DCD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DCD
Entrez Gene ID	117159
Full Name	dermcidin
Synonyms	AIDD,DCD-1,DSEP,HCAP,PIF
General protein information	Preferred Names dermcidin Names dermcidin diffusible survival/evasion peptide preproteolysin proteolysis inducing factor survival promoting peptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.2
Summary	This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Disorder MIM:	606634

mRNA and Protein(s)

mRNA	Protein	Name
NM_053283.3	NP_444513.1	dermcidin isoform 1 preproprotein
NM_001300854.2	NP_001287783.1	dermcidin isoform 2 preproprotein
NM_001300854.1	NP_001287783.1	dermcidin isoform 2 preproprotein
NM_053283.4	NP_444513.1	dermcidin isoform 1 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	DCD	NP_444513.1
Pan troglodytes (chimpanzee)	DCD	XP_001170688.1
	LOC704163	XP_001092492.2

Gene Ontology
Bibliography

Related articles in PubMed

Expression of dermcidin in human sinonasal secretions.
Cottrill EE, Chen B, Adappa ND, Palmer JN, Kennedy DW, Lee RJ, Cohen NA
International forum of allergy & rhinology7(2)154-159(2017 02)

PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease.
Kang S, Jeong H, Baek JH, Lee SJ, Han SH, Cho HJ, Kim H, Hong HS, Kim YH, Yi EC, Seo SW, Na DL, Hwang D, Mook-Jung I
Journal of Alzheimer's disease : JAD53(4)1563-76(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the first report of the presence of DCD in nasal mucosa and demonstration of DCD in clinical samples of human nasal secretions at clinically relevant concentrations, which may represent a novel arm of sinonasal airway innate defense.
Title: Expression of dermcidin in human sinonasal secretions.

this study shows that PIF regulates systemic immunity and targets protective regulatory and cytoskeleton proteins
Title: PreImplantation factor (PIF*) regulates systemic immunity and targets protective regulatory and cytoskeleton proteins.

Identification of dermcidin in human sebaceous gland cells supports the concept that sebocytes play an important role in the innate immunity of the skin through the expression of antimicrobial peptides and specific lipids.
Title: Expression of dermcidin in sebocytes supports a role for sebum in the constitutive innate defense of human skin.

Reduced DCD concentration in sweat in patients with inflammatory acne may permit proliferation of P. acnes in pilosebaceous units, resulting in progression of inflammatory acne.
Title: Reduced expression of dermcidin, a peptide active against propionibacterium acnes, in sweat of patients with acne vulgaris.

These findings imply that DCD promotes breast tumorigenesis via modulation of ERBB signaling pathways
Title: Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling.

The following DCD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DCD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30172	NM_053283.4 Latest version!	Homo sapiens dermcidin (DCD), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu46301	NM_001300854.2 Latest version!	Homo sapiens dermcidin (DCD), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu46301	NM_001300854.1	Homo sapiens dermcidin (DCD), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu30172	NM_053283.3	Homo sapiens dermcidin (DCD), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DCD ( NM_053283.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_444513.1 Homo sapiens dermcidin (DCD), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30172
Clone ID Related Accession (Same CDS sequence)	NM_053283.3 , NM_053283.4
Accession Version	NM_053283.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	dermcidin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EF503687.1 and AC079310.20. On Jul 15, 2014 this sequence version replaced NM_053283.2. Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 2. The encoded isoform (1) has a distinct C-terminus , and is shorter, compared to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF503687.1, BC062682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895, SAMN02400288 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 11694882 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG AGCCGTCCAT 
GACGTTAAAG ACGTCCTTGA CTCAGTACTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444513.1
CDS	191..523
Translation	MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL

Target ORF information:

RefSeq Version	NM_053283.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dermcidin (DCD), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053283.3

ORF Insert Sequence:

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG AGCCGTCCAT 
GACGTTAAAG ACGTCCTTGA CTCAGTACTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCD ( NM_053283.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_444513.1 Homo sapiens dermcidin (DCD), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30172
Clone ID Related Accession (Same CDS sequence)	NM_053283.3 , NM_053283.4
Accession Version	NM_053283.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	dermcidin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EF503687.1 and AC079310.20. On May 17, 2019 this sequence version replaced NM_053283.3. Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 2. The encoded isoform (1) has a distinct C-terminus , and is shorter, compared to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL598959.1, CD000439.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162895, SAMN02400288 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000293371.11/ ENSP00000293371.6 Protein has antimicrobial activity :: PMID: 11694882 RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG AGCCGTCCAT 
GACGTTAAAG ACGTCCTTGA CTCAGTACTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444513.1
CDS	63..395
Translation	MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL

Target ORF information:

RefSeq Version	NM_053283.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dermcidin (DCD), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053283.4

ORF Insert Sequence:

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG AGCCGTCCAT 
GACGTTAAAG ACGTCCTTGA CTCAGTACTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCD ( NM_001300854.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287783.1 Homo sapiens dermcidin (DCD), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu46301
Clone ID Related Accession (Same CDS sequence)	NM_001300854.2 , NM_001300854.1
Accession Version	NM_001300854.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	dermcidin isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EF503689.1 and AC079310.20. On May 31, 2019 this sequence version replaced NM_001300854.1. Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF503689.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN02400289 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG TGGGGAAGAG 
AGGTTGGTCT TTGGGGCTCC TGTGAATCTA ACCTCCATCC CTCTGACTTC TGTGAGCCGT 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287783.1
CDS	63..428
Translation	MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGGEERLVFGAPVNLTSIPLTSVSRP

Target ORF information:

RefSeq Version	NM_001300854.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dermcidin (DCD), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300854.2

ORF Insert Sequence:

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG TGGGGAAGAG 
AGGTTGGTCT TTGGGGCTCC TGTGAATCTA ACCTCCATCC CTCTGACTTC TGTGAGCCGT 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCD ( NM_001300854.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287783.1 Homo sapiens dermcidin (DCD), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu46301
Clone ID Related Accession (Same CDS sequence)	NM_001300854.2 , NM_001300854.1
Accession Version	NM_001300854.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	dermcidin isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EF503689.1 and AC079310.20. On Jul 16, 2014 this sequence version replaced XM_005268627.1. Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF503689.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN02400289 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG TGGGGAAGAG 
AGGTTGGTCT TTGGGGCTCC TGTGAATCTA ACCTCCATCC CTCTGACTTC TGTGAGCCGT 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287783.1
CDS	191..556
Translation	MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGGEERLVFGAPVNLTSIPLTSVSRP

Target ORF information:

RefSeq Version	NM_001300854.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dermcidin (DCD), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300854.1

ORF Insert Sequence:

ATGAGGTTCA TGACTCTCCT CTTCCTGACA GCTCTGGCAG GAGCCCTGGT CTGTGCCTAT 
GATCCAGAGG CCGCCTCTGC CCCAGGATCG GGGAACCCTT GCCATGAAGC ATCAGCAGCT 
CAAAAGGAAA ATGCAGGTGA AGACCCAGGG TTAGCCAGAC AGGCACCAAA GCCAAGGAAG 
CAGAGATCCA GCCTTCTGGA AAAAGGCCTA GACGGAGCAA AAAAAGCTGT GGGGGGACTC 
GGAAAACTAG GAAAAGATGC AGTCGAAGAT CTAGAAAGCG TGGGTAAAGG TGGGGAAGAG 
AGGTTGGTCT TTGGGGCTCC TGTGAATCTA ACCTCCATCC CTCTGACTTC TGTGAGCCGT 
CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of dermcidin in human sinonasal secretions.
International forum of allergy & rhinology7(2)154-159(2017 02)
Cottrill EE,Chen B,Adappa ND,Palmer JN,Kennedy DW,Lee RJ,Cohen NA

PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease.
Journal of Alzheimer's disease : JAD53(4)1563-76(2016 Jul)
Kang S,Jeong H,Baek JH,Lee SJ,Han SH,Cho HJ,Kim H,Hong HS,Kim YH,Yi EC,Seo SW,Na DL,Hwang D,Mook-Jung I

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DCD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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