CLCN7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLCN7
Entrez Gene ID	1186
Full Name	chloride voltage-gated channel 7
Synonyms	CLC-7,CLC7,OPTA2,OPTB4,PPP1R63
General protein information	Preferred Names chloride voltage-gated channel 7 Names H(+)/Cl(-) exchange transporter 7 chloride channel 7 alpha subunit chloride channel protein 7 chloride channel, voltage-sensitive 7 protein phosphatase 1, regulatory subunit 63
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008].
Disorder MIM:	602727
Disorder Html:	Osteopetrosis, autosomal recessive 4, 611490 (3); Osteopetrosis, autosomal dominant 2, 166600 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001287.5	NP_001278.1	H(+)/Cl(-) exchange transporter 7 isoform a
NM_001114331.2	NP_001107803.1	H(+)/Cl(-) exchange transporter 7 isoform b
XM_011522354.1	XP_011520656.1	H(+)/Cl(-) exchange transporter 7 isoform X1
NM_001287.6	NP_001278.1	H(+)/Cl(-) exchange transporter 7 isoform a

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CLCN7	NP_001025815.1
Homo sapiens (human)	CLCN7	NP_001278.1
Pan troglodytes (chimpanzee)	CLCN7	XP_001159424.1
	CLCN7	XP_002802404.1
Drosophila melanogaster (fruit fly)	ClC-b	NP_610798.1
Arabidopsis thaliana (thale cress)	AT5G33280	NP_198313.2
Canis lupus familiaris (dog)	CLCN7	XP_537014.2
Rattus norvegicus (Norway rat)	Clcn7	NP_113756.1
Danio rerio (zebrafish)	clcn7	NP_001071005.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007499	XP_308378.4
Arabidopsis thaliana (thale cress)	CLC-C	NP_199800.1
Xenopus tropicalis (tropical clawed frog)	clcn7	NP_001041533.1
Bos taurus (cattle)	CLCN7	NP_001020502.1
Mus musculus (house mouse)	Clcn7	NP_036060.1
Caenorhabditis elegans (roundworm)	clh-6	NP_506022.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel mutations of CLCN7 cause autosomal dominant osteopetrosis type II (ADOII) and intermediate autosomal recessive osteopetrosis (ARO) in seven Chinese families.
Zhang X, Wei Z, He J, Wang C, Zhang Z
Postgraduate medicine129(8)934-942(2017 Nov)

Autosomal dominant osteopetrosis associated with renal tubular acidosis is due to a CLCN7 mutation.
Piret SE, Gorvin CM, Trinh A, Taylor J, Lise S, Taylor JC, Ebeling PR, Thakker RV
American journal of medical genetics. Part A170(11)2988-2992(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present study revealed three novel mutations, showed the dense but brittle sclerotic bones of an autosomal dominant osteopetrosis type II (OPTA2) patient, characterized OPTA2 symptoms from benign to fatal and reported a rare intermediate case of autosomal recessive 4 in a Chinese population.
Title: Novel mutations of CLCN7 cause autosomal dominant osteopetrosis type II (ADOII) and intermediate autosomal recessive osteopetrosis (ARO) in seven Chinese families.

we identified a CLCN7 mutation in a family with autosomal dominant osteopetrosis, RTA, renal stones, epilepsy, and blindness.
Title: Autosomal dominant osteopetrosis associated with renal tubular acidosis is due to a CLCN7 mutation.

The present study identified seven novel mutations of the CLCN7 gene and reported the first case of intermediate autosomal recessive osteopetrosis. with compound heterozygous mutation in the Chinese population.
Title: Novel mutations of CLCN7 cause autosomal dominant osteopetrosis type II (ADO-II) and intermediate autosomal recessive osteopetrosis (IARO) in Chinese patients.

Exome sequencing and Sanger sequencing were conducted in Han Chinese family members, some of whom had typical osteopetrosis, and a novel missense variant c.2350A>T (p.R784W) in the chloride channel 7 gene (CLCN7) was identified.
Title: Novel CLCN7 mutation identified in a Han Chinese family with autosomal dominant osteopetrosis-2.

study demonstrates a wide heterogeneity in the progression of the phenotypes and expanded the mutational spectrum for the CLCN7 gene
Title: A novel mutation and a known mutation in the CLCN7 gene associated with relatively stable infantile malignant osteopetrosis in a Chinese patient.

