KRT74 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT74
Entrez Gene ID	121391
Full Name	keratin 74
Synonyms	ADWH,HTSS2,HYPT3,K6IRS4,KRT5C,KRT6IRS4
General protein information	Preferred Names keratin 74 Names keratin, type II cytoskeletal 74 CK-74 K5C K74 cytokeratin-74 keratin 5c keratin 6 irs4 keratin 74, type II type II inner root sheath-specific keratin-K6irs4 type-II keratin Kb37
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009].
Disorder MIM:	608248
Disorder Html:	Woolly hair, autosomal dominant, 194300 (3); ?Hypotrichosis 3, 613981 (3); ?Ectodermal dysplasia 7, hair/nail type, 614929 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_175053.3	NP_778223.2	keratin, type II cytoskeletal 74
NM_175053.4	NP_778223.2	keratin, type II cytoskeletal 74

Pathways from BioSystems

Homologies

	KRT74	XP_001097399.1
Canis lupus familiaris (dog)	KRT74	XP_543647.3
Homo sapiens (human)	KRT74	NP_778223.2
Pan troglodytes (chimpanzee)	KRT74	XP_522392.2
Bos taurus (cattle)	KRT74	NP_001076916.1

Gene Ontology
Bibliography

Related articles in PubMed

Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis.
Raykova D, Klar J, Azhar A, Khan TN, Malik NA, Iqbal M, Tariq M, Baig SM, Dahl N
PloS one9(4)e93607(2014)

Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families.
Wasif N, Naqvi SK, Basit S, Ali N, Ansar M, Ahmad W
Human genetics129(4)419-24(2011 Apr)

Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.
Shimomura Y, Wajid M, Petukhova L, Kurban M, Christiano AM
American journal of human genetics86(4)632-8(2010 Apr)

Gene variants associated with ischemic stroke: the cardiovascular health study.
Luke MM, O'Meara ES, Rowland CM, Shiffman D, Bare LA, Arellano AR, Longstreth WT Jr, Lumley T, Rice K, Tracy RP, Devlin JJ, Psaty BM
Stroke40(2)363-8(2009 Feb)

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM
Arteriosclerosis, thrombosis, and vascular biology28(1)173-9(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These observations show for the first time that homozygosity for a KRT74 missense variant may be associated with autosomal recessive pure hair and nail ectodermal dysplasia.
Title: Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis.

Data provide evidence implicating that the KRT74 gene in the pathogenesis of autosomal dominant hair loss disorders.
Title: Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Single Nucleotide Polymorphisms in KRT74 gene is associated with woolly hair.
Title: Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene variants associated with ischemic stroke: the cardiovascular health study.

The following KRT74 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT74 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18103	NM_175053.4 Latest version!	Homo sapiens keratin 74 (KRT74), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu18103	NM_175053.3	Homo sapiens keratin 74 (KRT74), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT74 ( NM_175053.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_778223.2 Homo sapiens keratin 74 (KRT74), mRNA.

