WFIKKN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WFIKKN1
Entrez Gene ID	117166
Full Name	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Synonyms	C16orf12,RJD2,WFDC20A,WFIKKN
General protein information	Preferred Names WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Names WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 GASP-2 WAP four-disulfide core domain 20A WAP, FS, Ig, KU, and NTR-containing protein WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing protein growth and differentiation factor-associated serum protein 2 hGASP-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008].
Disorder MIM:	608021

mRNA and Protein(s)

mRNA	Protein	Name
NM_053284.3	NP_444514.1	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor
NM_053284.2	NP_444514.1	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Wfikkn1	NP_001093924.1
Bos taurus (cattle)	WFIKKN1	NP_001192725.1
Xenopus tropicalis (tropical clawed frog)	wfikkn1	XP_002932495.1
	WFIKKN1	XP_001118498.2
Canis lupus familiaris (dog)	WFIKKN1	XP_547215.4
Rattus norvegicus (Norway rat)	Wfikkn1	NP_001123248.1
Gallus gallus (chicken)	WFIKKN1	XP_426858.2
Danio rerio (zebrafish)	wfikkn1	NP_999912.1
Homo sapiens (human)	WFIKKN1	NP_444514.1

Gene Ontology
Bibliography

Related articles in PubMed

Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin.
Szl?ma G, V?s?rhelyi V, Trexler M, Patthy L
The FEBS journal283(24)4515-4527(2016 12)

WFIKKN1 and WFIKKN2: "Companion" proteins regulating TGFB activity.
Monestier O, Blanquet V
Cytokine & growth factor reviews3275-84(2016 Dec)

Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2.
Szl?ma G, Trexler M, Patthy L
The FEBS journal280(16)3822-39(2013 Aug)

WFIKKN1 and WFIKKN2 bind growth factors TGF?1, BMP2 and BMP4 but do not inhibit their signalling activity.
Szl?ma G, Kond?s K, Trexler M, Patthy L
The FEBS journal277(24)5040-50(2010 Dec)

Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.
Kond?s K, Szl?ma G, Trexler M, Patthy L
The Journal of biological chemistry283(35)23677-84(2008 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity.
Title: Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin.

In this review, we summarize current knowledge about the WFIKKN proteins and propose that they are "companion" proteins for various growth factors by providing localized and sustained presentation of TGFB proteins to their respective receptors, thus regulating the balance between the activation of Smad and non-Smad pathways by TGFB.
Title: WFIKKN1 and WFIKKN2: "Companion" proteins regulating TGFB activity.

Data suggest that myostatin binding to its receptor (activin receptors type II) can be blocked by WFIKKN1 but not WFIKKN2; various forms of myostatin (promyostatin, myostatin pro-domain, and latent/processed myostatin) bind WFIKKN1 but not WFIKKN2.
Title: Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2.

data indicate that WFIKKN proteins are antagonists of GDF8 and GDF11, but in the case of TGFbeta1, BMP2 and BMP4 they function as growth factor binding proteins
Title: WFIKKN1 and WFIKKN2 bind growth factors TGF?1, BMP2 and BMP4 but do not inhibit their signalling activity.

Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.
Title: Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.

The following WFIKKN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WFIKKN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05652	NM_053284.3 Latest version!	Homo sapiens WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 (WFIKKN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu05652	NM_053284.2	Homo sapiens WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 (WFIKKN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WFIKKN1 ( NM_053284.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_444514.1 Homo sapiens WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 (WFIKKN1), mRNA.

