EXOSC6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EXOSC6
Entrez Gene ID	118460
Full Name	exosome component 6
Synonyms	EAP4,MTR3,Mtr3p,hMtr3p,p11
General protein information	Preferred Names exosome component 6 Names exosome complex component MTR3 Mtr3 (mRNA transport regulator 3)-homolog exosome complex exonuclease MTR3 hMtr3 homolog of yeast mRNA transport regulator 3 mRNA transport regulator 3 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q22.1
Summary	This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008].
Disorder MIM:	606490

mRNA and Protein(s)

mRNA	Protein	Name
NM_058219.2	NP_478126.1	exosome complex component MTR3
NM_058219.3	NP_478126.1	exosome complex component MTR3

Pathways from BioSystems

Homologies

Homo sapiens (human)	EXOSC6	NP_478126.1
Mus musculus (house mouse)	Exosc6	NP_082550.1
Schizosaccharomyces pombe (fission yeast)	SPBC211.08c	NP_596618.1
Oryza sativa (rice)	Os08g0116800	NP_001060856.1
Xenopus tropicalis (tropical clawed frog)	rarg	NP_001017016.1
Neurospora crassa	NCU08026	XP_962696.1
Arabidopsis thaliana (thale cress)	AT4G27490	NP_194479.2
Canis lupus familiaris (dog)	EXOSC6	XP_005620759.1
Danio rerio (zebrafish)	exosc6	NP_001018322.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011906	XP_552338.3
Magnaporthe oryzae (rice blast fungus)	MGG_07084	XP_003715270.1
Xenopus tropicalis (tropical clawed frog)	LOC101732722	XP_004918117.1
Pan troglodytes (chimpanzee)	EXOSC6	XP_523406.1
Rattus norvegicus (Norway rat)	Exosc6	XP_006255676.1
Xenopus tropicalis (tropical clawed frog)	LOC101735086	XP_004914387.1

Gene Ontology
Bibliography

Related articles in PubMed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW
Cell144(3)353-63(2011 Feb)

Dis3-like 1: a novel exoribonuclease associated with the human exosome.
Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ
The EMBO journal29(14)2358-67(2010 Jul)

Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.
Seth D, Hogg PJ, Gorrell MD, McCaughan GW, Haber PS
Journal of hepatology48(4)614-27(2008 Apr)

Reconstitution, activities, and structure of the eukaryotic RNA exosome.
Liu Q, Greimann JC, Lima CD
Cell127(6)1223-37(2006 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We have recently identified increased expression of p11 genes that implicate fibrinolysis in ALD progression.
Title: Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.

Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Title: Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

The following EXOSC6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29315	NM_058219.3 Latest version!	Homo sapiens exosome component 6 (EXOSC6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu29315	NM_058219.2	Homo sapiens exosome component 6 (EXOSC6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EXOSC6 ( NM_058219.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_478126.1 Homo sapiens exosome component 6 (EXOSC6), mRNA.

Price & Availability↑

CloneID	OHu29315
Clone ID Related Accession (Same CDS sequence)	NM_058219.2 , NM_058219.3
Accession Version	NM_058219.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	exosome complex component MTR3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009060.7 and BC052252.1. On Jul 9, 2003 this sequence version replaced NM_058219.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC052252.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTGGGG ATCACCGCCG CATCCGCGGC CCTGAAGAAT CGCAGCCGCC GCAGCTGTAC 
GCGGCCGACG AGGAGGAGGC GCCCGGCACC CGCGACCCAA CGCGGCTACG GCCCGTGTAC 
GCGCGCGCCG GGCTGCTGAG CCAGGCCAAG GGCTCGGCCT ACCTGGAGGC GGGAGGCACC 
AAGGTGCTGT GTGCCGTGTC GGGCCCGCGA CAGGCCGAGG GCGGCGAGCG CGGCGGCGGC 
CCGGCCGGAG CAGGCGGCGA GGCCCCGGCC GCGCTGCGCG GTCGCCTGCT CTGCGACTTC 
CGCCGCGCAC CCTTCGCGGG CCGCCGGCGC CGCGCTCCCC CGGGCGGCTG CGAGGAGCGT 
GAGCTGGCGC TGGCGCTGCA GGAGGCGCTG GAGCCGGCTG TGCGCCTGGG CCGCTACCCG 
CGCGCGCAGC TCGAGGTGTC GGCGCTGCTG CTGGAGGACG GTGGCTCGGC CCTGGCCGCC 
GCGCTCACCG CCGCCGCGCT CGCCCTGGCC GACGCGGGCG TGGAGATGTA CGACCTGGTG 
GTGGGCTGCG GCCTCAGCCT CGCGCCGGGG CCCGCGCCCA CCTGGCTCCT GGACCCCACG 
CGGCTCGAGG AAGAGCGCGC CGCCGCCGGC CTCACCGTGG CGCTCATGCC TGTGCTGAAT 
CAGGTGGCCG GGCTGCTGGG CAGCGGCGAG GGCGGCCTGA CAGAGAGCTG GGCGGAGGCC 
GTACGCCTGG GCCTCGAGGG CTGCCAGCGC CTCTACCCCG TGCTGCAGCA GAGCCTGGTG 
CGGGCCGCCC GCCGCAGGGG CGCCGCCGCC CAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_478126.1
CDS	31..849
Translation	MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGTKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP

Target ORF information:

RefSeq Version	NM_058219.2
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 6 (EXOSC6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058219.2

ORF Insert Sequence:

ATGCCTGGGG ATCACCGCCG CATCCGCGGC CCTGAAGAAT CGCAGCCGCC GCAGCTGTAC 
GCGGCCGACG AGGAGGAGGC GCCCGGCACC CGCGACCCAA CGCGGCTACG GCCCGTGTAC 
GCGCGCGCCG GGCTGCTGAG CCAGGCCAAG GGCTCGGCCT ACCTGGAGGC GGGAGGCACC 
AAGGTGCTGT GTGCCGTGTC GGGCCCGCGA CAGGCCGAGG GCGGCGAGCG CGGCGGCGGC 
CCGGCCGGAG CAGGCGGCGA GGCCCCGGCC GCGCTGCGCG GTCGCCTGCT CTGCGACTTC 
CGCCGCGCAC CCTTCGCGGG CCGCCGGCGC CGCGCTCCCC CGGGCGGCTG CGAGGAGCGT 
GAGCTGGCGC TGGCGCTGCA GGAGGCGCTG GAGCCGGCTG TGCGCCTGGG CCGCTACCCG 
CGCGCGCAGC TCGAGGTGTC GGCGCTGCTG CTGGAGGACG GTGGCTCGGC CCTGGCCGCC 
GCGCTCACCG CCGCCGCGCT CGCCCTGGCC GACGCGGGCG TGGAGATGTA CGACCTGGTG 
GTGGGCTGCG GCCTCAGCCT CGCGCCGGGG CCCGCGCCCA CCTGGCTCCT GGACCCCACG 
CGGCTCGAGG AAGAGCGCGC CGCCGCCGGC CTCACCGTGG CGCTCATGCC TGTGCTGAAT 
CAGGTGGCCG GGCTGCTGGG CAGCGGCGAG GGCGGCCTGA CAGAGAGCTG GGCGGAGGCC 
GTACGCCTGG GCCTCGAGGG CTGCCAGCGC CTCTACCCCG TGCTGCAGCA GAGCCTGGTG 
CGGGCCGCCC GCCGCAGGGG CGCCGCCGCC CAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXOSC6 ( NM_058219.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_478126.1 Homo sapiens exosome component 6 (EXOSC6), mRNA.

