM_001286430.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1821bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	RNA polymerase-associated protein LEO1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090971.3, AK055762.1 and BC018147.2. On Nov 5, 2013 this sequence version replaced XM_005254155.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055762.1, SRR1803615.211795.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAAG GTGAACCTTC CGGAAAGAGA 
AAAGCAGAAG ATGATGATAA AGCAAATAAA AAGCATAAGA AGTATGTGAT CAGCGATGAA 
GAGGAAGAAG ATGATGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273359.1
CDS	57..1877
Translation	MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD

Target ORF information:

RefSeq Version	NM_001286430.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286430.1

ORF Insert Sequence:

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAAG GTGAACCTTC CGGAAAGAGA 
AAAGCAGAAG ATGATGATAA AGCAAATAAA AAGCATAAGA AGTATGTGAT CAGCGATGAA 
GAGGAAGAAG ATGATGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEO1 ( NM_001323903.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001310832.1 Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 3, mRNA.

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CloneID	OHu82896
Clone ID Related Accession (Same CDS sequence)	NM_001323903.1
Accession Version	NM_001323903.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	RNA polymerase-associated protein LEO1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090971.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.79508.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAGT CTGGGAAAAG GGAAAGACCC 
AAGCTGAAAG AAACATGGAG ACAGTGGAAA GGAGAGGTAT CAAGGCCAAC CCTCAGCTTT 
CTTAGACAAA ACAGGAAGGT GAACCTTCCG GAAAGAGAAA AGCAGAAGAT GATGATAAAG 
CAAATAAAAA GCATAAGAAG TATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001310832.1
CDS	57..2123
Translation	MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEESGKRERPKLKETWRQWKGEVSRPTLSFLRQNRKVNLPEREKQKMMIKQIKSIRSM

Target ORF information:

RefSeq Version	NM_001323903.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323903.1

ORF Insert Sequence:

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGAGT CTGGGAAAAG GGAAAGACCC 
AAGCTGAAAG AAACATGGAG ACAGTGGAAA GGAGAGGTAT CAAGGCCAAC CCTCAGCTTT 
CTTAGACAAA ACAGGAAGGT GAACCTTCCG GAAAGAGAAA AGCAGAAGAT GATGATAAAG 
CAAATAAAAA GCATAAGAAG TATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEO1 ( NM_001323904.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001310833.1 Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu82899
Clone ID Related Accession (Same CDS sequence)	NM_001323904.1 , NM_001323904.2
Accession Version	NM_001323904.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	RNA polymerase-associated protein LEO1 isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090971.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.48683.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGTGA ACCTTCCGGA AAGAGAAAAG 
CAGAAGATGA TGATAAAGCA AATAAAAAGC ATAAGAAGTA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001310833.1
CDS	57..2021
Translation	MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEVNLPEREKQKMMIKQIKSIRSM

Target ORF information:

RefSeq Version	NM_001323904.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323904.1

ORF Insert Sequence:

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGTGA ACCTTCCGGA AAGAGAAAAG 
CAGAAGATGA TGATAAAGCA AATAAAAAGC ATAAGAAGTA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEO1 ( NM_001323904.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001310833.1 Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 4, mRNA.

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CloneID	OHu82899
Clone ID Related Accession (Same CDS sequence)	NM_001323904.1 , NM_001323904.2
Accession Version	NM_001323904.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	RNA polymerase-associated protein LEO1 isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090971.3. On May 31, 2019 this sequence version replaced NM_001323904.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.48683.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGTGA ACCTTCCGGA AAGAGAAAAG 
CAGAAGATGA TGATAAAGCA AATAAAAAGC ATAAGAAGTA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001310833.1
CDS	34..1998
Translation	MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEVNLPEREKQKMMIKQIKSIRSM

Target ORF information:

RefSeq Version	NM_001323904.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323904.2

ORF Insert Sequence:

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGGTGA ACCTTCCGGA AAGAGAAAAG 
CAGAAGATGA TGATAAAGCA AATAAAAAGC ATAAGAAGTA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEO1 ( XM_017021911.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877400.1 Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant X1, mRNA.

