TWIST2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TWIST2
Entrez Gene ID	117581
Full Name	twist family bHLH transcription factor 2
Synonyms	AMS,BBRSAY,DERMO1,FFDD3,SETLSS,bHLHa39
General protein information	Preferred Names twist family bHLH transcription factor 2 Names twist-related protein 2 class A basic helix-loop-helix protein 39 dermis-expressed protein 1 twist basic helix-loop-helix transcription factor 2 twist homolog 2 twist-related bHLH protein Dermo1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.3
Summary	The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014].
Disorder MIM:	607556
Disorder Html:	Focal facial dermal dysplasia 3, Setleis type, 227260 (3); Barber-Say syndrome, 209885 (3); Ablepharon-macrostomia syndrome, 200110 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_006712242.2	XP_006712305.1	twist-related protein 2 isoform X1
NM_057179.2	NP_476527.1	twist-related protein 2
NM_057179.3	NP_476527.1	twist-related protein 2
NM_001271893.4	NP_001258822.1	twist-related protein 2
NM_001271893.3	NP_001258822.1	twist-related protein 2

Pathways from BioSystems

Homologies

	TWIST2	XP_001087543.1
Mus musculus (house mouse)	Twist2	NP_031881.1
Homo sapiens (human)	TWIST2	NP_476527.1
Rattus norvegicus (Norway rat)	Twist2	NP_067723.1
Gallus gallus (chicken)	TWIST2	NP_990010.1
Bos taurus (cattle)	TWIST2	NP_001077217.1
Danio rerio (zebrafish)	twist2	NP_001005956.1
Pan troglodytes (chimpanzee)	TWIST2	XP_003309596.1
Canis lupus familiaris (dog)	TWIST2	XP_543311.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2.
Wei WF, Zhou CF, Wu XG, He LN, Wu LF, Chen XJ, Yan RM, Zhong M, Yu YH, Liang L, Wang W
Cell death & disease8(12)3220(2017 Dec)

EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells.
Han M, Xu W
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317718404(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

epithelial membrane protein 3 is a downstream effector of TWIST1/2 in inducing epithelial-to-mesenchymal transition in gastric cancer. Epithelial membrane protein 3 upregulation might be associated with gastric cancer metastasis and is a potential indicator of unfavorable overall survival and progression-free survival in gastric cancer patients
Title: EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells.

Findings indicated that HIF-2alpha promotes epithelial-mesenchymal transition in pancreatic cancer by regulating Twist2 binding to the promoter of E-cadherin.
Title: HIF-2? promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer.

TWIST2 regulates epithelial-mesenchymal transition by depriving the epithelial cell phenotype of E-cadherin and endowing the mesenchymal cell phenotype with Vimentin, which may be involved in the progression and prognosis of ovarian cancer.
Title: Role of TWIST2, E-cadherin and Vimentin in epithelial ovarian carcinogenesis and prognosis and their interaction in cancer progression.

After chronic NOD2 stimulation, Twist1 and Twist2 coordinate the regulation of both transcriptional activators and repressors, thereby mediating optimal cytokine down-regulation.
Title: Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators.

A substituted lysine at TWIST2 residue 75 results in Ablepharon Macrostomia Syndrome, whereas a glutamine or alanine yields Barber-Say Syndrome.
Title: Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes.

The following TWIST2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TWIST2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16999	NM_057179.3 Latest version!	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16999	NM_001271893.4 Latest version!	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16999	XM_006712242.2 Latest version!	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16999	NM_057179.2	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16999	NM_001271893.3	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TWIST2 ( NM_057179.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_476527.1 Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16999
Clone ID Related Accession (Same CDS sequence)	XM_006712242.2 , NM_057179.2 , NM_057179.3 , NM_001271893.4 , NM_001271893.3
Accession Version	NM_057179.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	twist-related protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC033168.1 and BU615717.1. This sequence is a reference standard in the RefSeqGene project. On Aug 11, 2010 this sequence version replaced NM_057179.1. Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033168.1, BU615717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476527.1
CDS	185..667
Translation	MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH

Target ORF information:

RefSeq Version	NM_057179.2
Organism	Homo sapiens(human)
Definition	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057179.2

ORF Insert Sequence:

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TWIST2 ( NM_057179.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_476527.1 Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16999
Clone ID Related Accession (Same CDS sequence)	XM_006712242.2 , NM_057179.2 , NM_057179.3 , NM_001271893.4 , NM_001271893.3
Accession Version	NM_057179.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	twist-related protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC033168.1, BU615717.1 and AC149644.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_057179.2. Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033168.1, BU615717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476527.1
CDS	132..614
Translation	MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH

Target ORF information:

RefSeq Version	NM_057179.3
Organism	Homo sapiens(human)
Definition	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057179.3

ORF Insert Sequence:

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TWIST2 ( NM_001271893.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258822.1 Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16999
Clone ID Related Accession (Same CDS sequence)	XM_006712242.2 , NM_057179.2 , NM_057179.3 , NM_001271893.4 , NM_001271893.3
Accession Version	NM_001271893.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	twist-related protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC017907.1 and AC142117.2. On Nov 23, 2018 this sequence version replaced NM_001271893.3. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017907.1, BU631564.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000612363.2/ ENSP00000482581.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258822.1
CDS	132..614
Translation	MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH

Target ORF information:

RefSeq Version	NM_001271893.4
Organism	Homo sapiens(human)
Definition	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271893.4

ORF Insert Sequence:

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TWIST2 ( NM_001271893.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258822.1 Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16999
Clone ID Related Accession (Same CDS sequence)	XM_006712242.2 , NM_057179.2 , NM_057179.3 , NM_001271893.4 , NM_001271893.3
Accession Version	NM_001271893.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	twist-related protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC033168.1, BC017907.1, AC142117.2 and DB359681.1. On Apr 23, 2014 this sequence version replaced NM_001271893.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279857.2150.1, ERR279862.3794.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258822.1
CDS	185..667
Translation	MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH

Target ORF information:

RefSeq Version	NM_001271893.3
Organism	Homo sapiens(human)
Definition	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271893.3

ORF Insert Sequence:

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TWIST2 ( XM_006712242.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006712305.1 Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu16999
Clone ID Related Accession (Same CDS sequence)	XM_006712242.2 , NM_057179.2 , NM_057179.3 , NM_001271893.4 , NM_001271893.3
Accession Version	XM_006712242.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	twist-related protein 2 isoform X1
Comment

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006712305.1
Translation	MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH

Target ORF information:

RefSeq Version	XM_006712242.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens twist family bHLH transcription factor 2 (TWIST2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006712242.2

ORF Insert Sequence:

ATGGAGGAGG GCTCCAGCTC GCCCGTGTCC CCCGTGGACA GCCTGGGCAC CAGCGAGGAG 
GAGCTCGAGA GGCAGCCCAA GCGCTTCGGC CGGAAGCGGC GCTACAGCAA GAAGTCGAGC 
GAAGATGGCA GCCCGACCCC GGGCAAGCGC GGCAAGAAGG GCAGCCCCAG CGCGCAGTCC 
TTCGAGGAGC TGCAGAGCCA GCGCATCCTG GCCAACGTGC GCGAGCGCCA GCGCACCCAG 
TCGCTCAACG AGGCCTTCGC GGCGCTGCGC AAGATCATCC CCACGCTGCC CTCTGACAAG 
CTGAGCAAGA TCCAGACGCT CAAGCTGGCC GCCAGGTACA TAGACTTCCT CTACCAGGTC 
CTGCAGAGCG ACGAGATGGA CAATAAGATG ACCAGCTGCA GCTACGTGGC CCACGAGCGC 
CTCAGCTACG CCTTCTCCGT GTGGCGCATG GAGGGCGCGT GGTCCATGTC CGCCTCCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2.
Cell death & disease8(12)3220(2017 Dec)
Wei WF,Zhou CF,Wu XG,He LN,Wu LF,Chen XJ,Yan RM,Zhong M,Yu YH,Liang L,Wang W

EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317718404(2017 Jul)
Han M,Xu W

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TWIST2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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