Price & Availability↑

CloneID	OHu18103
Clone ID Related Accession (Same CDS sequence)	NM_175053.3 , NM_175053.4
Accession Version	NM_175053.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 74
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ508777.1, AC055715.13 and AI092341.1. This sequence is a reference standard in the RefSeqGene project. On Jun 6, 2007 this sequence version replaced NM_175053.2. ##Evidence-Data-START## Transcript exon combination :: AJ508777.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCGGC AACTGAACAT CAAGTCCAGT GGTGACAAGG GCAACTTCAG TGTGCATTCG 
GCAGTGGTGC CAAGGAAGGC TGTGGGTAGC CTGGCTTCTT ACTGTGCAGC TGGCAGAGGG 
GCTGGCGCTG GCTTTGGCAG TCGGAGCCTC TATAGCCTTG GAGGGAATCG GCGTATTTCT 
TTCAATGTGG CTGGTGGCGG CGTTCGGGCT GGAGGTTACG GCTTCAGGCC TGGCTCTGGG 
TATGGAGGGG GCCGGGCCAG TGGCTTTGCT GGCAGTATGT TTGGCAGTGT GGCCCTGGGG 
CCTGCATGTT TGTCTGTGTG CCCACCTGGG GGCATCCACC AGGTCACTGT CAACAAGAGC 
CTCTTGGCCC CCCTCAACGT GGAGCTGGAC CCTGAGATCC AGAAGGTGCG CGCCCAGGAG 
CGGGAACAGA TCAAGGTGCT GAACGACAAG TTCGCCTCCT TCATTGACAA GGTACGCTTC 
CTAGAGCAGC AGAACCAGGT TCTAGAAACC AAGTGGGAGC TGCTGCAGCA GCTGGACCTG 
AACAACTGCA AGAAGAACCT GGAGCCCATC CTTGAGGGCT ACATCAGCAA CCTGCGGAAG 
CAGCTGGAGA CACTGTCTGG GGACAGGGTG AGGCTGGACT CGGAGCTGAG AAGCATGAGG 
GATCTGGTGG AGGACTATAA GAAGAGATAT GAAGTGGAGA TTAACCGGCG CACGACAGCA 
GAGAATGAGT TTGTGGTGCT TAAGAAGGAT GCAGATGCAG CCTACGCAGT CAAGGTGGAG 
CTTCAGGCCA AAGTGGACTC ACTGGACAAA GAAATCAAGT TCCTCAAGTG TCTGTATGAT 
GCAGAGATCG CTCAGATCCA GACTCACGCC AGTGAGACCT CTGTCATCCT GTCCATGGAC 
AACAACCGGG ACCTGGACCT TGACAGCATC ATCGCTGAGG TCCGCATGCA TTATGAGGAG 
ATCGCCCTGA AGAGCAAGGC CGAGGCCGAG GCCCTGTACC AGACCAAGAT CCAGGAGCTG 
CAGCTGGCAG CCAGTCGGCA TGGTGACGAC CTGAAACACA CCAGGAGCGA GATGGTGGAG 
CTGAACCGGC TCATCCAGAG GATCCGGTGT GAGATCGGGA ATGTGAAGAA GCAGCGTGCC 
AGCCTGGAGA CGGCCATCGC TGACGCTGAG CAGCGGGGAG ACAATGCCCT GAAGGATGCC 
CAGGCCAAGC TGGATGAGCT GGAGGGCGCC CTGCACCAGG CCAAGGAGGA GCTGGCGCGG 
ATGCTGCGCG AGTACCAGGA GCTCATGAGC CTGAAACTGG CCCTGGACAT GGAGATTGCC 
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TGCAGGATGT CTGGTGAGAA TCCATCCTCT 
GTGAGCATCT CTGTCATCAG CAGTAGCAGC TACAGCTACC ACCACCCCAG CTCTGCGGGT 
GTTGACCTTG GGGCCAGCGC TGTGGCAGGC AGCTCTGGCA GCACCCAGAG CGGGCAGACC 
AAGACCACAG AGGCGCGAGG GGGAGACCTC AAGGACACCC AGGGCAAGAG CACCCCAGCC 
AGCATCCCAG CAAGGAAAGC CACCCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778223.2
CDS	49..1638
Translation	MSRQLNIKSSGDKGNFSVHSAVVPRKAVGSLASYCAAGRGAGAGFGSRSLYSLGGNRRISFNVAGGGVRAGGYGFRPGSGYGGGRASGFAGSMFGSVALGPACLSVCPPGGIHQVTVNKSLLAPLNVELDPEIQKVRAQEREQIKVLNDKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGYISNLRKQLETLSGDRVRLDSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAAYAVKVELQAKVDSLDKEIKFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIAEVRMHYEEIALKSKAEAEALYQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIRCEIGNVKKQRASLETAIADAEQRGDNALKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLEGEECRMSGENPSSVSISVISSSSYSYHHPSSAGVDLGASAVAGSSGSTQSGQTKTTEARGGDLKDTQGKSTPASIPARKATR

Target ORF information:

RefSeq Version	NM_175053.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 74 (KRT74), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175053.3

ORF Insert Sequence:

ATGAGTCGGC AACTGAACAT CAAGTCCAGT GGTGACAAGG GCAACTTCAG TGTGCATTCG 
GCAGTGGTGC CAAGGAAGGC TGTGGGTAGC CTGGCTTCTT ACTGTGCAGC TGGCAGAGGG 
GCTGGCGCTG GCTTTGGCAG TCGGAGCCTC TATAGCCTTG GAGGGAATCG GCGTATTTCT 
TTCAATGTGG CTGGTGGCGG CGTTCGGGCT GGAGGTTACG GCTTCAGGCC TGGCTCTGGG 
TATGGAGGGG GCCGGGCCAG TGGCTTTGCT GGCAGTATGT TTGGCAGTGT GGCCCTGGGG 
CCTGCATGTT TGTCTGTGTG CCCACCTGGG GGCATCCACC AGGTCACTGT CAACAAGAGC 
CTCTTGGCCC CCCTCAACGT GGAGCTGGAC CCTGAGATCC AGAAGGTGCG CGCCCAGGAG 
CGGGAACAGA TCAAGGTGCT GAACGACAAG TTCGCCTCCT TCATTGACAA GGTACGCTTC 
CTAGAGCAGC AGAACCAGGT TCTAGAAACC AAGTGGGAGC TGCTGCAGCA GCTGGACCTG 
AACAACTGCA AGAAGAACCT GGAGCCCATC CTTGAGGGCT ACATCAGCAA CCTGCGGAAG 
CAGCTGGAGA CACTGTCTGG GGACAGGGTG AGGCTGGACT CGGAGCTGAG AAGCATGAGG 
GATCTGGTGG AGGACTATAA GAAGAGATAT GAAGTGGAGA TTAACCGGCG CACGACAGCA 
GAGAATGAGT TTGTGGTGCT TAAGAAGGAT GCAGATGCAG CCTACGCAGT CAAGGTGGAG 
CTTCAGGCCA AAGTGGACTC ACTGGACAAA GAAATCAAGT TCCTCAAGTG TCTGTATGAT 
GCAGAGATCG CTCAGATCCA GACTCACGCC AGTGAGACCT CTGTCATCCT GTCCATGGAC 
AACAACCGGG ACCTGGACCT TGACAGCATC ATCGCTGAGG TCCGCATGCA TTATGAGGAG 
ATCGCCCTGA AGAGCAAGGC CGAGGCCGAG GCCCTGTACC AGACCAAGAT CCAGGAGCTG 
CAGCTGGCAG CCAGTCGGCA TGGTGACGAC CTGAAACACA CCAGGAGCGA GATGGTGGAG 
CTGAACCGGC TCATCCAGAG GATCCGGTGT GAGATCGGGA ATGTGAAGAA GCAGCGTGCC 
AGCCTGGAGA CGGCCATCGC TGACGCTGAG CAGCGGGGAG ACAATGCCCT GAAGGATGCC 
CAGGCCAAGC TGGATGAGCT GGAGGGCGCC CTGCACCAGG CCAAGGAGGA GCTGGCGCGG 
ATGCTGCGCG AGTACCAGGA GCTCATGAGC CTGAAACTGG CCCTGGACAT GGAGATTGCC 
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TGCAGGATGT CTGGTGAGAA TCCATCCTCT 
GTGAGCATCT CTGTCATCAG CAGTAGCAGC TACAGCTACC ACCACCCCAG CTCTGCGGGT 
GTTGACCTTG GGGCCAGCGC TGTGGCAGGC AGCTCTGGCA GCACCCAGAG CGGGCAGACC 
AAGACCACAG AGGCGCGAGG GGGAGACCTC AAGGACACCC AGGGCAAGAG CACCCCAGCC 
AGCATCCCAG CAAGGAAAGC CACCCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT74 ( NM_175053.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_778223.2 Homo sapiens keratin 74 (KRT74), mRNA.