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CloneID	OHu85256
Clone ID Related Accession (Same CDS sequence)	XM_017021911.1
Accession Version	XM_017021911.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	RNA polymerase-associated protein LEO1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGATTT GTAAAAATTG TATCTGTTTA 
GGAAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877400.1
CDS	54..1982
Translation	MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEICKNCICLGR

Target ORF information:

RefSeq Version	XM_017021911.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEO1 homolog, Paf1/RNA polymerase II complex component (LEO1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017021911.1

ORF Insert Sequence:

ATGGCGGATA TGGAGGATCT CTTCGGGAGC GACGCCGACA GCGAAGCTGA GCGTAAAGAT 
TCTGATTCTG GATCTGACTC AGATTCTGAT CAAGAGAATG CTGCCTCTGG CAGTAATGCC 
TCTGGAAGTG AAAGTGATCA GGATGAAAGA GGTGATTCAG GACAACCAAG TAATAAGGAA 
CTGTTTGGAG ATGACAGTGA GGACGAGGGA GCTTCACATC ATAGTGGTAG TGATAATCAC 
TCTGAAAGAT CAGACAATAG ATCAGAAGCT TCTGAGCGTT CTGACCATGA GGACAATGAC 
CCCTCAGATG TAGATCAGCA CAGTGGATCA GAAGCCCCTA ATGATGATGA AGACGAAGGT 
CATAGATCGG ATGGAGGGAG CCATCATTCA GAAGCAGAAG GTTCTGAAAA AGCACATTCA 
GATGATGAAA AATGGGGCAG AGAAGATAAA AGTGACCAGT CAGATGATGA AAAGATACAA 
AATTCTGATG ATGAGGAGAG GGCACAAGGA TCTGATGAAG ATAAGCTGCA GAATTCTGAC 
GATGATGAGA AAATGCAGAA CACAGATGAT GAGGAGAGGC CTCAGCTTTC CGATGATGAG 
AGACAACAGC TATCTGAGGA GGAAAAGGCT AATTCTGATG ATGAACGGCC GGTAGCTTCT 
GATAATGATG ATGAGAAACA GAATTCTGAT GATGAAGAAC AACCACAGCT GTCTGATGAA 
GAGAAAATGC AAAATTCTGA TGATGAAAGG CCACAGGCCT CAGATGAAGA ACACAGGCAT 
TCAGATGATG AAGAGGAACA GGATCATAAA TCAGAATCTG CAAGAGGCAG TGATAGTGAA 
GATGAAGTTT TACGAATGAA ACGCAAGAAT GCGATTGCAT CTGATTCAGA AGCGGATAGT 
GACACTGAGG TGCCAAAAGA TAATAGTGGA ACCATGGATT TATTTGGAGG TGCAGATGAT 
ATCTCTTCAG GGAGTGATGG AGAAGACAAA CCACCTACTC CAGGACAGCC TGTTGATGAA 
AATGGATTGC CTCAGGATCA ACAGGAAGAG GAGCCAATTC CTGAGACCAG AATAGAAGTA 
GAAATACCCA AAGTAAACAC TGATTTAGGA AACGACTTAT ATTTTGTTAA ACTGCCCAAC 
TTTCTCAGTG TAGAGCCCAG ACCTTTTGAT CCTCAGTATT ATGAAGATGA ATTTGAAGAT 
GAAGAAATGC TGGATGAAGA AGGTAGAACC AGGTTAAAAT TAAAGGTAGA AAATACTATA 
AGATGGAGGA TACGCCGAGA TGAAGAAGGA AATGAAATTA AAGAAAGCAA TGCTCGGATA 
GTCAAGTGGT CAGATGGAAG CATGTCCCTG CATTTAGGCA ATGAAGTGTT TGATGTGTAC 
AAAGCCCCAC TGCAGGGCGA CCACAATCAT CTTTTTATAA GACAAGGTAC TGGTCTACAG 
GGACAAGCAG TCTTTAAAAC GAAACTCACC TTCAGACCTC ACTCTACGGA CAGTGCCACA 
CATAGAAAGA TGACTCTGTC ACTTGCAGAT AGGTGTTCAA AGACACAGAA GATTAGAATC 
TTGCCAATGG CTGGTCGTGA TCCTGAATGC CAACGCACAG AAATGATTAA GAAAGAAGAA 
GAACGTTTGA GGGCTTCCAT ACGTAGGGAA TCTCAGCAGC GCCGAATGAG AGAGAAACAG 
CACCAGCGGG GGCTGAGCGC CAGTTACCTG GAACCTGATC GATACGATGA GGAGGAGGAA 
GGCGAGGAGT CCATCAGCTT GGCTGCCATT AAAAACCGAT ATAAAGGGGG CATTCGAGAG 
GAACGAGCCA GAATCTATTC ATCAGACAGT GATGAGGGAT CAGAAGAAGA TAAAGCTCAA 
AGATTACTCA AAGCAAAGAA ACTTACCAGT GATGAGATTT GTAAAAATTG TATCTGTTTA 
GGAAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.
Cancer research74(11)3043-53(2014 Jun)
Chong PS,Zhou J,Cheong LL,Liu SC,Qian J,Guo T,Sze SK,Zeng Q,Chng WJ

Structural insights into Paf1 complex assembly and histone binding.
Nucleic acids research41(22)10619-29(2013 Dec)
Chu X,Qin X,Xu H,Li L,Wang Z,Li F,Xie X,Zhou H,Shen Y,Long J

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LEO1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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