DEFB118 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB118
Entrez Gene ID	117285
Full Name	defensin beta 118
Synonyms	C20orf63,DEFB-18,ESC42,ESP13.6
General protein information	Preferred Names defensin beta 118 Names beta-defensin 118 defensin, beta 18 epididymal secretory protein 13.6 epididymus specific clone 42
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.21
Summary	This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014].
Disorder MIM:	607650

mRNA and Protein(s)

mRNA	Protein	Name
NM_054112.3	NP_473453.1	beta-defensin 118 precursor
NM_054112.2	NP_473453.1	beta-defensin 118 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DEFB118	NP_001123238.1
Homo sapiens (human)	DEFB118	NP_473453.1
	DEFB118	NP_001032421.1

Gene Ontology
Bibliography

Related articles in PubMed

The androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin.
Yenugu S, Hamil KG, Radhakrishnan Y, French FS, Hall SH
Endocrinology145(7)3165-73(2004 Jul)

ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
Kao CY, Chen Y, Zhao YH, Wu R
American journal of respiratory cell and molecular biology29(1)71-80(2003 Jul)

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)

Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human.
Liu Q, Hamil KG, Sivashanmugam P, Grossman G, Soundararajan R, Rao AJ, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH
Endocrinology142(10)4529-39(2001 Oct)

Defensins: key players or bystanders in infection, injury, and repair in the lung?
van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS
The Journal of allergy and clinical immunology104(6)1131-8(1999 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Risk of meningioma and common variation in genes related to innate immunity.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Observational study of gene-disease association. (HuGE Navigator)
Title: Common variation in genes related to innate immunity and risk of adult glioma.

DEFB118 may contribute to epididymal innate immunity and provide antimicrobial activity against microorganisms attacking sperm in the male and female reproductive tracts.
Title: The androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin.

The following DEFB118 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB118 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05672	NM_054112.3 Latest version!	Homo sapiens defensin beta 118 (DEFB118), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu05672	NM_054112.2	Homo sapiens defensin beta 118 (DEFB118), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB118 ( NM_054112.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_473453.1 Homo sapiens defensin beta 118 (DEFB118), mRNA.

Price & Availability↑

CloneID	OHu05672
Clone ID Related Accession (Same CDS sequence)	NM_054112.3 , NM_054112.2
Accession Version	NM_054112.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	beta-defensin 118 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031650.22, BC035677.1 and AF347073.1. On May 17, 2019 this sequence version replaced NM_054112.2. ##Evidence-Data-START## Transcript exon combination :: BC035677.1, SRR5189667.351993.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253381.3/ ENSP00000253381.2 Protein has antimicrobial activity :: PMID: 15033915 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAACTCC TGCTGCTGGC TCTTCCTATG CTTGTGCTCC TACCCCAAGT GATCCCAGCC 
TATAGTGGTG AAAAAAAATG CTGGAACAGA TCAGGGCACT GCAGGAAACA ATGCAAAGAT 
GGAGAAGCAG TGAAAGATAC ATGCAAAAAT CTTCGAGCTT GCTGCATTCC ATCCAATGAA 
GACCACAGGC GAGTTCCTGC GACATCTCCC ACACCCTTGA GTGACTCAAC ACCAGGAATT 
ATTGATGATA TTTTAACAGT AAGGTTCACG ACAGACTACT TTGAAGTAAG CAGCAAGAAA 
GATATGGTTG AAGAGTCTGA GGCGGGAAGG GGAACTGAGA CCTCTCTTCC AAATGTTCAC 
CATAGCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_473453.1
CDS	51..422
Translation	MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPNVHHSS

Target ORF information:

RefSeq Version	NM_054112.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 118 (DEFB118), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054112.3

ORF Insert Sequence:

ATGAAACTCC TGCTGCTGGC TCTTCCTATG CTTGTGCTCC TACCCCAAGT GATCCCAGCC 
TATAGTGGTG AAAAAAAATG CTGGAACAGA TCAGGGCACT GCAGGAAACA ATGCAAAGAT 
GGAGAAGCAG TGAAAGATAC ATGCAAAAAT CTTCGAGCTT GCTGCATTCC ATCCAATGAA 
GACCACAGGC GAGTTCCTGC GACATCTCCC ACACCCTTGA GTGACTCAAC ACCAGGAATT 
ATTGATGATA TTTTAACAGT AAGGTTCACG ACAGACTACT TTGAAGTAAG CAGCAAGAAA 
GATATGGTTG AAGAGTCTGA GGCGGGAAGG GGAACTGAGA CCTCTCTTCC AAATGTTCAC 
CATAGCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB118 ( NM_054112.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_473453.1 Homo sapiens defensin beta 118 (DEFB118), mRNA.

Price & Availability↑

CloneID	OHu05672
Clone ID Related Accession (Same CDS sequence)	NM_054112.3 , NM_054112.2
Accession Version	NM_054112.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-08
Organism	Homo sapiens(human)
Product	beta-defensin 118 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC035677.1 and AF347073.1. On Dec 7, 2010 this sequence version replaced NM_054112.1. ##Evidence-Data-START## Transcript exon combination :: BC035677.1, AF347073.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 15033915 ##RefSeq-Attributes-END##

ATGAAACTCC TGCTGCTGGC TCTTCCTATG CTTGTGCTCC TACCCCAAGT GATCCCAGCC 
TATAGTGGTG AAAAAAAATG CTGGAACAGA TCAGGGCACT GCAGGAAACA ATGCAAAGAT 
GGAGAAGCAG TGAAAGATAC ATGCAAAAAT CTTCGAGCTT GCTGCATTCC ATCCAATGAA 
GACCACAGGC GAGTTCCTGC GACATCTCCC ACACCCTTGA GTGACTCAAC ACCAGGAATT 
ATTGATGATA TTTTAACAGT AAGGTTCACG ACAGACTACT TTGAAGTAAG CAGCAAGAAA 
GATATGGTTG AAGAGTCTGA GGCGGGAAGG GGAACTGAGA CCTCTCTTCC AAATGTTCAC 
CATAGCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_473453.1
CDS	34..405
Translation	MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPNVHHSS

Target ORF information:

RefSeq Version	NM_054112.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 118 (DEFB118), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054112.2

ORF Insert Sequence:

ATGAAACTCC TGCTGCTGGC TCTTCCTATG CTTGTGCTCC TACCCCAAGT GATCCCAGCC 
TATAGTGGTG AAAAAAAATG CTGGAACAGA TCAGGGCACT GCAGGAAACA ATGCAAAGAT 
GGAGAAGCAG TGAAAGATAC ATGCAAAAAT CTTCGAGCTT GCTGCATTCC ATCCAATGAA 
GACCACAGGC GAGTTCCTGC GACATCTCCC ACACCCTTGA GTGACTCAAC ACCAGGAATT 
ATTGATGATA TTTTAACAGT AAGGTTCACG ACAGACTACT TTGAAGTAAG CAGCAAGAAA 
GATATGGTTG AAGAGTCTGA GGCGGGAAGG GGAACTGAGA CCTCTCTTCC AAATGTTCAC 
CATAGCTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin.
Endocrinology145(7)3165-73(2004 Jul)
Yenugu S,Hamil KG,Radhakrishnan Y,French FS,Hall SH

ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
American journal of respiratory cell and molecular biology29(1)71-80(2003 Jul)
Kao CY,Chen Y,Zhao YH,Wu R

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)
Schutte BC,Mitros JP,Bartlett JA,Walters JD,Jia HP,Welsh MJ,Casavant TL,McCray PB Jr

Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human.
Endocrinology142(10)4529-39(2001 Oct)
Liu Q,Hamil KG,Sivashanmugam P,Grossman G,Soundararajan R,Rao AJ,Richardson RT,Zhang YL,O'Rand MG,Petrusz P,French FS,Hall SH

Defensins: key players or bystanders in infection, injury, and repair in the lung?
The Journal of allergy and clinical immunology104(6)1131-8(1999 Dec)
van Wetering S,Sterk PJ,Rabe KF,Hiemstra PS

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DEFB118 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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