Price & Availability↑

CloneID	OHu18103
Clone ID Related Accession (Same CDS sequence)	NM_175053.3 , NM_175053.4
Accession Version	NM_175053.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 74
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC055715.13, AJ508777.1 and AI092341.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_175053.3. ##Evidence-Data-START## Transcript exon combination :: AJ508777.1, SRR6380199.150681.9 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305620.3/ ENSP00000307240.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCGGC AACTGAACAT CAAGTCCAGT GGTGACAAGG GCAACTTCAG TGTGCATTCG 
GCAGTGGTGC CAAGGAAGGC TGTGGGTAGC CTGGCTTCTT ACTGTGCAGC TGGCAGAGGG 
GCTGGCGCTG GCTTTGGCAG TCGGAGCCTC TATAGCCTTG GAGGGAATCG GCGTATTTCT 
TTCAATGTGG CTGGTGGCGG CGTTCGGGCT GGAGGTTACG GCTTCAGGCC TGGCTCTGGG 
TATGGAGGGG GCCGGGCCAG TGGCTTTGCT GGCAGTATGT TTGGCAGTGT GGCCCTGGGG 
CCTGCATGTT TGTCTGTGTG CCCACCTGGG GGCATCCACC AGGTCACTGT CAACAAGAGC 
CTCTTGGCCC CCCTCAACGT GGAGCTGGAC CCTGAGATCC AGAAGGTGCG CGCCCAGGAG 
CGGGAACAGA TCAAGGTGCT GAACGACAAG TTCGCCTCCT TCATTGACAA GGTACGCTTC 
CTAGAGCAGC AGAACCAGGT TCTAGAAACC AAGTGGGAGC TGCTGCAGCA GCTGGACCTG 
AACAACTGCA AGAAGAACCT GGAGCCCATC CTTGAGGGCT ACATCAGCAA CCTGCGGAAG 
CAGCTGGAGA CACTGTCTGG GGACAGGGTG AGGCTGGACT CGGAGCTGAG AAGCATGAGG 
GATCTGGTGG AGGACTATAA GAAGAGATAT GAAGTGGAGA TTAACCGGCG CACGACAGCA 
GAGAATGAGT TTGTGGTGCT TAAGAAGGAT GCAGATGCAG CCTACGCAGT CAAGGTGGAG 
CTTCAGGCCA AAGTGGACTC ACTGGACAAA GAAATCAAGT TCCTCAAGTG TCTGTATGAT 
GCAGAGATCG CTCAGATCCA GACTCACGCC AGTGAGACCT CTGTCATCCT GTCCATGGAC 
AACAACCGGG ACCTGGACCT TGACAGCATC ATCGCTGAGG TCCGCATGCA TTATGAGGAG 
ATCGCCCTGA AGAGCAAGGC CGAGGCCGAG GCCCTGTACC AGACCAAGAT CCAGGAGCTG 
CAGCTGGCAG CCAGTCGGCA TGGTGACGAC CTGAAACACA CCAGGAGCGA GATGGTGGAG 
CTGAACCGGC TCATCCAGAG GATCCGGTGT GAGATCGGGA ATGTGAAGAA GCAGCGTGCC 
AGCCTGGAGA CGGCCATCGC TGACGCTGAG CAGCGGGGAG ACAATGCCCT GAAGGATGCC 
CAGGCCAAGC TGGATGAGCT GGAGGGCGCC CTGCACCAGG CCAAGGAGGA GCTGGCGCGG 
ATGCTGCGCG AGTACCAGGA GCTCATGAGC CTGAAACTGG CCCTGGACAT GGAGATTGCC 
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TGCAGGATGT CTGGTGAGAA TCCATCCTCT 
GTGAGCATCT CTGTCATCAG CAGTAGCAGC TACAGCTACC ACCACCCCAG CTCTGCGGGT 
GTTGACCTTG GGGCCAGCGC TGTGGCAGGC AGCTCTGGCA GCACCCAGAG CGGGCAGACC 
AAGACCACAG AGGCGCGAGG GGGAGACCTC AAGGACACCC AGGGCAAGAG CACCCCAGCC 
AGCATCCCAG CAAGGAAAGC CACCCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778223.2
CDS	67..1656
Translation	MSRQLNIKSSGDKGNFSVHSAVVPRKAVGSLASYCAAGRGAGAGFGSRSLYSLGGNRRISFNVAGGGVRAGGYGFRPGSGYGGGRASGFAGSMFGSVALGPACLSVCPPGGIHQVTVNKSLLAPLNVELDPEIQKVRAQEREQIKVLNDKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGYISNLRKQLETLSGDRVRLDSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAAYAVKVELQAKVDSLDKEIKFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIAEVRMHYEEIALKSKAEAEALYQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIRCEIGNVKKQRASLETAIADAEQRGDNALKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLEGEECRMSGENPSSVSISVISSSSYSYHHPSSAGVDLGASAVAGSSGSTQSGQTKTTEARGGDLKDTQGKSTPASIPARKATR

Target ORF information:

RefSeq Version	NM_175053.4
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 74 (KRT74), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175053.4

ORF Insert Sequence:

ATGAGTCGGC AACTGAACAT CAAGTCCAGT GGTGACAAGG GCAACTTCAG TGTGCATTCG 
GCAGTGGTGC CAAGGAAGGC TGTGGGTAGC CTGGCTTCTT ACTGTGCAGC TGGCAGAGGG 
GCTGGCGCTG GCTTTGGCAG TCGGAGCCTC TATAGCCTTG GAGGGAATCG GCGTATTTCT 
TTCAATGTGG CTGGTGGCGG CGTTCGGGCT GGAGGTTACG GCTTCAGGCC TGGCTCTGGG 
TATGGAGGGG GCCGGGCCAG TGGCTTTGCT GGCAGTATGT TTGGCAGTGT GGCCCTGGGG 
CCTGCATGTT TGTCTGTGTG CCCACCTGGG GGCATCCACC AGGTCACTGT CAACAAGAGC 
CTCTTGGCCC CCCTCAACGT GGAGCTGGAC CCTGAGATCC AGAAGGTGCG CGCCCAGGAG 
CGGGAACAGA TCAAGGTGCT GAACGACAAG TTCGCCTCCT TCATTGACAA GGTACGCTTC 
CTAGAGCAGC AGAACCAGGT TCTAGAAACC AAGTGGGAGC TGCTGCAGCA GCTGGACCTG 
AACAACTGCA AGAAGAACCT GGAGCCCATC CTTGAGGGCT ACATCAGCAA CCTGCGGAAG 
CAGCTGGAGA CACTGTCTGG GGACAGGGTG AGGCTGGACT CGGAGCTGAG AAGCATGAGG 
GATCTGGTGG AGGACTATAA GAAGAGATAT GAAGTGGAGA TTAACCGGCG CACGACAGCA 
GAGAATGAGT TTGTGGTGCT TAAGAAGGAT GCAGATGCAG CCTACGCAGT CAAGGTGGAG 
CTTCAGGCCA AAGTGGACTC ACTGGACAAA GAAATCAAGT TCCTCAAGTG TCTGTATGAT 
GCAGAGATCG CTCAGATCCA GACTCACGCC AGTGAGACCT CTGTCATCCT GTCCATGGAC 
AACAACCGGG ACCTGGACCT TGACAGCATC ATCGCTGAGG TCCGCATGCA TTATGAGGAG 
ATCGCCCTGA AGAGCAAGGC CGAGGCCGAG GCCCTGTACC AGACCAAGAT CCAGGAGCTG 
CAGCTGGCAG CCAGTCGGCA TGGTGACGAC CTGAAACACA CCAGGAGCGA GATGGTGGAG 
CTGAACCGGC TCATCCAGAG GATCCGGTGT GAGATCGGGA ATGTGAAGAA GCAGCGTGCC 
AGCCTGGAGA CGGCCATCGC TGACGCTGAG CAGCGGGGAG ACAATGCCCT GAAGGATGCC 
CAGGCCAAGC TGGATGAGCT GGAGGGCGCC CTGCACCAGG CCAAGGAGGA GCTGGCGCGG 
ATGCTGCGCG AGTACCAGGA GCTCATGAGC CTGAAACTGG CCCTGGACAT GGAGATTGCC 
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TGCAGGATGT CTGGTGAGAA TCCATCCTCT 
GTGAGCATCT CTGTCATCAG CAGTAGCAGC TACAGCTACC ACCACCCCAG CTCTGCGGGT 
GTTGACCTTG GGGCCAGCGC TGTGGCAGGC AGCTCTGGCA GCACCCAGAG CGGGCAGACC 
AAGACCACAG AGGCGCGAGG GGGAGACCTC AAGGACACCC AGGGCAAGAG CACCCCAGCC 
AGCATCCCAG CAAGGAAAGC CACCCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis.
PloS one9(4)e93607(2014)
Raykova D,Klar J,Azhar A,Khan TN,Malik NA,Iqbal M,Tariq M,Baig SM,Dahl N

Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families.
Human genetics129(4)419-24(2011 Apr)
Wasif N,Naqvi SK,Basit S,Ali N,Ansar M,Ahmad W

Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.
American journal of human genetics86(4)632-8(2010 Apr)
Shimomura Y,Wajid M,Petukhova L,Kurban M,Christiano AM

Gene variants associated with ischemic stroke: the cardiovascular health study.
Stroke40(2)363-8(2009 Feb)
Luke MM,O'Meara ES,Rowland CM,Shiffman D,Bare LA,Arellano AR,Longstreth WT Jr,Lumley T,Rice K,Tracy RP,Devlin JJ,Psaty BM

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Arteriosclerosis, thrombosis, and vascular biology28(1)173-9(2008 Jan)
Shiffman D,O'Meara ES,Bare LA,Rowland CM,Louie JZ,Arellano AR,Lumley T,Rice K,Iakoubova O,Luke MM,Young BA,Malloy MJ,Kane JP,Ellis SG,Tracy RP,Devlin JJ,Psaty BM

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KRT74 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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