Price & Availability↑

CloneID	OHu05652
Clone ID Related Accession (Same CDS sequence)	NM_053284.3 , NM_053284.2
Accession Version	NM_053284.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z84479.1, CN425794.1, AF422194.1 and AK075356.1. On Nov 22, 2018 this sequence version replaced NM_053284.2. ##Evidence-Data-START## Transcript exon combination :: AK075356.1, AK314757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000319070.3/ ENSP00000324763.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCGCCC TACGTCCACT CCTGCCGCTC CTGCTCCTCC TCCGGCTGAC CTCGGGGGCT 
GGCTTGCTGC CAGGGCTGGG GAGCCACCCG GGCGTGTGCC CCAACCAGCT CAGCCCCAAC 
CTGTGGGTGG ACGCCCAGAG CACCTGTGAG CGCGAGTGTA GCAGGGACCA GGACTGTGCG 
GCTGCTGAGA AGTGCTGCAT CAACGTGTGT GGACTGCACA GCTGCGTGGC AGCACGCTTC 
CCCGGCAGCC CAGCTGCGCC GACGACAGCG GCCTCCTGCG AGGGCTTTGT GTGCCCACAG 
CAGGGCTCGG ACTGCGACAT CTGGGACGGG CAGCCCGTGT GCCGCTGCCG CGACCGCTGT 
GAGAAGGAGC CCAGCTTCAC CTGCGCCTCG GACGGCCTCA CCTACTACAA CCGCTGCTAT 
ATGGACGCCG AGGCCTGCCT GCGGGGCCTG CACCTCCACA TCGTGCCCTG CAAGCACGTG 
CTCAGCTGGC CGCCCAGCAG CCCGGGGCCG CCGGAGACCA CTGCCCGCCC CACACCTGGG 
GCCGCGCCCG TGCCTCCTGC CCTGTACAGC AGCCCCTCCC CACAGGCGGT GCAGGTTGGG 
GGTACGGCCA GCCTCCACTG CGACGTCAGC GGCCGCCCGC CGCCTGCTGT GACCTGGGAG 
AAGCAGAGTC ACCAGCGAGA GAACCTGATC ATGCGCCCTG ATCAGATGTA TGGCAACGTG 
GTGGTCACCA GCATCGGGCA GCTGGTGCTC TACAACGCGC GGCCCGAAGA CGCCGGCCTG 
TACACCTGCA CCGCGCGCAA CGCTGCTGGG CTGCTGCGGG CTGACTTCCC ACTCTCTGTG 
GTCCAGCGAG AGCCGGCCAG GGACGCAGCC CCCAGCATCC CAGCCCCGGC CGAGTGCCTG 
CCGGATGTGC AGGCCTGCAC GGGCCCCACT TCCCCACACC TTGTCCTCTG GCACTACGAC 
CCGCAGCGGG GCGGCTGCAT GACCTTCCCG GCCCGTGGCT GTGATGGGGC GGCCCGCGGC 
TTTGAGACCT ACGAGGCATG CCAGCAGGCC TGTGCCCGCG GCCCCGGCGA CGCCTGCGTG 
CTGCCTGCCG TGCAGGGCCC CTGCCGGGGC TGGGAGCCGC GCTGGGCCTA CAGCCCGCTG 
CTGCAGCAGT GCCATCCCTT CGTGTACGGT GGCTGCGAGG GCAACGGCAA CAACTTCCAC 
AGCCGCGAGA GCTGCGAGGA TGCCTGCCCC GTGCCGCGCA CACCGCCCTG CCGCGCCTGC 
CGCCTCCGGA GCAAGCTGGC GCTGAGCCTG TGCCGCAGCG ACTTCGCCAT CGTGGGGCGG 
CTCACGGAGG TGCTGGAGGA GCCCGAGGCC GCCGGCGGCA TCGCCCGCGT GGCGCTCGAG 
GACGTGCTCA AGGATGACAA GATGGGCCTC AAGTTCTTGG GCACCAAGTA CCTGGAGGTG 
ACGCTGAGTG GCATGGACTG GGCCTGCCCC TGCCCCAACA TGACGGCGGG CGACGGGCCG 
CTGGTCATCA TGGGTGAGGT GCGCGATGGC GTGGCCGTGC TGGACGCCGG CAGCTACGTC 
CGCGCCGCCA GCGAGAAGCG CGTCAAGAAG ATCTTGGAGC TGCTGGAGAA GCAGGCCTGC 
GAGCTGCTCA ACCGCTTCCA GGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444514.1
CDS	270..1916
Translation	MPALRPLLPLLLLLRLTSGAGLLPGLGSHPGVCPNQLSPNLWVDAQSTCERECSRDQDCAAAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTARPTPGAAPVPPALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPARDAAPSIPAPAECLPDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRESCEDACPVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD

Target ORF information:

RefSeq Version	NM_053284.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 (WFIKKN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053284.3

ORF Insert Sequence:

