TPP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TPP1
Entrez Gene ID	1200
Full Name	tripeptidyl peptidase 1
Synonyms	CLN2,GIG1,LPIC,SCAR7,TPP-1
General protein information	Preferred Names tripeptidyl peptidase 1 Names tripeptidyl-peptidase 1 cell growth-inhibiting gene 1 protein growth-inhibiting protein 1 lysosomal pepstatin insensitive protease tripeptidyl aminopeptidase tripeptidyl peptidase I
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008].
Disorder MIM:	607998
Disorder Html:	Ceroid lipofuscinosis, neuronal, 2, 204500 (3); Spinocerebellar ataxia, autosomal recessive 7, 609270 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000391.4	NP_000382.3	tripeptidyl-peptidase 1 preproprotein
NM_000391.3	NP_000382.3	tripeptidyl-peptidase 1 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TPP1	NP_001013025.1
Rattus norvegicus (Norway rat)	Tpp1	NP_112647.1
Gallus gallus (chicken)	TPP1	XP_423326.3
Magnaporthe oryzae (rice blast fungus)	MGG_07404	XP_003711284.1
Homo sapiens (human)	TPP1	NP_000382.3
	LOC709838	XP_001108748.1
Canis lupus familiaris (dog)	TPP1	NP_001013869.1
Bos taurus (cattle)	TPP1	NP_001069186.1
Xenopus tropicalis (tropical clawed frog)	tpp1	NP_001096294.1
Mus musculus (house mouse)	Tpp1	NP_034036.1
Danio rerio (zebrafish)	tpp1	NP_001122270.1
Neurospora crassa	NCU08418	XP_963178.1
Neurospora crassa	NCU10306	XP_001728119.1

Gene Ontology
Bibliography

Related articles in PubMed

Extraneuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression.
Katz ML, Johnson GC, Leach SB, Williamson BG, Coates JR, Whiting REH, Vansteenkiste DP, Whitney MS
Gene therapy24(4)215-223(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies indicate that optimal treatment outcomes for CLN2 disease may require delivery of TPP1 systemically as well as directly to the central nervous system.
Title: Extraneuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression.

TPP1 is overexpressed in hepatocellular carcinoma tissues and significantly correlated with poor prognosis of hepatocellular carcinoma patients.RFX5 acts as a direct positive transcriptional regulator of TPP1 in hepatocellular carcinoma.
Title: The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.

Together, these functional data combined with biophysical analyses and homology modeling provide a molecular understanding of the diverse contributions of TPP1 in telomere maintenance.
Title: Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.

To confirm clinical suspicion of CLN2 disease, the recommended gold standard for laboratory diagnosis is demonstration of deficient TPP1 enzyme activity (in leukocytes, fibroblasts, or dried blood spots) and the identification of causative mutations in each allele of the TPP1/CLN2 gene.
Title: Diagnosis of neuronal ceroid lipofuscinosis type 2 (CLN2 disease): Expert recommendations for early detection and laboratory diagnosis.

We found that NEK6-mediated phosphorylation of TPP1 Ser255 in G2/M phase regulates the association between telomerase activity and TPP1. Furthermore, we found evidence that POT1 negatively regulates TPP1 phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 mutant lacking its OB-fold domains
Title: NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment.

The following TPP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TPP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28414	NM_000391.4 Latest version!	Homo sapiens tripeptidyl peptidase 1 (TPP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu28414	NM_000391.3	Homo sapiens tripeptidyl peptidase 1 (TPP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TPP1 ( NM_000391.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000382.3 Homo sapiens tripeptidyl peptidase 1 (TPP1), mRNA.