The following CLCN7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLCN7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20641	NM_001287.6 Latest version!	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu56928	XM_011522354.1 Latest version!	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
OHu20440	NM_001114331.2 Latest version!	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu20641	NM_001287.5	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLCN7 ( NM_001287.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278.1 Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20641
Clone ID Related Accession (Same CDS sequence)	NM_001287.5 , NM_001287.6
Accession Version	NM_001287.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	H(+)/Cl(-) exchange transporter 7 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031705.25, BC012737.2, AL031600.4 and AA741117.1. This sequence is a reference standard in the RefSeqGene project. On Mar 7, 2012 this sequence version replaced NM_001287.4. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK122944.1, BC012737.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAACG TCTCTAAGAA GGTGTCCTGG TCCGGCCGGG ACCGGGACGA CGAGGAGGCG 
GCGCCGCTGC TGCGGAGGAC GGCGCGGCCC GGCGGGGGGA CGCCGCTGCT GAACGGGGCT 
GGGCCTGGGG CTGCGCGCCA GTCACCACGT TCTGCGCTTT TCCGAGTCGG ACATATGAGC 
AGCGTGGAGC TGGATGATGA ACTTTTGGAC CCGGATATGG ACCCTCCACA TCCCTTCCCC 
AAGGAGATCC CACACAACGA GAAGCTCCTG TCCCTCAAGT ATGAGAGCTT GGACTATGAC 
AACAGTGAGA ACCAGCTGTT CCTGGAGGAG GAGCGGCGGA TCAATCACAC GGCCTTCCGG 
ACGGTGGAGA TCAAGCGCTG GGTCATCTGC GCCCTCATTG GGATCCTCAC GGGCCTCGTG 
GCCTGCTTCA TTGACATCGT GGTGGAAAAC CTGGCTGGCC TCAAGTACAG GGTCATCAAG 
GGCAATATCG ACAAGTTCAC AGAGAAGGGC GGACTGTCCT TCTCCCTGTT GCTGTGGGCC 
ACGCTGAACG CCGCCTTCGT GCTCGTGGGC TCTGTGATTG TGGCTTTCAT AGAGCCGGTG 
GCTGCTGGCA GCGGAATCCC CCAGATCAAG TGCTTCCTCA ACGGGGTGAA GATCCCCCAC 
GTGGTGCGGC TCAAGACGTT GGTGATCAAA GTGTCCGGTG TGATCCTGTC CGTGGTCGGG 
GGCCTGGCCG TGGGAAAGGA AGGGCCGATG ATCCACTCAG GTTCAGTGAT TGCCGCCGGG 
ATCTCTCAGG GAAGGTCAAC GTCACTGAAA CGAGATTTCA AGATCTTCGA GTACTTCCGC 
AGAGACACAG AGAAGCGGGA CTTCGTCTCC GCAGGGGCTG CGGCCGGAGT GTCAGCGGCG 
TTTGGAGCCC CCGTGGGTGG GGTCCTGTTC AGCTTGGAGG AGGGTGCGTC CTTCTGGAAC 
CAGTTCCTGA CCTGGAGGAT CTTCTTTGCT TCCATGATCT CCACGTTCAC CCTGAATTTT 
GTTCTGAGCA TTTACCACGG GAACATGTGG GACCTGTCCA GCCCAGGCCT CATCAACTTC 
GGAAGGTTTG ACTCGGAGAA AATGGCCTAC ACGATCCACG AGATCCCGGT CTTCATCGCC 
ATGGGCGTGG TGGGCGGTGT GCTTGGAGCA GTGTTCAATG CCTTGAACTA CTGGCTGACC 
ATGTTTCGAA TCAGGTACAT CCACCGGCCC TGCCTGCAGG TGATTGAGGC CGTGCTGGTG 
GCCGCCGTCA CGGCCACAGT TGCCTTCGTG CTGATCTACT CGTCGCGGGA TTGCCAGCCC 
CTGCAGGGGG GCTCCATGTC CTACCCGCTG CAGCTCTTTT GTGCAGATGG CGAGTACAAC 
TCCATGGCTG CGGCCTTCTT CAACACCCCG GAGAAGAGCG TGGTGAGCCT CTTCCACGAC 
CCGCCAGGCT CCTACAACCC CCTGACCCTC GGCCTGTTCA CGCTGGTCTA CTTCTTCCTG 
GCCTGCTGGA CCTACGGGCT CACGGTGTCT GCCGGGGTCT TCATCCCGTC CCTGCTCATC 
GGGGCTGCCT GGGGCCGGCT CTTTGGGATC TCCCTGTCCT ACCTCACGGG GGCGGCGATC 
TGGGCGGACC CCGGCAAATA CGCCCTGATG GGAGCTGCTG CCCAGCTGGG CGGGATTGTG 
CGGATGACAC TGAGCCTGAC CGTCATCATG ATGGAGGCCA CCAGCAACGT GACCTACGGC 
TTCCCCATCA TGCTGGTGCT CATGACCGCC AAGATCGTGG GCGACGTCTT CATTGAGGGC 
CTGTACGACA TGCACATTCA GCTGCAGAGT GTGCCCTTCC TGCACTGGGA GGCCCCGGTC 
ACCTCACACT CACTCACTGC CAGGGAGGTG ATGAGCACAC CAGTGACCTG CCTGAGGCGG 
CGTGAGAAGG TCGGCGTCAT TGTGGACGTG CTGAGCGACA CGGCGTCCAA TCACAACGGC 
TTCCCCGTGG TGGAGCATGC CGATGACACC CAGCCTGCCC GGCTCCAGGG CCTGATCCTG 
CGCTCCCAGC TCATCGTTCT CCTAAAGCAC AAGGTGTTTG TGGAGCGGTC CAACCTGGGC 
CTGGTACAGC GGCGCCTGAG GCTGAAGGAC TTCCGAGACG CCTACCCGCG CTTCCCACCC 
ATCCAGTCCA TCCACGTGTC CCAGGACGAG CGGGAGTGCA CCATGGACCT CTCCGAGTTC 
ATGAACCCCT CCCCCTACAC GGTGCCCCAG GAGGCGTCGC TCCCACGGGT GTTCAAGCTG 
TTCCGGGCCC TGGGCCTGCG GCACCTGGTG GTGGTGGACA ACCGCAATCA GGTTGTCGGG 
TTGGTGACCA GGAAGGACCT CGCCAGGTAC CGCCTGGGAA AGAGAGGCTT GGAGGAGCTC 
TCGCTGGCCC AGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278.1
CDS	111..2528
Translation	MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT

Target ORF information:

RefSeq Version	NM_001287.5
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001287.5

ORF Insert Sequence:

ATGGCCAACG TCTCTAAGAA GGTGTCCTGG TCCGGCCGGG ACCGGGACGA CGAGGAGGCG 
GCGCCGCTGC TGCGGAGGAC GGCGCGGCCC GGCGGGGGGA CGCCGCTGCT GAACGGGGCT 
GGGCCTGGGG CTGCGCGCCA GTCACCACGT TCTGCGCTTT TCCGAGTCGG ACATATGAGC 
AGCGTGGAGC TGGATGATGA ACTTTTGGAC CCGGATATGG ACCCTCCACA TCCCTTCCCC 
AAGGAGATCC CACACAACGA GAAGCTCCTG TCCCTCAAGT ATGAGAGCTT GGACTATGAC 
AACAGTGAGA ACCAGCTGTT CCTGGAGGAG GAGCGGCGGA TCAATCACAC GGCCTTCCGG 
ACGGTGGAGA TCAAGCGCTG GGTCATCTGC GCCCTCATTG GGATCCTCAC GGGCCTCGTG 
GCCTGCTTCA TTGACATCGT GGTGGAAAAC CTGGCTGGCC TCAAGTACAG GGTCATCAAG 
GGCAATATCG ACAAGTTCAC AGAGAAGGGC GGACTGTCCT TCTCCCTGTT GCTGTGGGCC 
ACGCTGAACG CCGCCTTCGT GCTCGTGGGC TCTGTGATTG TGGCTTTCAT AGAGCCGGTG 
GCTGCTGGCA GCGGAATCCC CCAGATCAAG TGCTTCCTCA ACGGGGTGAA GATCCCCCAC 
GTGGTGCGGC TCAAGACGTT GGTGATCAAA GTGTCCGGTG TGATCCTGTC CGTGGTCGGG 
GGCCTGGCCG TGGGAAAGGA AGGGCCGATG ATCCACTCAG GTTCAGTGAT TGCCGCCGGG 
ATCTCTCAGG GAAGGTCAAC GTCACTGAAA CGAGATTTCA AGATCTTCGA GTACTTCCGC 
AGAGACACAG AGAAGCGGGA CTTCGTCTCC GCAGGGGCTG CGGCCGGAGT GTCAGCGGCG 
TTTGGAGCCC CCGTGGGTGG GGTCCTGTTC AGCTTGGAGG AGGGTGCGTC CTTCTGGAAC 
CAGTTCCTGA CCTGGAGGAT CTTCTTTGCT TCCATGATCT CCACGTTCAC CCTGAATTTT 
GTTCTGAGCA TTTACCACGG GAACATGTGG GACCTGTCCA GCCCAGGCCT CATCAACTTC 
GGAAGGTTTG ACTCGGAGAA AATGGCCTAC ACGATCCACG AGATCCCGGT CTTCATCGCC 
ATGGGCGTGG TGGGCGGTGT GCTTGGAGCA GTGTTCAATG CCTTGAACTA CTGGCTGACC 
ATGTTTCGAA TCAGGTACAT CCACCGGCCC TGCCTGCAGG TGATTGAGGC CGTGCTGGTG 
GCCGCCGTCA CGGCCACAGT TGCCTTCGTG CTGATCTACT CGTCGCGGGA TTGCCAGCCC 
CTGCAGGGGG GCTCCATGTC CTACCCGCTG CAGCTCTTTT GTGCAGATGG CGAGTACAAC 
TCCATGGCTG CGGCCTTCTT CAACACCCCG GAGAAGAGCG TGGTGAGCCT CTTCCACGAC 
CCGCCAGGCT CCTACAACCC CCTGACCCTC GGCCTGTTCA CGCTGGTCTA CTTCTTCCTG 
GCCTGCTGGA CCTACGGGCT CACGGTGTCT GCCGGGGTCT TCATCCCGTC CCTGCTCATC 
GGGGCTGCCT GGGGCCGGCT CTTTGGGATC TCCCTGTCCT ACCTCACGGG GGCGGCGATC 
TGGGCGGACC CCGGCAAATA CGCCCTGATG GGAGCTGCTG CCCAGCTGGG CGGGATTGTG 
CGGATGACAC TGAGCCTGAC CGTCATCATG ATGGAGGCCA CCAGCAACGT GACCTACGGC 
TTCCCCATCA TGCTGGTGCT CATGACCGCC AAGATCGTGG GCGACGTCTT CATTGAGGGC 
CTGTACGACA TGCACATTCA GCTGCAGAGT GTGCCCTTCC TGCACTGGGA GGCCCCGGTC 
ACCTCACACT CACTCACTGC CAGGGAGGTG ATGAGCACAC CAGTGACCTG CCTGAGGCGG 
CGTGAGAAGG TCGGCGTCAT TGTGGACGTG CTGAGCGACA CGGCGTCCAA TCACAACGGC 
TTCCCCGTGG TGGAGCATGC CGATGACACC CAGCCTGCCC GGCTCCAGGG CCTGATCCTG 
CGCTCCCAGC TCATCGTTCT CCTAAAGCAC AAGGTGTTTG TGGAGCGGTC CAACCTGGGC 
CTGGTACAGC GGCGCCTGAG GCTGAAGGAC TTCCGAGACG CCTACCCGCG CTTCCCACCC 
ATCCAGTCCA TCCACGTGTC CCAGGACGAG CGGGAGTGCA CCATGGACCT CTCCGAGTTC 
ATGAACCCCT CCCCCTACAC GGTGCCCCAG GAGGCGTCGC TCCCACGGGT GTTCAAGCTG 
TTCCGGGCCC TGGGCCTGCG GCACCTGGTG GTGGTGGACA ACCGCAATCA GGTTGTCGGG 
TTGGTGACCA GGAAGGACCT CGCCAGGTAC CGCCTGGGAA AGAGAGGCTT GGAGGAGCTC 
TCGCTGGCCC AGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLCN7 ( NM_001287.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001278.1 Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20641
Clone ID Related Accession (Same CDS sequence)	NM_001287.5 , NM_001287.6
Accession Version	NM_001287.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	H(+)/Cl(-) exchange transporter 7 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031705.25, BC012737.2, AL031600.4 and AA741117.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001287.5. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK122944.1, BC012737.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382745.9/ ENSP00000372193.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAACG TCTCTAAGAA GGTGTCCTGG TCCGGCCGGG ACCGGGACGA CGAGGAGGCG 
GCGCCGCTGC TGCGGAGGAC GGCGCGGCCC GGCGGGGGGA CGCCGCTGCT GAACGGGGCT 
GGGCCTGGGG CTGCGCGCCA GTCACCACGT TCTGCGCTTT TCCGAGTCGG ACATATGAGC 
AGCGTGGAGC TGGATGATGA ACTTTTGGAC CCGGATATGG ACCCTCCACA TCCCTTCCCC 
AAGGAGATCC CACACAACGA GAAGCTCCTG TCCCTCAAGT ATGAGAGCTT GGACTATGAC 
AACAGTGAGA ACCAGCTGTT CCTGGAGGAG GAGCGGCGGA TCAATCACAC GGCCTTCCGG 
ACGGTGGAGA TCAAGCGCTG GGTCATCTGC GCCCTCATTG GGATCCTCAC GGGCCTCGTG 
GCCTGCTTCA TTGACATCGT GGTGGAAAAC CTGGCTGGCC TCAAGTACAG GGTCATCAAG 
GGCAATATCG ACAAGTTCAC AGAGAAGGGC GGACTGTCCT TCTCCCTGTT GCTGTGGGCC 
ACGCTGAACG CCGCCTTCGT GCTCGTGGGC TCTGTGATTG TGGCTTTCAT AGAGCCGGTG 
GCTGCTGGCA GCGGAATCCC CCAGATCAAG TGCTTCCTCA ACGGGGTGAA GATCCCCCAC 
GTGGTGCGGC TCAAGACGTT GGTGATCAAA GTGTCCGGTG TGATCCTGTC CGTGGTCGGG 
GGCCTGGCCG TGGGAAAGGA AGGGCCGATG ATCCACTCAG GTTCAGTGAT TGCCGCCGGG 
ATCTCTCAGG GAAGGTCAAC GTCACTGAAA CGAGATTTCA AGATCTTCGA GTACTTCCGC 
AGAGACACAG AGAAGCGGGA CTTCGTCTCC GCAGGGGCTG CGGCCGGAGT GTCAGCGGCG 
TTTGGAGCCC CCGTGGGTGG GGTCCTGTTC AGCTTGGAGG AGGGTGCGTC CTTCTGGAAC 
CAGTTCCTGA CCTGGAGGAT CTTCTTTGCT TCCATGATCT CCACGTTCAC CCTGAATTTT 
GTTCTGAGCA TTTACCACGG GAACATGTGG GACCTGTCCA GCCCAGGCCT CATCAACTTC 
GGAAGGTTTG ACTCGGAGAA AATGGCCTAC ACGATCCACG AGATCCCGGT CTTCATCGCC 
ATGGGCGTGG TGGGCGGTGT GCTTGGAGCA GTGTTCAATG CCTTGAACTA CTGGCTGACC 
ATGTTTCGAA TCAGGTACAT CCACCGGCCC TGCCTGCAGG TGATTGAGGC CGTGCTGGTG 
GCCGCCGTCA CGGCCACAGT TGCCTTCGTG CTGATCTACT CGTCGCGGGA TTGCCAGCCC 
CTGCAGGGGG GCTCCATGTC CTACCCGCTG CAGCTCTTTT GTGCAGATGG CGAGTACAAC 
TCCATGGCTG CGGCCTTCTT CAACACCCCG GAGAAGAGCG TGGTGAGCCT CTTCCACGAC 
CCGCCAGGCT CCTACAACCC CCTGACCCTC GGCCTGTTCA CGCTGGTCTA CTTCTTCCTG 
GCCTGCTGGA CCTACGGGCT CACGGTGTCT GCCGGGGTCT TCATCCCGTC CCTGCTCATC 
GGGGCTGCCT GGGGCCGGCT CTTTGGGATC TCCCTGTCCT ACCTCACGGG GGCGGCGATC 
TGGGCGGACC CCGGCAAATA CGCCCTGATG GGAGCTGCTG CCCAGCTGGG CGGGATTGTG 
CGGATGACAC TGAGCCTGAC CGTCATCATG ATGGAGGCCA CCAGCAACGT GACCTACGGC 
TTCCCCATCA TGCTGGTGCT CATGACCGCC AAGATCGTGG GCGACGTCTT CATTGAGGGC 
CTGTACGACA TGCACATTCA GCTGCAGAGT GTGCCCTTCC TGCACTGGGA GGCCCCGGTC 
ACCTCACACT CACTCACTGC CAGGGAGGTG ATGAGCACAC CAGTGACCTG CCTGAGGCGG 
CGTGAGAAGG TCGGCGTCAT TGTGGACGTG CTGAGCGACA CGGCGTCCAA TCACAACGGC 
TTCCCCGTGG TGGAGCATGC CGATGACACC CAGCCTGCCC GGCTCCAGGG CCTGATCCTG 
CGCTCCCAGC TCATCGTTCT CCTAAAGCAC AAGGTGTTTG TGGAGCGGTC CAACCTGGGC 
CTGGTACAGC GGCGCCTGAG GCTGAAGGAC TTCCGAGACG CCTACCCGCG CTTCCCACCC 
ATCCAGTCCA TCCACGTGTC CCAGGACGAG CGGGAGTGCA CCATGGACCT CTCCGAGTTC 
ATGAACCCCT CCCCCTACAC GGTGCCCCAG GAGGCGTCGC TCCCACGGGT GTTCAAGCTG 
TTCCGGGCCC TGGGCCTGCG GCACCTGGTG GTGGTGGACA ACCGCAATCA GGTTGTCGGG 
TTGGTGACCA GGAAGGACCT CGCCAGGTAC CGCCTGGGAA AGAGAGGCTT GGAGGAGCTC 
TCGCTGGCCC AGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278.1
CDS	55..2472
Translation	MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT

Target ORF information:

RefSeq Version	NM_001287.6
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001287.6

ORF Insert Sequence:

ATGGCCAACG TCTCTAAGAA GGTGTCCTGG TCCGGCCGGG ACCGGGACGA CGAGGAGGCG 
GCGCCGCTGC TGCGGAGGAC GGCGCGGCCC GGCGGGGGGA CGCCGCTGCT GAACGGGGCT 
GGGCCTGGGG CTGCGCGCCA GTCACCACGT TCTGCGCTTT TCCGAGTCGG ACATATGAGC 
AGCGTGGAGC TGGATGATGA ACTTTTGGAC CCGGATATGG ACCCTCCACA TCCCTTCCCC 
AAGGAGATCC CACACAACGA GAAGCTCCTG TCCCTCAAGT ATGAGAGCTT GGACTATGAC 
AACAGTGAGA ACCAGCTGTT CCTGGAGGAG GAGCGGCGGA TCAATCACAC GGCCTTCCGG 
ACGGTGGAGA TCAAGCGCTG GGTCATCTGC GCCCTCATTG GGATCCTCAC GGGCCTCGTG 
GCCTGCTTCA TTGACATCGT GGTGGAAAAC CTGGCTGGCC TCAAGTACAG GGTCATCAAG 
GGCAATATCG ACAAGTTCAC AGAGAAGGGC GGACTGTCCT TCTCCCTGTT GCTGTGGGCC 
ACGCTGAACG CCGCCTTCGT GCTCGTGGGC TCTGTGATTG TGGCTTTCAT AGAGCCGGTG 
GCTGCTGGCA GCGGAATCCC CCAGATCAAG TGCTTCCTCA ACGGGGTGAA GATCCCCCAC 
GTGGTGCGGC TCAAGACGTT GGTGATCAAA GTGTCCGGTG TGATCCTGTC CGTGGTCGGG 
GGCCTGGCCG TGGGAAAGGA AGGGCCGATG ATCCACTCAG GTTCAGTGAT TGCCGCCGGG 
ATCTCTCAGG GAAGGTCAAC GTCACTGAAA CGAGATTTCA AGATCTTCGA GTACTTCCGC 
AGAGACACAG AGAAGCGGGA CTTCGTCTCC GCAGGGGCTG CGGCCGGAGT GTCAGCGGCG 
TTTGGAGCCC CCGTGGGTGG GGTCCTGTTC AGCTTGGAGG AGGGTGCGTC CTTCTGGAAC 
CAGTTCCTGA CCTGGAGGAT CTTCTTTGCT TCCATGATCT CCACGTTCAC CCTGAATTTT 
GTTCTGAGCA TTTACCACGG GAACATGTGG GACCTGTCCA GCCCAGGCCT CATCAACTTC 
GGAAGGTTTG ACTCGGAGAA AATGGCCTAC ACGATCCACG AGATCCCGGT CTTCATCGCC 
ATGGGCGTGG TGGGCGGTGT GCTTGGAGCA GTGTTCAATG CCTTGAACTA CTGGCTGACC 
ATGTTTCGAA TCAGGTACAT CCACCGGCCC TGCCTGCAGG TGATTGAGGC CGTGCTGGTG 
GCCGCCGTCA CGGCCACAGT TGCCTTCGTG CTGATCTACT CGTCGCGGGA TTGCCAGCCC 
CTGCAGGGGG GCTCCATGTC CTACCCGCTG CAGCTCTTTT GTGCAGATGG CGAGTACAAC 
TCCATGGCTG CGGCCTTCTT CAACACCCCG GAGAAGAGCG TGGTGAGCCT CTTCCACGAC 
CCGCCAGGCT CCTACAACCC CCTGACCCTC GGCCTGTTCA CGCTGGTCTA CTTCTTCCTG 
GCCTGCTGGA CCTACGGGCT CACGGTGTCT GCCGGGGTCT TCATCCCGTC CCTGCTCATC 
GGGGCTGCCT GGGGCCGGCT CTTTGGGATC TCCCTGTCCT ACCTCACGGG GGCGGCGATC 
TGGGCGGACC CCGGCAAATA CGCCCTGATG GGAGCTGCTG CCCAGCTGGG CGGGATTGTG 
CGGATGACAC TGAGCCTGAC CGTCATCATG ATGGAGGCCA CCAGCAACGT GACCTACGGC 
TTCCCCATCA TGCTGGTGCT CATGACCGCC AAGATCGTGG GCGACGTCTT CATTGAGGGC 
CTGTACGACA TGCACATTCA GCTGCAGAGT GTGCCCTTCC TGCACTGGGA GGCCCCGGTC 
ACCTCACACT CACTCACTGC CAGGGAGGTG ATGAGCACAC CAGTGACCTG CCTGAGGCGG 
CGTGAGAAGG TCGGCGTCAT TGTGGACGTG CTGAGCGACA CGGCGTCCAA TCACAACGGC 
TTCCCCGTGG TGGAGCATGC CGATGACACC CAGCCTGCCC GGCTCCAGGG CCTGATCCTG 
CGCTCCCAGC TCATCGTTCT CCTAAAGCAC AAGGTGTTTG TGGAGCGGTC CAACCTGGGC 
CTGGTACAGC GGCGCCTGAG GCTGAAGGAC TTCCGAGACG CCTACCCGCG CTTCCCACCC 
ATCCAGTCCA TCCACGTGTC CCAGGACGAG CGGGAGTGCA CCATGGACCT CTCCGAGTTC 
ATGAACCCCT CCCCCTACAC GGTGCCCCAG GAGGCGTCGC TCCCACGGGT GTTCAAGCTG 
TTCCGGGCCC TGGGCCTGCG GCACCTGGTG GTGGTGGACA ACCGCAATCA GGTTGTCGGG 
TTGGTGACCA GGAAGGACCT CGCCAGGTAC CGCCTGGGAA AGAGAGGCTT GGAGGAGCTC 
TCGCTGGCCC AGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLCN7 ( XM_011522354.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520656.1 Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant X1, mRNA.