ATGCCCGCCC TACGTCCACT CCTGCCGCTC CTGCTCCTCC TCCGGCTGAC CTCGGGGGCT 
GGCTTGCTGC CAGGGCTGGG GAGCCACCCG GGCGTGTGCC CCAACCAGCT CAGCCCCAAC 
CTGTGGGTGG ACGCCCAGAG CACCTGTGAG CGCGAGTGTA GCAGGGACCA GGACTGTGCG 
GCTGCTGAGA AGTGCTGCAT CAACGTGTGT GGACTGCACA GCTGCGTGGC AGCACGCTTC 
CCCGGCAGCC CAGCTGCGCC GACGACAGCG GCCTCCTGCG AGGGCTTTGT GTGCCCACAG 
CAGGGCTCGG ACTGCGACAT CTGGGACGGG CAGCCCGTGT GCCGCTGCCG CGACCGCTGT 
GAGAAGGAGC CCAGCTTCAC CTGCGCCTCG GACGGCCTCA CCTACTACAA CCGCTGCTAT 
ATGGACGCCG AGGCCTGCCT GCGGGGCCTG CACCTCCACA TCGTGCCCTG CAAGCACGTG 
CTCAGCTGGC CGCCCAGCAG CCCGGGGCCG CCGGAGACCA CTGCCCGCCC CACACCTGGG 
GCCGCGCCCG TGCCTCCTGC CCTGTACAGC AGCCCCTCCC CACAGGCGGT GCAGGTTGGG 
GGTACGGCCA GCCTCCACTG CGACGTCAGC GGCCGCCCGC CGCCTGCTGT GACCTGGGAG 
AAGCAGAGTC ACCAGCGAGA GAACCTGATC ATGCGCCCTG ATCAGATGTA TGGCAACGTG 
GTGGTCACCA GCATCGGGCA GCTGGTGCTC TACAACGCGC GGCCCGAAGA CGCCGGCCTG 
TACACCTGCA CCGCGCGCAA CGCTGCTGGG CTGCTGCGGG CTGACTTCCC ACTCTCTGTG 
GTCCAGCGAG AGCCGGCCAG GGACGCAGCC CCCAGCATCC CAGCCCCGGC CGAGTGCCTG 
CCGGATGTGC AGGCCTGCAC GGGCCCCACT TCCCCACACC TTGTCCTCTG GCACTACGAC 
CCGCAGCGGG GCGGCTGCAT GACCTTCCCG GCCCGTGGCT GTGATGGGGC GGCCCGCGGC 
TTTGAGACCT ACGAGGCATG CCAGCAGGCC TGTGCCCGCG GCCCCGGCGA CGCCTGCGTG 
CTGCCTGCCG TGCAGGGCCC CTGCCGGGGC TGGGAGCCGC GCTGGGCCTA CAGCCCGCTG 
CTGCAGCAGT GCCATCCCTT CGTGTACGGT GGCTGCGAGG GCAACGGCAA CAACTTCCAC 
AGCCGCGAGA GCTGCGAGGA TGCCTGCCCC GTGCCGCGCA CACCGCCCTG CCGCGCCTGC 
CGCCTCCGGA GCAAGCTGGC GCTGAGCCTG TGCCGCAGCG ACTTCGCCAT CGTGGGGCGG 
CTCACGGAGG TGCTGGAGGA GCCCGAGGCC GCCGGCGGCA TCGCCCGCGT GGCGCTCGAG 
GACGTGCTCA AGGATGACAA GATGGGCCTC AAGTTCTTGG GCACCAAGTA CCTGGAGGTG 
ACGCTGAGTG GCATGGACTG GGCCTGCCCC TGCCCCAACA TGACGGCGGG CGACGGGCCG 
CTGGTCATCA TGGGTGAGGT GCGCGATGGC GTGGCCGTGC TGGACGCCGG CAGCTACGTC 
CGCGCCGCCA GCGAGAAGCG CGTCAAGAAG ATCTTGGAGC TGCTGGAGAA GCAGGCCTGC 
GAGCTGCTCA ACCGCTTCCA GGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFIKKN1 ( NM_053284.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_444514.1 Homo sapiens WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 (WFIKKN1), mRNA.