Price & Availability↑

CloneID	OHu28414
Clone ID Related Accession (Same CDS sequence)	NM_000391.4 , NM_000391.3
Accession Version	NM_000391.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1692bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	tripeptidyl-peptidase 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP279860.1, BC014863.1, AC091564.12 and AI023962.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_000391.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.99248.1, SRR1803617.135364.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299427.12/ ENSP00000299427.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGACTCC AAGCCTGCCT CCTAGGGCTC TTTGCCCTCA TCCTCTCTGG CAAATGCAGT 
TACAGCCCGG AGCCCGACCA GCGGAGGACG CTGCCCCCAG GCTGGGTGTC CCTGGGCCGT 
GCGGACCCTG AGGAAGAGCT GAGTCTCACC TTTGCCCTGA GACAGCAGAA TGTGGAAAGA 
CTCTCGGAGC TGGTGCAGGC TGTGTCGGAT CCCAGCTCTC CTCAATACGG AAAATACCTG 
ACCCTAGAGA ATGTGGCTGA TCTGGTGAGG CCATCCCCAC TGACCCTCCA CACGGTGCAA 
AAATGGCTCT TGGCAGCCGG AGCCCAGAAG TGCCATTCTG TGATCACACA GGACTTTCTG 
ACTTGCTGGC TGAGCATCCG ACAAGCAGAG CTGCTGCTCC CTGGGGCTGA GTTTCATCAC 
TATGTGGGAG GACCTACGGA AACCCATGTT GTAAGGTCCC CACATCCCTA CCAGCTTCCA 
CAGGCCTTGG CCCCCCATGT GGACTTTGTG GGGGGACTGC ACCGTTTTCC CCCAACATCA 
TCCCTGAGGC AACGTCCTGA GCCGCAGGTG ACAGGGACTG TAGGCCTGCA TCTGGGGGTA 
ACCCCCTCTG TGATCCGTAA GCGATACAAC TTGACCTCAC AAGACGTGGG CTCTGGCACC 
AGCAATAACA GCCAAGCCTG TGCCCAGTTC CTGGAGCAGT ATTTCCATGA CTCAGACCTG 
GCTCAGTTCA TGCGCCTCTT CGGTGGCAAC TTTGCACATC AGGCATCAGT AGCCCGTGTG 
GTTGGACAAC AGGGCCGGGG CCGGGCCGGG ATTGAGGCCA GTCTAGATGT GCAGTACCTG 
ATGAGTGCTG GTGCCAACAT CTCCACCTGG GTCTACAGTA GCCCTGGCCG GCATGAGGGA 
CAGGAGCCCT TCCTGCAGTG GCTCATGCTG CTCAGTAATG AGTCAGCCCT GCCACATGTG 
CATACTGTGA GCTATGGAGA TGATGAGGAC TCCCTCAGCA GCGCCTACAT CCAGCGGGTC 
AACACTGAGC TCATGAAGGC TGCCGCTCGG GGTCTCACCC TGCTCTTCGC CTCAGGTGAC 
AGTGGGGCCG GGTGTTGGTC TGTCTCTGGA AGACACCAGT TCCGCCCTAC CTTCCCTGCC 
TCCAGCCCCT ATGTCACCAC AGTGGGAGGC ACATCCTTCC AGGAACCTTT CCTCATCACA 
AATGAAATTG TTGACTATAT CAGTGGTGGT GGCTTCAGCA ATGTGTTCCC ACGGCCTTCA 
TACCAGGAGG AAGCTGTAAC GAAGTTCCTG AGCTCTAGCC CCCACCTGCC ACCATCCAGT 
TACTTCAATG CCAGTGGCCG TGCCTACCCA GATGTGGCTG CACTTTCTGA TGGCTACTGG 
GTGGTCAGCA ACAGAGTGCC CATTCCATGG GTGTCCGGAA CCTCGGCCTC TACTCCAGTG 
TTTGGGGGGA TCCTATCCTT GATCAATGAG CACAGGATCC TTAGTGGCCG CCCCCCTCTT 
GGCTTTCTCA ACCCAAGGCT CTACCAGCAG CATGGGGCAG GACTCTTTGA TGTAACCCGT 
GGCTGCCATG AGTCCTGTCT GGATGAAGAG GTAGAGGGCC AGGGTTTCTG CTCTGGTCCT 
GGCTGGGATC CTGTAACAGG CTGGGGAACA CCCAACTTCC CAGCTTTGCT GAAGACTCTA 
CTCAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000382.3
CDS	23..1714
Translation	MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP

Target ORF information:

RefSeq Version	NM_000391.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tripeptidyl peptidase 1 (TPP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000391.4

ORF Insert Sequence:

ATGGGACTCC AAGCCTGCCT CCTAGGGCTC TTTGCCCTCA TCCTCTCTGG CAAATGCAGT 
TACAGCCCGG AGCCCGACCA GCGGAGGACG CTGCCCCCAG GCTGGGTGTC CCTGGGCCGT 
GCGGACCCTG AGGAAGAGCT GAGTCTCACC TTTGCCCTGA GACAGCAGAA TGTGGAAAGA 
CTCTCGGAGC TGGTGCAGGC TGTGTCGGAT CCCAGCTCTC CTCAATACGG AAAATACCTG 
ACCCTAGAGA ATGTGGCTGA TCTGGTGAGG CCATCCCCAC TGACCCTCCA CACGGTGCAA 
AAATGGCTCT TGGCAGCCGG AGCCCAGAAG TGCCATTCTG TGATCACACA GGACTTTCTG 
ACTTGCTGGC TGAGCATCCG ACAAGCAGAG CTGCTGCTCC CTGGGGCTGA GTTTCATCAC 
TATGTGGGAG GACCTACGGA AACCCATGTT GTAAGGTCCC CACATCCCTA CCAGCTTCCA 
CAGGCCTTGG CCCCCCATGT GGACTTTGTG GGGGGACTGC ACCGTTTTCC CCCAACATCA 
TCCCTGAGGC AACGTCCTGA GCCGCAGGTG ACAGGGACTG TAGGCCTGCA TCTGGGGGTA 
ACCCCCTCTG TGATCCGTAA GCGATACAAC TTGACCTCAC AAGACGTGGG CTCTGGCACC 
AGCAATAACA GCCAAGCCTG TGCCCAGTTC CTGGAGCAGT ATTTCCATGA CTCAGACCTG 
GCTCAGTTCA TGCGCCTCTT CGGTGGCAAC TTTGCACATC AGGCATCAGT AGCCCGTGTG 
GTTGGACAAC AGGGCCGGGG CCGGGCCGGG ATTGAGGCCA GTCTAGATGT GCAGTACCTG 
ATGAGTGCTG GTGCCAACAT CTCCACCTGG GTCTACAGTA GCCCTGGCCG GCATGAGGGA 
CAGGAGCCCT TCCTGCAGTG GCTCATGCTG CTCAGTAATG AGTCAGCCCT GCCACATGTG 
CATACTGTGA GCTATGGAGA TGATGAGGAC TCCCTCAGCA GCGCCTACAT CCAGCGGGTC 
AACACTGAGC TCATGAAGGC TGCCGCTCGG GGTCTCACCC TGCTCTTCGC CTCAGGTGAC 
AGTGGGGCCG GGTGTTGGTC TGTCTCTGGA AGACACCAGT TCCGCCCTAC CTTCCCTGCC 
TCCAGCCCCT ATGTCACCAC AGTGGGAGGC ACATCCTTCC AGGAACCTTT CCTCATCACA 
AATGAAATTG TTGACTATAT CAGTGGTGGT GGCTTCAGCA ATGTGTTCCC ACGGCCTTCA 
TACCAGGAGG AAGCTGTAAC GAAGTTCCTG AGCTCTAGCC CCCACCTGCC ACCATCCAGT 
TACTTCAATG CCAGTGGCCG TGCCTACCCA GATGTGGCTG CACTTTCTGA TGGCTACTGG 
GTGGTCAGCA ACAGAGTGCC CATTCCATGG GTGTCCGGAA CCTCGGCCTC TACTCCAGTG 
TTTGGGGGGA TCCTATCCTT GATCAATGAG CACAGGATCC TTAGTGGCCG CCCCCCTCTT 
GGCTTTCTCA ACCCAAGGCT CTACCAGCAG CATGGGGCAG GACTCTTTGA TGTAACCCGT 
GGCTGCCATG AGTCCTGTCT GGATGAAGAG GTAGAGGGCC AGGGTTTCTG CTCTGGTCCT 
GGCTGGGATC CTGTAACAGG CTGGGGAACA CCCAACTTCC CAGCTTTGCT GAAGACTCTA 
CTCAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TPP1 ( NM_000391.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000382.3 Homo sapiens tripeptidyl peptidase 1 (TPP1), mRNA.