Price & Availability↑

CloneID	OHu29315
Clone ID Related Accession (Same CDS sequence)	NM_058219.2 , NM_058219.3
Accession Version	NM_058219.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	exosome complex component MTR3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX866575.1, BC052252.1 and AC009060.7. On Nov 28, 2018 this sequence version replaced NM_058219.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000435634.3/ ENSP00000398597.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGGGG ATCACCGCCG CATCCGCGGC CCTGAAGAAT CGCAGCCGCC GCAGCTGTAC 
GCGGCCGACG AGGAGGAGGC GCCCGGCACC CGCGACCCAA CGCGGCTACG GCCCGTGTAC 
GCGCGCGCCG GGCTGCTGAG CCAGGCCAAG GGCTCGGCCT ACCTGGAGGC GGGAGGCACC 
AAGGTGCTGT GTGCCGTGTC GGGCCCGCGA CAGGCCGAGG GCGGCGAGCG CGGCGGCGGC 
CCGGCCGGAG CAGGCGGCGA GGCCCCGGCC GCGCTGCGCG GTCGCCTGCT CTGCGACTTC 
CGCCGCGCAC CCTTCGCGGG CCGCCGGCGC CGCGCTCCCC CGGGCGGCTG CGAGGAGCGT 
GAGCTGGCGC TGGCGCTGCA GGAGGCGCTG GAGCCGGCTG TGCGCCTGGG CCGCTACCCG 
CGCGCGCAGC TCGAGGTGTC GGCGCTGCTG CTGGAGGACG GTGGCTCGGC CCTGGCCGCC 
GCGCTCACCG CCGCCGCGCT CGCCCTGGCC GACGCGGGCG TGGAGATGTA CGACCTGGTG 
GTGGGCTGCG GCCTCAGCCT CGCGCCGGGG CCCGCGCCCA CCTGGCTCCT GGACCCCACG 
CGGCTCGAGG AAGAGCGCGC CGCCGCCGGC CTCACCGTGG CGCTCATGCC TGTGCTGAAT 
CAGGTGGCCG GGCTGCTGGG CAGCGGCGAG GGCGGCCTGA CAGAGAGCTG GGCGGAGGCC 
GTACGCCTGG GCCTCGAGGG CTGCCAGCGC CTCTACCCCG TGCTGCAGCA GAGCCTGGTG 
CGGGCCGCCC GCCGCAGGGG CGCCGCCGCC CAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_478126.1
CDS	41..859
Translation	MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGTKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP

Target ORF information:

RefSeq Version	NM_058219.3
Organism	Homo sapiens(human)
Definition	Homo sapiens exosome component 6 (EXOSC6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058219.3

ORF Insert Sequence:

ATGCCTGGGG ATCACCGCCG CATCCGCGGC CCTGAAGAAT CGCAGCCGCC GCAGCTGTAC 
GCGGCCGACG AGGAGGAGGC GCCCGGCACC CGCGACCCAA CGCGGCTACG GCCCGTGTAC 
GCGCGCGCCG GGCTGCTGAG CCAGGCCAAG GGCTCGGCCT ACCTGGAGGC GGGAGGCACC 
AAGGTGCTGT GTGCCGTGTC GGGCCCGCGA CAGGCCGAGG GCGGCGAGCG CGGCGGCGGC 
CCGGCCGGAG CAGGCGGCGA GGCCCCGGCC GCGCTGCGCG GTCGCCTGCT CTGCGACTTC 
CGCCGCGCAC CCTTCGCGGG CCGCCGGCGC CGCGCTCCCC CGGGCGGCTG CGAGGAGCGT 
GAGCTGGCGC TGGCGCTGCA GGAGGCGCTG GAGCCGGCTG TGCGCCTGGG CCGCTACCCG 
CGCGCGCAGC TCGAGGTGTC GGCGCTGCTG CTGGAGGACG GTGGCTCGGC CCTGGCCGCC 
GCGCTCACCG CCGCCGCGCT CGCCCTGGCC GACGCGGGCG TGGAGATGTA CGACCTGGTG 
GTGGGCTGCG GCCTCAGCCT CGCGCCGGGG CCCGCGCCCA CCTGGCTCCT GGACCCCACG 
CGGCTCGAGG AAGAGCGCGC CGCCGCCGGC CTCACCGTGG CGCTCATGCC TGTGCTGAAT 
CAGGTGGCCG GGCTGCTGGG CAGCGGCGAG GGCGGCCTGA CAGAGAGCTG GGCGGAGGCC 
GTACGCCTGG GCCTCGAGGG CTGCCAGCGC CTCTACCCCG TGCTGCAGCA GAGCCTGGTG 
CGGGCCGCCC GCCGCAGGGG CGCCGCCGCC CAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
Cell144(3)353-63(2011 Feb)
Basu U,Meng FL,Keim C,Grinstein V,Pefanis E,Eccleston J,Zhang T,Myers D,Wasserman CR,Wesemann DR,Januszyk K,Gregory RI,Deng H,Lima CD,Alt FW

Dis3-like 1: a novel exoribonuclease associated with the human exosome.
The EMBO journal29(14)2358-67(2010 Jul)
Staals RH,Bronkhorst AW,Schilders G,Slomovic S,Schuster G,Heck AJ,Raijmakers R,Pruijn GJ

Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.
Journal of hepatology48(4)614-27(2008 Apr)
Seth D,Hogg PJ,Gorrell MD,McCaughan GW,Haber PS

Reconstitution, activities, and structure of the eukaryotic RNA exosome.
Cell127(6)1223-37(2006 Dec)
Liu Q,Greimann JC,Lima CD

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EXOSC6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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