Price & Availability↑

CloneID	OHu05652
Clone ID Related Accession (Same CDS sequence)	NM_053284.3 , NM_053284.2
Accession Version	NM_053284.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN425794.1, AF422194.1 and AK075356.1. On Sep 3, 2004 this sequence version replaced NM_053284.1. ##Evidence-Data-START## Transcript exon combination :: AK075356.1, AK314757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGCCC TACGTCCACT CCTGCCGCTC CTGCTCCTCC TCCGGCTGAC CTCGGGGGCT 
GGCTTGCTGC CAGGGCTGGG GAGCCACCCG GGCGTGTGCC CCAACCAGCT CAGCCCCAAC 
CTGTGGGTGG ACGCCCAGAG CACCTGTGAG CGCGAGTGTA GCAGGGACCA GGACTGTGCG 
GCTGCTGAGA AGTGCTGCAT CAACGTGTGT GGACTGCACA GCTGCGTGGC AGCACGCTTC 
CCCGGCAGCC CAGCTGCGCC GACGACAGCG GCCTCCTGCG AGGGCTTTGT GTGCCCACAG 
CAGGGCTCGG ACTGCGACAT CTGGGACGGG CAGCCCGTGT GCCGCTGCCG CGACCGCTGT 
GAGAAGGAGC CCAGCTTCAC CTGCGCCTCG GACGGCCTCA CCTACTACAA CCGCTGCTAT 
ATGGACGCCG AGGCCTGCCT GCGGGGCCTG CACCTCCACA TCGTGCCCTG CAAGCACGTG 
CTCAGCTGGC CGCCCAGCAG CCCGGGGCCG CCGGAGACCA CTGCCCGCCC CACACCTGGG 
GCCGCGCCCG TGCCTCCTGC CCTGTACAGC AGCCCCTCCC CACAGGCGGT GCAGGTTGGG 
GGTACGGCCA GCCTCCACTG CGACGTCAGC GGCCGCCCGC CGCCTGCTGT GACCTGGGAG 
AAGCAGAGTC ACCAGCGAGA GAACCTGATC ATGCGCCCTG ATCAGATGTA TGGCAACGTG 
GTGGTCACCA GCATCGGGCA GCTGGTGCTC TACAACGCGC GGCCCGAAGA CGCCGGCCTG 
TACACCTGCA CCGCGCGCAA CGCTGCTGGG CTGCTGCGGG CTGACTTCCC ACTCTCTGTG 
GTCCAGCGAG AGCCGGCCAG GGACGCAGCC CCCAGCATCC CAGCCCCGGC CGAGTGCCTG 
CCGGATGTGC AGGCCTGCAC GGGCCCCACT TCCCCACACC TTGTCCTCTG GCACTACGAC 
CCGCAGCGGG GCGGCTGCAT GACCTTCCCG GCCCGTGGCT GTGATGGGGC GGCCCGCGGC 
TTTGAGACCT ACGAGGCATG CCAGCAGGCC TGTGCCCGCG GCCCCGGCGA CGCCTGCGTG 
CTGCCTGCCG TGCAGGGCCC CTGCCGGGGC TGGGAGCCGC GCTGGGCCTA CAGCCCGCTG 
CTGCAGCAGT GCCATCCCTT CGTGTACGGT GGCTGCGAGG GCAACGGCAA CAACTTCCAC 
AGCCGCGAGA GCTGCGAGGA TGCCTGCCCC GTGCCGCGCA CACCGCCCTG CCGCGCCTGC 
CGCCTCCGGA GCAAGCTGGC GCTGAGCCTG TGCCGCAGCG ACTTCGCCAT CGTGGGGCGG 
CTCACGGAGG TGCTGGAGGA GCCCGAGGCC GCCGGCGGCA TCGCCCGCGT GGCGCTCGAG 
GACGTGCTCA AGGATGACAA GATGGGCCTC AAGTTCTTGG GCACCAAGTA CCTGGAGGTG 
ACGCTGAGTG GCATGGACTG GGCCTGCCCC TGCCCCAACA TGACGGCGGG CGACGGGCCG 
CTGGTCATCA TGGGTGAGGT GCGCGATGGC GTGGCCGTGC TGGACGCCGG CAGCTACGTC 
CGCGCCGCCA GCGAGAAGCG CGTCAAGAAG ATCTTGGAGC TGCTGGAGAA GCAGGCCTGC 
GAGCTGCTCA ACCGCTTCCA GGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444514.1
CDS	243..1889
Translation	MPALRPLLPLLLLLRLTSGAGLLPGLGSHPGVCPNQLSPNLWVDAQSTCERECSRDQDCAAAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTARPTPGAAPVPPALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPARDAAPSIPAPAECLPDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRESCEDACPVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD

Target ORF information:

RefSeq Version	NM_053284.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 (WFIKKN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053284.2

ORF Insert Sequence:

ATGCCCGCCC TACGTCCACT CCTGCCGCTC CTGCTCCTCC TCCGGCTGAC CTCGGGGGCT 
GGCTTGCTGC CAGGGCTGGG GAGCCACCCG GGCGTGTGCC CCAACCAGCT CAGCCCCAAC 
CTGTGGGTGG ACGCCCAGAG CACCTGTGAG CGCGAGTGTA GCAGGGACCA GGACTGTGCG 
GCTGCTGAGA AGTGCTGCAT CAACGTGTGT GGACTGCACA GCTGCGTGGC AGCACGCTTC 
CCCGGCAGCC CAGCTGCGCC GACGACAGCG GCCTCCTGCG AGGGCTTTGT GTGCCCACAG 
CAGGGCTCGG ACTGCGACAT CTGGGACGGG CAGCCCGTGT GCCGCTGCCG CGACCGCTGT 
GAGAAGGAGC CCAGCTTCAC CTGCGCCTCG GACGGCCTCA CCTACTACAA CCGCTGCTAT 
ATGGACGCCG AGGCCTGCCT GCGGGGCCTG CACCTCCACA TCGTGCCCTG CAAGCACGTG 
CTCAGCTGGC CGCCCAGCAG CCCGGGGCCG CCGGAGACCA CTGCCCGCCC CACACCTGGG 
GCCGCGCCCG TGCCTCCTGC CCTGTACAGC AGCCCCTCCC CACAGGCGGT GCAGGTTGGG 
GGTACGGCCA GCCTCCACTG CGACGTCAGC GGCCGCCCGC CGCCTGCTGT GACCTGGGAG 
AAGCAGAGTC ACCAGCGAGA GAACCTGATC ATGCGCCCTG ATCAGATGTA TGGCAACGTG 
GTGGTCACCA GCATCGGGCA GCTGGTGCTC TACAACGCGC GGCCCGAAGA CGCCGGCCTG 
TACACCTGCA CCGCGCGCAA CGCTGCTGGG CTGCTGCGGG CTGACTTCCC ACTCTCTGTG 
GTCCAGCGAG AGCCGGCCAG GGACGCAGCC CCCAGCATCC CAGCCCCGGC CGAGTGCCTG 
CCGGATGTGC AGGCCTGCAC GGGCCCCACT TCCCCACACC TTGTCCTCTG GCACTACGAC 
CCGCAGCGGG GCGGCTGCAT GACCTTCCCG GCCCGTGGCT GTGATGGGGC GGCCCGCGGC 
TTTGAGACCT ACGAGGCATG CCAGCAGGCC TGTGCCCGCG GCCCCGGCGA CGCCTGCGTG 
CTGCCTGCCG TGCAGGGCCC CTGCCGGGGC TGGGAGCCGC GCTGGGCCTA CAGCCCGCTG 
CTGCAGCAGT GCCATCCCTT CGTGTACGGT GGCTGCGAGG GCAACGGCAA CAACTTCCAC 
AGCCGCGAGA GCTGCGAGGA TGCCTGCCCC GTGCCGCGCA CACCGCCCTG CCGCGCCTGC 
CGCCTCCGGA GCAAGCTGGC GCTGAGCCTG TGCCGCAGCG ACTTCGCCAT CGTGGGGCGG 
CTCACGGAGG TGCTGGAGGA GCCCGAGGCC GCCGGCGGCA TCGCCCGCGT GGCGCTCGAG 
GACGTGCTCA AGGATGACAA GATGGGCCTC AAGTTCTTGG GCACCAAGTA CCTGGAGGTG 
ACGCTGAGTG GCATGGACTG GGCCTGCCCC TGCCCCAACA TGACGGCGGG CGACGGGCCG 
CTGGTCATCA TGGGTGAGGT GCGCGATGGC GTGGCCGTGC TGGACGCCGG CAGCTACGTC 
CGCGCCGCCA GCGAGAAGCG CGTCAAGAAG ATCTTGGAGC TGCTGGAGAA GCAGGCCTGC 
GAGCTGCTCA ACCGCTTCCA GGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin.
The FEBS journal283(24)4515-4527(2016 12)
Szl?ma G,V?s?rhelyi V,Trexler M,Patthy L

WFIKKN1 and WFIKKN2: "Companion" proteins regulating TGFB activity.
Cytokine & growth factor reviews3275-84(2016 Dec)
Monestier O,Blanquet V

Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2.
The FEBS journal280(16)3822-39(2013 Aug)
Szl?ma G,Trexler M,Patthy L

WFIKKN1 and WFIKKN2 bind growth factors TGF?1, BMP2 and BMP4 but do not inhibit their signalling activity.
The FEBS journal277(24)5040-50(2010 Dec)
Szl?ma G,Kond?s K,Trexler M,Patthy L

Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.
The Journal of biological chemistry283(35)23677-84(2008 Aug)
Kond?s K,Szl?ma G,Trexler M,Patthy L

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

WFIKKN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報