Price & Availability↑

CloneID	OHu28414
Clone ID Related Accession (Same CDS sequence)	NM_000391.4 , NM_000391.3
Accession Version	NM_000391.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1692bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	tripeptidyl-peptidase 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP287220.1, BP279860.1, BC014863.1, AC091564.12 and AI023962.1. This sequence is a reference standard in the RefSeqGene project. On Dec 1, 2006 this sequence version replaced NM_000391.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.237744.1, SRR1803613.201514.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:11054422) ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGACTCC AAGCCTGCCT CCTAGGGCTC TTTGCCCTCA TCCTCTCTGG CAAATGCAGT 
TACAGCCCGG AGCCCGACCA GCGGAGGACG CTGCCCCCAG GCTGGGTGTC CCTGGGCCGT 
GCGGACCCTG AGGAAGAGCT GAGTCTCACC TTTGCCCTGA GACAGCAGAA TGTGGAAAGA 
CTCTCGGAGC TGGTGCAGGC TGTGTCGGAT CCCAGCTCTC CTCAATACGG AAAATACCTG 
ACCCTAGAGA ATGTGGCTGA TCTGGTGAGG CCATCCCCAC TGACCCTCCA CACGGTGCAA 
AAATGGCTCT TGGCAGCCGG AGCCCAGAAG TGCCATTCTG TGATCACACA GGACTTTCTG 
ACTTGCTGGC TGAGCATCCG ACAAGCAGAG CTGCTGCTCC CTGGGGCTGA GTTTCATCAC 
TATGTGGGAG GACCTACGGA AACCCATGTT GTAAGGTCCC CACATCCCTA CCAGCTTCCA 
CAGGCCTTGG CCCCCCATGT GGACTTTGTG GGGGGACTGC ACCGTTTTCC CCCAACATCA 
TCCCTGAGGC AACGTCCTGA GCCGCAGGTG ACAGGGACTG TAGGCCTGCA TCTGGGGGTA 
ACCCCCTCTG TGATCCGTAA GCGATACAAC TTGACCTCAC AAGACGTGGG CTCTGGCACC 
AGCAATAACA GCCAAGCCTG TGCCCAGTTC CTGGAGCAGT ATTTCCATGA CTCAGACCTG 
GCTCAGTTCA TGCGCCTCTT CGGTGGCAAC TTTGCACATC AGGCATCAGT AGCCCGTGTG 
GTTGGACAAC AGGGCCGGGG CCGGGCCGGG ATTGAGGCCA GTCTAGATGT GCAGTACCTG 
ATGAGTGCTG GTGCCAACAT CTCCACCTGG GTCTACAGTA GCCCTGGCCG GCATGAGGGA 
CAGGAGCCCT TCCTGCAGTG GCTCATGCTG CTCAGTAATG AGTCAGCCCT GCCACATGTG 
CATACTGTGA GCTATGGAGA TGATGAGGAC TCCCTCAGCA GCGCCTACAT CCAGCGGGTC 
AACACTGAGC TCATGAAGGC TGCCGCTCGG GGTCTCACCC TGCTCTTCGC CTCAGGTGAC 
AGTGGGGCCG GGTGTTGGTC TGTCTCTGGA AGACACCAGT TCCGCCCTAC CTTCCCTGCC 
TCCAGCCCCT ATGTCACCAC AGTGGGAGGC ACATCCTTCC AGGAACCTTT CCTCATCACA 
AATGAAATTG TTGACTATAT CAGTGGTGGT GGCTTCAGCA ATGTGTTCCC ACGGCCTTCA 
TACCAGGAGG AAGCTGTAAC GAAGTTCCTG AGCTCTAGCC CCCACCTGCC ACCATCCAGT 
TACTTCAATG CCAGTGGCCG TGCCTACCCA GATGTGGCTG CACTTTCTGA TGGCTACTGG 
GTGGTCAGCA ACAGAGTGCC CATTCCATGG GTGTCCGGAA CCTCGGCCTC TACTCCAGTG 
TTTGGGGGGA TCCTATCCTT GATCAATGAG CACAGGATCC TTAGTGGCCG CCCCCCTCTT 
GGCTTTCTCA ACCCAAGGCT CTACCAGCAG CATGGGGCAG GACTCTTTGA TGTAACCCGT 
GGCTGCCATG AGTCCTGTCT GGATGAAGAG GTAGAGGGCC AGGGTTTCTG CTCTGGTCCT 
GGCTGGGATC CTGTAACAGG CTGGGGAACA CCCAACTTCC CAGCTTTGCT GAAGACTCTA 
CTCAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000382.3
CDS	62..1753
Translation	MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP

Target ORF information:

RefSeq Version	NM_000391.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tripeptidyl peptidase 1 (TPP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000391.3

ORF Insert Sequence:

ATGGGACTCC AAGCCTGCCT CCTAGGGCTC TTTGCCCTCA TCCTCTCTGG CAAATGCAGT 
TACAGCCCGG AGCCCGACCA GCGGAGGACG CTGCCCCCAG GCTGGGTGTC CCTGGGCCGT 
GCGGACCCTG AGGAAGAGCT GAGTCTCACC TTTGCCCTGA GACAGCAGAA TGTGGAAAGA 
CTCTCGGAGC TGGTGCAGGC TGTGTCGGAT CCCAGCTCTC CTCAATACGG AAAATACCTG 
ACCCTAGAGA ATGTGGCTGA TCTGGTGAGG CCATCCCCAC TGACCCTCCA CACGGTGCAA 
AAATGGCTCT TGGCAGCCGG AGCCCAGAAG TGCCATTCTG TGATCACACA GGACTTTCTG 
ACTTGCTGGC TGAGCATCCG ACAAGCAGAG CTGCTGCTCC CTGGGGCTGA GTTTCATCAC 
TATGTGGGAG GACCTACGGA AACCCATGTT GTAAGGTCCC CACATCCCTA CCAGCTTCCA 
CAGGCCTTGG CCCCCCATGT GGACTTTGTG GGGGGACTGC ACCGTTTTCC CCCAACATCA 
TCCCTGAGGC AACGTCCTGA GCCGCAGGTG ACAGGGACTG TAGGCCTGCA TCTGGGGGTA 
ACCCCCTCTG TGATCCGTAA GCGATACAAC TTGACCTCAC AAGACGTGGG CTCTGGCACC 
AGCAATAACA GCCAAGCCTG TGCCCAGTTC CTGGAGCAGT ATTTCCATGA CTCAGACCTG 
GCTCAGTTCA TGCGCCTCTT CGGTGGCAAC TTTGCACATC AGGCATCAGT AGCCCGTGTG 
GTTGGACAAC AGGGCCGGGG CCGGGCCGGG ATTGAGGCCA GTCTAGATGT GCAGTACCTG 
ATGAGTGCTG GTGCCAACAT CTCCACCTGG GTCTACAGTA GCCCTGGCCG GCATGAGGGA 
CAGGAGCCCT TCCTGCAGTG GCTCATGCTG CTCAGTAATG AGTCAGCCCT GCCACATGTG 
CATACTGTGA GCTATGGAGA TGATGAGGAC TCCCTCAGCA GCGCCTACAT CCAGCGGGTC 
AACACTGAGC TCATGAAGGC TGCCGCTCGG GGTCTCACCC TGCTCTTCGC CTCAGGTGAC 
AGTGGGGCCG GGTGTTGGTC TGTCTCTGGA AGACACCAGT TCCGCCCTAC CTTCCCTGCC 
TCCAGCCCCT ATGTCACCAC AGTGGGAGGC ACATCCTTCC AGGAACCTTT CCTCATCACA 
AATGAAATTG TTGACTATAT CAGTGGTGGT GGCTTCAGCA ATGTGTTCCC ACGGCCTTCA 
TACCAGGAGG AAGCTGTAAC GAAGTTCCTG AGCTCTAGCC CCCACCTGCC ACCATCCAGT 
TACTTCAATG CCAGTGGCCG TGCCTACCCA GATGTGGCTG CACTTTCTGA TGGCTACTGG 
GTGGTCAGCA ACAGAGTGCC CATTCCATGG GTGTCCGGAA CCTCGGCCTC TACTCCAGTG 
TTTGGGGGGA TCCTATCCTT GATCAATGAG CACAGGATCC TTAGTGGCCG CCCCCCTCTT 
GGCTTTCTCA ACCCAAGGCT CTACCAGCAG CATGGGGCAG GACTCTTTGA TGTAACCCGT 
GGCTGCCATG AGTCCTGTCT GGATGAAGAG GTAGAGGGCC AGGGTTTCTG CTCTGGTCCT 
GGCTGGGATC CTGTAACAGG CTGGGGAACA CCCAACTTCC CAGCTTTGCT GAAGACTCTA 
CTCAACCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Extraneuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression.
Gene therapy24(4)215-223(2017 Apr)
Katz ML,Johnson GC,Leach SB,Williamson BG,Coates JR,Whiting REH,Vansteenkiste DP,Whitney MS

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

TPP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報