CHCHD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHCHD1
Entrez Gene ID	118487
Full Name	coiled-coil-helix-coiled-coil-helix domain containing 1
Synonyms	C10orf34,C2360,MRP-S37
General protein information	Preferred Names coiled-coil-helix-coiled-coil-helix domain containing 1 Names coiled-coil-helix-coiled-coil-helix domain-containing protein 1 28S ribosomal protein S37, mitochondrial mitochondrial small ribosomal subunit protein mS37 nuclear protein C2360
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q22.2
Disorder MIM:	608842

mRNA and Protein(s)

mRNA	Protein	Name
NM_203298.2	NP_976043.1	coiled-coil-helix-coiled-coil-helix domain-containing protein 1
NM_203298.3	NP_976043.1	coiled-coil-helix-coiled-coil-helix domain-containing protein 1

Pathways from BioSystems

Homologies

	CHCHD1	XP_001100699.1
Rattus norvegicus (Norway rat)	Chchd1	NP_001101839.1
Xenopus tropicalis (tropical clawed frog)	chchd1	XP_004915985.1
Mus musculus (house mouse)	Chchd1	NP_079642.1
Homo sapiens (human)	CHCHD1	NP_976043.1
Pan troglodytes (chimpanzee)	CHCHD1	XP_521508.1
Canis lupus familiaris (dog)	CHCHD1	XP_005619097.1
Bos taurus (cattle)	CHCHD1	NP_001039949.1
Gallus gallus (chicken)	CHCHD1	XP_421616.2
Danio rerio (zebrafish)	chchd1	NP_001076283.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome.
Koc EC, Cimen H, Kumcuoglu B, Abu N, Akpinar G, Haque ME, Spremulli LL, Koc H
Frontiers in physiology4183(2013)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Global landscape of HIV-human protein complexes.
J?ger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ
Nature481(7381)365-70(2011 Dec)

Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.
Smits P, Rodenburg RJ, Smeitink JA, van den Heuvel LP
Journal of inherited metabolic disease33 Suppl 3S13-9(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CHCHD1 mutations could not explain phenotype of patients with combined oxidative phosphorylation system deficiencies.
Title: Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

C2360, a nuclear protein expressed in cytotrophoblasts, is a representative member of a multifamily of proteins, sharing a protein domain that is conserved in eukaryotes.
Title: C2360, a nuclear protein expressed in human proliferative cytotrophoblasts, is a representative member of a novel protein family with a conserved coiled coil-helix-coiled coil-helix domain.

The following CHCHD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHCHD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15801	NM_203298.3 Latest version!	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15801	NM_203298.2	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHCHD1 ( NM_203298.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_976043.1 Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1), mRNA.

Price & Availability↑

CloneID	OHu15801
Clone ID Related Accession (Same CDS sequence)	NM_203298.2 , NM_203298.3
Accession Version	NM_203298.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	coiled-coil-helix-coiled-coil-helix domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM787401.1, BC020852.1 and AC022400.9. On May 7, 2008 this sequence version replaced NM_203298.1. ##Evidence-Data-START## Transcript exon combination :: BM790198.1, SRR1803614.228437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCGACAC CCAGCCTGCG GGGTCGTCTG GCGCGGTTTG GGAACCCGCG GAAGCCTGTG 
CTGAAGCCCA ATAAACCTCT CATTCTAGCT AACCGCGTCG GGGAGCGGCG CCGGGAGAAG 
GGCGAGGCGA CTTGCATCAC GGAGATGTCG GTGATGATGG CTTGCTGGAA GCAGAATGAA 
TTCCGCGACG ATGCGTGCAG AAAAGAGATC CAGGGCTTCC TCGATTGTGC CGCGAGGGCT 
CAGGAAGCCC GAAAGATGAG ATCAATACAG GAAACCCTGG GAGAGTCTGG GAGTTTACTT 
CCAAATAAAT TGAATAAGTT GTTACAGAGG TTTCCTAACA AACCTTACCT CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_976043.1
CDS	27..383
Translation	MATPSLRGRLARFGNPRKPVLKPNKPLILANRVGERRREKGEATCITEMSVMMACWKQNEFRDDACRKEIQGFLDCAARAQEARKMRSIQETLGESGSLLPNKLNKLLQRFPNKPYLS

Target ORF information:

RefSeq Version	NM_203298.2
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203298.2

ORF Insert Sequence:

ATGGCGACAC CCAGCCTGCG GGGTCGTCTG GCGCGGTTTG GGAACCCGCG GAAGCCTGTG 
CTGAAGCCCA ATAAACCTCT CATTCTAGCT AACCGCGTCG GGGAGCGGCG CCGGGAGAAG 
GGCGAGGCGA CTTGCATCAC GGAGATGTCG GTGATGATGG CTTGCTGGAA GCAGAATGAA 
TTCCGCGACG ATGCGTGCAG AAAAGAGATC CAGGGCTTCC TCGATTGTGC CGCGAGGGCT 
CAGGAAGCCC GAAAGATGAG ATCAATACAG GAAACCCTGG GAGAGTCTGG GAGTTTACTT 
CCAAATAAAT TGAATAAGTT GTTACAGAGG TTTCCTAACA AACCTTACCT CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHCHD1 ( NM_203298.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_976043.1 Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1), mRNA.

Price & Availability↑

CloneID	OHu15801
Clone ID Related Accession (Same CDS sequence)	NM_203298.2 , NM_203298.3
Accession Version	NM_203298.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	coiled-coil-helix-coiled-coil-helix domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC022400.9, BM787401.1 and BC020852.1. On Nov 22, 2018 this sequence version replaced NM_203298.2. ##Evidence-Data-START## Transcript exon combination :: ERR279835.10596.1, SRR1803614.228437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372833.6/ ENSP00000361923.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGACAC CCAGCCTGCG GGGTCGTCTG GCGCGGTTTG GGAACCCGCG GAAGCCTGTG 
CTGAAGCCCA ATAAACCTCT CATTCTAGCT AACCGCGTCG GGGAGCGGCG CCGGGAGAAG 
GGCGAGGCGA CTTGCATCAC GGAGATGTCG GTGATGATGG CTTGCTGGAA GCAGAATGAA 
TTCCGCGACG ATGCGTGCAG AAAAGAGATC CAGGGCTTCC TCGATTGTGC CGCGAGGGCT 
CAGGAAGCCC GAAAGATGAG ATCAATACAG GAAACCCTGG GAGAGTCTGG GAGTTTACTT 
CCAAATAAAT TGAATAAGTT GTTACAGAGG TTTCCTAACA AACCTTACCT CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_976043.1
CDS	29..385
Translation	MATPSLRGRLARFGNPRKPVLKPNKPLILANRVGERRREKGEATCITEMSVMMACWKQNEFRDDACRKEIQGFLDCAARAQEARKMRSIQETLGESGSLLPNKLNKLLQRFPNKPYLS

Target ORF information:

RefSeq Version	NM_203298.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203298.3

ORF Insert Sequence:

ATGGCGACAC CCAGCCTGCG GGGTCGTCTG GCGCGGTTTG GGAACCCGCG GAAGCCTGTG 
CTGAAGCCCA ATAAACCTCT CATTCTAGCT AACCGCGTCG GGGAGCGGCG CCGGGAGAAG 
GGCGAGGCGA CTTGCATCAC GGAGATGTCG GTGATGATGG CTTGCTGGAA GCAGAATGAA 
TTCCGCGACG ATGCGTGCAG AAAAGAGATC CAGGGCTTCC TCGATTGTGC CGCGAGGGCT 
CAGGAAGCCC GAAAGATGAG ATCAATACAG GAAACCCTGG GAGAGTCTGG GAGTTTACTT 
CCAAATAAAT TGAATAAGTT GTTACAGAGG TTTCCTAACA AACCTTACCT CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome.
Frontiers in physiology4183(2013)
Koc EC,Cimen H,Kumcuoglu B,Abu N,Akpinar G,Haque ME,Spremulli LL,Koc H

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Global landscape of HIV-human protein complexes.
Nature481(7381)365-70(2011 Dec)
J?ger S,Cimermancic P,Gulbahce N,Johnson JR,McGovern KE,Clarke SC,Shales M,Mercenne G,Pache L,Li K,Hernandez H,Jang GM,Roth SL,Akiva E,Marlett J,Stephens M,D'Orso I,Fernandes J,Fahey M,Mahon C,O'Donoghue AJ,Todorovic A,Morris JH,Maltby DA,Alber T,Cagney G,Bushman FD,Young JA,Chanda SK,Sundquist WI,Kortemme T,Hernandez RD,Craik CS,Burlingame A,Sali A,Frankel AD,Krogan NJ

Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.
Journal of inherited metabolic disease33 Suppl 3S13-9(2010 Dec)
Smits P,Rodenburg RJ,Smeitink JA,van den Heuvel LP

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CHCHD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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