CLPS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLPS
Entrez Gene ID	1208
Full Name	colipase
General protein information	Preferred Names colipase Names colipase colipase, pancreatic pancreatic colipase preproprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.31
Summary	The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Disorder MIM:	120105

mRNA and Protein(s)

mRNA	Protein	Name
NM_001832.3	NP_001823.1	colipase isoform 1 preproprotein
NM_001252598.1	NP_001239527.1	colipase isoform 3 preproprotein
NM_001252597.2	NP_001239526.1	colipase isoform 2
NM_001252597.1	NP_001239526.1	colipase isoform 2
NM_001832.4	NP_001823.1	colipase isoform 1 preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Clps	NP_037271.1
	CLPS	XP_001116700.1
Canis lupus familiaris (dog)	CLPS	NP_001003287.1
Mus musculus (house mouse)	Clps	NP_079745.1
Gallus gallus (chicken)	CLPS	NP_001138963.1
Homo sapiens (human)	CLPS	NP_001823.1
Pan troglodytes (chimpanzee)	CLPS	XP_527612.1
Bos taurus (cattle)	CLPS	NP_001071435.1
Xenopus tropicalis (tropical clawed frog)	clps	NP_001107327.1

Gene Ontology
Bibliography

Related articles in PubMed

Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR, Hussain SP
Clinical cancer research : an official journal of the American Association for Cancer Research19(18)4983-93(2013 Sep)

The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding.
Xiao X, Ferguson MR, Magee KE, Hale PD, Wang Y, Lowe ME
Journal of lipid research54(2)514-21(2013 Feb)

Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians.
Weyrich P, Albet S, Lammers R, Machicao F, Fritsche A, Stefan N, H?ring HU
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association117(2)83-7(2009 Feb)

Procolipase gene: no association with early-onset obesity or fat intake.
Wermter AK, Scherag A, Holter K, Reichwald K, Lichtner P, Siegfried W, Blundell J, Lawton C, Whybrow S, Stubbs J, Arch JR, Meitinger T, Platzer M, Hinney A, Hebebrand J
Obesity facts2(1)40-4(2009)

A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides.
D'Silva S, Xiao X, Lowe ME
Journal of lipid research48(11)2478-84(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low CLPS expression is associated with pancreatic cancer.
Title: Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.

humans with the Arg92Cys substitution will secrete less functional colipase
Title: The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Procolipase gene: no association with early-onset obesity or fat intake.

Our findings demonstrate that the Arg92Cys polymorphism decreases the function of Cys92 colipase. This change may contribute to the development of type 2 diabetes.
Title: A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides.

The following CLPS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLPS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29002	NM_001832.4 Latest version!	Homo sapiens colipase (CLPS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu55900	NM_001252598.1 Latest version!	Homo sapiens colipase (CLPS), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu55903	NM_001252597.2 Latest version!	Homo sapiens colipase (CLPS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu55903	NM_001252597.1	Homo sapiens colipase (CLPS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu29002	NM_001832.3	Homo sapiens colipase (CLPS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLPS ( NM_001832.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001823.1 Homo sapiens colipase (CLPS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29002
Clone ID Related Accession (Same CDS sequence)	NM_001832.3 , NM_001832.4
Accession Version	NM_001832.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	colipase isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ271978.1 and BP324927.1. On Nov 19, 2011 this sequence version replaced NM_001832.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP324927.1, BC007061.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151405, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGAAGA TCCTGATCCT CCTGCTTGTC GCCCTCTCTG TGGCCTATGC AGCTCCTGGC 
CCCCGGGGGA TCATTATCAA CCTGGAGAAC GGTGAGCTCT GCATGAATAG TGCCCAGTGT 
AAGAGCAATT GCTGCCAGCA TTCAAGTGCG CTGGGCCTGG CCCGCTGCAC ATCCATGGCC 
AGCGAGAACA GCGAGTGCTC TGTCAAGACG CTCTATGGGA TTTACTACAA GTGTCCCTGT 
GAGCGTGGCC TGACCTGTGA GGGAGACAAG ACCATCGTGG GCTCCATCAC CAACACCAAC 
TTTGGCATCT GCCATGACGC TGGACGCTCC AAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001823.1
CDS	57..395
Translation	MEKILILLLVALSVAYAAPGPRGIIINLENGELCMNSAQCKSNCCQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ

Target ORF information:

RefSeq Version	NM_001832.3
Organism	Homo sapiens(human)
Definition	Homo sapiens colipase (CLPS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001832.3

ORF Insert Sequence:

ATGGAGAAGA TCCTGATCCT CCTGCTTGTC GCCCTCTCTG TGGCCTATGC AGCTCCTGGC 
CCCCGGGGGA TCATTATCAA CCTGGAGAAC GGTGAGCTCT GCATGAATAG TGCCCAGTGT 
AAGAGCAATT GCTGCCAGCA TTCAAGTGCG CTGGGCCTGG CCCGCTGCAC ATCCATGGCC 
AGCGAGAACA GCGAGTGCTC TGTCAAGACG CTCTATGGGA TTTACTACAA GTGTCCCTGT 
GAGCGTGGCC TGACCTGTGA GGGAGACAAG ACCATCGTGG GCTCCATCAC CAACACCAAC 
TTTGGCATCT GCCATGACGC TGGACGCTCC AAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPS ( NM_001832.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001823.1 Homo sapiens colipase (CLPS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29002
Clone ID Related Accession (Same CDS sequence)	NM_001832.3 , NM_001832.4
Accession Version	NM_001832.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	colipase isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP324927.1. On May 17, 2019 this sequence version replaced NM_001832.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP324927.1, BP322637.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151405, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259938.7/ ENSP00000259938.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAAGA TCCTGATCCT CCTGCTTGTC GCCCTCTCTG TGGCCTATGC AGCTCCTGGC 
CCCCGGGGGA TCATTATCAA CCTGGAGAAC GGTGAGCTCT GCATGAATAG TGCCCAGTGT 
AAGAGCAATT GCTGCCAGCA TTCAAGTGCG CTGGGCCTGG CCCGCTGCAC ATCCATGGCC 
AGCGAGAACA GCGAGTGCTC TGTCAAGACG CTCTATGGGA TTTACTACAA GTGTCCCTGT 
GAGCGTGGCC TGACCTGTGA GGGAGACAAG ACCATCGTGG GCTCCATCAC CAACACCAAC 
TTTGGCATCT GCCATGACGC TGGACGCTCC AAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001823.1
CDS	36..374
Translation	MEKILILLLVALSVAYAAPGPRGIIINLENGELCMNSAQCKSNCCQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ

Target ORF information:

RefSeq Version	NM_001832.4
Organism	Homo sapiens(human)
Definition	Homo sapiens colipase (CLPS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001832.4

ORF Insert Sequence:

ATGGAGAAGA TCCTGATCCT CCTGCTTGTC GCCCTCTCTG TGGCCTATGC AGCTCCTGGC 
CCCCGGGGGA TCATTATCAA CCTGGAGAAC GGTGAGCTCT GCATGAATAG TGCCCAGTGT 
AAGAGCAATT GCTGCCAGCA TTCAAGTGCG CTGGGCCTGG CCCGCTGCAC ATCCATGGCC 
AGCGAGAACA GCGAGTGCTC TGTCAAGACG CTCTATGGGA TTTACTACAA GTGTCCCTGT 
GAGCGTGGCC TGACCTGTGA GGGAGACAAG ACCATCGTGG GCTCCATCAC CAACACCAAC 
TTTGGCATCT GCCATGACGC TGGACGCTCC AAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPS ( NM_001252598.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001239527.1 Homo sapiens colipase (CLPS), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu55900
Clone ID Related Accession (Same CDS sequence)	NM_001252598.1
Accession Version	NM_001252598.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	colipase isoform 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ271978.1, BP324927.1 and BP321569.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP321569.1, AW583243.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2151405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGAAGA TCCTGATCCT CCTGCTTGTC GCCCTCTCTG TGGCCTATGC AGCTCCTGGC 
CCCCGGGGGA TCATTATCAA CCTGACGCTC TATGGGATTT ACTACAAGTG TCCCTGTGAG 
CGTGGCCTGA CCTGTGAGGG AGACAAGACC ATCGTGGGCT CCATCACCAA CACCAACTTT 
GGCATCTGCC ATGACGCTGG ACGCTCCAAG CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239527.1
CDS	57..272
Translation	MEKILILLLVALSVAYAAPGPRGIIINLTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ

Target ORF information:

RefSeq Version	NM_001252598.1
Organism	Homo sapiens(human)
Definition	Homo sapiens colipase (CLPS), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252598.1

ORF Insert Sequence:

ATGGAGAAGA TCCTGATCCT CCTGCTTGTC GCCCTCTCTG TGGCCTATGC AGCTCCTGGC 
CCCCGGGGGA TCATTATCAA CCTGACGCTC TATGGGATTT ACTACAAGTG TCCCTGTGAG 
CGTGGCCTGA CCTGTGAGGG AGACAAGACC ATCGTGGGCT CCATCACCAA CACCAACTTT 
GGCATCTGCC ATGACGCTGG ACGCTCCAAG CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPS ( NM_001252597.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001239526.1 Homo sapiens colipase (CLPS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55903
Clone ID Related Accession (Same CDS sequence)	NM_001252597.2 , NM_001252597.1
Accession Version	NM_001252597.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	colipase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ271978.1, BP322637.1, BI439786.1 and BP324927.1. On May 31, 2019 this sequence version replaced NM_001252597.1. Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. Translation of variant 2 begins in the alternate exon, and the resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI439786.1, BI324822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151405, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATTCTCC TGCCTCAGCC TCCCAAGAAG CTGGGATTAC AGGAGAACGG TGAGCTCTGC 
ATGAATAGTG CCCAGTGTAA GAGCAATTGC TGCCAGCATT CAAGTGCGCT GGGCCTGGCC 
CGCTGCACAT CCATGGCCAG CGAGAACAGC GAGTGCTCTG TCAAGACGCT CTATGGGATT 
TACTACAAGT GTCCCTGTGA GCGTGGCCTG ACCTGTGAGG GAGACAAGAC CATCGTGGGC 
TCCATCACCA ACACCAACTT TGGCATCTGC CATGACGCTG GACGCTCCAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239526.1
CDS	176..472
Translation	MILLPQPPKKLGLQENGELCMNSAQCKSNCCQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ

Target ORF information:

RefSeq Version	NM_001252597.2
Organism	Homo sapiens(human)
Definition	Homo sapiens colipase (CLPS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252597.2

ORF Insert Sequence:

ATGATTCTCC TGCCTCAGCC TCCCAAGAAG CTGGGATTAC AGGAGAACGG TGAGCTCTGC 
ATGAATAGTG CCCAGTGTAA GAGCAATTGC TGCCAGCATT CAAGTGCGCT GGGCCTGGCC 
CGCTGCACAT CCATGGCCAG CGAGAACAGC GAGTGCTCTG TCAAGACGCT CTATGGGATT 
TACTACAAGT GTCCCTGTGA GCGTGGCCTG ACCTGTGAGG GAGACAAGAC CATCGTGGGC 
TCCATCACCA ACACCAACTT TGGCATCTGC CATGACGCTG GACGCTCCAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPS ( NM_001252597.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001239526.1 Homo sapiens colipase (CLPS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55903
Clone ID Related Accession (Same CDS sequence)	NM_001252597.2 , NM_001252597.1
Accession Version	NM_001252597.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	colipase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ271978.1, BP322637.1, BI439786.1 and BP324927.1. Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. Translation of variant 2 begins in the alternate exon, and the resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI439786.1, BI324822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151405, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATTCTCC TGCCTCAGCC TCCCAAGAAG CTGGGATTAC AGGAGAACGG TGAGCTCTGC 
ATGAATAGTG CCCAGTGTAA GAGCAATTGC TGCCAGCATT CAAGTGCGCT GGGCCTGGCC 
CGCTGCACAT CCATGGCCAG CGAGAACAGC GAGTGCTCTG TCAAGACGCT CTATGGGATT 
TACTACAAGT GTCCCTGTGA GCGTGGCCTG ACCTGTGAGG GAGACAAGAC CATCGTGGGC 
TCCATCACCA ACACCAACTT TGGCATCTGC CATGACGCTG GACGCTCCAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239526.1
CDS	197..493
Translation	MILLPQPPKKLGLQENGELCMNSAQCKSNCCQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGICHDAGRSKQ

Target ORF information:

RefSeq Version	NM_001252597.1
Organism	Homo sapiens(human)
Definition	Homo sapiens colipase (CLPS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252597.1

ORF Insert Sequence:

ATGATTCTCC TGCCTCAGCC TCCCAAGAAG CTGGGATTAC AGGAGAACGG TGAGCTCTGC 
ATGAATAGTG CCCAGTGTAA GAGCAATTGC TGCCAGCATT CAAGTGCGCT GGGCCTGGCC 
CGCTGCACAT CCATGGCCAG CGAGAACAGC GAGTGCTCTG TCAAGACGCT CTATGGGATT 
TACTACAAGT GTCCCTGTGA GCGTGGCCTG ACCTGTGAGG GAGACAAGAC CATCGTGGGC 
TCCATCACCA ACACCAACTT TGGCATCTGC CATGACGCTG GACGCTCCAA GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research19(18)4983-93(2013 Sep)
Zhang G,He P,Tan H,Budhu A,Gaedcke J,Ghadimi BM,Ried T,Yfantis HG,Lee DH,Maitra A,Hanna N,Alexander HR,Hussain SP

The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding.
Journal of lipid research54(2)514-21(2013 Feb)
Xiao X,Ferguson MR,Magee KE,Hale PD,Wang Y,Lowe ME

Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association117(2)83-7(2009 Feb)
Weyrich P,Albet S,Lammers R,Machicao F,Fritsche A,Stefan N,H?ring HU

Procolipase gene: no association with early-onset obesity or fat intake.
Obesity facts2(1)40-4(2009)
Wermter AK,Scherag A,Holter K,Reichwald K,Lichtner P,Siegfried W,Blundell J,Lawton C,Whybrow S,Stubbs J,Arch JR,Meitinger T,Platzer M,Hinney A,Hebebrand J

A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides.
Journal of lipid research48(11)2478-84(2007 Nov)
D'Silva S,Xiao X,Lowe ME

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CLPS cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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