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CloneID	OHu56928
Clone ID Related Accession (Same CDS sequence)	XM_011522354.1
Accession Version	XM_011522354.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2244bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	H(+)/Cl(-) exchange transporter 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAGCG TGGAGCTGGA TGATGAACTT TTGGACCCGG ATATGGACCC TCCACATCCC 
TTCCCCAAGG AGATCCCACA CAACGAGAAG CTCCTGTCCC TCAAGTATGA GAGCTTGGAC 
TATGACAACA GTGAGAACCA GCTGTTCCTG GAGGAGGAGC GGCGGATCAA TCACACGGCC 
TTCCGGACGG TGGAGATCAA GCGCTGGGTC ATCTGCGCCC TCATTGGGAT CCTCACGGGC 
CTCGTGGCCT GCTTCATTGA CATCGTGGTG GAAAACCTGG CTGGCCTCAA GTACAGGGTC 
ATCAAGGGCA ATATCGACAA GTTCACAGAG AAGGGCGGAC TGTCCTTCTC CCTGTTGCTG 
TGGGCCACGC TGAACGCCGC CTTCGTGCTC GTGGGCTCTG TGATTGTGGC TTTCATAGAG 
CCGGTGGCTG CTGGCAGCGG AATCCCCCAG ATCAAGTGCT TCCTCAACGG GGTGAAGATC 
CCCCACGTGG TGCGGCTCAA GACGTTGGTG ATCAAAGTGT CCGGTGTGAT CCTGTCCGTG 
GTCGGGGGCC TGGCCGTGGG AAAGGAAGGG CCGATGATCC ACTCAGGTTC AGTGATTGCC 
GCCGGGATCT CTCAGGGAAG GTCAACGTCA CTGAAACGAG ATTTCAAGAT CTTCGAGTAC 
TTCCGCAGAG ACACAGAGAA GCGGGACTTC GTCTCCGCAG GGGCTGCGGC CGGAGTGTCA 
GCGGCGTTTG GAGCCCCCGT GGGTGGGGTC CTGTTCAGCT TGGAGGAGGG TGCGTCCTTC 
TGGAACCAGT TCCTGACCTG GAGGATCTTC TTTGCTTCCA TGATCTCCAC GTTCACCCTG 
AATTTTGTTC TGAGCATTTA CCACGGGAAC ATGTGGGACC TGTCCAGCCC AGGCCTCATC 
AACTTCGGAA GGTTTGACTC GGAGAAAATG GCCTACACGA TCCACGAGAT CCCGGTCTTC 
ATCGCCATGG GCGTGGTGGG CGGTGTGCTT GGAGCAGTGT TCAATGCCTT GAACTACTGG 
CTGACCATGT TTCGAATCAG GTACATCCAC CGGCCCTGCC TGCAGGTGAT TGAGGCCGTG 
CTGGTGGCCG CCGTCACGGC CACAGTTGCC TTCGTGCTGA TCTACTCGTC GCGGGATTGC 
CAGCCCCTGC AGGGGGGCTC CATGTCCTAC CCGCTGCAGC TCTTTTGTGC AGATGGCGAG 
TACAACTCCA TGGCTGCGGC CTTCTTCAAC ACCCCGGAGA AGAGCGTGGT GAGCCTCTTC 
CACGACCCGC CAGGCTCCTA CAACCCCCTG ACCCTCGGCC TGTTCACGCT GGTCTACTTC 
TTCCTGGCCT GCTGGACCTA CGGGCTCACG GTGTCTGCCG GGGTCTTCAT CCCGTCCCTG 
CTCATCGGGG CTGCCTGGGG CCGGCTCTTT GGGATCTCCC TGTCCTACCT CACGGGGGCG 
GCGATCTGGG CGGACCCCGG CAAATACGCC CTGATGGGAG CTGCTGCCCA GCTGGGCGGG 
ATTGTGCGGA TGACACTGAG CCTGACCGTC ATCATGATGG AGGCCACCAG CAACGTGACC 
TACGGCTTCC CCATCATGCT GGTGCTCATG ACCGCCAAGA TCGTGGGCGA CGTCTTCATT 
GAGGGCCTGT ACGACATGCA CATTCAGCTG CAGAGTGTGC CCTTCCTGCA CTGGGAGGCC 
CCGGTCACCT CACACTCACT CACTGCCAGG GAGGTGATGA GCACACCAGT GACCTGCCTG 
AGGCGGCGTG AGAAGGTCGG CGTCATTGTG GACGTGCTGA GCGACACGGC GTCCAATCAC 
AACGGCTTCC CCGTGGTGGA GCATGCCGAT GACACCCAGC CTGCCCGGCT CCAGGGCCTG 
ATCCTGCGCT CCCAGCTCAT CGTTCTCCTA AAGCACAAGG TGTTTGTGGA GCGGTCCAAC 
CTGGGCCTGG TACAGCGGCG CCTGAGGCTG AAGGACTTCC GAGACGCCTA CCCGCGCTTC 
CCACCCATCC AGTCCATCCA CGTGTCCCAG GACGAGCGGG AGTGCACCAT GGACCTCTCC 
GAGTTCATGA ACCCCTCCCC CTACACGGTG CCCCAGGAGG CGTCGCTCCC ACGGGTGTTC 
AAGCTGTTCC GGGCCCTGGG CCTGCGGCAC CTGGTGGTGG TGGACAACCG CAATCAGGTT 
GTCGGGTTGG TGACCAGGAA GGACCTCGCC AGGTACCGCC TGGGAAAGAG AGGCTTGGAG 
GAGCTCTCGC TGGCCCAGAC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520656.1
CDS	367..2610
Translation	MSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT

Target ORF information:

RefSeq Version	XM_011522354.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522354.1

ORF Insert Sequence:

ATGAGCAGCG TGGAGCTGGA TGATGAACTT TTGGACCCGG ATATGGACCC TCCACATCCC 
TTCCCCAAGG AGATCCCACA CAACGAGAAG CTCCTGTCCC TCAAGTATGA GAGCTTGGAC 
TATGACAACA GTGAGAACCA GCTGTTCCTG GAGGAGGAGC GGCGGATCAA TCACACGGCC 
TTCCGGACGG TGGAGATCAA GCGCTGGGTC ATCTGCGCCC TCATTGGGAT CCTCACGGGC 
CTCGTGGCCT GCTTCATTGA CATCGTGGTG GAAAACCTGG CTGGCCTCAA GTACAGGGTC 
ATCAAGGGCA ATATCGACAA GTTCACAGAG AAGGGCGGAC TGTCCTTCTC CCTGTTGCTG 
TGGGCCACGC TGAACGCCGC CTTCGTGCTC GTGGGCTCTG TGATTGTGGC TTTCATAGAG 
CCGGTGGCTG CTGGCAGCGG AATCCCCCAG ATCAAGTGCT TCCTCAACGG GGTGAAGATC 
CCCCACGTGG TGCGGCTCAA GACGTTGGTG ATCAAAGTGT CCGGTGTGAT CCTGTCCGTG 
GTCGGGGGCC TGGCCGTGGG AAAGGAAGGG CCGATGATCC ACTCAGGTTC AGTGATTGCC 
GCCGGGATCT CTCAGGGAAG GTCAACGTCA CTGAAACGAG ATTTCAAGAT CTTCGAGTAC 
TTCCGCAGAG ACACAGAGAA GCGGGACTTC GTCTCCGCAG GGGCTGCGGC CGGAGTGTCA 
GCGGCGTTTG GAGCCCCCGT GGGTGGGGTC CTGTTCAGCT TGGAGGAGGG TGCGTCCTTC 
TGGAACCAGT TCCTGACCTG GAGGATCTTC TTTGCTTCCA TGATCTCCAC GTTCACCCTG 
AATTTTGTTC TGAGCATTTA CCACGGGAAC ATGTGGGACC TGTCCAGCCC AGGCCTCATC 
AACTTCGGAA GGTTTGACTC GGAGAAAATG GCCTACACGA TCCACGAGAT CCCGGTCTTC 
ATCGCCATGG GCGTGGTGGG CGGTGTGCTT GGAGCAGTGT TCAATGCCTT GAACTACTGG 
CTGACCATGT TTCGAATCAG GTACATCCAC CGGCCCTGCC TGCAGGTGAT TGAGGCCGTG 
CTGGTGGCCG CCGTCACGGC CACAGTTGCC TTCGTGCTGA TCTACTCGTC GCGGGATTGC 
CAGCCCCTGC AGGGGGGCTC CATGTCCTAC CCGCTGCAGC TCTTTTGTGC AGATGGCGAG 
TACAACTCCA TGGCTGCGGC CTTCTTCAAC ACCCCGGAGA AGAGCGTGGT GAGCCTCTTC 
CACGACCCGC CAGGCTCCTA CAACCCCCTG ACCCTCGGCC TGTTCACGCT GGTCTACTTC 
TTCCTGGCCT GCTGGACCTA CGGGCTCACG GTGTCTGCCG GGGTCTTCAT CCCGTCCCTG 
CTCATCGGGG CTGCCTGGGG CCGGCTCTTT GGGATCTCCC TGTCCTACCT CACGGGGGCG 
GCGATCTGGG CGGACCCCGG CAAATACGCC CTGATGGGAG CTGCTGCCCA GCTGGGCGGG 
ATTGTGCGGA TGACACTGAG CCTGACCGTC ATCATGATGG AGGCCACCAG CAACGTGACC 
TACGGCTTCC CCATCATGCT GGTGCTCATG ACCGCCAAGA TCGTGGGCGA CGTCTTCATT 
GAGGGCCTGT ACGACATGCA CATTCAGCTG CAGAGTGTGC CCTTCCTGCA CTGGGAGGCC 
CCGGTCACCT CACACTCACT CACTGCCAGG GAGGTGATGA GCACACCAGT GACCTGCCTG 
AGGCGGCGTG AGAAGGTCGG CGTCATTGTG GACGTGCTGA GCGACACGGC GTCCAATCAC 
AACGGCTTCC CCGTGGTGGA GCATGCCGAT GACACCCAGC CTGCCCGGCT CCAGGGCCTG 
ATCCTGCGCT CCCAGCTCAT CGTTCTCCTA AAGCACAAGG TGTTTGTGGA GCGGTCCAAC 
CTGGGCCTGG TACAGCGGCG CCTGAGGCTG AAGGACTTCC GAGACGCCTA CCCGCGCTTC 
CCACCCATCC AGTCCATCCA CGTGTCCCAG GACGAGCGGG AGTGCACCAT GGACCTCTCC 
GAGTTCATGA ACCCCTCCCC CTACACGGTG CCCCAGGAGG CGTCGCTCCC ACGGGTGTTC 
AAGCTGTTCC GGGCCCTGGG CCTGCGGCAC CTGGTGGTGG TGGACAACCG CAATCAGGTT 
GTCGGGTTGG TGACCAGGAA GGACCTCGCC AGGTACCGCC TGGGAAAGAG AGGCTTGGAG 
GAGCTCTCGC TGGCCCAGAC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLCN7 ( NM_001114331.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001107803.1 Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 2, mRNA.

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CloneID	OHu20440
Clone ID Related Accession (Same CDS sequence)	NM_001114331.2
Accession Version	NM_001114331.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2346bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	H(+)/Cl(-) exchange transporter 7 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB061109.1, AK056551.1, AL031600.4 and AA741117.1. On Mar 7, 2012 this sequence version replaced NM_001114331.1. Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK056551.1, AK292136.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAACG TCTCTAAGAA GGTGTCCTGG TCCGGCCGGG ACCGGGACGA CGAGGAGGCG 
GCGCCGCTGC TGCGGAGGAC GGCGCGGCCC GGCGGGGGGA CGCCGCTGCT GAACGGGGCT 
GGGCCTGGGG CTGCGCGCCA GGATATGGAC CCTCCACATC CCTTCCCCAA GGAGATCCCA 
CACAACGAGA AGCTCCTGTC CCTCAAGTAT GAGAGCTTGG ACTATGACAA CAGTGAGAAC 
CAGCTGTTCC TGGAGGAGGA GCGGCGGATC AATCACACGG CCTTCCGGAC GGTGGAGATC 
AAGCGCTGGG TCATCTGCGC CCTCATTGGG ATCCTCACGG GCCTCGTGGC CTGCTTCATT 
GACATCGTGG TGGAAAACCT GGCTGGCCTC AAGTACAGGG TCATCAAGGG CAATATCGAC 
AAGTTCACAG AGAAGGGCGG ACTGTCCTTC TCCCTGTTGC TGTGGGCCAC GCTGAACGCC 
GCCTTCGTGC TCGTGGGCTC TGTGATTGTG GCTTTCATAG AGCCGGTGGC TGCTGGCAGC 
GGAATCCCCC AGATCAAGTG CTTCCTCAAC GGGGTGAAGA TCCCCCACGT GGTGCGGCTC 
AAGACGTTGG TGATCAAAGT GTCCGGTGTG ATCCTGTCCG TGGTCGGGGG CCTGGCCGTG 
GGAAAGGAAG GGCCGATGAT CCACTCAGGT TCAGTGATTG CCGCCGGGAT CTCTCAGGGA 
AGGTCAACGT CACTGAAACG AGATTTCAAG ATCTTCGAGT ACTTCCGCAG AGACACAGAG 
AAGCGGGACT TCGTCTCCGC AGGGGCTGCG GCCGGAGTGT CAGCGGCGTT TGGAGCCCCC 
GTGGGTGGGG TCCTGTTCAG CTTGGAGGAG GGTGCGTCCT TCTGGAACCA GTTCCTGACC 
TGGAGGATCT TCTTTGCTTC CATGATCTCC ACGTTCACCC TGAATTTTGT TCTGAGCATT 
TACCACGGGA ACATGTGGGA CCTGTCCAGC CCAGGCCTCA TCAACTTCGG AAGGTTTGAC 
TCGGAGAAAA TGGCCTACAC GATCCACGAG ATCCCGGTCT TCATCGCCAT GGGCGTGGTG 
GGCGGTGTGC TTGGAGCAGT GTTCAATGCC TTGAACTACT GGCTGACCAT GTTTCGAATC 
AGGTACATCC ACCGGCCCTG CCTGCAGGTG ATTGAGGCCG TGCTGGTGGC CGCCGTCACG 
GCCACAGTTG CCTTCGTGCT GATCTACTCG TCGCGGGATT GCCAGCCCCT GCAGGGGGGC 
TCCATGTCCT ACCCGCTGCA GCTCTTTTGT GCAGATGGCG AGTACAACTC CATGGCTGCG 
GCCTTCTTCA ACACCCCGGA GAAGAGCGTG GTGAGCCTCT TCCACGACCC GCCAGGCTCC 
TACAACCCCC TGACCCTCGG CCTGTTCACG CTGGTCTACT TCTTCCTGGC CTGCTGGACC 
TACGGGCTCA CGGTGTCTGC CGGGGTCTTC ATCCCGTCCC TGCTCATCGG GGCTGCCTGG 
GGCCGGCTCT TTGGGATCTC CCTGTCCTAC CTCACGGGGG CGGCGATCTG GGCGGACCCC 
GGCAAATACG CCCTGATGGG AGCTGCTGCC CAGCTGGGCG GGATTGTGCG GATGACACTG 
AGCCTGACCG TCATCATGAT GGAGGCCACC AGCAACGTGA CCTACGGCTT CCCCATCATG 
CTGGTGCTCA TGACCGCCAA GATCGTGGGC GACGTCTTCA TTGAGGGCCT GTACGACATG 
CACATTCAGC TGCAGAGTGT GCCCTTCCTG CACTGGGAGG CCCCGGTCAC CTCACACTCA 
CTCACTGCCA GGGAGGTGAT GAGCACACCA GTGACCTGCC TGAGGCGGCG TGAGAAGGTC 
GGCGTCATTG TGGACGTGCT GAGCGACACG GCGTCCAATC ACAACGGCTT CCCCGTGGTG 
GAGCATGCCG ATGACACCCA GCCTGCCCGG CTCCAGGGCC TGATCCTGCG CTCCCAGCTC 
ATCGTTCTCC TAAAGCACAA GGTGTTTGTG GAGCGGTCCA ACCTGGGCCT GGTACAGCGG 
CGCCTGAGGC TGAAGGACTT CCGAGACGCC TACCCGCGCT TCCCACCCAT CCAGTCCATC 
CACGTGTCCC AGGACGAGCG GGAGTGCACC ATGGACCTCT CCGAGTTCAT GAACCCCTCC 
CCCTACACGG TGCCCCAGGA GGCGTCGCTC CCACGGGTGT TCAAGCTGTT CCGGGCCCTG 
GGCCTGCGGC ACCTGGTGGT GGTGGACAAC CGCAATCAGG TTGTCGGGTT GGTGACCAGG 
AAGGACCTCG CCAGGTACCG CCTGGGAAAG AGAGGCTTGG AGGAGCTCTC GCTGGCCCAG 
ACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001107803.1
CDS	111..2456
Translation	MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT

Target ORF information:

RefSeq Version	NM_001114331.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114331.2

ORF Insert Sequence:

ATGGCCAACG TCTCTAAGAA GGTGTCCTGG TCCGGCCGGG ACCGGGACGA CGAGGAGGCG 
GCGCCGCTGC TGCGGAGGAC GGCGCGGCCC GGCGGGGGGA CGCCGCTGCT GAACGGGGCT 
GGGCCTGGGG CTGCGCGCCA GGATATGGAC CCTCCACATC CCTTCCCCAA GGAGATCCCA 
CACAACGAGA AGCTCCTGTC CCTCAAGTAT GAGAGCTTGG ACTATGACAA CAGTGAGAAC 
CAGCTGTTCC TGGAGGAGGA GCGGCGGATC AATCACACGG CCTTCCGGAC GGTGGAGATC 
AAGCGCTGGG TCATCTGCGC CCTCATTGGG ATCCTCACGG GCCTCGTGGC CTGCTTCATT 
GACATCGTGG TGGAAAACCT GGCTGGCCTC AAGTACAGGG TCATCAAGGG CAATATCGAC 
AAGTTCACAG AGAAGGGCGG ACTGTCCTTC TCCCTGTTGC TGTGGGCCAC GCTGAACGCC 
GCCTTCGTGC TCGTGGGCTC TGTGATTGTG GCTTTCATAG AGCCGGTGGC TGCTGGCAGC 
GGAATCCCCC AGATCAAGTG CTTCCTCAAC GGGGTGAAGA TCCCCCACGT GGTGCGGCTC 
AAGACGTTGG TGATCAAAGT GTCCGGTGTG ATCCTGTCCG TGGTCGGGGG CCTGGCCGTG 
GGAAAGGAAG GGCCGATGAT CCACTCAGGT TCAGTGATTG CCGCCGGGAT CTCTCAGGGA 
AGGTCAACGT CACTGAAACG AGATTTCAAG ATCTTCGAGT ACTTCCGCAG AGACACAGAG 
AAGCGGGACT TCGTCTCCGC AGGGGCTGCG GCCGGAGTGT CAGCGGCGTT TGGAGCCCCC 
GTGGGTGGGG TCCTGTTCAG CTTGGAGGAG GGTGCGTCCT TCTGGAACCA GTTCCTGACC 
TGGAGGATCT TCTTTGCTTC CATGATCTCC ACGTTCACCC TGAATTTTGT TCTGAGCATT 
TACCACGGGA ACATGTGGGA CCTGTCCAGC CCAGGCCTCA TCAACTTCGG AAGGTTTGAC 
TCGGAGAAAA TGGCCTACAC GATCCACGAG ATCCCGGTCT TCATCGCCAT GGGCGTGGTG 
GGCGGTGTGC TTGGAGCAGT GTTCAATGCC TTGAACTACT GGCTGACCAT GTTTCGAATC 
AGGTACATCC ACCGGCCCTG CCTGCAGGTG ATTGAGGCCG TGCTGGTGGC CGCCGTCACG 
GCCACAGTTG CCTTCGTGCT GATCTACTCG TCGCGGGATT GCCAGCCCCT GCAGGGGGGC 
TCCATGTCCT ACCCGCTGCA GCTCTTTTGT GCAGATGGCG AGTACAACTC CATGGCTGCG 
GCCTTCTTCA ACACCCCGGA GAAGAGCGTG GTGAGCCTCT TCCACGACCC GCCAGGCTCC 
TACAACCCCC TGACCCTCGG CCTGTTCACG CTGGTCTACT TCTTCCTGGC CTGCTGGACC 
TACGGGCTCA CGGTGTCTGC CGGGGTCTTC ATCCCGTCCC TGCTCATCGG GGCTGCCTGG 
GGCCGGCTCT TTGGGATCTC CCTGTCCTAC CTCACGGGGG CGGCGATCTG GGCGGACCCC 
GGCAAATACG CCCTGATGGG AGCTGCTGCC CAGCTGGGCG GGATTGTGCG GATGACACTG 
AGCCTGACCG TCATCATGAT GGAGGCCACC AGCAACGTGA CCTACGGCTT CCCCATCATG 
CTGGTGCTCA TGACCGCCAA GATCGTGGGC GACGTCTTCA TTGAGGGCCT GTACGACATG 
CACATTCAGC TGCAGAGTGT GCCCTTCCTG CACTGGGAGG CCCCGGTCAC CTCACACTCA 
CTCACTGCCA GGGAGGTGAT GAGCACACCA GTGACCTGCC TGAGGCGGCG TGAGAAGGTC 
GGCGTCATTG TGGACGTGCT GAGCGACACG GCGTCCAATC ACAACGGCTT CCCCGTGGTG 
GAGCATGCCG ATGACACCCA GCCTGCCCGG CTCCAGGGCC TGATCCTGCG CTCCCAGCTC 
ATCGTTCTCC TAAAGCACAA GGTGTTTGTG GAGCGGTCCA ACCTGGGCCT GGTACAGCGG 
CGCCTGAGGC TGAAGGACTT CCGAGACGCC TACCCGCGCT TCCCACCCAT CCAGTCCATC 
CACGTGTCCC AGGACGAGCG GGAGTGCACC ATGGACCTCT CCGAGTTCAT GAACCCCTCC 
CCCTACACGG TGCCCCAGGA GGCGTCGCTC CCACGGGTGT TCAAGCTGTT CCGGGCCCTG 
GGCCTGCGGC ACCTGGTGGT GGTGGACAAC CGCAATCAGG TTGTCGGGTT GGTGACCAGG 
AAGGACCTCG CCAGGTACCG CCTGGGAAAG AGAGGCTTGG AGGAGCTCTC GCTGGCCCAG 
ACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel mutations of CLCN7 cause autosomal dominant osteopetrosis type II (ADOII) and intermediate autosomal recessive osteopetrosis (ARO) in seven Chinese families.
Postgraduate medicine129(8)934-942(2017 Nov)
Zhang X,Wei Z,He J,Wang C,Zhang Z

Autosomal dominant osteopetrosis associated with renal tubular acidosis is due to a CLCN7 mutation.
American journal of medical genetics. Part A170(11)2988-2992(2016 Nov)
Piret SE,Gorvin CM,Trinh A,Taylor J,Lise S,Taylor JC,Ebeling PR,Thakker RV

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CLCN7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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